Community consensus on core open science practices to monitor in biomedicine.

Cobey KD; Haustein S; Brehaut J; Dirnagl U; Franzen DL; Hemkens LG; Presseau J; Riedel N; Strech D; Alperin JP; Costas R; Sena ES; van Leeuwen T; Ardern CL; Bacellar IOL; Camack N; Britto Correa M; Buccione R; Cenci MS; Fergusson DA; Gould van Praag C; Hoffman MM; Moraes Bielemann R; Moschini U; Paschetta M; Pasquale V; Rac VE; Roskams-Edris D; Schatzl HM; Stratton JA; Moher D. PLoS Biology. 2023.

Effect of dulaglutide in promoting abstinence during smoking cessation: a single-centre, randomized, double-blind, placebo-controlled, parallel group trial.

Lengsfeld S; Burkard T; Meienberg A; Jeanloz N; Vukajlovic T; Bologna K; Steinmetz M; Bathelt C; Sailer CO; Vogt DR; Hemkens LG; Speich B; Urwyler SA; Kühne J; Baur F; Lutz LN; Erlanger TE; Christ-Crain M; Winzeler B. EClinicalMedicine. 2023.

Glucagon-like peptide-1 analogues: a new way to quit smoking? (SKIP)-a structured summary of a study protocol for a randomized controlled study.

Lengsfeld S; Burkard T; Meienberg A; Jeanloz N; Coynel D; Vogt DR; Hemkens LG; Speich B; Zanchi D; Erlanger TE; Christ-Crain M; Winzeler B. Trials. 2023.

GRADE concept 4: rating the certainty of evidence when study interventions or comparators differ from PICO targets.

Goldkuhle M; Guyatt GH; Kreuzberger N; Akl EA; Dahm P; van Dalen EC; Hemkens LG; Klugar M; Mustafa RA; Nonino F; Schünemann HJ; Trivella M; Skoetz N. Journal of Clinical Epidemiology. 2023.

Meta-epidemiological review identified variable reporting and handling of time-to-event analyses in publications of trials included in meta-analyses of systematic reviews.

Goldkuhle M; Hirsch C; Iannizzi C; Bora AM; Bender R; van Dalen EC; Hemkens LG; Trivella M; Monsef I; Kreuzberger N; Skoetz N. Journal of Clinical Epidemiology. 2023.

Meta-research on pragmatism of randomized trials: rationale and design of the PragMeta database.

Hirt J; Janiaud P; Düblin P; Hemkens LG. Trials. 2023.

The evidence base of US Food and Drug Administration approvals of novel cancer therapies from 2000 to 2020.

Gloy V; Schmitt AM; Düblin P; Hirt J; Axfors C; Kuk H; Pereira TV; Locher C; Caquelin L; Walter-Claudi M; Lythgoe MP; Herbrand A; Kasenda B; Hemkens LG. International Journal of Cancer. 2023.

Using the phases of clinical development of medicines to describe clinical trials assessing other interventions is widespread but not useful.

Dal-Ré R; Banzi R; Cristea IA; Fernández-de-Las-Peñas C; Hemkens LG; Janiaud P; Jansen MS; Naudet F; Rosendaal FR. Journal of Clinical Epidemiology. 2023.

Association of the COVID-19 outbreak with acute stroke care in Switzerland.

De Marchis GM; Wright PR; Michel P; Strambo D; Carrera E; Dirren E; Luft AR; Wegener S; Cereda CW; Kägi G; Vehoff J; Gensicke H; Lyrer P; Nedeltchev K; Khales T; Bolognese M; Salmen S; Sturzenegger R; Bonvin C; Berger C; Schelosky L; Mono ML; Rodic B; von Reding A; Schwegler G; Tarnutzer AA; Medlin F; Humm AM; Peters N; Beyeler M; Kriemler L; Bervini D; Fandino J; Hemkens LG; Mordasini P; Arnold M; Fischer U; Bonati LH; Swiss Stroke Registry Investigators. European Journal of Neurology. 2022.

A systematic survey of methods guidance suggests areas for improvement regarding access, development, and transparency.

Hirt J; Ewald H; Lawson DO; Hemkens LG; Briel M; Schandelmaier S. Journal of Clinical Epidemiology. 2022.

Central diabetes insipidus from a patient's perspective: management, psychological co-morbidities, and renaming of the condition: results from an international web-based survey

Atila C.; Loughrey P.B.; Garrahy A.; Winzeler B.; Refardt J.; Gildroy P.; Hamza M.; Pal A.; Verbalis J.G.; Thompson C.J.; Hemkens L.G.; Hunter S.J.; Sherlock M.; Levy M.J.; Karavitaki N.; Newell-Price J.; Wass J.A.H.; Christ-Crain M.. The lancet. Diabetes & endocrinology. 2022.

Characteristics and survival of patients with cancer with intended off-label use-a cohort study.

Schmitt AM; Walter M; Herbrand AK; Jörger M; Moffa G; Novak U; Hemkens L; Kasenda B. BMJ Open. 2022.

Clinical trial research agenda on COVID-19 - the first two years in Germany and beyond.

Hirt J; Janiaud P; Hemkens LG. Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen. 2022.

Effect of Wearing Glasses on Risk of Infection With SARS-CoV-2 in the Community: A Randomized Clinical Trial.

Fretheim A; Elgersma IH; Helleve A; Elstrøm P; Kacelnik O; Hemkens LG. . 2022.

High quality (certainty) evidence changes less often than low-quality evidence, but the magnitude of effect size does not systematically differ between studies with low versus high-quality evidence.

Djulbegovic B; Ahmed MM; Hozo I; Koletsi D; Hemkens L; Price A; Riera R; Nadanovsky P; Dos Santos APP; Melo D; Pathak R; Pacheco RL; Fontes LE; Miranda E; Nunan D. Journal of Evaluation in Clinical Practice. 2022.

Nonregistration, discontinuation, and nonpublication of randomized trials: A repeated metaresearch analysis.

