Departement
Klinische Forschung
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Publications Briel Matthias

Accelerating clinical trial implementation in the context of the COVID-19 pandemic: challenges, lessons learned and recommendations from DisCoVeRy and the EU-SolidAct EU response group.

EU-Response investigators group.; Diallo A; Trøseid M; Simensen VC; Boston A; Demotes J; Olsen IC; Chung F; Paiva JA; Hites M; Ader F; Arribas JR; Baratt-Due A; Melien Ø; Tacconelli E; Staub T; Greil R; Tsiodras S; Briel M; Esperou H; Mentré F; Eustace J; Saillard J; Delmas C; LeMestre S; Dumousseaux M; Costagliola D; Røttingen JA; Yazdanpanah Y. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. 2022.

A Contextual Analysis and Logic Model for Integrated Care for Frail Older Adults Living at Home: The INSPIRE Project.

Yip O; Huber E; Stenz S; Zullig LL; Zeller A; De Geest SM; Deschodt M; INSPIRE consortium.. International Journal of Integrated Care. 2021.

A meta-research study revealed several challenges in obtaining placebos for investigator-initiated drug trials.

Speich B; Logullo P; Deuster S; Marian IR; Moschandreas J; Taji Heravi A; Gloy V; Briel M; Hopewell S; MAking Randomized Trials Affordable (MARTA) Group.. Journal of clinical epidemiology. 2021.

Association of Supporting Trial Evidence and Reimbursement for Off-Label Use of Cancer Drugs.

Herbrand AK; Schmitt AM; Briel M; Ewald H; Goldkuhle M; Diem S; Hoogkamer A; Joerger M; Moffa G; Novak U; Hemkens LG; Kasenda B. JAMA Network Open. 2021.

A trial platform to assess approved SARS-CoV-2 vaccines in immunocompromised patients: first sub-protocol for a pilot trial comparing the mRNA vaccines Comirnaty® and COVID-19 mRNA Vaccine Moderna®

Speich B.; Chammartin F.; Smith D.; Stoeckle M.P.; Amico P.; Eichenberger A.L.; Hasse B.; Schuurmans M.M.; Muller T.; Tamm M.; Dickenmann M.; Abela I.A.; Trkola A.; Hirsch H.H.; Manuel O.; Cavassini M.; Hemkens L.G.; Briel M.; Mueller N.J.; Rauch A.; Gunthard H.F.; Koller M.T.; Bucher H.C.; Kusejko K.. Trials. 2021.

Barriers and Facilitating Factors for Conducting Systematic Evidence Assessments in Academic Clinical Trials.

McLennan S; Nussbaumer-Streit B; Hemkens LG; Briel M. JAMA Network Open. 2021.

Duration of antibiotic treatment using procalcitonin-guided treatment algorithms in older patients: A patient-level meta-analysis from randomized controlled trials

Heilmann E.; Gregoriano C.; Annane D.; Reinhart K.; Bouadma L.; Wolff M.; Chastre J.; Luyt C.-E.; Tubach F.; Branche A.R.; Briel M.; Christ-Crain M.; Welte T.; Corti C.; De Jong E.; Nijsten M.; De Lange D.W.; Van Oers J.A.H.; Beishuizen A.; Girbes A.R.J.; Deliberato R.O.; Schroeder S.; Kristoffersen K.B.; Layios N.; Damas P.; Lima S.S.S.; Nobre V.; Wei L.; Oliveira C.F.; Shehabi Y.; Stolz D.; Tamm M.; Verduri A.; Wang J.-X.; Drevet S.; Gavazzi G.; Mueller B.; Schuetz P.. Age and Ageing. 2021.

Evaluation of Planned Subgroup Analysis in Protocols of Randomized Clinical Trials.

Taji Heravi A; Gryaznov D; Schandelmaier S; Kasenda B; Briel M; Adherence to SPIRIT Recommendations (ASPIRE) Study Group.. JAMA Network Open. 2021.

Exploring reasons for recruitment failure in clinical trials: a qualitative study with clinical trial stakeholders in Switzerland, Germany, and Canada.

Briel M; Elger BS; McLennan S; Schandelmaier S; von Elm E; Satalkar P. Trials. 2021.

Influence of Prednisone on Inflammatory Biomarkers in Community-Acquired Pneumonia: Secondary Analysis of a Randomized Trial

Raess N.; Schuetz P.; Cesana-Nigro N.; Winzeler B.; Urwyler S.A.; Schaedelin S.; Rodondi N.; Blum M.R.; Briel M.; Mueller B.; Christ-Crain M.; Blum C.A.. Journal of Clinical Pharmacology. 2021.

Practices and Attitudes of Swiss Stakeholders Regarding Investigator-Initiated Clinical Trial Funding Acquisition and Cost Management

McLennan S.; Griessbach A.; Briel M.. JAMA Network Open. 2021.

Reliability of Trial Information Across Registries for Trials With Multiple Registrations: A Systematic Review.

Speich B; Gloy VL; Klatte K; Gryaznov D; Taji Heravi A; Ghosh N; Marian IR; Lee H; Mansouri A; Lohner S; Saccilotto R; Nury E; Chan AW; Blümle A; Odutayo A; Hopewell S; Briel M; Adherence to Spirit Recommendations (ASPIRE) Study Group.. JAMA Network Open. 2021.

Reporting quality of trial protocols improved for non-regulated interventions but not regulated interventions: A repeated cross-sectional study.

Lohner S; Gryaznov D; von Niederhäusern B; Speich B; Kasenda B; Ojeda-Ruiz E; Schandelmaier S; Mertz D; Odutayo A; Tomonaga Y; Amstutz A; Pauli-Magnus C; Gloy V; Bischoff K; Wollmann K; Rehner L; Meerpohl JJ; Nordmann A; Klatte K; Ghosh N; Heravi AT; Wong J; Chow N; Hong PJ; McCord K; Sricharoenchai S; Busse JW; Agarwal A; Saccilotto R; Schwenkglenks M; Moffa G; Hemkens LG; Hopewell S; von Elm E; Blümle A; Briel M. Journal of clinical epidemiology. 2021.

Surgery for obstructive sleep apnoea in adults

Berg B.-I.; Werz S.M.; Pfeifle M.; Schrader F.; Jurgens P.; Briel M.. Cochrane Database of Systematic Reviews. 2021.

The INSPIRE Population Survey: development, dissemination and respondent characteristics.

Siqeca F; Obas K; Yip O; Stenz S; Vounatsou P; Briel M; Schwenkglenks M; Quinto C; Blozik E; Zeller A; Zullig LL; De Geest S; Deschodt M. BMC Medical Research Methodology. 2021.

Treatment for gastrointestinal and pancreatic neuroendocrine tumours: a network meta-analysis

Walter M.A.; Nesti C.; Spanjol M.; Kollar A.; Butikofer L.; Gloy V.L.; Dumont R.A.; Seiler C.A.; Christ E.R.; Radojewski P.; Briel M.; Kaderli R.M.. Cochrane Database of Systematic Reviews. 2021.

A scoping review shows that several nonvalidated budget planning tools for randomized trials are available.

Speich B; Gloy V; Schur N; Ewald H; Hemkens LG; Schwenkglenks M; Briel M; MAking Randomized Trials Affordable (MARTA) Group.. Journal of clinical epidemiology. 2020.

A systematic survey of randomised trials that stopped early for reasons of futility.

Walter SD; Han H; Guyatt GH; Bassler D; Bhatnagar N; Gloy V; Schandelmaier S; Briel M. BMC Medical Research Methodology. 2020.

Characteristics and interpretation of subgroup analyses based on tumour characteristics in randomised trials testing target-specific anticancer drugs: design of a systematic survey.

Schandelmaier S; Schmitt AM; Herbrand AK; Glinz D; Ewald H; Briel M; Guyatt GH; Hemkens LG; Kasenda B. BMJ Open. 2020.

Clinical Trial Evidence Supporting US Food and Drug Administration Approval of Novel Cancer Therapies Between 2000 and 2016.

Ladanie A; Schmitt AM; Speich B; Naudet F; Agarwal A; Pereira TV; Sclafani F; Herbrand AK; Briel M; Martin-Liberal J; Schmid T; Ewald H; Ioannidis JPA; Bucher HC; Kasenda B; Hemkens LG. JAMA Network Open. 2020.

Core components and impact of nurse-led integrated care models for home-dwelling older people: A systematic review and meta-analysis.

Deschodt M; Laurent G; Cornelissen L; Yip O; Zúñiga F; Denhaerynck K; Briel M; Karabegovic A; De Geest S; INSPIRE consortium.. INTERNATIONAL JOURNAL OF NURSING STUDIES. 2020.

COVID-19 randomised trial protocols: rapid publication without barriers.

Treweek S; Jüni P; Li T; Collin J; Briel M; Chan AW; Hemming K; Meurer WJ; Sydes MR; Grimshaw JM. . 2020.

Design, analysis and reporting of multi-arm trials and strategies to address multiple testing.

Odutayo A; Gryaznov D; Copsey B; Monk P; Speich B; Roberts C; Vadher K; Dutton P; Briel M; Hopewell S; Altman DG; ASPIRE study group.. International journal of epidemiology. 2020.

Development of the Instrument to assess the Credibility of Effect Modification Analyses (ICEMAN) in randomized controlled trials and meta-analyses.

Schandelmaier S; Briel M; Varadhan R; Schmid CH; Devasenapathy N; Hayward RA; Gagnier J; Borenstein M; van der Heijden GJMG; Dahabreh IJ; Sun X; Sauerbrei W; Walsh M; Ioannidis JPA; Thabane L; Guyatt GH. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne. 2020.

Digital tools for trial recruitment and retention-plenty of tools but rigorous evaluation is in short supply.

Treweek S; Briel M. . 2020.

Erratum to "A systematic survey identified 36 criteria for assessing effect modification claims in randomized trials or meta-analyses" [J Clin Epidemiol. 2019;113:159-67].

Schandelmaier S; Chang Y; Bala MM; Devasenapathy N; Devji T; Kwong JSW; Colunga Lozano LE; Lee Y; Agarwal A; Bhatnagar N; Ewald H; Zhang Y; Sun X; Thabane L; Walsh M; Briel M; Guyatt GH. . 2020.

Evaluating prophylactic heparin in ambulatory patients with solid tumours: a systematic review and individual participant data meta-analysis.

Schünemann HJ; Ventresca M; Crowther M; Briel M; Zhou Q; Noble S; Macbeth F; Griffiths G; Garcia D; Lyman GH; Di Nisio M; Iorio A; Mbuagbaw L; Neumann I; van Es N; Brouwers M; Guyatt G; Streiff MB; Marcucci M; Baldeh T; Florez ID; Alma OG; Solh Z; Bossuyt PM; Kahale LA; Ageno W; Bozas G; Büller HR; Lebeau B; Lecumberri R; Loprinzi C; McBane R; Sideras K; Maraveyas A; Pelzer U; Perry J; Klerk C; Agnelli G; Akl EA. Lancet Haematology. 2020.

