Klinische Forschung
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Publications Kyburz Diego

Comparison of drug retention of TNF inhibitors, other biologics and JAK inhibitors in RA patients who discontinued JAK inhibitor therapy.

Amstad A; Papagiannoulis E; Scherer A; Rubbert-Roth A; Finckh A; Mueller R; Dudler J; Möller B; Villiger PM; Schulz MMP; Kyburz D. Rheumatology (United Kingdom). 2022.

Current differentiation between radiographic and non-radiographic axial spondyloarthritis is of limited benefit for prediction of important clinical outcomes: data from a large, prospective, observational cohort.

Ciurea A; Kissling S; Bürki K; Baraliakos X; de Hooge M; Hebeisen M; Papagiannoulis E; Exer P; Bräm R; Nissen MJ; Möller B; Kyburz D; Andor M; Distler O; Scherer A; Micheroli R. RMD open. 2022.

Discontinuation of biologic DMARDs in a real-world population of patients with rheumatoid arthritis in remission: outcome and risk factors

Arnold S.; Jaeger V.K.; Scherer A.; Ciurea A.; Walker U.A.; Kyburz D.. Rheumatology (United Kingdom). 2022.

IgA rheumatoid factor in rheumatoid arthritis.

Van Hoovels L; Vander Cruyssen B; Sieghart D; Bonroy C; Nagy E; Pullerits R; Čučnik S; Dahle C; Heijnen I; Bernasconi L; Benkhadra F; Bogaert L; Van Den Bremt S; Van Liedekerke A; Vanheule G; Robbrecht J; Studholme L; Wirth C; Müller R; Kyburz D; Sjöwall C; Kastbom A; Ješe R; Jovancevic B; Kiss E; Jacques P; Aletaha D; Steiner G; Verschueren P; Bossuyt X. Clinical Chemistry and Laboratory Medicine. 2022.

Multicentre study to improve clinical interpretation of rheumatoid factor and anti-citrullinated protein/peptide antibodies test results.

Van Hoovels L; Vander Cruyssen B; Sieghart D; Bonroy C; Nagy E; Pullerits R; Čučnik S; Dahle C; Heijnen I; Bernasconi L; Benkhadra F; Bogaert L; Van Den Bremt S; Van Liedekerke A; Vanheule G; Robbrecht J; Studholme L; Wirth C; Müller R; Kyburz D; Sjöwall C; Kastbom A; Ješe R; Jovancevic B; Kiss E; Jacques P; Aletaha D; Steiner G; Verschueren P; Bossuyt X. RMD open. 2022.

Nonhematopoietic IRAK1 drives arthritis via neutrophil chemoattractants.

Hoyler T; Bannert B; André C; Beck D; Boulay T; Buffet D; Caesar N; Calzascia T; Dawson J; Kyburz D; Hennze R; Huppertz C; Littlewood-Evans A; Loetscher P; Mertz KD; Niwa S; Robert G; Rush JS; Ruzzante G; Sarret S; Stein T; Touil I; Wieczorek G; Zipfel G; Hawtin S; Junt T. JCI Insight. 2022.

Reversed Halo Sign on Chest Computed Tomography in a 33-Year-Old Man Without Immunosuppression.

Dräger S; Jahn K; Vogt M; Hopfer H; Kyburz D; Osthoff M. The American journal of medicine. 2022.

Skeletal Muscle Disorders: A Noncardiac Source of Cardiac Troponin T.

du Fay de Lavallaz J; Prepoudis A; Wendebourg MJ; Kesenheimer E; Kyburz D; Daikeler T; Haaf P; Wanschitz J; Löscher WN; Schreiner B; Katan M; Jung HH; Maurer B; Hammerer-Lercher A; Mayr A; Gualandro DM; Acket A; Puelacher C; Boeddinghaus J; Nestelberger T; Lopez-Ayala P; Glarner N; Shrestha S; Manka R; Gawinecka J; Piscuoglio S; Gallon J; Wiedemann S; Sinnreich M; Mueller C; BASEL XII Investigators. Circulation. 2022.

Standardisation of ACPA tests: evaluation of a new candidate reference preparation.

Van Hoovels L; Studholme L; Vander Cruyssen B; Sieghart D; Bonroy C; Nagy E; Pullerits R; Čučnik S; Dahle C; Heijnen I; Bernasconi L; Benkhadra F; Bogaert L; Van Den Bremt S; Van Liedekerke A; Vanheule G; Robbrecht J; Wirth C; Müller R; Kyburz D; Sjöwall C; Kastbom A; Ješe R; Jovancevic B; Kiss E; Jacques P; Aletaha D; Steiner G; Verschueren P; Bossuyt X. Annals of the Rheumatic Diseases. 2022.