Speich B; Gryaznov D; Busse JW; Gloy VL; Lohner S; Klatte K; Taji Heravi A; Ghosh N; Lee H; Mansouri A; Marian IR; Saccilotto R; Nury E; Kasenda B; Ojeda-Ruiz E; Schandelmaier S; Tomonaga Y; Amstutz A; Pauli-Magnus C; Bischoff K; Wollmann K; Rehner L; Meerpohl JJ; Nordmann A; Wong J; Chow N; Hong PJ; Mc Cord-De Iaco K; Sricharoenchai S; Agarwal A; Schwenkglenks M; Hemkens LG; von Elm E; Copsey B; Griessbach AN; Schönenberger C; Mertz D; Blümle A; von Niederhäusern B; Hopewell S; Odutayo A; Briel M. PLoS Medicine. 2022.

Randomized trials on non-pharmaceutical interventions for COVID-19: a scoping review.

Hirt J; Janiaud P; Hemkens LG. BMJ evidence-based medicine. 2022.

Reporting quality of clinical trial protocols: a repeated cross-sectional study about the Adherence to SPIrit Recommendations in Switzerland, CAnada and GErmany (ASPIRE-SCAGE).

Gryaznov D; von Niederhäusern B; Speich B; Kasenda B; Ojeda-Ruiz E; Blümle A; Schandelmaier S; Mertz D; Odutayo A; Tomonaga Y; Amstutz A; Pauli-Magnus C; Gloy V; Lohner S; Bischoff K; Wollmann K; Rehner L; Meerpohl JJ; Nordmann A; Klatte K; Ghosh N; Taji Heravi A; Wong J; Chow N; Hong P; McCord-De Iaco KA; Sricharoenchai S; Busse JW; Agarwal A; Saccilotto R; Schwenkglenks M; Moffa G; Hemkens L; Hopewell S; Von Elm E; Briel M. BMJ Open. 2022.

Reporting transparency and completeness in trials: Paper 1: Introduction - Better reporting for disruptive clinical trials using routinely collected data.

Hemkens LG; Juszczak E; Thombs BD. . 2022.

Reporting transparency and completeness in Trials: Paper 2 - reporting of randomised trials using registries was often inadequate and hindered the interpretation of results.

Mc Cord KA; Imran M; Rice DB; McCall SJ; Kwakkenbos L; Sampson M; Fröbert O; Gale C; Langan SM; Moher D; Relton C; Zwarenstein M; Juszczak E; Thombs BD; Hemkens LG; CONSORT Extension for Trials Conducted Using Cohorts and Routinely Collected Data Group. Journal of Clinical Epidemiology. 2022.

Reporting transparency and completeness in trials: Paper 3 - trials conducted using administrative databases do not adequately report elements related to use of databases.

Imran M; Mc Cord K; McCall SJ; Kwakkenbos L; Sampson M; Fröbert O; Gale C; Hemkens LG; Langan SM; Moher D; Relton C; Zwarenstein M; Juszczak E; Thombs BD; CONSORT Extension for Trials Conducted Using Cohorts and Routinely Collected Data Group. Journal of Clinical Epidemiology. 2022.

Reporting transparency and completeness in trials: Paper 4 - reporting of randomised controlled trials conducted using routinely collected electronic records - room for improvement.

McCall SJ; Imran M; Hemkens LG; Mc Cord K; Kwakkenbos L; Sampson M; Jawad S; Zwarenstein M; Relton C; Langan SM; Moher D; Fröbert O; Thombs BD; Gale C; Juszczak E; CONSORT Extension for Trials Conducted Using Cohorts and RoutinelyCollected Data Group. Journal of Clinical Epidemiology. 2022.

Robustness of reported postacute health outcomes in children with SARS-CoV-2 infection: A systematic review

Hirt J.; Janiaud P.; Gloy V.L.; Schandelmaier S.; Pereira T.V.; Contopoulos-Ioannidis D.; Goodman S.N.; Ioannidis J.; Munkholm K.; Hemkens L.G.. Archives of Disease in Childhood. 2022.

Searching two or more databases decreased the risk of missing relevant studies: a metaresearch study.

Ewald H; Klerings I; Wagner G; Heise TL; Stratil JM; Lhachimi SK; Hemkens LG; Gartlehner G; Armijo-Olivo S; Nussbaumer-Streit B. Journal of Clinical Epidemiology. 2022.

Subclinical giant cell arteritis in new onset polymyalgia rheumatica A systematic review and meta-analysis of individual patient data.

Hemmig AK; Gozzoli D; Werlen L; Ewald H; Aschwanden M; Blockmans D; Brouwer E; Buchanan RRC; Camellino D; Campochiaro C; Cimmino MA; Corominas H; Gloy V; Henckaerts L; Kyburz D; Moya-Alvarado P; Owen CE; Stegert M; Tomelleri A; van Sleen Y; Yamashita H; Imfeld S; Berger CT; Hemkens LG; Daikeler T. Seminars in arthritis and rheumatism. 2022.

Ten simple rules for good research practice.

Schwab S; Janiaud P; Dayan M; Amrhein V; Panczak R; Palagi PM; Hemkens LG; Ramon M; Rothen N; Senn S; Furrer E; Held L. . 2022.

[Benefit assessment of digital health applications-challenges and opportunities].

Hemkens LG. Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz. 2021.

Association between convalescent plasma treatment and mortality in COVID-19: a collaborative systematic review and meta-analysis of randomized clinical trials.