Impact of a short version of the CONSORT checklist for peer reviewers to improve the reporting of randomised controlled trials published in biomedical journals: study protocol for a randomised controlled trial.

Speich B; Schroter S; Briel M; Moher D; Puebla I; Clark A; Maia Schlüssel M; Ravaud P; Boutron I; Hopewell S. BMJ Open. 2020.

Individual participant data meta-analysis of 14 randomized trials evaluating prophylactic heparin in ambulatory cancer patients

Schünemann HJ; Ventresca M; Crowther M; Briel M; Zhou Q; Noble S; Macbeth F; Griffiths G, Garcia D; Lyman G; DiNisio M; Iorio A; Beyene J; Mbuagbaw L; Neumann I; Van Es N; Brouwers M; Brozek J; Guyatt G; Moll S; Santesso N; Streiff M; Marcucci M; Baldeh T; Florez I; Alma OG; Solh Z; Ozkan M; Altinbas M; Ageno W; Bleker S; Bozas G; Büller HR; Evans J; Lebeau B; Lecumberri R; Loprinzi C; McBane R; Sideras K; Zulian G; Maraveyas A; Pelzer U; Perry J; Akl EA; and the IPDMA heparin use in cancer patients research group. . 2020.

Introduction to statistical simulations in health research

Boulesteix A.-L.; Groenwold R.H.H.; Abrahamowicz M.; Binder H.; Briel M.; Hornung R.; Morris T.P.; Rahnenfuhrer J.; Sauerbrei W.. BMJ Open. 2020.

Obtaining and managing data sets for individual participant data meta-analysis: scoping review and practical guide.

Ventresca M; Schünemann HJ; Macbeth F; Clarke M; Thabane L; Griffiths G; Noble S; Garcia D; Marcucci M; Iorio A; Zhou Q; Crowther M; Akl EA; Lyman GH; Gloy V; DiNisio M; Briel M. BMC Medical Research Methodology. 2020.

Prediction of RECRUITment In randomized clinical Trials (RECRUIT-IT)-rationale and design for an international collaborative study.

Kasenda B; Liu J; Jiang Y; Gajewski B; Wu C; von Elm E; Schandelmaier S; Moffa G; Trelle S; Schmitt AM; Herbrand AK; Gloy V; Speich B; Hopewell S; Hemkens LG; Sluka C; McGill K; Meade M; Cook D; Lamontagne F; Tréluyer JM; Haidich AB; Ioannidis JPA; Treweek S; Briel M. Trials. 2020.

Rationale and design of repeated cross-sectional studies to evaluate the reporting quality of trial protocols: the Adherence to SPIrit REcommendations (ASPIRE) study and associated projects.

Gryaznov D; Odutayo A; von Niederhäusern B; Speich B; Kasenda B; Ojeda-Ruiz E; Blümle A; Schandelmaier S; Mertz D; Tomonaga Y; Amstutz A; Pauli-Magnus C; Gloy V; Bischoff K; Wollmann K; Rehner L; Lohner S; Meerpohl JJ; Nordmann A; Klatte K; Ghosh N; Heravi AT; Wong J; Chow N; Hong PJ; Cord KM; Sricharoenchai S; Busse JW; Agarwal A; Saccilotto R; Schwenkglenks M; Moffa G; Hemkens LG; Hopewell S; von Elm E; Briel M. Trials. 2020.

Reporting of methodological studies in health research: A protocol for the development of the MethodologIcal STudy reportIng Checklist (MISTIC)

Lawson D.O.; Puljak L.; Pieper D.; Schandelmaier S.; Collins G.S.; Brignardello-Petersen R.; Moher D.; Tugwell P.; Welch V.A.; Samaan Z.; Thombs B.D.; Norskov A.K.; Jakobsen J.C.; Allison D.B.; Mayo-Wilson E.; Young T.; Chan A.-W.; Briel M.; Guyatt G.H.; Thabane L.; Mbuagbaw L.. BMJ Open. 2020.

The fragility of trial results involves more than statistical significance alone.

Walter SD; Thabane L; Briel M. Journal of clinical epidemiology. 2020.

The Khorana score for prediction of venous thromboembolism in cancer patients: An individual patient data meta-analysis.

van Es N; Ventresca M; Di Nisio M; Zhou Q; Noble S; Crowther M; Briel M; Garcia D; Lyman GH; Macbeth F; Griffiths G; Iorio A; Mbuagbaw L; Neumann I; Brozek J; Guyatt G; Streiff MB; Baldeh T; Florez ID; Gurunlu Alma O; Agnelli G; Ageno W; Marcucci M; Bozas G; Zulian G; Maraveyas A; Lebeau B; Lecumberri R; Sideras K; Loprinzi C; McBane R; Pelzer U; Riess H; Solh Z; Perry J; Kahale LA; Bossuyt PM; Klerk C; Büller HR; Akl EA; Schünemann HJ; IPDMA Heparin Use in Cancer Patients Research Group.. Journal of thrombosis and haemostasis : JTH. 2020.

Treatment for gastrointestinal and pancreatic neuroendocrine tumours: a network meta-analysis

Walter M.A.; Spanjol M.; Kollar A.; Butikofer L.; Gloy V.L.; Dumont R.A.; Seiler C.A.; Christ E.R.; Radojewski P.; Briel M.; Kaderli R.M.. Cochrane Database of Systematic Reviews. 2020.

Trial Forge Guidance 2: how to decide if a further Study Within A Trial (SWAT) is needed.

Treweek S; Bevan S; Bower P; Briel M; Campbell M; Christie J; Collett C; Cotton S; Devane D; El Feky A; Galvin S; Gardner H; Gillies K; Hood K; Jansen J; Littleford R; Parker A; Ramsay C; Restrup L; Sullivan F; Torgerson D; Tremain L; von Elm E; Westmore M; Williams H; Williamson PR; Clarke M. Trials. 2020.

Uncertainties about the need for ethics approval in Switzerland: a mixed-methods study.

Gloy V; McLennan S; Rinderknecht M; Ley B; Meier B; Driessen S; Gervasoni P; Hirschel B; Benkert P; Gilles I; von Elm E; Briel M. Swiss medical weekly. 2020.

Working Through Ethics Review of Big Data Research Projects: An Investigation into the Experiences of Swiss and American Researchers

Favaretto M.; De Clercq E.; Briel M.; Elger B.S.. Journal of Empirical Research on Human Research Ethics. 2020.

A guidance was developed to identify participants with missing outcome data in randomized controlled trials.

Kahale LA; Guyatt GH; Agoritsas T; Briel M; Busse JW; Carrasco-Labra A; Khamis AM; Zhang Y; Hooft L; Scholten RJPM; Akl EA. Journal of clinical epidemiology. 2019.

A systematic survey identified 36 criteria for assessing effect modification claims in randomized trials or meta-analyses.

Schandelmaier S; Chang Y; Devasenapathy N; Devji T; Kwong JSW; Colunga Lozano LE; Lee Y; Agarwal A; Bhatnagar N; Ewald H; Zhang Y; Sun X; Thabane L; Walsh M; Briel M; Guyatt GH. Journal of clinical epidemiology. 2019.

Comparison of randomized controlled trials discontinued or revised for poor recruitment and completed trials with the same research question: a matched qualitative study.

Briel M; Speich B; von Elm E; Gloy V. Trials. 2019.

Contrasting evidence to reimbursement reality for off-label use (OLU) of drug treatments in cancer care: rationale and design of the CEIT-OLU project.

Herbrand AK; Schmitt AM; Briel M; Diem S; Ewald H; Hoogkamer A; Joerger M; Mc Cord KA; Novak U; Sricharoenchai S; Hemkens LG; Kasenda B. ESMO open. 2019.

Cosyntropin testing does not predict response to glucocorticoids in community-acquired pneumonia in a randomized controlled trial.

Blum CA; Schuetz P; Nigro N; Winzeler B; Arici B; Refardt J; Urwyler SA; Rodondi N; Blum MR; Briel M; Mueller B; Christ-Crain M. Clinical endocrinology. 2019.

Current use and costs of electronic health records for clinical trial research: a descriptive study.

Mc Cord KA; Ewald H; Ladanie A; Briel M; Speich B; Bucher HC; Hemkens LG; RCD for RCTs initiative and the Making Randomized Trials More Affordable Group.. CMAJ open. 2019.

Functional aging in health and heart failure: The COmPLETE Study

Wagner J.; Knaier R.; Infanger D.; Arbeev K.; Briel M.; Dieterle T.; Hanssen H.; Faude O.; Roth R.; Hinrichs T.; Schmidt-Trucksass A.. BMC Cardiovascular Disorders. 2019.

Incidence and predictors of atrial fibrillation progression: A systematic review and meta-analysis.

Blum S; Meyre P; Aeschbacher S; Berger S; Auberson C; Briel M; Osswald S; Conen D. Heart rhythm. 2019.

Monitoring strategies for clinical intervention studies

Klatte K.; Pauli-Magnus C.; Love S.; Sydes M.; Benkert P.; Bruni N.; Ewald H.; Arnaiz Jimenez P.; Bonde M.M.; Briel M.. Cochrane Database of Systematic Reviews. 2019.

Patient-reported outcomes

Johnston B.C.; Patrick D.L.; Devji T.; Maxwell L.J.; Bingham C.O.; Beaton D.E.; Boers M.; Briel M.; Busse J.W.; Carrasco-Labra A.; Christensen R.; Da Costa B.R.; Dib R.E.; Lyddiatt A.; Ostelo R.W.; Shea B.; Singh J.; Terwee C.B.; Williamson P.R.; Gagnier J.J.; Tugwell P.; Guyatt G.H.. . 2019.

Randomised trials with provision for early stopping for benefit (or harm): The impact on the estimated treatment effect.

Walter SD; Guyatt GH; Bassler D; Briel M; Ramsay T; Han HD. STATISTICS IN MEDICINE. 2019.

Reporting Quality of Journal Abstracts for Surgical Randomized Controlled Trials Before and After the Implementation of the CONSORT Extension for Abstracts.

Speich B; Mc Cord KA; Agarwal A; Gloy V; Gryaznov D; Moffa G; Hopewell S; Briel M. World journal of surgery. 2019.

Resource use, costs, and approval times for planning and preparing a randomized clinical trial before and after the implementation of the new Swiss human research legislation.

Speich B; Schur N; Gryaznov D; von Niederhäusern B; Hemkens LG; Schandelmaier S; Amstutz A; Kasenda B; Pauli-Magnus C; Ojeda-Ruiz E; Tomonaga Y; McCord K; Nordmann A; von Elm E; Briel M; Schwenkglenks M; a collaboration of the MARTA (MAking Randomized Trials Affordable) and ASPIRE (Adherence to Standard Protocol Items: REcommendations for interventional trials) Study Groups.. PLoS One. 2019.