Subclinical giant cell arteritis in new onset polymyalgia rheumatica A systematic review and meta-analysis of individual patient data.

Hemmig AK; Gozzoli D; Werlen L; Ewald H; Aschwanden M; Blockmans D; Brouwer E; Buchanan RRC; Camellino D; Campochiaro C; Cimmino MA; Corominas H; Gloy V; Henckaerts L; Kyburz D; Moya-Alvarado P; Owen CE; Stegert M; Tomelleri A; van Sleen Y; Yamashita H; Imfeld S; Berger CT; Hemkens LG; Daikeler T. Seminars in arthritis and rheumatism. 2022.

The role of C5a-C5aR1 axis in bone pathophysiology: A mini-review.

Ruocco A; Sirico A; Novelli R; Iannelli S; Van Breda SV; Kyburz D; Hasler P; Aramini A; Amendola PG. Frontiers in Cell and Developmental Biology. 2022.

[CME Rheumatology 24: DISH of the Hand and Undifferentiated Polyarthritis].

Tamborrini G; Kyburz D; Studler U. Praxis. 2021.

[CME Rheumatology 24/Answers: DISH of the Hand and Undifferentiated Polyarthritis].

Tamborrini G; Kyburz D; Studler U. Praxis. 2021.

Bilateral proximal hamstring muscle avulsion after treatment with immune checkpoint inhibitors and corticosteroids.

Frei N; Caobelli F; Kyburz D. Swiss medical weekly. 2021.

Circulating mitochondrial DNA copy numbers represent a sensitive marker for diagnosis and monitoring of disease activity in systemic lupus erythematosus.

Giaglis S; Daoudlarian D; Voll RE; Kyburz D; Venhoff N; Walker UA. RMD open. 2021.

Cohort profile: SCREEN-RA: design, methods and perspectives of a Swiss cohort study of first-degree relatives of patients with rheumatoid arthritis.

Gilbert BTP; Lamacchia C; Mongin D; Lauper K; Trunk E; Studer O; Courvoisier DS; Rubbert-Roth A; Kyburz D; Moeller B; Finckh A. BMJ Open. 2021.

Impact of the COVID-19 pandemic on the disease course of patients with inflammatory rheumatic diseases: results from the Swiss Clinical Quality Management cohort.

Ciurea A; Papagiannoulis E; Bürki K; von Loga I; Micheroli R; Möller B; Rubbert-Roth A; Andor M; Bräm R; Müller A; Dan D; Kyburz D; Distler O; Scherer A; Finckh A. Annals of the Rheumatic Diseases. 2021.

Prediction of sustained biologic and targeted synthetic DMARD-free remission in rheumatoid arthritis patients.

Burkard T; Williams RD; Vallejo-Yagüe E; Hügle T; Finckh A; Kyburz D; Burden AM. Rheumatology advances in practice. 2021.

Assessment of the anti-CD40 antibody iscalimab in patients with primary Sjögren's syndrome: a multicentre, randomised, double-blind, placebo-controlled, proof-of-concept study

Fisher B.A.; Szanto A.; Ng W.-F.; Bombardieri M.; Posch M.G.; Papas A.S.; Farag A.M.; Daikeler T.; Bannert B.; Kyburz D.; Kivitz A.J.; Carsons S.E.; Isenberg D.A.; Barone F.; Bowman S.J.; Espie P.; Floch D.; Dupuy C.; Ren X.; Faerber P.M.; Wright A.M.; Hockey H.-U.; Rotte M.; Milojevic J.; Avrameas A.; Valentin M.-A.; Rush J.S.; Gergely P.. The Lancet Rheumatology. 2020.

Comparative effectiveness of antitumour necrosis factor agents, biologics with an alternative mode of action and tofacitinib in an observational cohort of patients with rheumatoid arthritis in Switzerland.

Finckh A; Tellenbach C; Herzog L; Scherer A; Moeller B; Ciurea A; von Muehlenen I; Gabay C; Kyburz D; Brulhart L; Müller R; Hasler P; Zufferey P; physicians and patients of the SCQM. RMD open. 2020.

Effectiveness of secukinumab versus an alternative TNF inhibitor in patients with axial spondyloarthritis previously exposed to TNF inhibitors in the Swiss Clinical Quality Management cohort.