Axfors C; Janiaud P; Schmitt AM; Van't Hooft J; Smith ER; Haber NA; Abayomi A; Abduljalil M; Abdulrahman A; Acosta-Ampudia Y; Aguilar-Guisado M; Al-Beidh F; Alejandria MM; Alfonso RN; Ali M; AlQahtani M; AlZamrooni A; Anaya JM; Ang MAC; Aomar IF; Argumanis LE; Averyanov A; Baklaushev VP; Balionis O; Benfield T; Berry S; Birocco N; Bonifacio LB; Bowen AC; Bown A; Cabello-Gutierrez C; Camacho B; Camacho-Ortiz A; Campbell-Lee S; Cao DH; Cardesa A; Carnate JM; Castillo GJJ; Cavallo R; Chowdhury FR; Chowdhury FUH; Ciccone G; Cingolani A; Climacosa FMM; Compernolle V; Cortez CFN; Costa Neto A; D'Antico S; Daly J; Danielle F; Davis JS; De Rosa FG; Denholm JT; Denkinger CM; Desmecht D; Díaz-Coronado JC; Díaz Ponce-Medrano JA; Donneau AF; Dumagay TE; Dunachie S; Dungog CC; Erinoso O; Escasa IMS; Estcourt LJ; Evans A; Evasan ALM; Fareli CJ; Fernandez-Sanchez V; Galassi C; Gallo JE; Garcia PJ; Garcia PL; Garcia JA; Garigliany M; Garza-Gonzalez E; Gauiran DTV; Gaviria García PA; Giron-Gonzalez JA; Gómez-Almaguer D; Gordon AC; Gothot A; Grass Guaqueta JS; Green C; Grimaldi D; Hammond NE; Harvala H; Heralde FM; Herrick J; Higgins AM; Hills TE; Hines J; Holm K; Hoque A; Hoste E; Ignacio JM; Ivanov AV; Janssen M; Jennings JH; Jha V; King RAN; Kjeldsen-Kragh J; Klenerman P; Kotecha A; Krapp F; Labanca L; Laing E; Landin-Olsson M; Laterre PF; Lim LL; Lim J; Ljungquist O; Llaca-Díaz JM; López-Robles C; López-Cárdenas S; Lopez-Plaza I; Lucero JAC; Lundgren M; Macías J; Maganito SC; Malundo AFG; Manrique RD; Manzini PM; Marcos M; Marquez I; Martínez-Marcos FJ; Mata AM; McArthur CJ; McQuilten ZK; McVerry BJ; Menon DK; Meyfroidt G; Mirasol MAL; Misset B; Molton JS; Mondragon AV; Monsalve DM; Moradi Choghakabodi P; Morpeth SC; Mouncey PR; Moutschen M; Müller-Tidow C; Murphy E; Najdovski T; Nichol AD; Nielsen H; Novak RM; O'Sullivan MVN; Olalla J; Osibogun A; Osikomaiya B; Oyonarte S; Pardo-Oviedo JM; Patel MC; Paterson DL; Peña-Perez CA; Perez-Calatayud AA; Pérez-Alba E; Perkina A; Perry N; Pouladzadeh M; Poyato I; Price DJ; Quero AKH; Rahman MM; Rahman MS; Ramesh M; Ramírez-Santana C; Rasmussen M; Rees MA; Rego E; Roberts JA; Roberts DJ; Rodríguez Y; Rodríguez-Baño J; Rogers BA; Rojas M; Romero A; Rowan KM; Saccona F; Safdarian M; Santos MCM; Sasadeusz J; Scozzari G; Shankar-Hari M; Sharma G; Snelling T; Soto A; Tagayuna PY; Tang A; Tatem G; Teofili L; Tong SYC; Turgeon AF; Veloso JD; Venkatesh B; Ventura-Enriquez Y; Webb SA; Wiese L; Wikén C; Wood EM; Yusubalieva GM; Zacharowski K; Zarychanski R; Khanna N; Moher D; Goodman SN; Ioannidis JPA; Hemkens LG. BMC INFECTIOUS DISEASES. 2021.

Association of Convalescent Plasma Treatment With Clinical Outcomes in Patients With COVID-19: A Systematic Review and Meta-analysis.

Janiaud P; Axfors C; Schmitt AM; Gloy V; Ebrahimi F; Hepprich M; Smith ER; Haber NA; Khanna N; Moher D; Goodman SN; Ioannidis JPA; Hemkens LG. JAMA. 2021.

Association of Supporting Trial Evidence and Reimbursement for Off-Label Use of Cancer Drugs.

Herbrand AK; Schmitt AM; Briel M; Ewald H; Goldkuhle M; Diem S; Hoogkamer A; Joerger M; Moffa G; Novak U; Hemkens LG; Kasenda B. JAMA Network Open. 2021.

A study protocol for the development of a SPIRIT extension for trials conducted using cohorts and routinely collected data (SPIRIT-ROUTINE).

McCarthy M; O'Keeffe L; Williamson PR; Sydes MR; Farrin A; Lugg-Widger F; Davies G; Avery K; Chan AW; Kwakkenbos L; Thombs BD; Watkins A; Hemkens LG; Gale C; Zwarenstein M; Langan SM; Thabane L; Juszczak E; Moher D; Kearney PM. HRB open research. 2021.

A trial platform to assess approved SARS-CoV-2 vaccines in immunocompromised patients: first sub-protocol for a pilot trial comparing the mRNA vaccines Comirnaty® and COVID-19 mRNA Vaccine Moderna®.

Speich B; Chammartin F; Smith D; Stoeckle MP; Amico P; Eichenberger AL; Hasse B; Schuurmans MM; Müller T; Tamm M; Dickenmann M; Abela IA; Trkola A; Hirsch HH; Manuel O; Cavassini M; Hemkens LG; Briel M; Mueller NJ; Rauch A; Günthard HF; Koller MT; Bucher HC; Kusejko K; study groups from the Swiss HIV Cohort Study and the Swiss Transplant Cohort Study. Trials. 2021.

Author Correction: Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials.

Axfors C; Schmitt AM; Janiaud P; Van't Hooft J; Abd-Elsalam S; Abdo EF; Abella BS; Akram J; Amaravadi RK; Angus DC; Arabi YM; Azhar S; Baden LR; Baker AW; Belkhir L; Benfield T; Berrevoets MAH; Chen CP; Chen TC; Cheng SH; Cheng CY; Chung WS; Cohen YZ; Cowan LN; Dalgard O; de Almeida E Val FF; de Lacerda MVG; de Melo GC; Derde L; Dubee V; Elfakir A; Gordon AC; Hernandez-Cardenas CM; Hills T; Hoepelman AIM; Huang YW; Igau B; Jin R; Jurado-Camacho F; Khan KS; Kremsner PG; Kreuels B; Kuo CY; Le T; Lin YC; Lin WP; Lin TH; Lyngbakken MN; McArthur C; McVerry BJ; Meza-Meneses P; Monteiro WM; Morpeth SC; Mourad A; Mulligan MJ; Murthy S; Naggie S; Narayanasamy S; Nichol A; Novack LA; O'Brien SM; Okeke NL; Perez L; Perez-Padilla R; Perrin L; Remigio-Luna A; Rivera-Martinez NE; Rockhold FW; Rodriguez-Llamazares S; Rolfe R; Rosa R; Røsjø H; Sampaio VS; Seto TB; Shahzad M; Soliman S; Stout JE; Thirion-Romero I; Troxel AB; Tseng TY; Turner NA; Ulrich RJ; Walsh SR; Webb SA; Weehuizen JM; Velinova M; Wong HL; Wrenn R; Zampieri FG; Zhong W; Moher D; Goodman SN; Ioannidis JPA; Hemkens LG. . 2021.