Risk of Hospital Admissions in Patients With Atrial Fibrillation: A Systematic Review and Meta-analysis.

Meyre P; Blum S; Berger S; Aeschbacher S; Schoepfer H; Briel M; Osswald S; Conen D. The Canadian journal of cardiology. 2019.

Single pivotal trials with few corroborating characteristics were used for FDA approval of cancer therapies.

Ladanie A; Speich B; Briel M; Sclafani F; Bucher HC; Agarwal A; Ioannidis JPA; Pereira TV; Kasenda B; Hemkens LG. Journal of clinical epidemiology. 2019.

Therapeutic Options for Neuroendocrine Tumors: A Systematic Review and Network Meta-analysis.

Kaderli RM; Spanjol M; Kollár A; Bütikofer L; Gloy V; Dumont RA; Seiler CA; Christ ER; Radojewski P; Briel M; Walter MA. JAMA oncology. 2019.

The sensitivity and specificity of the mannitol bronchial challenge test to identify asthma in different populations: a systematic review.

Kernen P; Steveling-Klein EH; Saccilotto RT; Raatz H; Briel M; Koller MT; Westwood M; Bucher HC; Miedinger D; Leuppi JD. Swiss medical weekly. 2019.

Academic response to improving value and reducing waste: A comprehensive framework for INcreasing QUality In patient-oriented academic clinical REsearch (INQUIRE).

von Niederhäusern B; Guyatt GH; Briel M; Pauli-Magnus C. PLoS medicine. 2018.

Bariatric surgery among patients with heart failure: a systematic review and meta-analysis.

Berger S; Meyre P; Blum S; Aeschbacher S; Ruegg M; Briel M; Conen D. Open Heart. 2018.

Corticosteroids in Patients Hospitalized With Community-Acquired Pneumonia: Systematic Review and Individual Patient Data Metaanalysis.

Briel M; Spoorenberg SMC; Snijders D; Torres A; Fernandez-Serrano S; Meduri GU; Gabarrús A; Blum CA; Confalonieri M; Kasenda B; Siemieniuk RAC; Boersma W; Bos WJW; Christ-Crain M; Ovidius Study Group.; Capisce Study Group.; STEP Study Group.. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2018.

Corticosteroid therapy for sepsis: a clinical practice guideline.

Lamontagne F; Rochwerg B; Lytvyn L; Guyatt GH; Møller MH; Annane D; Kho ME; Adhikari NKJ; Machado F; Vandvik PO; Dodek P; Leboeuf R; Briel M; Hashmi M; Camsooksai J; Shankar-Hari M; Baraki MK; Fugate K; Chua S; Marti C; Cohen D; Botton E; Agoritsas T; Siemieniuk RAC. BMJ (Clinical research ed.). 2018.

Effect of procalcitonin-guided antibiotic treatment on mortality in acute respiratory infections: a patient level meta-analysis.

Schuetz P; Wirz Y; Sager R; Christ-Crain M; Stolz D; Tamm M; Bouadma L; Luyt CE; Wolff M; Chastre J; Tubach F; Kristoffersen KB; Burkhardt O; Welte T; Schroeder S; Nobre V; Wei L; Bucher HC; Annane D; Reinhart K; Falsey AR; Branche A; Damas P; Nijsten M; de Lange DW; Deliberato RO; Oliveira CF; Maravić-Stojković V; Verduri A; Beghé B; Cao B; Shehabi Y; Jensen JS; Corti C; van Oers JAH; Beishuizen A; Girbes ARJ; de Jong E; Briel M; Mueller B. The Lancet. Infectious diseases. 2018.

Funding characteristics of randomised clinical trials supported by the Swiss National Science Foundation: a retrospective cohort study.

Amstutz A; Schandelmaier S; Frei R; Surina J; Agarwal A; Alturki R; von Niederhäusern B; von Elm E; Briel M; On Behalf Of The MAking Randomized Trials Affordable Marta Group. Swiss medical weekly. 2018.

How to Conceptualize and Implement a PhD Program in Health Sciences-The Basel Approach.

Keller F; Dhaini S; Briel M; Henrichs S; Höchsmann C; Kalbermatten D; Künzli N; Mollet A; Puelacher C; Schmidt-Trucksäss A; von Niederhäusern B; De Geest S. Journal of medical education and curricular development. 2018.

Procalcitonin-guided antibiotic therapy algorithms for different types of acute respiratory infections based on previous trials.

Schuetz P; Bolliger R; Merker M; Christ-Crain M; Stolz D; Tamm M; Luyt CE; Wolff M; Schroeder S; Nobre V; Reinhart K; Branche A; Damas P; Nijsten M; Deliberato RO; Verduri A; Beghé B; Cao B; Shehabi Y; Jensen JS; Beishuizen A; de Jong E; Briel M; Welte T; Mueller B. Expert Review of Anti-Infective Therapy. 2018.

Reply to Stern et al.

Briel M; Spoorenberg SMC; Bos WJW; Christ-Crain M. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2018.

Retrospective assessment of resource use and costs in two investigator-initiated randomized trials exemplified a comprehensive cost item list

Speich B.; von Niederhausern B.; Keiser J.; Furst T.; Kasenda B.; Christ-Crain M.; Hemkens L.G.; Pauli-Magnus C.; Schwenkglenks M.; Briel M.. Journal of clinical epidemiology. 2018.

Systematic review on costs and resource use of randomized clinical trials shows a lack of transparent and comprehensive data

Speich B.; von Niederhausern B.; Schur N.; Hemkens L.G.; Furst T.; Bhatnagar N.; Alturki R.; Agarwal A.; Kasenda B.; Pauli-Magnus C.; Schwenkglenks M.; Briel M.. Journal of clinical epidemiology. 2018.

Systematic reviews do not adequately report or address missing outcome data in their analyses: a methodological survey

Kahale L.A.; Diab B.; Brignardello-Petersen R.; Agarwal A.; Mustafa R.A.; Kwong J.; Neumann I.; Li L.; Lopes L.C.; Briel M.; Busse J.W.; Iorio A.; Vandvik P.O.; Alexander P.E.; Guyatt G.; Akl E.A.. Journal of clinical epidemiology. 2018.

Authors seldom report the most patient-important outcomes and absolute effect measures in systematic review abstracts.

Agarwal A; Johnston BC; Vernooij RW; Carrasco-Labra A; Brignardello-Petersen R; Neumann I; Akl EA; Sun X; Briel M; Busse JW; Ebrahim S; Granados CE; Iorio A; Irfan A; Martínez García L; Mustafa RA; Ramirez-Morera A; Selva A; Solà I; Sanabrai AJ; Tikkinen KA; Vandvik PO; Zhang Y; Zazueta OE; Zhou Q; Schunemann HJ; Guyatt GH; Alonso-Coello P. Journal of clinical epidemiology. 2017.

Comparative effectiveness of tenofovir in HIV-infected treatment-experienced patients: systematic review and meta-analysis.

Ewald H; Santini-Oliveira M; Bühler JE; Vuichard D; Schandelmaier S; Stöckle M; Briel M; Bucher HC; Hemkens LG. HIV clinical trials. 2017.

Discontinuation and non-publication of randomised clinical trials supported by the main public funding body in Switzerland: a retrospective cohort study.

Amstutz A; Schandelmaier S; Frei R; Surina J; Agarwal A; Olu KK; Alturki R; Von Niederhäusern B; Von Elm E; Briel M. BMJ Open. 2017.

Early nutritional therapy for malnourished or nutritionally at-risk adult medical inpatients

Bally M.R.; Bounoure L.; Gomes F.; Blaser Yildirim P.Z.; Gloy V.L.; Briel M.; Schuetz P.. Cochrane Database of Systematic Reviews. 2017.

Effects of procalcitonin testing on antibiotic use and clinical outcomes in patients with upper respiratory tract infections. An individual patient data meta-analysis.

Odermatt J; Friedli N; Kutz A; Briel M; Bucher HC; Christ-Crain M; Burkhardt O; Welte T; Mueller B; Schuetz P. Clinical chemistry and laboratory medicine. 2017.

Generating evidence on a risk-based monitoring approach in the academic setting - lessons learned.

von Niederhäusern B; Orleth A; Schädelin S; Rawi N; Velkopolszky M; Becherer C; Benkert P; Satalkar P; Briel M; Pauli-Magnus C. BMC Medical Research Methodology. 2017.

GRADE equity guidelines 1: considering health equity in GRADE guideline development: introduction and rationale.

Welch VA; Akl EA; Guyatt G; Pottie K; Eslava-Schmalbach J; Ansari MT; de Beer H; Briel M; Dans T; Dans I; Hultcrantz M; Jull J; Katikireddi SV; Meerpohl J; Morton R; Mosdol A; Petkovic J; Schünemann HJ; Sharaf RN; Singh JA; Stanev R; Tonia T; Tristan M; Vitols S; Watine J; Tugwell P. Journal of clinical epidemiology. 2017.

GRADE equity guidelines 2: considering health equity in GRADE guideline development: equity extension of the guideline development checklist.

Akl EA; Welch V; Pottie K; Eslava-Schmalbach J; Darzi A; Sola I; Katikireddi SV; Singh J; Murad MH; Meerpohl J; Stanev R; Lang E; Matovinovic E; Shea B; Agoritsas T; Alexander PE; Snellman A; Brignardello-Petersen R; Gloss D; Thabane L; Shi C; Stein AT; Sharaf R; Briel M; Guyatt G; Schünemann H; Tugwell P. Journal of clinical epidemiology. 2017.

GRADE equity guidelines 3: considering health equity in GRADE guideline development: rating the certainty of synthesized evidence

Welch V.A.; Akl E.A.; Pottie K.; Ansari M.T.; Briel M.; Christensen R.; Dans A.; Dans L.; Eslava-Schmalbach J.; Guyatt G.; Hultcrantz M.; Jull J.; Katikireddi S.V.; Lang E.; Matovinovic E.; Meerpohl J.J.; Morton R.L.; Mosdol A.; Murad M.H.; Petkovic J.; Schunemann H.; Sharaf R.; Shea B.; Singh J.A.; Sola I.; Stanev R.; Stein A.; Thabaneii L.; Tonia T.; Tristan M.; Vitols S.; Watine J.; Tugwell P.. Journal of clinical epidemiology. 2017.

GRADE equity guidelines 4: considering health equity in GRADE guideline development: evidence to decision process.

Pottie K; Welch V; Morton R; Akl EA; Eslava-Schmalbach JH; Katikireddi V; Singh J; Moja L; Lang E; Magrini N; Thabane L; Stanev R; Matovinovic E; Snellman A; Briel M; Shea B; Tugwell P; Schunemann H; Guyatt G; Alonso-Coello P. Journal of clinical epidemiology. 2017.