Micheroli R; Tellenbach C; Scherer A; Bürki K; Niederman K; Nissen MJ; Zufferey P; Exer P; Möller B; Kyburz D; Ciurea A. Annals of the Rheumatic Diseases. 2020.

High-intensity interval training modulates retinal microvascular phenotype and DNA methylation of p66Shc gene: a randomized controlled trial (EXAMIN AGE).

Streese L; Khan AW; Deiseroth A; Hussain S; Suades R; Tiaden A; Kyburz D; Cosentino F; Hanssen H. European Heart Journal. 2020.

Mild Course of COVID-19 and Spontaneous Virus Clearance in a Patient With Depleted Peripheral Blood B Cells Due to Rituximab Treatment

Fallet B.; Kyburz D.; Walker U.A.. Arthritis and Rheumatology. 2020.

Physical activity may drive healthy microvascular ageing via downregulation of p66(Shc).

Streese L; Khan AW; Deiseroth A; Hussain S; Suades R; Tiaden A; Kyburz D; Hanssen H; Cosentino F. European Journal of Preventive Cardiology. 2020.

Rheumatoid cervical pannus: feasibility of volume and perfusion quantification using dynamic contrast enhanced time resolved MRI.

Fasler DA; Ingrisch M; Nanz D; Weckbach S; Kyburz D; Fischer DR; Guggenberger R; Andreisek G. Acta radiologica (Stockholm, Sweden : 1987). 2020.

Brief Report: Influence of Disease Activity in Rheumatoid Arthritis on Radiographic Progression of Concomitant Interphalangeal Joint Osteoarthritis.

Lechtenboehmer CA; Jaeger VK; Kyburz D; Walker UA; Hügle T. Arthritis and Rheumatology. 2019.

Differential effects of specific cathepsin S inhibition in biocompartments from patients with primary Sjögren syndrome.

Hargreaves P; Daoudlarian D; Theron M; Kolb FA; Manchester Young M; Reis B; Tiaden A; Bannert B; Kyburz D; Manigold T. Arthritis Research and Therapy. 2019.

miR-221-3p Drives the Shift of M2-Macrophages to a Pro-Inflammatory Function by Suppressing JAK3/STAT3 Activation.

Quero L; Tiaden AN; Hanser E; Roux J; Laski A; Hall J; Kyburz D. Frontiers in Immunology. 2019.

Safety and immunogenicity of tetanus/diphtheria vaccination in patients with rheumatic diseases-a prospective multi-centre cohort study.

Bühler S; Jaeger VK; Adler S; Bannert B; Brümmerhoff C; Ciurea A; Distler O; Franz J; Gabay C; Hagenbuch N; Herzog C; Hasler P; Kling K; Kyburz D; Müller R; Nissen MJ; Siegrist CA; Villiger PM; Walker UA; Hatz C. Rheumatology (United Kingdom). 2019.

The links of hepcidin and erythropoietin in the interplay of inflammation and iron deficiency in a large observational study of rheumatoid arthritis.

Scholz GA; Leichtle AB; Scherer A; Arndt U; Fiedler M; Aeberli D; Finckh A; Gabay C; Kyburz D; Villiger PM; Möller B. British Journal of Haematology. 2019.

The target uric acid level in multimorbid patients with gout is difficult to achieve: data from a longitudinal Swiss single-centre cohort.

Ankli B; Berger CT; Haeni N; Kyburz D; Hügle T; So AK; Daikeler T. Swiss medical weekly. 2019.

[18F]FDG positron emission tomography in patients presenting with suspicion of giant cell arteritis-lessons from a vasculitis clinic.

Imfeld S; Rottenburger C; Schegk E; Aschwanden M; Juengling F; Staub D; Recher M; Kyburz D; Berger CT; Daikeler T. European heart journal. Cardiovascular Imaging. 2018.

[S3 guidelines on treatment of polymyalgia rheumatica : Evidence-based guidelines of the German Society of Rheumatology (DGRh), the Austrian Society of Rheumatology and Rehabilitation (ÖGR) and the Swiss Society of Rheumatology (SGT) and participating medical scientific specialist societies and other organizations].

Buttgereit F; DGRh; Brabant T; DGG; Dinges H; DGOOC; Hiemer I; Rheuma-Liga; Kaplani M; DGIM; Kiltz U; Kyburz D; SGR; Reißhauer A; DGPMR; Schneider M; Weseloh C; Dejaco C; ÖGR. Zeitschrift fur Rheumatologie. 2018.

Calcium pyrophosphate deposition disease: a frequent finding in patients with long-standing erosive gout.