Barriers and Facilitating Factors for Conducting Systematic Evidence Assessments in Academic Clinical Trials.

McLennan S; Nussbaumer-Streit B; Hemkens LG; Briel M. JAMA Network Open. 2021.

Challenges and Lessons Learned From COVID-19 Trials: Should We Be Doing Clinical Trials Differently?

Janiaud P; Hemkens LG; Ioannidis JPA. Canadian Journal of Cardiology. 2021.

CONSORT extension for the reporting of randomised controlled trials conducted using cohorts and routinely collected data (CONSORT-ROUTINE): checklist with explanation and elaboration.

Kwakkenbos L; Imran M; McCall SJ; McCord KA; Fröbert O; Hemkens LG; Zwarenstein M; Relton C; Rice DB; Langan SM; Benchimol EI; Thabane L; Campbell MK; Sampson M; Erlinge D; Verkooijen HM; Moher D; Boutron I; Ravaud P; Nicholl J; Uher R; Sauvé M; Fletcher J; Torgerson D; Gale C; Juszczak E; Thombs BD. BMJ (Clinical research ed.). 2021.

Evaluation of Planned Subgroup Analysis in Protocols of Randomized Clinical Trials.

Taji Heravi A; Gryaznov D; Schandelmaier S; Kasenda B; Briel M; Adherence to SPIRIT Recommendations (ASPIRE) Study Group. JAMA Network Open. 2021.

Methods and results used in the development of a consensus-driven extension to the Consolidated Standards of Reporting Trials (CONSORT) statement for trials conducted using cohorts and routinely collected data (CONSORT-ROUTINE).

Imran M; Kwakkenbos L; McCall SJ; McCord KA; Fröbert O; Hemkens LG; Zwarenstein M; Relton C; Rice DB; Langan SM; Benchimol EI; Thabane L; Campbell MK; Sampson M; Erlinge D; Verkooijen HM; Moher D; Boutron I; Ravaud P; Nicholl J; Uher R; Sauvé M; Fletcher J; Torgerson D; Gale C; Juszczak E; Thombs BD. BMJ Open. 2021.

Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials.

Axfors C; Schmitt AM; Janiaud P; Van't Hooft J; Abd-Elsalam S; Abdo EF; Abella BS; Akram J; Amaravadi RK; Angus DC; Arabi YM; Azhar S; Baden LR; Baker AW; Belkhir L; Benfield T; Berrevoets MAH; Chen CP; Chen TC; Cheng SH; Cheng CY; Chung WS; Cohen YZ; Cowan LN; Dalgard O; de Almeida E Val FF; de Lacerda MVG; de Melo GC; Derde L; Dubee V; Elfakir A; Gordon AC; Hernandez-Cardenas CM; Hills T; Hoepelman AIM; Huang YW; Igau B; Jin R; Jurado-Camacho F; Khan KS; Kremsner PG; Kreuels B; Kuo CY; Le T; Lin YC; Lin WP; Lin TH; Lyngbakken MN; McArthur C; McVerry BJ; Meza-Meneses P; Monteiro WM; Morpeth SC; Mourad A; Mulligan MJ; Murthy S; Naggie S; Narayanasamy S; Nichol A; Novack LA; O'Brien SM; Okeke NL; Perez L; Perez-Padilla R; Perrin L; Remigio-Luna A; Rivera-Martinez NE; Rockhold FW; Rodriguez-Llamazares S; Rolfe R; Rosa R; Røsjø H; Sampaio VS; Seto TB; Shahzad M; Soliman S; Stout JE; Thirion-Romero I; Troxel AB; Tseng TY; Turner NA; Ulrich RJ; Walsh SR; Webb SA; Weehuizen JM; Velinova M; Wong HL; Wrenn R; Zampieri FG; Zhong W; Moher D; Goodman SN; Ioannidis JPA; Hemkens LG. Nature Communications. 2021.

Prepectoral versus subpectoral implant-based breast reconstruction after skin-sparing mastectomy or nipple-sparing mastectomy (OPBC-02/ PREPEC): a pragmatic, multicentre, randomised, superiority trial.

Kappos EA; Schulz A; Regan MM; Moffa G; Harder Y; Ribi K; Potter S; Pusic AL; Fehr MK; Hemkens LG; Holzbach T; Farhadi J; Simonson C; Knauer M; Verstappen R; Bucher HC; Zwahlen D; Zimmermann F; Schwenkglenks M; Mucklow R; Shaw J; Bjelic-Radisic V; Chiorescu A; Chun YS; Farah S; Xiaosong C; Nigard L; Kuemmel S; Reitsamer R; Hauschild M; Fulco I; Tausch C; Fischer T; Sarlos D; Constantinescu MA; Lupatsch JE; Fitzal F; Heil J; Matrai Z; de Boniface J; Kurzeder C; Haug M; Weber WP. BMJ Open. 2021.

Randomized COVID-19 vaccination rollout can offer direct real-world evidence.

Hemkens LG; Goodman SN. Journal of Clinical Epidemiology. 2021.

Recruitment and Results Reporting of COVID-19 Randomized Clinical Trials Registered in the First 100 Days of the Pandemic.

Janiaud P; Axfors C; Ioannidis JPA; Hemkens LG. JAMA Network Open. 2021.

Reporting quality of trial protocols improved for non-regulated interventions but not regulated interventions: A repeated cross-sectional study.

Lohner S; Gryaznov D; von Niederhäusern B; Speich B; Kasenda B; Ojeda-Ruiz E; Schandelmaier S; Mertz D; Odutayo A; Tomonaga Y; Amstutz A; Pauli-Magnus C; Gloy V; Bischoff K; Wollmann K; Rehner L; Meerpohl JJ; Nordmann A; Klatte K; Ghosh N; Heravi AT; Wong J; Chow N; Hong PJ; McCord K; Sricharoenchai S; Busse JW; Agarwal A; Saccilotto R; Schwenkglenks M; Moffa G; Hemkens LG; Hopewell S; von Elm E; Blümle A; Briel M. Journal of Clinical Epidemiology. 2021.

Treatment effects in randomised trials using routinely collected data for outcome assessment versus traditional trials: meta-research study.