GRADE guidelines 17: assessing the risk of bias associated with missing participant outcome data in a body of evidence.

Guyatt GH; Ebrahim S; Alonso-Coello P; Johnston BC; Mathioudakis AG; Briel M; Mustafa RA; Sun X; Walter SD; Heels-Ansdell D; Neumann I; Kahale LA; Iorio A; Meerpohl J; Schünemann HJ; Akl EA. Journal of clinical epidemiology. 2017.

Insufficient recruitment and premature discontinuation of clinical trials in Switzerland: qualitative study with trialists and other stakeholders.

Briel M; Elger B; von Elm E; Satalkar P. Swiss medical weekly. 2017.

Niacin for primary and secondary prevention of cardiovascular events

Schandelmaier S.; Briel M.; Saccilotto R.; Olu K.K.; Arpagaus A.; Hemkens L.G.; Nordmann A.J.. Cochrane Database of Systematic Reviews. 2017.

Premature Discontinuation of Pediatric Randomized Controlled Trials: A Retrospective Cohort Study.

Schandelmaier S; Tomonaga Y; Bassler D; Meerpohl JJ; von Elm E; You JJ; Bluemle A; Lamontagne F; Saccilotto R; Amstutz A; Bengough T; Stegert M; Olu KK; Tikkinen KAO; Neumann I; Carrasco-Labra A; Faulhaber M; Mulla SM; Mertz D; Akl EA; Sun X; Busse JW; Ferreira-González I; Nordmann A; Gloy V; Raatz H; Moja L; Rosenthal R; Ebrahim S; Vandvik PO; Johnston BC; Walter MA; Burnand B; Schwenkglenks M; Hemkens LG; Guyatt G; Bucher HC; Kasenda B; Briel M. The Journal of pediatrics. 2017.

Premature trial discontinuation often not accurately reflected in registries: comparison of registry records with publications.

Alturki R; Schandelmaier S; Olu KK; von Niederhäusern B; Agarwal A; Frei R; Bhatnagar N; Hooft L; von Elm E; Briel M. Journal of clinical epidemiology. 2017.

Pro-Adrenomedullin predicts 10-year all-cause mortality in community-dwelling patients: a prospective cohort study.

Odermatt J; Meili M; Hersberger L; Bolliger R; Christ-Crain M; Briel M; Bucher HC; Mueller B; Schuetz P. BMC cardiovascular disorders. 2017.

Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections

Schuetz P.; Wirz Y.; Sager R.; Christ-Crain M.; Stolz D.; Tamm M.; Bouadma L.; Luyt C.E.; Wolff M.; Chastre J.; Tubach F.; Kristoffersen K.B.; Burkhardt O.; Welte T.; Schroeder S.; Nobre V.; Wei L.; Bucher H.C.; Bhatnagar N.; Annane D.; Reinhart K.; Branche A.; Damas P.; Nijsten M.; de Lange D.W.; Deliberato R.O.; Lima S.S.; Maravic-Stojkovic V.; Verduri A.; Cao B.; Shehabi Y.; Beishuizen A.; Jensen J.-U.S.; Corti C.; Van Oers J.A.; Falsey A.R.; de Jong E.; Oliveira C.F.; Beghe B.; Briel M.; Mueller B.. Cochrane Database of Systematic Reviews. 2017.

Quantifying the bias in the estimated treatment effect in randomized trials having interim analyses and a rule for early stopping for futility.

Walter SD; Han H; Briel M; Guyatt GH. STATISTICS IN MEDICINE. 2017.

Randomized trials addressing a similar question are commonly published after a trial stopped early for benefit.

Murad MH; Guyatt GH; Domecq JP; Vernooij RWM; Erwin PJ; Meerpohl JJ; Prutsky GJ; Akl EA; Mueller K; Bassler D; Schandelmaier S; Walter SD; Busse JW; Kasenda B; Pagano G; Pardo-Hernandez H; Montori VM; Wang Z; Briel M. Journal of clinical epidemiology. 2017.

Surgery for obstructive sleep apnoea in adults

Werz S.M.; Pfeifle M.; Schrader F.; Jurgens P.; Briel M.; Berg B.-I.. Cochrane Database of Systematic Reviews. 2017.

Systematic review finds that study data not published in full text articles have unclear impact on meta-analyses results in medical research.

Schmucker CM; Blümle A; Schell LK; Schwarzer G; Oeller P; Cabrera L; von Elm E; Briel M; Meerpohl JJ; OPEN consortium.. PLoS One. 2017.

The natriuretic peptide MR-proANP predicts all-cause mortality and adverse outcome in community patients: a 10-year follow-up study.

Odermatt J; Hersberger L; Bolliger R; Graedel L; Christ-Crain M; Briel M; Bucher HC; Mueller B; Schuetz P. Clinical chemistry and laboratory medicine. 2017.

The prognostic and predictive value of sstr<sub>2</sub>-immunohistochemistry and sstr<sub>2</sub>-targeted imaging in neuroendocrine tumors.

Brunner P; Jörg AC; Glatz K; Bubendorf L; Radojewski P; Umlauft M; Marincek N; Spanjol PM; Krause T; Dumont RA; Maecke HR; Müller-Brand J; Briel M; Schmitt A; Perren A; Walter MA. European journal of nuclear medicine and molecular imaging. 2017.

Towards the development of a comprehensive framework: Qualitative systematic survey of definitions of clinical research quality.

von Niederhäusern B; Schandelmaier S; Mi Bonde M; Brunner N; Hemkens LG; Rutquist M; Bhatnagar N; Guyatt GH; Pauli-Magnus C; Briel M. PLoS One. 2017.

Agreements between Industry and Academia on Publication Rights: A Retrospective Study of Protocols and Publications of Randomized Clinical Trials.

Kasenda B; von Elm E; You JJ; Blümle A; Tomonaga Y; Saccilotto R; Amstutz A; Bengough T; Meerpohl JJ; Stegert M; Olu KK; Tikkinen KA; Neumann I; Carrasco-Labra A; Faulhaber M; Mulla SM; Mertz D; Akl EA; Bassler D; Busse JW; Ferreira-González I; Lamontagne F; Nordmann A; Gloy V; Raatz H; Moja L; Ebrahim S; Schandelmaier S; Sun X; Vandvik PO; Johnston BC; Walter MA; Burnand B; Schwenkglenks M; Hemkens LG; Bucher HC; Guyatt GH; Briel M. PLoS medicine. 2016.

An analysis of protocols and publications suggested that most discontinuations of clinical trials were not based on preplanned interim analyses or stopping rules.

Stegert M; Kasenda B; von Elm E; You JJ; Blümle A; Tomonaga Y; Saccilotto R; Amstutz A; Bengough T; Briel M; DISCO study group.. Journal of clinical epidemiology. 2016.

A systematic review of discontinued trials suggested that most reasons for recruitment failure were preventable.

Briel M; Olu KK; von Elm E; Kasenda B; Alturki R; Agarwal A; Bhatnagar N; Schandelmaier S. Journal of clinical epidemiology. 2016.

Bariatric surgery versus non-surgical treatment for obesity

Gloy, Viktoria L.; Briel, Matthias; Bhatt, Deepak L.; Kashyap, Sangeeta R.; Schauer, Philip R.; Mingrone, Geltrude; Bucher, Heiner C.; Nordmann, Alain J.. British journal of sports medicine. 2016.

Bias in dissemination of clinical research findings: structured OPEN framework of what, who and why, based on literature review and expert consensus.

Bassler D; Mueller KF; Briel M; Kleijnen J; Marusic A; Wager E; Antes G; von Elm E; Altman DG; Meerpohl JJ; OPEN Consortium.. BMJ Open. 2016.

Cardiovascular effects and safety of long-term colchicine treatment: Cochrane review and meta-analysis.

Hemkens LG; Ewald H; Gloy VL; Arpagaus A; Olu KK; Nidorf M; Glinz D; Nordmann AJ; Briel M. Heart (British Cardiac Society). 2016.

Cochrane corner: early statin therapy in acute coronary syndromes--what is the clinical benefit?

Nordmann A; Schwartz G; Vale N; Bucher HC; Briel M. Heart (British Cardiac Society). 2016.

Colchicine and Prevention of Cardiovascular Events.

Hemkens LG; Ewald H; Briel M. JAMA. 2016.

Colchicine for prevention of cardiovascular events.

Hemkens LG; Ewald H; Gloy VL; Arpagaus A; Olu KK; Nidorf M; Glinz D; Nordmann AJ; Briel M. The Cochrane database of systematic reviews. 2016.

Copeptin predicts 10-year all-cause mortality in community patients: a 10-year prospective cohort study.

Odermatt J; Bolliger R; Hersberger L; Ottiger M; Christ-Crain M; Briel M; Bucher HC; Mueller B; Schuetz P. Clinical chemistry and laboratory medicine. 2016.

Fibrates for primary prevention of cardiovascular disease events.

Jakob T; Nordmann AJ; Schandelmaier S; Ferreira-González I; Briel M. The Cochrane database of systematic reviews. 2016.

Fibrates for the primary prevention of cardiovascular disease

Nordmann, A.; Jakob, T.; Schandelmaier, S.; Ferreira-Gonzalez, I.; Briel, M.. European Heart Journal. 2016.

Guideline of guidelines: thromboprophylaxis for urological surgery.

Violette PD; Cartwright R; Briel M; Tikkinen KA; Guyatt GH. BJU INTERNATIONAL. 2016.

Infection biomarkers in primary care patients with acute respiratory tract infections-comparison of Procalcitonin and C-reactive protein.

Meili M; Kutz A; Briel M; Christ-Crain M; Bucher HC; Mueller B; Schuetz P. BMC Pulmonary Medicine. 2016.

Influence of hospital characteristics on quality of care in patients with community-acquired pneumonia.

Straubhaar K; Schuetz P; Blum CA; Nigro N; Briel M; Christ-Crain M; Mueller B; Step Study Group. Swiss medical weekly. 2016.

In reply.

Mueller,Christian; Giannitsis,Evangelos; Lindahl,Bertil. ANNALS OF EMERGENCY MEDICINE. 2016.

Methods for detecting, quantifying, and adjusting for dissemination bias in meta-analysis are described.

Mueller KF; Meerpohl JJ; Briel M; Antes G; von Elm E; Lang B; Motschall E; Schwarzer G; Bassler D. Journal of clinical epidemiology. 2016.

Multivariable fractional polynomial interaction to investigate continuous effect modifiers in a meta-analysis on higher versus lower PEEP for patients with ARDS.

Kasenda B; Sauerbrei W; Royston P; Mercat A; Slutsky AS; Cook D; Guyatt GH; Brochard L; Richard JC; Stewart TE; Meade M; Briel M. BMJ Open. 2016.