Ankli B; Kyburz D; Hirschmann A; Hügle T; Manigold T; Berger CT; Daikeler T. SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2018.

Retinal Vessel Diameters and Physical Activity in Patients With Mild to Moderate Rheumatic Disease Without Cardiovascular Comorbidities.

Deiseroth A; Marcin T; Berger C; Infanger D; Schäfer J; Bannert B; Schmidt-Trucksäss A; Voll RE; Kyburz D; Hanssen H. Frontiers in Physiology. 2018.

[CME Rheumatology 13: Shoulder Pain, Muscle Weakness and Skin Rash].

Tamborrini G; Kyburz D. Praxis. 2017.

[CME Rheumatology 13/Solution: Shoulder Pain, Muscle Weakness and Skin Rash].

Tamborrini G; Kyburz D. Praxis. 2017.

Disease activity dynamics in rheumatoid arthritis: patients' self-assessment of disease activity via WebApp.

Walker UA; Mueller RB; Jaeger VK; Theiler R; Forster A; Dufner P; Ganz F; Kyburz D. Rheumatology (United Kingdom). 2017.

Female hormonal factors and the development of anti-citrullinated protein antibodies in women at risk of rheumatoid arthritis.

Alpizar-Rodriguez D; Mueller RB; Möller B; Dudler J; Ciurea A; Zufferey P; Kyburz D; Walker UA; von Mühlenen I; Roux-Lombard P; Mahler M; Lamacchia C; Courvoisier DS; Gabay C; Finckh A. Rheumatology (United Kingdom). 2017.

Impact of tofacitinib treatment on human B-cells in vitro and in vivo.

Rizzi M; Lorenzetti R; Fischer K; Staniek J; Janowska I; Troilo A; Strohmeier V; Erlacher M; Kunze M; Bannert B; Kyburz D; Voll RE; Venhoff N; Thiel J. Journal of Autoimmunity. 2017.

The prevalence of anticitrullinated protein antibodies increases with age in healthy individuals at risk for rheumatoid arthritis.

Alpizar-Rodriguez D; Brulhart L; Mueller RB; Möller B; Dudler J; Ciurea A; Walker UA; Von Mühlenen I; Kyburz D; Zufferey P; Mahler M; Bas S; Gascon D; Lamacchia C; Roux-Lombard P; Lauper K; Nissen MJ; Courvoisier DS; Gabay C; Finckh A. Clinical rheumatology. 2017.

TLR2 stimulation impairs anti-inflammatory activity of M2-like macrophages, generating a chimeric M1/M2 phenotype.

Quero L; Hanser E; Manigold T; Tiaden AN; Kyburz D. Arthritis Research and Therapy. 2017.

Effect of rituximab on pulmonary function in patients with rheumatoid arthritis.

Franzen D; Ciurea A; Bratton DJ; Clarenbach CF; Latshang TD; Russi EW; Kyburz D; Kohler M. Pulmonary pharmacology & therapeutics. 2016.

Gouty Arthritis of the Atlantodental Joint.

Manigold T; Hirschmann A; Kybur D; Daikeler T; Ankli B; Büttner F. Arthritis and Rheumatology. 2016.

Correlation of findings in clinical and high resolution ultrasonography examinations of the painful shoulder.

Micheroli R; Kyburz D; Ciurea A; Dubs B; Toniolo M; Bisig SP; Tamborrini G. Journal of ultrasonography. 2015.

New and emerging roles of small RNAs in neurodegeneration, muscle, cardiovascular and inflammatory diseases.

Hruska-Plochan M; Li B; Kyburz D; Krützfeld J; Landmesser U; Aguzzi A; Polymenidou M. Swiss medical weekly. 2015.

The dermatologists' role in managing psoriatic arthritis: results of a Swiss Delphi exercise intended to improve collaboration with rheumatologists.

Boehncke WH; Anliker MD; Conrad C; Dudler J; Hasler F; Hasler P; Häusermann P; Kyburz D; Laffitte E; Michel BA; Möller B; Navarini AA; Villiger PM; Yawalkar N; Gabay C. Dermatology. 2015.

Vaccination recommendations for adult patients with autoimmune inflammatory rheumatic diseases.

Bühler S; Eperon G; Ribi C; Kyburz D; van Gompel F; Visser LG; Siegrist CA; Hatz C. Swiss medical weekly. 2015.

Biological agents in monotherapy for the treatment of rheumatoid arthritis.

Gabay C; Hasler P; Kyburz D; So A; Villiger P; von Kempis J; Walker U. Swiss medical weekly. 2014.