Mc Cord KA; Ewald H; Agarwal A; Glinz D; Aghlmandi S; Ioannidis JPA; Hemkens LG. BMJ (Clinical research ed.). 2021.

Abbreviated and comprehensive literature searches led to identical or very similar effect estimates: a meta-epidemiological study

Ewald H.; Klerings I.; Wagner G.; Heise T.L.; Dobrescu A.I.; Armijo-Olivo S.; Stratil J.M.; Lhachimi S.K.; Mittermayr T.; Gartlehner G.; Nussbaumer-Streit B.; Hemkens L.G.. Journal of Clinical Epidemiology. 2020.

A scoping review shows that several nonvalidated budget planning tools for randomized trials are available.

Speich B; Gloy V; Schur N; Ewald H; Hemkens LG; Schwenkglenks M; Briel M; MAking Randomized Trials Affordable (MARTA) Group. Journal of Clinical Epidemiology. 2020.

Characteristics and interpretation of subgroup analyses based on tumour characteristics in randomised trials testing target-specific anticancer drugs: design of a systematic survey.

Schandelmaier S; Schmitt AM; Herbrand AK; Glinz D; Ewald H; Briel M; Guyatt GH; Hemkens LG; Kasenda B. BMJ Open. 2020.

Clinical Trial Evidence Supporting US Food and Drug Administration Approval of Novel Cancer Therapies Between 2000 and 2016.

Ladanie A; Schmitt AM; Speich B; Naudet F; Agarwal A; Pereira TV; Sclafani F; Herbrand AK; Briel M; Martin-Liberal J; Schmid T; Ewald H; Ioannidis JPA; Bucher HC; Kasenda B; Hemkens LG. JAMA Network Open. 2020.

Commentary on Bertagnolli et al: Clinical trial designs with routinely collected real-world data—issues of data quality and beyond

Hemkens L.G.. Clinical Trials. 2020.

Consideration of confounding was suboptimal in the reporting of observational studies in psychiatry: a meta-epidemiological study.

Munkholm K; Faurholt-Jepsen M; Ioannidis JPA; Hemkens LG. Journal of Clinical Epidemiology. 2020.

Design, analysis and reporting of multi-arm trials and strategies to address multiple testing.

Odutayo A; Gryaznov D; Copsey B; Monk P; Speich B; Roberts C; Vadher K; Dutton P; Briel M; Hopewell S; Altman DG; ASPIRE study group.. International Journal of Epidemiology. 2020.

Knowledge gaps in oncoplastic breast surgery.

Weber WP; Morrow M; Boniface J; Pusic A; Montagna G; Kappos EA; Ritter M; Haug M; Kurzeder C; Saccilotto R; Schulz A; Benson J; Fitzal F; Matrai Z; Shaw J; Peeters MV; Potter S; Heil J; Oncoplastic Breast Consortium.. The Lancet Oncology. 2020.

Nonrandomized studies using causal-modeling may give different answers than RCTs: a meta-epidemiological study.

Ewald H; Ioannidis JPA; Ladanie A; Mc Cord K; Bucher HC; Hemkens LG. Journal of Clinical Epidemiology. 2020.

Online randomized controlled experiments at scale: lessons and extensions to medicine.

Kohavi R; Tang D; Xu Y; Hemkens LG; Ioannidis JPA. Trials. 2020.

Oral corticosteroids for post-infectious cough in adults: study protocol for a double-blind randomized placebo-controlled trial in Swiss family practices (OSPIC trial).

Merlo C; Essig S; Brancati-Badarau DO; Leuppi JD; Speich B; Erlanger TE; Hemkens LG; Zeller A. Trials. 2020.

Patient involvement to inform the design of a clinical trial in postbariatric hypoglycaemia.

Hepprich M; Donath MY; Hemkens LG. BMC Medical Research Methodology. 2020.

Prediction of RECRUITment In randomized clinical Trials (RECRUIT-IT)-rationale and design for an international collaborative study.

Kasenda B; Liu J; Jiang Y; Gajewski B; Wu C; von Elm E; Schandelmaier S; Moffa G; Trelle S; Schmitt AM; Herbrand AK; Gloy V; Speich B; Hopewell S; Hemkens LG; Sluka C; McGill K; Meade M; Cook D; Lamontagne F; Tréluyer JM; Haidich AB; Ioannidis JPA; Treweek S; Briel M. Trials. 2020.

Rationale and design of repeated cross-sectional studies to evaluate the reporting quality of trial protocols: the Adherence to SPIrit REcommendations (ASPIRE) study and associated projects.

Gryaznov D; Odutayo A; von Niederhäusern B; Speich B; Kasenda B; Ojeda-Ruiz E; Blümle A; Schandelmaier S; Mertz D; Tomonaga Y; Amstutz A; Pauli-Magnus C; Gloy V; Bischoff K; Wollmann K; Rehner L; Lohner S; Meerpohl JJ; Nordmann A; Klatte K; Ghosh N; Heravi AT; Wong J; Chow N; Hong PJ; Cord KM; Sricharoenchai S; Busse JW; Agarwal A; Saccilotto R; Schwenkglenks M; Moffa G; Hemkens LG; Hopewell S; von Elm E; Briel M. Trials. 2020.

The worldwide clinical trial research response to the COVID-19 pandemic - the first 100 days.

Janiaud P; Axfors C; Van't Hooft J; Saccilotto R; Agarwal A; Appenzeller-Herzog C; Contopoulos-Ioannidis DG; Danchev V; Dirnagl U; Ewald H; Gartlehner G; Goodman SN; Haber NA; Ioannidis AD; Ioannidis JPA; Lythgoe MP; Ma W; Macleod M; Malički M; Meerpohl JJ; Min Y; Moher D; Nagavci B; Naudet F; Pauli-Magnus C; O'Sullivan JW; Riedel N; Roth JA; Sauermann M; Schandelmaier S; Schmitt AM; Speich B; Williamson PR; Hemkens LG. F1000Research. 2020.

Contrasting evidence to reimbursement reality for off-label use (OLU) of drug treatments in cancer care: rationale and design of the CEIT-OLU project.

Herbrand AK; Schmitt AM; Briel M; Diem S; Ewald H; Hoogkamer A; Joerger M; Mc Cord KA; Novak U; Sricharoenchai S; Hemkens LG; Kasenda B. ESMO Open. 2019.