Nutritional Support and Outcomes in Malnourished Medical Inpatients: A Systematic Review and Meta-analysis.

Bally MR; Blaser Yildirim PZ; Bounoure L; Gloy VL; Mueller B; Briel M; Schuetz P. JAMA internal medicine. 2016.

Other Measures of Event Reduction Reply

Ewald, Hannah; Gloy, Viktoria; Briel, Matthias. Deutsches Arzteblatt International. 2016.

Planning and reporting of quality-of-life outcomes in cancer trials.

Schandelmaier S; Conen K; von Elm E; You JJ; Blümle A; Tomonaga Y; Saccilotto R; Amstutz A; Bengough T; Meerpohl JJ; Stegert M; Olu KK; Tikkinen KA; Neumann I; Carrasco-Labra A; Faulhaber M; Mulla SM; Mertz D; Akl EA; Sun X; Bassler D; Busse JW; Ferreira-González I; Lamontagne F; Nordmann A; Gloy V; Raatz H; Moja L; Rosenthal R; Ebrahim S; Vandvik PO; Johnston BC; Walter MA; Burnand B; Schwenkglenks M; Hemkens LG; Bucher HC; Guyatt GH; Briel M; Kasenda B; DISCO study group.. Annals of oncology : official journal of the European Society for Medical Oncology. 2016.

Premature discontinuation of prospective clinical studies approved by a research ethics committee - A comparison of randomised and non-randomised studies

Blumle A.; Schandelmaier S.; Oeller P.; Kasenda B.; Briel M.; von Elm E.; Akl E.A.; Amstutz A.; Bassler D.; Bengough T.; Bucher H.C.; Burnand B.; Busse J.W.; Carrasco-Labra A.; Ebrahim S.; Faulhaber M.; Gloy V.; Ferreira-Gonzalez I.; Guyatt G.H.; Hemkens L.G.; Johnston B.C.; Lamontagne F.; Meerpohl J.J.; Mertz D.; Moja L.; Mulla S.; Neumann I.; Nordmann A.; Olu K.K.; Raatz H.; Rosenthal R.; Saccilotto R.; Schwenkglenks M.; Stegert M.; Sun X.; Tikkinen K.A.O.; Tomonaga Y.; Walter M.A.; Vandvik P.O.; You J.J.. PLoS One. 2016.

Premature discontinuation of randomized trials in critical and emergency care: A retrospective cohort study

Schandelmaier S.; Von Elm E.; You J.J.; Blumle A.; Tomonaga Y.; Lamontagne F.; Saccilotto R.; Amstutz A.; Bengough T.; Meerpohl J.J.; Stegert M.; Olu K.K.; Tikkinen K.A.O.; Neumann I.; Carrasco-Labra A.; Faulhaber M.; Mulla S.M.; Mertz D.; Akl E.A.; Sun X.; Bassler D.; Busse J.W.; Ferreira-Gonzalez I.; Nordmann A.; Gloy V.; Raatz H.; Moja L.; Rosenthal R.; Ebrahim S.; Vandvik P.O.; Johnston B.C.; Walter M.A.; Burnand B.; Schwenkglenks M.; Hemkens L.G.; Cook D.J.; Meade M.O.; Bucher H.C.; Kasenda B.; Briel M.. Critical Care Medicine. 2016.

Reply: Somatostatin Receptor-Targeted Radiopeptide Therapy in Patients with Progressive Unresectable Meningioma.

Radojewski P; Dumont RA; Marincek N; Brunner P; Müller-Brand J; Maecke HR; Briel M; Walter MA. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2016.

Systematic reviews experience major limitations in reporting absolute effects

Alonso-Coello P.; Carrasco-Labra A.; Brignardello-Petersen R.; Neumann I.; Akl E.A.; Vernooij R.W.M.; Johnston B.C.; Sun X.; Briel M.; Busse J.W.; Ebrahim S.; Granados C.E.; Iorio A.; Irfan A.; Martinez Garcia L.; Mustafa R.A.; Ramirez-Morera A.; Selva A.; Sola I.; Sanabria A.J.; Tikkinen K.A.O.; Vandvik P.O.; Zazueta O.E.; Zhang Y.; Zhou Q.; Schunemann H.; Guyatt G.H.. Journal of clinical epidemiology. 2016.

The Clinical Effectiveness of Pneumococcal Conjugate Vaccines: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Ewald H; Briel M; Vuichard D; Kreutle V; Zhydkov A; Gloy V. Deutsches Arzteblatt International. 2016.

The reporting of studies using routinely collected health data was often insufficient.

Hemkens LG; Benchimol EI; Langan SM; Briel M; Kasenda B; Januel JM; Herrett E; von Elm E. Journal of clinical epidemiology. 2016.

Use of heparins in patients with cancer: individual participant data meta-analysis of randomised trials study protocol.

Schünemann HJ; Ventresca M; Crowther M; Briel M; Zhou Q; Garcia D; Lyman G; Noble S; Macbeth F; Griffiths G; DiNisio M; Iorio A; Beyene J; Mbuagbaw L; Neumann I; Van Es N; Brouwers M; Brozek J; Guyatt G; Levine M; Moll S; Santesso N; Streiff M; Baldeh T; Florez I; Gurunlu Alma O; Solh Z; Ageno W; Marcucci M; Bozas G; Zulian G; Maraveyas A; Lebeau B; Buller H; Evans J; McBane R; Bleker S; Pelzer U; Akl EA; IPDMA heparin use in cancer patients research group.. BMJ Open. 2016.

[About the certainty of study results. What p-value and confidence intervalls tell us on it].

Günther J; Briel M; Suter K. Medizinische Monatsschrift fur Pharmazeuten. 2015.

[Four numbers and a bit more basic knowledge of mathematics].

Günther J; Briel M; Suter K. Medizinische Monatsschrift fur Pharmazeuten. 2015.

[Four numbers and basic knowledge of mathematics].

Suter K; Briel M; Günther J. Medizinische Monatsschrift fur Pharmazeuten. 2015.

[Instructions for aggregated evidence: About reviews, systematic reviews and meta-analyses (part 2)].

Günther J; Briel M; Schindler B. Medizinische Monatsschrift fur Pharmazeuten. 2015.

[Instructions for aggregated evidence: Systematic reviews and meta-analyses (part 1)].

Schindler B; Briel M; Günther J. Medizinische Monatsschrift fur Pharmazeuten. 2015.

[Painting by number--Survival curves and Kaplan-Meier method].

Schindler B; Briel M; Günther J. Medizinische Monatsschrift fur Pharmazeuten. 2015.

[Why bother with regression models?].

Schindler B; Briel M; Günther J. Medizinische Monatsschrift fur Pharmazeuten. 2015.

Adjunctive corticosteroids for Pneumocystis jiroveci pneumonia in patients with HIV infection.

Ewald H; Raatz H; Boscacci R; Furrer H; Bucher HC; Briel M. Cochrane Database of Systematic Reviews. 2015.

Adjunct prednisone therapy for patients with community-acquired pneumonia: a multicentre, double-blind, randomised, placebo-controlled trial.

Blum CA; Nigro N; Briel M; Schuetz P; Ullmer E; Suter-Widmer I; Winzeler B; Bingisser R; Elsaesser H; Drozdov D; Arici B; Urwyler SA; Refardt J; Tarr P; Wirz S; Thomann R; Baumgartner C; Duplain H; Burki D; Zimmerli W; Rodondi N; Mueller B; Christ-Crain M. Lancet (London, England). 2015.

Association between shortened leukocyte telomere length and cardiometabolic outcomes: systematic review and meta-analysis.

D'Mello MJ; Ross SA; Briel M; Anand SS; Gerstein H; Paré G. Circ Cardiovasc Genet (ONLINE-AUSGABE). 2015.

Blood pressure targets for vasopressor therapy: a systematic review.

D'Aragon F; Belley-Cote EP; Meade MO; Lauzier F; Adhikari NK; Briel M; Lalu M; Kanji S; Asfar P; Turgeon AF; Fox-Robichaud A; Marshall JC; Lamontagne F; Canadian Critical Care Trials Group.. Shock (Augusta, Ga.). 2015.

Comparative effectiveness of tenofovir in treatment-naïve HIV-infected patients: systematic review and meta-analysis.

Hemkens, Lars G; Ewald, Hannah; Santini-Oliveira, Marilia; Bühler, Julian-Emanuel; Vuichard, Danielle; Schandelmaier, Stefan; Stöckle, Marcel; Briel, Matthias; Bucher, Heiner C. HIV clinical trials. 2015.

Completion and Publication Rates of Randomized Controlled Trials in Surgery: An Empirical Study.

Rosenthal R; Kasenda B; Dell-Kuster S; von Elm E; You J; Blümle A; Tomonaga Y; Saccilotto R; Amstutz A; Bengough T; Meerpohl JJ; Stegert M; Tikkinen KA; Neumann I; Carrasco-Labra A; Faulhaber M; Mulla S; Mertz D; Akl EA; Bassler D; Busse JW; Ferreira-González I; Lamontagne F; Nordmann A; Gloy V; Olu KK; Raatz H; Moja L; Ebrahim S; Schandelmaier S; Sun X; Vandvik PO; Johnston BC; Walter MA; Burnand B; Schwenkglenks M; Hemkens LG; Bucher HC; Guyatt GH; Briel M. Annals of surgery. 2015.

Corticosteroid Therapy for Patients Hospitalized With Community-Acquired Pneumonia: A Systematic Review and Meta-analysis.

Siemieniuk RA; Meade MO; Alonso-Coello P; Briel M; Evaniew N; Prasad M; Alexander PE; Fei Y; Vandvik PO; Loeb M; Guyatt GH. Annals of internal medicine. 2015.

Corticosteroid therapy for pneumonia - Author's reply.

Blum CA; Briel M; Schuetz P; Mueller B; Christ-Crain M. Lancet (London, England). 2015.

Driving pressure and survival in the acute respiratory distress syndrome.

Amato MB; Meade MO; Slutsky AS; Brochard L; Costa EL; Schoenfeld DA; Stewart TE; Briel M; Talmor D; Mercat A; Richard JC; Carvalho CR; Brower RG. The New England journal of medicine. 2015.

Economic evaluation of procalcitonin-guided antibiotic therapy in acute respiratory infections: a US health system perspective.

Schuetz P; Balk R; Briel M; Kutz A; Christ-Crain M; Stolz D; Bouadma L; Wolff M; Kristoffersen KB; Wei L; Burkhardt O; Welte T; Schroeder S; Nobre V; Tamm M; Bhatnagar N; Bucher HC; Luyt CE; Chastre J; Tubach F; Mueller B; Lacey MJ; Ohsfeldt RL; Scheibling CM; Schneider JE. Clinical chemistry and laboratory medicine. 2015.