Epigenetic changes: the missing link.


Methotrexate in chronic-recurrent calcium pyrophosphate deposition disease: no significant effect in a randomized crossover trial

Finckh, Axel; Mc Carthy, Geraldine M.; Madigan, Anne; Van Linthoudt, Daniel; Weber, Marcel; Neto, David; Rappoport, Georges; Blumhardt, Sandra; Kyburz, Diego; Guerne, Pierre-Andre. Arthritis Research and Therapy. 2014.

SIRT6 regulates the cigarette smoke-induced signalling in rheumatoid arthritis synovial fibroblasts.

Engler A; Niederer F; Klein K; Gay RE; Kyburz D; Camici GG; Gay S; Ospelt C. Journal of molecular medicine (Berlin, Germany). 2014.

BAFF levels in patients with ankylosing spondylitis and response to anti-tumor necrosis factor treatment.

Niederer F; Scherer A; Kyburz D; Gay RE; Gay S; Michel BA; Ciurea A. Joint bone spine. 2013.

Infection risk after orthopedic surgery in patients with inflammatory rheumatic diseases treated with immunosuppressive drugs.

Scherrer CB; Mannion AF; Kyburz D; Vogt M; Kramers-de Quervain IA. ARTHRITIS CARE & RESEARCH. 2013.

Long-term survival of GSB III elbow prostheses and risk factors for revisions.

Schöni M; Drerup S; Angst F; Kyburz D; Simmen BR; Goldhahn J. Archives of Orthopaedic and Trauma Surgery. 2013.

Nicotinamide phosphoribosyltransferase/visfatin expression by inflammatory monocytes mediates arthritis pathogenesis.

Présumey J; Courties G; Louis-Plence P; Escriou V; Scherman D; Pers YM; Yssel H; Pène J; Kyburz D; Gay S; Jorgensen C; Apparailly F. Annals of the Rheumatic Diseases. 2013.

Recommendations for the use of ultrasound in rheumatoid arthritis: literature review and SONAR score experience.

Zufferey P; Tamborrini G; Gabay C; Krebs A; Kyburz D; Michel B; Moser U; Villiger PM; So A; Ziswiler HR. Swiss medical weekly. 2013.

The importance of early treatment for the prognosis of rheumatoid arthritis

Kyburz, Diego; Finckh, Axel. Swiss Medical Weekly. 2013.

Down-regulation of microRNA-34a* in rheumatoid arthritis synovial fibroblasts promotes apoptosis resistance.

Niederer F; Trenkmann M; Ospelt C; Karouzakis E; Neidhart M; Stanczyk J; Kolling C; Gay RE; Detmar M; Gay S; Jüngel A; Kyburz D. Arthritis and Rheumatism. 2012.

Evolution of radiographic joint damage in rituximab-treated versus TNF-treated rheumatoid arthritis cases with inadequate response to TNF antagonists.

Finckh,Axel; Möller,Burkhard; Dudler,Jean; Walker,Ulrich A; Kyburz,Diego; Gabay,Cem; physicians of the Swiss Clinical Quality Management for Rheumatoid Arthritis; physicians of SCQM-RA. Annals of the Rheumatic Diseases. 2012.

Use of abatacept in rheumatoid arthritis: Recommendations based on current evidence

Von Kempis J.; Dudler J.; Hasler P.; Kyburz D.; Tyndall A.; Zufferey P.; Villiger P.M.. Swiss Medical Weekly. 2012.

Visfatin/pre-B-cell colony-enhancing factor (PBEF), a proinflammatory and cell motility-changing factor in rheumatoid arthritis.

Meier FM; Frommer KW; Peters MA; Brentano F; Lefèvre S; Schröder D; Kyburz D; Steinmeyer J; Rehart S; Gay S; Müller-Ladner U; Neumann E. Journal of Biological Chemistry. 2012.

[The rheumatic hand - diagnostics in practice].

Micheroli R; Kyburz D; Ciurea A; Tamborrini G. Praxis. 2011.

A BAFF/APRIL-dependent TLR3-stimulated pathway enhances the capacity of rheumatoid synovial fibroblasts to induce AID expression and Ig class-switching in B cells.

Bombardieri M; Kam NW; Brentano F; Choi K; Filer A; Kyburz D; McInnes IB; Gay S; Buckley C; Pitzalis C. Annals of the Rheumatic Diseases. 2011.

Altered expression of microRNA-203 in rheumatoid arthritis synovial fibroblasts and its role in fibroblast activation.