Current use and costs of electronic health records for clinical trial research: a descriptive study.

Mc Cord KA; Ewald H; Ladanie A; Briel M; Speich B; Bucher HC; Hemkens LG; RCD for RCTs initiative and the Making Randomized Trials More Affordable Group. CMAJ open. 2019.

Dopaminergic agents versus control for enhancing stroke recovery and rehabilitation

Engelter S.; Hemkens L.G.; Speich B.; Traenka C.. Cochrane Database of Systematic Reviews. 2019.

Effect of Combination l-Citrulline and Metformin Treatment on Motor Function in Patients With Duchenne Muscular Dystrophy: A Randomized Clinical Trial.

Hafner P; Bonati U; Klein A; Rubino D; Gocheva V; Schmidt S; Schroeder J; Bernert G; Laugel V; Steinlin M; Capone A; Gloor M; Bieri O; Hemkens LG; Speich B; Zumbrunn T; Gueven N; Fischer D. JAMA Network Open. 2019.

Marginal structural models and other analyses allow multiple estimates of treatment effects in randomized clinical trials: Meta-epidemiological analysis.

Ewald H; Speich B; Ladanie A; Bucher HC; Ioannidis JPA; Hemkens LG. Journal of Clinical Epidemiology. 2019.

Resource use, costs, and approval times for planning and preparing a randomized clinical trial before and after the implementation of the new Swiss human research legislation.

Speich B; Schur N; Gryaznov D; von Niederhäusern B; Hemkens LG; Schandelmaier S; Amstutz A; Kasenda B; Pauli-Magnus C; Ojeda-Ruiz E; Tomonaga Y; McCord K; Nordmann A; von Elm E; Briel M; Schwenkglenks M; a collaboration of the MARTA (MAking Randomized Trials Affordable) and ASPIRE (Adherence to Standard Protocol Items: REcommendations for interventional trials) Study Groups. PLoS ONE. 2019.

Rituximab in primary central nervous system lymphoma-A systematic review and meta-analysis.

Schmitt AM; Herbrand AK; Fox CP; Bakunina K; Bromberg JEC; Cwynarski K; Doorduijn JK; Ferreri AJM; Illerhaus G; Issa S; Schorb E; Zucca E; Hemkens LG; Schandelmaier S; Kasenda B. Hematological oncology. 2019.

Single-dose versus 3-day cotrimoxazole prophylaxis in transurethral resection or greenlight laser vaporisation of the prostate: study protocol for a multicentre randomised placebo controlled non-inferiority trial (CITrUS trial).

Speich B; Bausch K; Roth JA; Hemkens LG; Ewald H; Vogt DR; Bruni N; Deuster S; Seifert HH; Widmer AF. Trials. 2019.

Single pivotal trials with few corroborating characteristics were used for FDA approval of cancer therapies.

Ladanie A; Speich B; Briel M; Sclafani F; Bucher HC; Agarwal A; Ioannidis JPA; Pereira TV; Kasenda B; Hemkens LG. Journal of Clinical Epidemiology. 2019.

The Guidelines for Reporting of Studies Conducted Using Observational Routinely Collected Health Data Statement for Pharmacoepidemiology (RECORD-PE) La déclaration RECORD-PE (Reporting of Studies Conducted Using Observational Routinely Collected Health Data Statement for Pharmacoepdemiology) : directives pour la communication des études realisées à partir de données de santé observationelles collectées en routine en pharmacoépidémiologie

Langan S.M.; Schmidt S.A.J.; Wing K.; Ehrenstein V.; Nicholls S.G.; Filion K.B.; Klungel O.; Petersen I.; SOrensen H.T.; Dixon W.G.; Guttmann A.; Harron K.; Hemkens L.G.; Moher D.; Schneeweiss S.; Smeeth L.; Sturkenboom M.; Von Elm E.; Wang S.V.; Benchimol E.I.. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne. 2019.

The REporting of studies Conducted using Observational Routinely collected health Data (RECORD) statement: Guidelines for the reporting of studies conducted based on routinely collected health data La déclaration RECORD (Reporting of Studies Conducted Using Observational Routinely Collected Health Data): Directives pour la communication des études réalisées à partir de données de santé collectées en routine

Benchimol E.I.; Smeeth L.; Guttmann A.; Harron K.; Moher D.; Petersen I.; SOrensen H.T.; Januel J.; Von Elm E.; Langan S.M.; Altman D.; De Klerk N.; Hemkens L.G.; Henry D.; Le Pogam M.; Manuel D.; Patrick K.; Perel P.; Romano P.S.; Tugwell P.; Warren J.; Weber W.; Winker M.. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne. 2019.

Using electronic health records for clinical trials: Where do we stand and where can we go?

Mc Cord KA; Hemkens LG. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne. 2019.

Abbreviated literature searches were viable alternatives to comprehensive searches: a meta-epidemiological study.

Nussbaumer-Streit B; Klerings I; Wagner G; Heise TL; Dobrescu AI; Armijo-Olivo S; Stratil JM; Persad E; Lhachimi SK; Van Noord MG; Mittermayr T; Zeeb H; Hemkens L; Gartlehner G. Journal of Clinical Epidemiology. 2018.

How Routinely Collected Data for Randomized Trials Provide Long-term Randomized Real-World Evidence.

Hemkens LG. JAMA Network Open. 2018.

How to use FDA drug approval documents for evidence syntheses.

Ladanie A; Ewald H; Kasenda B; Hemkens LG. BMJ (Clinical research ed.). 2018.

Interpretation of epidemiologic studies very often lacked adequate consideration of confounding

Hemkens L.G.; Ewald H.; Naudet F.; Ladanie A.; Shaw J.G.; Sajeev G.; Ioannidis J.P.A.. Journal of Clinical Epidemiology. 2018.

Off-label prescription: experience is a gloomy lantern that does not even illuminate its bearer. Author response.

Ladanie A; Ioannidis JPA; Stafford RS; Ewald H; Bucher HC; Hemkens LG; Hemkens LG. Journal of Clinical Epidemiology. 2018.

Off-label treatments were not consistently better or worse than approved drug treatments in randomized trials.

Ladanie A; Ioannidis JPA; Stafford RS; Ewald H; Bucher HC; Hemkens LG. Journal of Clinical Epidemiology. 2018.