Evidence-informed recommendations to reduce dissemination bias in clinical research: conclusions from the OPEN (Overcome failure to Publish nEgative fiNdings) project based on an international consensus meeting.

Meerpohl JJ; Schell LK; Bassler D; Gallus S; Kleijnen J; Kulig M; La Vecchia C; Marušić A; Ravaud P; Reis A; Schmucker C; Strech D; Urrútia G; Wager E; Antes G; OPEN project consortium.. BMJ Open. 2015.

First-line treatment and outcome of elderly patients with primary central nervous system lymphoma (PCNSL)--a systematic review and individual patient data meta-analysis.

Kasenda B; Ferreri AJ; Marturano E; Forst D; Bromberg J; Ghesquieres H; Ferlay C; Blay JY; Hoang-Xuan K; Pulczynski EJ; Fosså A; Okoshi Y; Chiba S; Fritsch K; Omuro A; O'Neill BP; Bairey O; Schandelmaier S; Gloy V; Bhatnagar N; Haug S; Rahner S; Batchelor TT; Illerhaus G; Briel M. Annals of oncology : official journal of the European Society for Medical Oncology. 2015.

Planning and reporting of quality-of-life outcomes in cancer trials.

Schandelmaier S; Conen K; von Elm E; You JJ; Blümle A; Tomonaga Y; Amstutz A; Briel M; Kasenda B; DISCO study group.. Annals of oncology : official journal of the European Society for Medical Oncology. 2015.

Prognostic value of procalcitonin in respiratory tract infections across clinical settings.

Kutz A; Briel M; Christ-Crain M; Stolz D; Bouadma L; Wolff M; Kristoffersen KB; Wei L; Burkhardt O; Welte T; Schroeder S; Nobre V; Tamm M; Bhatnagar N; Bucher HC; Luyt CE; Chastre J; Tubach F; Mueller B; Schuetz P. Critical care (London, England). 2015.

Prospective analysis of adrenal function in patients with acute exacerbations of COPD: the Reduction in the Use of Corticosteroids in Exacerbated COPD (REDUCE) trial.

Schuetz P; Leuppi JD; Bingisser R; Bodmer M; Briel M; Drescher T; Duerring U; Henzen C; Leibbrandt Y; Maier S; Miedinger D; Mueller B; Scherr A; Schindler C; Stoeckli R; Viatte S; von Garnier C; Tamm M; Rutishauser J. European journal of endocrinology. 2015.

Reporting, handling and assessing the risk of bias associated with missing participant data in systematic reviews: a methodological survey.

Akl EA; Carrasco-Labra A; Brignardello-Petersen R; Neumann I; Johnston BC; Sun X; Briel M; Busse JW; Ebrahim S; Granados CE; Iorio A; Irfan A; Martínez García L; Mustafa RA; Ramírez-Morera A; Selva A; Solà I; Sanabria AJ; Tikkinen KA; Vandvik PO; Vernooij RW; Zazueta OE; Zhou Q; Guyatt GH; Alonso-Coello P. BMJ Open. 2015.

Somatostatin receptor-targeted radiopeptide therapy with 90Y-DOTATOC and 177Lu-DOTATOC in progressive meningioma: long-term results of a phase II clinical trial.

Marincek N; Radojewski P; Dumont RA; Brunner P; Müller-Brand J; Maecke HR; Briel M; Walter MA. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2015.

Survival after somatostatin based radiopeptide therapy with (90)Y-DOTATOC vs. (90)Y-DOTATOC plus (177)Lu-DOTATOC in metastasized gastrinoma.

Dumont RA; Seiler D; Marincek N; Brunner P; Radojewski P; Rochlitz C; Müller-Brand J; Maecke HR; Briel M; Walter MA. American journal of nuclear medicine and molecular imaging. 2015.

The number needed to treat (NNT) and the number needed to harm (NNH) Number needed to treat (NNT) und Number needed to harm (NNH)

Suter K.; Briel M.; Gunther J.. Medizinische Monatsschrift fur Pharmazeuten. 2015.

The Principle of Intention-to-Treat and Ambiguous Dropouts

Briel,M; Montori,VM; Durieux,P; Devereaux,PJ; Guyatt,GH. . 2015.

Towards tailored radiopeptide therapy.

Radojewski P; Dumont R; Marincek N; Brunner P; Mäcke HR; Müller-Brand J; Briel M; Walter MA. European journal of nuclear medicine and molecular imaging. 2015.

Understanding Class Effects

Mills,EJ; Gardner,D; Thorlund,K; Briel,M; Bucher,H; Bryan,S; Hutton,B; Guyatt,GH. . 2015.

A users' guide to understanding therapeutic substitutions.

Mills EJ; Gardner D; Thorlund K; Briel M; Bryan S; Hutton B; Guyatt GH. Journal of clinical epidemiology. 2014.

Cerebrovascular reactivity predicts stroke in high-grade carotid artery disease

Reinhard M.; Schwarzer G.; Briel M.; Altamura C.; Palazzo P.; King A.; Bornstein N.M.; Petersen N.; Motschall E.; Hetzel A.; Marshall R.S.; Klijn C.J.M.; Silvestrini M.; Markus H.S.; Vernieri F.. Neurology. 2014.

Correction: A methodological survey of the analysis, reporting and interpretation of Absolute Risk ReductiOn in systematic revieWs (ARROW): A study protocol

Alonso-Coello P.; Carrasco-Labra A.; Brignardello-Petersen R.; Neumann I.; Akl E.A.; Sun X.; Johnston B.C.; Briel M.; Busse J.W.; Glujovsky D.; Granados C.E.; Iorio A.; Irfan A.; Garcia L.M.; Mustafa R.A.; Ramirez-Morera A.; Sola I.; Tikkinen K.A.O.; Ebrahim S.; Vandvik P.O.; Zhang Y.; Selva A.; Sanabria A.J.; Zazueta O.E.; Vernooij R.W.M.; Schunemann H.J.; Guyatt G.H.. Systematic reviews. 2014.

Corticosteroid treatment for community-acquired pneumonia--the STEP trial: study protocol for a randomized controlled trial.

Blum CA; Nigro N; Winzeler B; Suter-Widmer I; Schuetz P; Briel M; Bingisser R; Zimmerli W; Ullmer E; Elsaesser H; Tarr P; Wirz S; Thomann R; Hofmann E; Rodondi N; Duplain H; Burki D; Mueller B; Christ-Crain M. Trials. 2014.

Dissemination bias in systematic reviews of animal research: a systematic review.

Mueller KF; Briel M; Strech D; Meerpohl JJ; Lang B; Motschall E; Gloy V; Lamontagne F; Bassler D. PLoS One. 2014.

Early nutritional therapy for malnourished or nutritionally at-risk adult medical inpatients

Schuetz P.; Blaser Yildirim P.Z.; Gloy V.L.; Briel M.; Bally M.R.. Cochrane Database of Systematic Reviews. 2014.

How to write a surgical clinical research protocol: literature review and practical guide.

Rosenthal R; Schäfer J; Briel M; Bucher HC; Oertli D; Dell-Kuster S. American journal of surgery. 2014.

Impact of missing participant data for dichotomous outcomes on pooled effect estimates in systematic reviews: a protocol for a methodological study.

Akl EA; Kahale LA; Agarwal A; Al-Matari N; Ebrahim S; Alexander PE; Briel M; Brignardello-Petersen R; Busse JW; Diab B; Iorio A; Kwong J; Li L; Lopes LC; Mustafa R; Neumann I; Tikkinen KA; Vandvik PO; Zhang Y; Alonso-Coello P; Guyatt G. Systematic reviews. 2014.

Investigation of continuous effect modifiers in a meta-analysis on higher versus lower PEEP in patients requiring mechanical ventilation--protocol of the ICEM study.

Kasenda B; Sauerbrei W; Royston P; Briel M. Systematic reviews. 2014.

Methodological survey of designed uneven randomization trials (DU-RANDOM): a protocol.

Wu D; Akl EA; Guyatt GH; Devereaux PJ; Brignardello-Petersen R; Prediger B; Patel K; Patel N; Lu T; Zhang Y; Falavigna M; Santesso N; Mustafa RA; Zhou Q; Briel M; Schünemann HJ. Trials. 2014.

Prevalence, characteristics, and publication of discontinued randomized trials

Kasenda B.; Von Elm E.; You J.; Blumle A.; Tomonaga Y.; Saccilotto R.; Amstutz A.; Bengough T.; Meerpohl J.J.; Stegert M.; Tikkinen K.A.O.; Neumann I.; Carrasco-Labra A.; Faulhaber M.; Mulla S.M.; Mertz D.; Akl E.A.; Bassler D.; Busse J.W.; Ferreira-Gonzalez I.; Lamontagne F.; Nordmann A.; Gloy V.; Raatz H.; Moja L.; Rosenthal R.; Ebrahim S.; Schandelmaier S.; Xin S.; Vandvik P.O.; Johnston B.C.; Walter M.A.; Burnand B.; Schwenkglenks M.; Hemkens L.G.; Bucher H.C.; Guyatt G.H.; Briel M.. JAMA. 2014.

Somatostatin-based radiopeptide therapy with [177Lu-DOTA]-TOC versus [90Y-DOTA]-TOC in neuroendocrine tumours.

Romer A; Seiler D; Marincek N; Brunner P; Koller MT; Ng QK; Maecke HR; Müller-Brand J; Rochlitz C; Briel M; Schindler C; Walter MA. European journal of nuclear medicine and molecular imaging. 2014.

Statins for acute coronary syndrome

Vale N.; Nordmann A.J.; Schwartz G.G.; de Lemos J.; Colivicchi F.; den Hartog F.; Ostadal P.; Macin S.M.; Liem A.H.; Mills E.J.; Bhatnagar N.; Bucher H.C.; Briel M.. Cochrane Database of Systematic Reviews. 2014.

Statins for acute coronary syndrome.

Vale,Noah; Nordmann,Alain J; Schwartz,Gregory G; de Lemos,James; Colivicchi,Furio; den Hartog,Frank; Ostadal,Petr; Macin,Stella M; Liem,Anho H; Mills,Edward J; Bhatnagar,Neera; Bucher,Heiner C; Briel,Matthias. Cochrane Database of Systematic Reviews. 2014.

Subgroup analyses in randomised controlled trials: cohort study on trial protocols and journal publications.

Kasenda B; Schandelmaier S; Sun X; von Elm E; You J; Blümle A; Tomonaga Y; Saccilotto R; Amstutz A; Bengough T; Meerpohl JJ; Stegert M; Olu KK; Tikkinen KA; Neumann I; Carrasco-Labra A; Faulhaber M; Mulla SM; Mertz D; Akl EA; Bassler D; Busse JW; Ferreira-González I; Lamontagne F; Nordmann A; Gloy V; Raatz H; Moja L; Rosenthal R; Ebrahim S; Vandvik PO; Johnston BC; Walter MA; Burnand B; Schwenkglenks M; Hemkens LG; Bucher HC; Guyatt GH; Briel M; DISCO Study Group.. BMJ (Clinical research ed.). 2014.