Stanczyk J; Ospelt C; Karouzakis E; Filer A; Raza K; Kolling C; Gay R; Buckley CD; Tak PP; Gay S; Kyburz D. Arthritis and Rheumatism. 2011.

Delays in assessment of patients with rheumatoid arthritis: variations across Europe.

Raza,Karim; Stack,Rebecca; Kumar,Kanta; Filer,Andrew; Detert,Jacqueline; Bastian,Hans; Burmester,Gerd R; Sidiropoulos,Prodromos; Kteniadaki,Eleni; Repa,Argyro; Saxne,Tore; Turesson,Carl; Mann,Herman; Vencovsky,Jiri; Catrina,Anca; Chatzidionysiou,Aikaterini; Hensvold,Aase; Rantapää-Dahlqvist,Solbritt; Binder,Alexa; Machold,Klaus; Kwiakowska,Brygida; Ciurea,Adrian; Tamborrini,Giorgio; Kyburz,Diego; Buckley,Christopher D. Annals of the Rheumatic Diseases. 2011.

MicroRNAs as new player in rheumatoid arthritis.

Duroux-Richard I; Presumey J; Courties G; Gay S; Gordeladze J; Jorgensen C; Kyburz D; Apparailly F. Joint bone spine. 2011.

SIRT1 overexpression in the rheumatoid arthritis synovium contributes to proinflammatory cytokine production and apoptosis resistance.

Niederer F; Ospelt C; Brentano F; Hottiger MO; Gay RE; Gay S; Detmar M; Kyburz D. Annals of the Rheumatic Diseases. 2011.

Th17 cells generated in the absence of TGF-β induce experimental allergic encephalitis upon adoptive transfer.

Kyburz D; Corr M. Expert Review of Clinical Immunology. 2011.

The long-term impact of early treatment of rheumatoid arthritis on radiographic progression: a population-based cohort study.

Kyburz D; Gabay C; Michel BA; Finckh A; physicians of SCQM-RA. Rheumatology (United Kingdom). 2011.

18F-fluoride PET/CT for detection of sacroiliitis in ankylosing spondylitis.

Strobel K; Fischer DR; Tamborrini G; Kyburz D; Stumpe KD; Hesselmann RG; Johayem A; von Schulthess GK; Michel BA; Ciurea A. European Journal of Nuclear Medicine and Molecular Imaging. 2010.

Influence of anti-infliximab antibodies and residual infliximab concentrations on the occurrence of acquired drug resistance to infliximab in rheumatoid arthritis patients.

Finckh A; Dudler J; Wermelinger F; Ciurea A; Kyburz D; Gabay C; Bas S; physicians of SCQM. Joint bone spine. 2010.

Swiss consensus statement: Recommendations for optimising re-treatment with MabThera (rituximab) in rheumatoid arthritis.

Dudler J; Finckh A; Kyburz D; Langenegger T; Möller B; Schmiedel U; Walker UA. Swiss medical weekly. 2010.

Which subgroup of patients with rheumatoid arthritis benefits from switching to rituximab versus alternative anti-tumour necrosis factor (TNF) agents after previous failure of an anti-TNF agent?

Finckh A; Ciurea A; Brulhart L; Möller B; Walker UA; Courvoisier D; Kyburz D; Dudler J; Gabay C; Arthritis. Annals of the Rheumatic Diseases. 2010.

Abundant expression of the interleukin (IL)23 subunit p19, but low levels of bioactive IL23 in the rheumatoid synovium: differential expression and Toll-like receptor-(TLR) dependent regulation of the IL23 subunits, p19 and p40, in rheumatoid arthritis.

Brentano F; Ospelt C; Stanczyk J; Gay RE; Gay S; Kyburz D. Annals of the Rheumatic Diseases. 2009.

Herpesvirus entry mediator-Ig treatment during immunization aggravates rheumatoid arthritis in the collagen-induced arthritis model.

Pierer M; Schulz A; Rossol M; Kendzia E; Kyburz D; Haentzschel H; Baerwald C; Wagner U. Journal of Immunology. 2009.

Toll-like receptors and rheumatoid arthritis.

Brentano F; Kyburz D; Gay S. Methods in Molecular Biology. 2009.

Type I interferons might form the link between Toll-like receptor (TLR) 3/7 and TLR4-mediated synovial inflammation in rheumatoid arthritis (RA).