Protocol for a scoping review to support development of a CONSORT extension for randomised controlled trials using cohorts and routinely collected health data

Kwakkenbos L.; Imran M.; McCord K.A.; Sampson M.; Frobert O.; Gale C.; Hemkens L.G.; Langan S.M.; Moher D.; Relton C.; Zwarenstein M.; Benchimol E.I.; Boutron I.; Campbell M.K.; Erlinge D.; Jawad S.; Ravaud P.; Rice D.B.; Sauve M.; Van Staa T.P.; Thabane L.; Uher R.; Verkooijen H.M.; Juszczak E.; Thombs B.D.. BMJ Open. 2018.

Protocol for the development of a CONSORT extension for RCTs using cohorts and routinely collected health data.

Kwakkenbos L; Juszczak E; Hemkens LG; Sampson M; Fröbert O; Relton C; Gale C; Zwarenstein M; Langan SM; Moher D; Boutron I; Ravaud P; Campbell MK; Mc Cord KA; van Staa TP; Thabane L; Uher R; Verkooijen HM; Benchimol EI; Erlinge D; Sauvé M; Torgerson D; Thombs BD. Research integrity and peer review. 2018.

Retrospective assessment of resource use and costs in two investigator-initiated randomized trials exemplified a comprehensive cost item list

Speich B.; von Niederhausern B.; Keiser J.; Furst T.; Kasenda B.; Christ-Crain M.; Hemkens L.G.; Pauli-Magnus C.; Schwenkglenks M.; Briel M.. Journal of Clinical Epidemiology. 2018.

Routinely collected data for randomized trials: promises, barriers, and implications.

Mc Cord KA; Al-Shahi Salman R; Treweek S; Gardner H; Strech D; Whiteley W; Ioannidis JPA; Hemkens LG. Trials. 2018.

Systematic review and simulation study of ignoring clustered data in surgical trials

Dell-Kuster S.; Droeser R.A.; Schafer J.; Gloy V.; Ewald H.; Schandelmaier S.; Hemkens L.G.; Bucher H.C.; Young J.; Rosenthal R.. The British journal of surgery. 2018.

Systematic review on costs and resource use of randomized clinical trials shows a lack of transparent and comprehensive data

Speich B.; von Niederhausern B.; Schur N.; Hemkens L.G.; Furst T.; Bhatnagar N.; Alturki R.; Agarwal A.; Kasenda B.; Pauli-Magnus C.; Schwenkglenks M.; Briel M.. Journal of Clinical Epidemiology. 2018.

The Comparative Effectiveness of Innovative Treatments for Cancer (CEIT-Cancer) project: Rationale and design of the database and the collection of evidence available at approval of novel drugs.

Ladanie A; Speich B; Naudet F; Agarwal A; Pereira TV; Sclafani F; Martin-Liberal J; Schmid T; Ewald H; Ioannidis JPA; Bucher HC; Kasenda B; Hemkens LG. Trials. 2018.

The reporting of studies conducted using observational routinely collected health data statement for pharmacoepidemiology (RECORD-PE).

Langan SM; Schmidt SA; Wing K; Ehrenstein V; Nicholls SG; Filion KB; Klungel O; Petersen I; Sorensen HT; Dixon WG; Guttmann A; Harron K; Hemkens LG; Moher D; Schneeweiss S; Smeeth L; Sturkenboom M; von Elm E; Wang SV; Benchimol EI. BMJ (Clinical research ed.). 2018.

Treatments for subacute cough in primary care: systematic review and meta-analyses of randomised clinical trials.

Speich B; Thomer A; Aghlmandi S; Ewald H; Zeller A; Hemkens LG. The British journal of general practice : the journal of the Royal College of General Practitioners. 2018.

Comparative effectiveness of tenofovir in HIV-infected treatment-experienced patients: systematic review and meta-analysis.

Ewald H; Santini-Oliveira M; Bühler JE; Vuichard D; Schandelmaier S; Stöckle M; Briel M; Bucher HC; Hemkens LG. HIV clinical trials. 2017.

Niacin for primary and secondary prevention of cardiovascular events.

Schandelmaier S; Briel M; Saccilotto R; Olu KK; Arpagaus A; Hemkens LG; Nordmann AJ. The Cochrane database of systematic reviews. 2017.

Personalized prescription feedback using routinely collected data to reduce antibiotic use in primary care a randomized clinical trial

Hemkens L.G.; Saccilotto R.; Reyes S.L.; Glinz D.; Zumbrunn T.; Grolimund O.; Gloy V.; Raatz H.; Widmer A.; Zeller A.; Bucher H.C.. JAMA internal medicine. 2017.

Premature Discontinuation of Pediatric Randomized Controlled Trials: A Retrospective Cohort Study.

Schandelmaier S; Tomonaga Y; Bassler D; Meerpohl JJ; von Elm E; You JJ; Bluemle A; Lamontagne F; Saccilotto R; Amstutz A; Bengough T; Stegert M; Olu KK; Tikkinen KAO; Neumann I; Carrasco-Labra A; Faulhaber M; Mulla SM; Mertz D; Akl EA; Sun X; Busse JW; Ferreira-González I; Nordmann A; Gloy V; Raatz H; Moja L; Rosenthal R; Ebrahim S; Vandvik PO; Johnston BC; Walter MA; Burnand B; Schwenkglenks M; Hemkens LG; Guyatt G; Bucher HC; Kasenda B; Briel M. Journal of Pediatrics. 2017.

Quality of antibiotic prescribing of Swiss primary care physicians with high prescription rates: a nationwide survey.

Glinz D; Leon Reyes S; Saccilotto R; Widmer AF; Zeller A; Bucher HC; Hemkens LG. Journal of Antimicrobial Chemotherapy. 2017.

Towards the development of a comprehensive framework: Qualitative systematic survey of definitions of clinical research quality.

von Niederhäusern B; Schandelmaier S; Mi Bonde M; Brunner N; Hemkens LG; Rutquist M; Bhatnagar N; Guyatt GH; Pauli-Magnus C; Briel M. PLoS ONE. 2017.

[The REporting of studies Conducted using Observational Routinely-collected health Data (RECORD) statement].

Benchimol EI; Smeeth L; Guttmann A; Harron K; Hemkens LG; Moher D; Petersen I; Sørensen HT; von Elm E; Langan SM; RECORD Working Committee. Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen. 2016.