[Is procalcitonin determination for control of antibiotic therapy in acute respiratory infections of value?].

Schütz P; Müller B; Briel M. Praxis. 2013.

Addressing dichotomous data for participants excluded from trial analysis: a guide for systematic reviewers.

Akl EA; Johnston BC; Alonso-Coello P; Neumann I; Ebrahim S; Briel M; Cook DJ; Guyatt GH. PLoS One. 2013.

A methodological survey of the analysis, reporting and interpretation of Absolute Risk ReductiOn in systematic revieWs (ARROW): a study protocol.

Alonso-Coello P; Carrasco-Labra A; Brignardello-Petersen R; Neumann I; Akl EA; Sun X; Johnston BC; Briel M; Busse JW; Glujovsky D; Granados CE; Iorio A; Irfan A; Martínez García L; Mustafa RA; Ramirez-Morera A; Solà I; Tikkinen KA; Ebrahim S; Vandvik PO; Zhang Y; Selva A; Sanabria AJ; Zazueta OE; Vernooij RW; Schünemann HJ; Guyatt GH. Systematic reviews. 2013.

A protocol for a systematic review on the impact of unpublished studies and studies published in the gray literature in meta-analyses.

Schmucker C; Bluemle A; Briel M; Portalupi S; Lang B; Motschall E; Schwarzer G; Bassler D; Mueller KF; von Elm E; Meerpohl JJ; OPEN Consortium.. Systematic reviews. 2013.

A systematic review of nonabsorbable, absorbable, and steroid-impregnated spacers following endoscopic sinus surgery.

Zhao X; Grewal A; Briel M; Lee JM. International Forum of Allergy & Rhinology. 2013.

Bariatric surgery versus non-surgical treatment for obesity: a systematic review and meta-analysis of randomised controlled trials.

Gloy VL; Briel M; Bhatt DL; Kashyap SR; Schauer PR; Mingrone G; Bucher HC; Nordmann AJ. BMJ (Clinical research ed.). 2013.

BARIATRIC SURGERY VERSUS NON-SURGICAL TREATMENT FOR OBESITY: A SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS

Gloy, V. L.; Briel, M.; Bhatt, D.; Kashyap, S.; Schauer, P.; Mingrone, G.; Bucher, H. C.; Nordmann, A. J.. CARDIOLOGY. 2013.

Blockade of the renin-angiotensin-aldosterone system (RAAS) for primary prevention of non-valvular atrial fibrillation: a systematic review and meta analysis of randomized controlled trials.

Khatib R; Joseph P; Briel M; Yusuf S; Healey J. International journal of cardiology. 2013.

Clinical outcomes associated with procalcitonin algorithms to guide antibiotic therapy in respiratory tract infections.

Schuetz P; Briel M; Mueller B. JAMA. 2013.

Commentaries on 'Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections' with a response from the review authors

Sabhaney V.; Enarson P.; Irwin A.D.; Carrol E.D.; Schuetz P.; Briel M.; Bucher H.C.; Mueller B.. Evidence-based child health : a Cochrane review journal. 2013.

Defining publication bias: protocol for a systematic review of highly cited articles and proposal for a new framework.

Müller KF; Briel M; D'Amario A; Kleijnen J; Marusic A; Wager E; Antes G; von Elm E; Lang B; Motschall E; Gloy V; Schwarzer G; Altman D; Meerpohl JJ; Bassler D. Systematic reviews. 2013.

Detecting, quantifying and adjusting for publication bias in meta-analyses: protocol of a systematic review on methods.

Mueller KF; Meerpohl JJ; Briel M; Antes G; von Elm E; Lang B; Gloy V; Motschall E; Schwarzer G; Bassler D. Systematic reviews. 2013.

Initiation and continuation of randomized trials after the publication of a trial stopped early for benefit asking the same study question: STOPIT-3 study design.

Prutsky GJ; Domecq JP; Erwin PJ; Briel M; Montori VM; Akl EA; Meerpohl JJ; Bassler D; Schandelmaier S; Walter SD; Zhou Q; Coello PA; Moja L; Walter M; Thorlund K; Glasziou P; Kunz R; Ferreira-Gonzalez I; Busse J; Sun X; Kristiansen A; Kasenda B; Qasim-Agha O; Pagano G; Pardo-Hernandez H; Urrutia G; Murad MH; Guyatt G. Trials. 2013.

Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections.

Schuetz P; Müller B; Christ-Crain M; Stolz D; Tamm M; Bouadma L; Luyt CE; Wolff M; Chastre J; Tubach F; Kristoffersen KB; Burkhardt O; Welte T; Schroeder S; Nobre V; Wei L; Bhatnagar N; Bucher HC; Briel M. Evidence-based child health : a Cochrane review journal. 2013.

Publication bias in animal research: a systematic review protocol.

Briel M; Müller KF; Meerpohl JJ; von Elm E; Lang B; Motschall E; Gloy V; Lamontagne F; Schwarzer G; Bassler D; OPEN Consortium.. Systematic reviews. 2013.

Randomized trials published in higher vs. lower impact journals differ in design, conduct, and analysis.

Bala MM; Akl EA; Sun X; Bassler D; Mertz D; Mejza F; Vandvik PO; Malaga G; Johnston BC; Dahm P; Alonso-Coello P; Diaz-Granados N; Srinathan SK; Hassouneh B; Briel M; Busse JW; You JJ; Walter SD; Altman DG; Guyatt GH. Journal of clinical epidemiology. 2013.

Reflections on meta-analyses involving trials stopped early for benefit: is there a problem and if so, what is it?

Bassler D; Montori VM; Briel M; Glasziou P; Walter SD; Ramsay T; Guyatt G. STATISTICAL METHODS IN MEDICAL RESEARCH. 2013.

Short-term vs conventional glucocorticoid therapy in acute exacerbations of chronic obstructive pulmonary disease: the REDUCE randomized clinical trial.

Leuppi JD; Schuetz P; Bingisser R; Bodmer M; Briel M; Drescher T; Duerring U; Henzen C; Leibbrandt Y; Maier S; Miedinger D; Müller B; Scherr A; Schindler C; Stoeckli R; Viatte S; von Garnier C; Tamm M; Rutishauser J. JAMA. 2013.

Somatostatin-based radiotherapy with [90Y-DOTA]-TOC in neuroendocrine tumors: long-term outcome of a phase I dose escalation study.

Marincek N; Jörg AC; Brunner P; Schindler C; Koller MT; Rochlitz C; Müller-Brand J; Maecke HR; Briel M; Walter MA. Journal of Translational Medicine. 2013.

Substitutes of structural and non-structural autologous bone grafts in hindfoot arthrodeses and osteotomies: a systematic review.

Müller MA; Frank A; Briel M; Valderrabano V; Vavken P; Entezari V; Mehrkens A. BMC MUSCULOSKELETAL DISORDERS. 2013.

Adverse events associated with individual statin treatments for cardiovascular disease: an indirect comparison meta-analysis.

Alberton M; Wu P; Druyts E; Briel M; Mills EJ. QJM : monthly journal of the Association of Physicians. 2012.

Cohort study of somatostatin-based radiopeptide therapy with [(90)Y-DOTA]-TOC versus [(90)Y-DOTA]-TOC plus [(177)Lu-DOTA]-TOC in neuroendocrine cancers.

Villard L; Romer A; Marincek N; Brunner P; Koller MT; Schindler C; Ng QK; Mäcke HR; Müller-Brand J; Rochlitz C; Briel M; Walter MA. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2012.

Credibility of claims of subgroup effects in randomised controlled trials: systematic review.

Sun X; Briel M; Busse JW; You JJ; Akl EA; Mejza F; Bala MM; Bassler D; Mertz D; Diaz-Granados N; Vandvik PO; Malaga G; Srinathan SK; Dahm P; Johnston BC; Alonso-Coello P; Hassouneh B; Walter SD; Heels-Ansdell D; Bhatnagar N; Altman DG; Guyatt GH. BMJ (Clinical research ed.). 2012.

Dipeptidyl Peptidase-4 Inhibitors May Reduce the Risk of Major Adverse Cardiovascular Events and All-cause Mortality In Patients With Type 2 Diabetes: Meta-analyses Oof Randomized Controlled Trials

Sun, Xin; Hazzan, Afeez A.; Bala, Malgorzata; Russe, Jason W.; Johnston, Bradley C.; Carrasco-Labra, Alonso; Jankowski, Milosz; Neumann, Ignacio; Ferreira-Gonzalez, Ignacio; Fernandez-Balsells, Merce; Rios, Lorena; Bassler, Dirk; Briel, Matthias; Lopes, Luciane; Nordmann, Alain; Tikkinen, Kari A.; Ismaila, Nofisat; Zhou, Qi; Mukherjee, Jayanti; Frederich, Robert; Iqbal, Nayyar; Walter, Stephen; Guyatt, Gordon. Circulation. 2012.

Fibrates for primary prevention of cardiovascular disease events.

Nordmann AJ; Ferreira-González I; Kasenda B; Saccilotto R; Bassler D; Bhatnagar N; Briel M. The Cochrane database of systematic reviews. 2012.

Inconsistent definitions for intention-to-treat in relation to missing outcome data: systematic review of the methods literature.

Alshurafa M; Briel M; Akl EA; Haines T; Moayyedi P; Gentles SJ; Rios L; Tran C; Bhatnagar N; Lamontagne F; Walter SD; Guyatt GH. PLoS One. 2012.

Learning from failure - Rationale and design for a study about discontinuation of randomized trials (DISCO study)

Kasenda B.; Von Elm E.B.; You J.; Blumle A.; Tomonaga Y.; Saccilotto R.; Amstutz A.; Bengough T.; Meerpohl J.; Stegert M.; Tikkinen K.A.O.; Neumann I.; Carrasco-Labra A.; Faulhaber M.; Mulla S.; Mertz D.; Akl E.A.; Bassler D.; Busse J.W.; Ferreira-Gonzalez I.; Lamontagne F.; Nordmann A.; Rosenthal R.; Schandelmaier S.; Sun X.; Vandvik P.O.; Johnston B.C.; Walter M.A.; Burnand B.; Schwenkglenks M.; Bucher H.C.; Guyatt G.H.; Briel M.. BMC Medical Research Methodology. 2012.

Meta-analyses: what they can and cannot do.

Nordmann AJ; Kasenda B; Briel M. Swiss medical weekly. 2012.