Roelofs MF; Wenink MH; Brentano F; Abdollahi-Roodsaz S; Oppers-Walgreen B; Barrera P; van Riel PL; Joosten LA; Kyburz D; van den Berg WB; Radstake TR. Annals of the Rheumatic Diseases. 2009.

Altered expression of microRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis

Stanczyk, Joanna; Pedrioli, Deena A. Leslie; Brentano, Fabia; Sanchez-Pernaute, Olga; Kolling, Christoph; Gay, Renate E.; Detmar, Michael; Gay, Steffen; Kyburz, Diego. Arthritis and Rheumatism. 2008.

Overexpression of toll-like receptors 3 and 4 in synovial tissue from patients with early rheumatoid arthritis: toll-like receptor expression in early and longstanding arthritis.

Ospelt C; Brentano F; Rengel Y; Stanczyk J; Kolling C; Tak PP; Gay RE; Gay S; Kyburz D. Arthritis and Rheumatism. 2008.

B cell depletion may be more effective than switching to an alternative anti-tumor necrosis factor agent in rheumatoid arthritis patients with inadequate response to anti-tumor necrosis factor agents

Finckh, Axel; Ciurea, Adrian; Brulhart, Laure; Kyburz, Diego; Moeller, Burkhard; Dehler, Silvia; Revaz, Sylvie; Dudler, Jean; Gabay, Cem. Arthritis and Rheumatism. 2007.

Pre-B cell colony-enhancing factor/visfatin, a new marker of inflammation in rheumatoid arthritis with proinflammatory and matrix-degrading activities.

Brentano F; Schorr O; Ospelt C; Stanczyk J; Gay RE; Gay S; Kyburz D. Arthritis and Rheumatism. 2007.

The TNF superfamily member LIGHT contributes to survival and activation of synovial fibroblasts in rheumatoid arthritis.

Pierer M; Brentano F; Rethage J; Wagner U; Hantzschel H; Gay RE; Gay S; Kyburz D. Rheumatology (United Kingdom). 2007.

Tolerance and effectiveness of anti-tumor necrosis factor alpha therapies in elderly patients with rheumatoid arthritis: a population-based cohort study.

Genevay S; Finckh A; Ciurea A; Chamot AM; Kyburz D; Gabay C; Physicians of the Swiss Clinical Quality Management Program for Rheumatoid Arthritis. Arthritis and Rheumatism. 2007.

[Evidence-based therapy of Raynaud's syndrome].

Distler M; Distler J; Ciurea A; Kyburz D; Müller-Ladner U; Reich K; Distler O. Zeitschrift fur Rheumatologie. 2006.

Efficacy of B cell depletion in patients with rheumatoid arthritis refractory to anti-tumour necrosis factor alpha agents: an open-label observational study

Brulhart, L.; Ciurea, A.; Finckh, A.; Notter, A.; Waldburger, J. M.; Kyburz, D.; Gabay, C.. Annals of the Rheumatic Diseases. 2006.

Mode of action of hydroxychloroquine in RA-evidence of an inhibitory effect on toll-like receptor signaling.

Kyburz D; Brentano F; Gay S. NAT CLIN PRACT RHEUM (PRINT-AUSGABE). 2006.

RNA released from necrotic synovial fluid cells activates rheumatoid arthritis synovial fibroblasts via Toll-like receptor 3.

Brentano F; Schorr O; Gay RE; Gay S; Kyburz D. Arthritis and Rheumatism. 2005.

The role of Toll-like receptor signalling in the pathogenesis of arthritis.

Brentano F; Kyburz D; Schorr O; Gay R; Gay S. Cellular immunology. 2005.

Chemokine secretion of rheumatoid arthritis synovial fibroblasts stimulated by Toll-like receptor 2 ligands.

Pierer M; Rethage J; Seibl R; Lauener R; Brentano F; Wagner U; Hantzschel H; Michel BA; Gay RE; Gay S; Kyburz D. Journal of Immunology. 2004.

Pattern recognition receptors and their involvement in the pathogenesis of arthritis.

Seibl R; Kyburz D; Lauener RP; Gay S. Current opinion in rheumatology. 2004.

Toll-like receptors in rheumatoid arthritis joint destruction mediated by two distinct pathways.

Ospelt C; Kyburz D; Pierer M; Seibl R; Kurowska M; Distler O; Neidhart M; Muller-Ladner U; Pap T; Gay RE; Gay S. Annals of the Rheumatic Diseases. 2004.

Bacterial peptidoglycans but not CpG oligodeoxynucleotides activate synovial fibroblasts by toll-like receptor signaling.