Agreement of treatment effects for mortality from routinely collected data and subsequent randomized trials: meta-epidemiological survey.

Hemkens LG; Contopoulos-Ioannidis DG; Ioannidis JP. BMJ (Clinical research ed.). 2016.

Agreement of treatment effects for mortality from routinely collected data and subsequent randomized trials: meta-epidemiological survey - The authors respond 1

Hemkens,Lars G.; Contopoulos-Ioannidis,Despina G.; Ioannidis,John P.A.. . 2016.

Agreement of treatment effects for mortality from routinely collected data and subsequent randomized trials: meta-epidemiological survey - The authors respond 2

Hemkens,Lars G.; Contopoulos-Ioannidis,Despina G.; Ioannidis,John P.A.. . 2016.

Agreement of treatment effects for mortality from routinely collected data and subsequent randomized trials: meta-epidemiological survey - The authors respond 3

Hemkens,Lars G.; Contopoulos-Ioannidis,Despina G.; Ioannidis,John P.A.. . 2016.

Agreements between Industry and Academia on Publication Rights: A Retrospective Study of Protocols and Publications of Randomized Clinical Trials.

Kasenda B; von Elm E; You JJ; Blümle A; Tomonaga Y; Saccilotto R; Amstutz A; Bengough T; Meerpohl JJ; Stegert M; Olu KK; Tikkinen KA; Neumann I; Carrasco-Labra A; Faulhaber M; Mulla SM; Mertz D; Akl EA; Bassler D; Busse JW; Ferreira-González I; Lamontagne F; Nordmann A; Gloy V; Raatz H; Moja L; Ebrahim S; Schandelmaier S; Sun X; Vandvik PO; Johnston BC; Walter MA; Burnand B; Schwenkglenks M; Hemkens LG; Bucher HC; Guyatt GH; Briel M. PLoS Medicine. 2016.

Authors' reply to Pérol and colleagues.

Hemkens,Lars G; Contopoulos-Ioannidis,Despina G; Ioannidis,John P A. BRIT MED J (PRINT-AUSGABE). 2016.

Better research reporting to improve the utility of routine data for making better treatment decisions.

Hemkens LG; Langan SM; Benchimol EI. Journal of Comparative Effectiveness Research. 2016.

Cardiovascular effects and safety of long-term colchicine treatment: Cochrane review and meta-analysis.

Hemkens LG; Ewald H; Gloy VL; Arpagaus A; Olu KK; Nidorf M; Glinz D; Nordmann AJ; Briel M. Heart. 2016.

Colchicine and Prevention of Cardiovascular Events.

Hemkens LG; Ewald H; Briel M. JAMA. 2016.

Colchicine for prevention of cardiovascular events.

Hemkens LG; Ewald H; Gloy VL; Arpagaus A; Olu KK; Nidorf M; Glinz D; Nordmann AJ; Briel M. The Cochrane database of systematic reviews. 2016.

Current use of routinely collected health data to complement randomized controlled trials: a meta-epidemiological survey.

Hemkens LG; Contopoulos-Ioannidis DG; Ioannidis JP. CMAJ open. 2016.

Personalized prescription feedback to reduce antibiotic overuse in primary care: rationale and design of a nationwide pragmatic randomized trial.

Hemkens LG; Saccilotto R; Reyes SL; Glinz D; Zumbrunn T; Grolimund O; Gloy V; Raatz H; Widmer A; Zeller A; Bucher HC. BMC INFECTIOUS DISEASES. 2016.

Planning and reporting of quality-of-life outcomes in cancer trials.

Schandelmaier S; Conen K; von Elm E; You JJ; Blümle A; Tomonaga Y; Saccilotto R; Amstutz A; Bengough T; Meerpohl JJ; Stegert M; Olu KK; Tikkinen KA; Neumann I; Carrasco-Labra A; Faulhaber M; Mulla SM; Mertz D; Akl EA; Sun X; Bassler D; Busse JW; Ferreira-González I; Lamontagne F; Nordmann A; Gloy V; Raatz H; Moja L; Rosenthal R; Ebrahim S; Vandvik PO; Johnston BC; Walter MA; Burnand B; Schwenkglenks M; Hemkens LG; Bucher HC; Guyatt GH; Briel M; Kasenda B; DISCO study group. Annals of Oncology. 2016.

Premature discontinuation of prospective clinical studies approved by a research ethics committee - A comparison of randomised and non-randomised studies

Blumle A.; Schandelmaier S.; Oeller P.; Kasenda B.; Briel M.; von Elm E.; Akl E.A.; Amstutz A.; Bassler D.; Bengough T.; Bucher H.C.; Burnand B.; Busse J.W.; Carrasco-Labra A.; Ebrahim S.; Faulhaber M.; Gloy V.; Ferreira-Gonzalez I.; Guyatt G.H.; Hemkens L.G.; Johnston B.C.; Lamontagne F.; Meerpohl J.J.; Mertz D.; Moja L.; Mulla S.; Neumann I.; Nordmann A.; Olu K.K.; Raatz H.; Rosenthal R.; Saccilotto R.; Schwenkglenks M.; Stegert M.; Sun X.; Tikkinen K.A.O.; Tomonaga Y.; Walter M.A.; Vandvik P.O.; You J.J.. PLoS ONE. 2016.

Premature discontinuation of randomized trials in critical and emergency care: A retrospective cohort study

Schandelmaier S.; Von Elm E.; You J.J.; Blumle A.; Tomonaga Y.; Lamontagne F.; Saccilotto R.; Amstutz A.; Bengough T.; Meerpohl J.J.; Stegert M.; Olu K.K.; Tikkinen K.A.O.; Neumann I.; Carrasco-Labra A.; Faulhaber M.; Mulla S.M.; Mertz D.; Akl E.A.; Sun X.; Bassler D.; Busse J.W.; Ferreira-Gonzalez I.; Nordmann A.; Gloy V.; Raatz H.; Moja L.; Rosenthal R.; Ebrahim S.; Vandvik P.O.; Johnston B.C.; Walter M.A.; Burnand B.; Schwenkglenks M.; Hemkens L.G.; Cook D.J.; Meade M.O.; Bucher H.C.; Kasenda B.; Briel M.. Critical care medicine. 2016.