Kyburz D; Rethage J; Seibl R; Lauener R; Gay RE; Carson DA; Gay S. Arthritis and Rheumatism. 2003.

Cartilage destruction mediated by synovial fibroblasts does not depend on proliferation in rheumatoid arthritis.

Seemayer CA; Kuchen S; Kuenzler P; Rihosková V; Rethage J; Aicher WK; Michel BA; Gay RE; Kyburz D; Neidhart M; Gay S. American Journal of Pathology. 2003.

Efficient T cell repertoire selection in tetraparental chimeric mice independent of thymic epithelial MHC.

Martinic MM; Rülicke T; Althage A; Odermatt B; Höchli M; Lamarre A; Dumrese T; Speiser DE; Kyburz D; Hengartner H; Zinkernagel RM. Proceedings of the National Academy of Sciences of the United States of America. 2003.

Galectin 3 and its binding protein in rheumatoid arthritis.

Ohshima S; Kuchen S; Seemayer CA; Kyburz D; Hirt A; Klinzing S; Michel BA; Gay RE; Liu FT; Gay S; Neidhart M. Arthritis and Rheumatism. 2003.

Selection of oligonucleotide aptamers with enhanced uptake and activation of human leukemia B cells.

Wu CC; Castro JE; Motta M; Cottam HB; Kyburz D; Kipps TJ; Corr M; Carson DA. Human Gene Therapy. 2003.

The KRN mouse model of inflammatory arthritis.

Kyburz D; Corr M. SPRINGER SEMIN IMMUN. 2003.

Toll-like receptors direct antimicrobial immune responses--and driving arthritis?

Kyburz,Diego; Gay,Steffen. Curr Rheumatol Rep. 2003.

The role of CD40 ligand and tumor necrosis factor alpha signaling in the transgenic K/BxN mouse model of rheumatoid arthritis.

Kyburz D; Carson DA; Corr M. Arthritis and Rheumatism. 2000.

Human rheumatoid factor production is dependent on CD40 signaling and autoantigen.

Kyburz D; Corr M; Brinson DC; Von Damm A; Tighe H; Carson DA. Journal of Immunology. 1999.

Rheumatoid factor B cell tolerance via autonomous Fas/FasL-independent apoptosis.

Warnatz K; Kyburz D; Brinson DC; Lee DJ; Von Damm A; Engelhart M; Corr M; Carson DA; Tighe H. Cellular immunology. 1999.

[A case from practice (366). Jellyfish sting--neurotoxic activity on the sensory nerves].

Kyburz D. Praxis. 1996.

Der fall aus der Praxis (366)

Kyburz D.. Praxis. 1996.

Peptides control the gain and loss of allele specificity by mutated MHC class I molecules.

Hengel H; Burke K; Kyburz D; Zinkernagel RM; Koszinowski UH. Journal of Immunology. 1995.

Viral peptide specific cytotoxic T lymphocytes are of high avidity to host-MHC but only low avidity to donor-MHC after allogeneic bone marrow transplantation.

Kyburz D; Speiser DE. TRANSPLANT IMMUNOLOGY. 1995.


AICHELE, P; KYBURZ, D; OHASHI, PS; ODERMATT, B; ZINKERNAGEL, RM; HENGARTNER, H; PIRCHER, H. Proceedings of the National Academy of Sciences of the United States of America. 1994.

Enhancement of disease by neutralizing antiviral antibodies in the absence of primed antiviral cytotoxic T cells.

Battegay M; Kyburz D; Hengartner H; Zinkernagel RM. European Journal of Immunology. 1993.

Lysis of infected cells in vivo by antiviral cytolytic T cells demonstrated by release of cell internal viral proteins.

Kyburz D; Speiser DE; Battegay M; Hengartner H; Zinkernagel RM. European Journal of Immunology. 1993.

T cell immunity after a viral infection versus T cell tolerance induced by soluble viral peptides.

Kyburz D; Aichele P; Speiser DE; Hengartner H; Zinkernagel RM; Pircher H. European Journal of Immunology. 1993.

Virus-specific cytotoxic T cell-mediated lysis of lymphocytes in vitro and in vivo

Kyburz D.; Speiser D.E.; Aebischer T.; Hengartner H.; Zinkernagel R.M.. Journal of Immunology. 1993.

Clonal deletion induced by either radioresistant thymic host cells or lymphohemopoietic donor cells at different stages of class I-restricted T cell ontogeny.

Speiser DE; Pircher H; Ohashi PS; Kyburz D; Hengartner H; Zinkernagel RM. Journal of Experimental Medicine. 1992.