Mould-active compared with fluconazole prophylaxis to prevent invasive fungal diseases in cancer patients receiving chemotherapy or haematopoietic stem-cell transplantation: a systematic review and meta-analysis of randomised controlled trials

Ethier, M. C.; Science, M.; Beyene, J.; Briel, M.; Lehrnbecher, T.; Sung, L.. British journal of cancer. 2012.

Potential impact on estimated treatment effects of information lost to follow-up in randomised controlled trials (LOST-IT): systematic review.

Akl EA; Briel M; You JJ; Sun X; Johnston BC; Busse JW; Mulla S; Lamontagne F; Bassler D; Vera C; Alshurafa M; Katsios CM; Zhou Q; Cukierman-Yaffe T; Gangji A; Mills EJ; Walter SD; Cook DJ; Schünemann HJ; Altman DG; Guyatt GH. BMJ (Clinical research ed.). 2012.

Problems of stopping trials early.

Guyatt GH; Briel M; Glasziou P; Bassler D; Montori VM. BMJ (Clinical research ed.). 2012.

Procalcitonin to guide initiation and duration of antibiotic treatment in acute respiratory infections: an individual patient data meta-analysis.

Schuetz P; Briel M; Christ-Crain M; Stolz D; Bouadma L; Wolff M; Luyt CE; Chastre J; Tubach F; Kristoffersen KB; Wei L; Burkhardt O; Welte T; Schroeder S; Nobre V; Tamm M; Bhatnagar N; Bucher HC; Mueller B. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2012.

Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections.

Schuetz P; Müller B; Christ-Crain M; Stolz D; Tamm M; Bouadma L; Luyt CE; Wolff M; Chastre J; Tubach F; Kristoffersen KB; Burkhardt O; Welte T; Schroeder S; Nobre V; Wei L; Bhatnagar N; Bucher HC; Briel M. Cochrane Database of Systematic Reviews. 2012.

Specific instructions for estimating unclearly reported blinding status in randomized trials were reliable and valid.

Akl EA; Sun X; Busse JW; Johnston BC; Briel M; Mulla S; You JJ; Bassler D; Lamontagne F; Vera C; Alshurafa M; Katsios CM; Heels-Ansdell D; Zhou Q; Mills E; Guyatt GH. Journal of clinical epidemiology. 2012.

Statins: pleiotropic, but less than previously thought.

Nordmann AJ; Briel M. European Heart Journal. 2012.

The dangers of stopping a trial too early.

Briel M; Bassler D; Wang AT; Guyatt GH; Montori VM. The Journal of bone and joint surgery. American volume. 2012.

The impact of 18F-FDG PET on the management of patients with suspected large vessel vasculitis.

Fuchs M; Briel M; Daikeler T; Walker UA; Rasch H; Berg S; Ng QK; Raatz H; Jayne D; Kötter I; Blockmans D; Cid MC; Prieto-González S; Lamprecht P; Salvarani C; Karageorgaki Z; Watts R; Luqmani R; Müller-Brand J; Tyndall A; Walter MA. European journal of nuclear medicine and molecular imaging. 2012.

Updated evidence on early statin therapy for acute coronary syndromes: meta-analysis of 18 randomized trials involving over 14,000 patients.

Briel M; Vale N; Schwartz GG; de Lemos JA; Colivicchi F; den Hartog FR; Ostadal P; Macin SM; Liem A; Mills E; Bhatnagar N; Bucher HC; Nordmann AJ. International journal of cardiology. 2012.

Economic evaluation of reamed versus unreamed intramedullary nailing in patients with closed and open tibial fractures: results from the study to prospectively evaluate reamed intramedullary nails in patients with tibial fractures (SPRINT).

SPRINT Investigators.; Briel M; Sprague S; Heels-Ansdell D; Guyatt G; Bhandari M; Blackhouse G; Sanders D; Schemitsch E; Swiontkowski M; Tornetta P 3rd; Walter SD; Goeree R. Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research. 2011.

Efficacy and safety of statin treatment for cardiovascular disease: a network meta-analysis of 170,255 patients from 76 randomized trials.

Mills EJ; Wu P; Chong G; Ghement I; Singh S; Akl EA; Eyawo O; Guyatt G; Berwanger O; Briel M. QJM : monthly journal of the Association of Physicians. 2011.

Intensive statin therapy compared with moderate dosing for prevention of cardiovascular events: a meta-analysis of &gt;40 000 patients.

Mills EJ; O'Regan C; Eyawo O; Wu P; Mills F; Berwanger O; Briel M. European Heart Journal. 2011.

Meta-analysis comparing Mediterranean to low-fat diets for modification of cardiovascular risk factors.

Nordmann AJ; Suter-Zimmermann K; Bucher HC; Shai I; Tuttle KR; Estruch R; Briel M. The American journal of medicine. 2011.

Procalcitonin algorithms for antibiotic therapy decisions: a systematic review of randomized controlled trials and recommendations for clinical algorithms.

Schuetz P; Chiappa V; Briel M; Greenwald JL. Archives of internal medicine. 2011.

Randomisation to protect against selection bias in healthcare trials

Odgaard-Jensen J.; Vist G.E.; Timmer A.; Kunz R.; Akl E.A.; Schunemann H.; Briel M.; Nordmann A.J.; Pregno S.; Oxman A.D.. Cochrane Database of Systematic Reviews. 2011.

Response, survival, and long-term toxicity after therapy with the radiolabeled somatostatin analogue [90Y-DOTA]-TOC in metastasized neuroendocrine cancers.

Imhof A; Brunner P; Marincek N; Briel M; Schindler C; Rasch H; Mäcke HR; Rochlitz C; Müller-Brand J; Walter MA. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2011.

Statins for acute coronary syndrome.

Vale N; Nordmann AJ; Schwartz GG; de Lemos J; Colivicchi F; den Hartog F; Ostadal P; Macin SM; Liem AH; Mills E; Bhatnagar N; Bucher HC; Briel M. Cochrane Database of Systematic Reviews. 2011.

The influence of study characteristics on reporting of subgroup analyses in randomised controlled trials: systematic review

Sun, Xin; Briel, Matthias; Busse, Jason W.; You, John J.; Akl, Elie A.; Mejza, Filip; Bala, Malgorzata M.; Bassler, Dirk; Mertz, Dominik; Diaz-Granados, Natalia; Vandvik, Per Olav; Malaga, German; Srinathan, Sadeesh K.; Dahm, Philipp; Johnston, Bradley C.; Alonso-Coello, Pablo; Hassouneh, Basil; Truong, Jessica; Dattani, Neil D.; Walter, Stephen D.; Heels-Ansdell, Diane; Bhatnagar, Neera; Altman, Douglas G.; Guyatt, Gordon H.. BMJ (Clinical research ed.). 2011.

Vasopressor administration and sepsis: a survey of Canadian intensivists.

Lamontagne F; Cook DJ; Adhikari NKJ; Briel M; Duffett M; Kho ME; Burns KEA; Guyatt G; Turgeon AF; Zhou Q; Meade MO. Journal of critical care. 2011.

Corticosteroid therapy for acute lung injury, acute respiratory distress syndrome, and severe pneumonia: a meta-analysis of randomized controlled trials.

Lamontagne F; Briel M; Guyatt GH; Cook DJ; Bhatnagar N; Meade M. Journal of critical care. 2010.

Higher vs lower positive end-expiratory pressure in patients with acute lung injury and acute respiratory distress syndrome: systematic review and meta-analysis.

Briel M; Meade M; Mercat A; Brower RG; Talmor D; Walter SD; Slutsky AS; Pullenayegum E; Zhou Q; Cook D; Brochard L; Richard JC; Lamontagne F; Bhatnagar N; Stewart TE; Guyatt G. JAMA. 2010.

Interactive booklet reduces antibiotic prescribing for respiratory tract infections in children, but not parent satisfaction.

Briel M. Evidence-based nursing. 2010.

Is a subgroup effect believable? Updating criteria to evaluate the credibility of subgroup analyses.

Sun X; Briel M; Walter SD; Guyatt GH. BMJ (Clinical research ed.). 2010.

Short versus conventional term glucocorticoid therapy in acute exacerbation of chronic obstructive pulmonary disease - the "REDUCE" trial.

Schuetz P; Leuppi JD; Tamm M; Briel M; Bingisser R; Dürring U; Müller B; Schindler C; Viatte S; Rutishauser J. Swiss medical weekly. 2010.

Stopping randomized trials early for benefit and estimation of treatment effects: Systematic review and meta-regression analysis

Bassler D.; Briel M.; Montori V.M.; Lane M.; Glasziou P.; Zhou Q.; Heels-Ansdell D.; Walter S.D.; Guyatt G.H.; Flynn D.N.; Elamin M.B.; Murad M.H.; Abu Elnour N.O.; Lampropulos J.F.; Sood A.; Mullan R.J.; Erwin P.J.; Bankhead C.R.; Perera R.; Culebro C.R.; You J.J.; Mulla S.M.; Kaur J.; Nerenberg K.A.; Schunemann H.; Cook D.J.; Lutz K.; Ribic C.M.; Vale N.; Malaga G.; Akl E.A.; Ferreira-Gonzalez I.; Alonso-Coello P.; Urrutia G.; Kunz R.; Bucher H.C.; Nordmann A.J.; Raatz H.; Da Silva S.A.; Tuche F.; Strahm B.; Djulbegovic B.; Adhikari N.K.J.; Mills E.J.; Gwadry-Sridhar F.; Kirpalani H.; Soares H.P.; Karanicolas P.J.; Burns K.E.A.; Vandvik P.O.; Coto-Yglesias F.; Chrispim P.P.M.; Ramsay T.. JAMA. 2010.

Systematic review of reviews including animal studies addressing therapeutic interventions for sepsis.

Lamontagne F; Briel M; Duffett M; Fox-Robichaud A; Cook DJ; Guyatt G; Lesur O; Meade MO. Critical Care Medicine. 2010.

Association between change in high density lipoprotein cholesterol and cardiovascular disease morbidity and mortality: systematic review and meta-regression analysis.

Briel M; Ferreira-Gonzalez I; You JJ; Karanicolas PJ; Akl EA; Wu P; Blechacz B; Bassler D; Wei X; Sharman A; Whitt I; Alves da Silva S; Khalid Z; Nordmann AJ; Zhou Q; Walter SD; Vale N; Bhatnagar N; O'Regan C; Mills EJ; Bucher HC; Montori VM; Guyatt GH. BMJ (Clinical research ed.). 2009.

Choice of data extraction tools for systematic reviews depends on resources and review complexity.

Elamin MB; Flynn DN; Bassler D; Briel M; Alonso-Coello P; Karanicolas PJ; Guyatt GH; Malaga G; Furukawa TA; Kunz R; Schünemann H; Murad MH; Barbui C; Cipriani A; Montori VM. Journal of clinical epidemiology. 2009.

Cost-effectiveness of drug-eluting stents in a US Medicare setting:a cost-utility analysis with 3-year clinical follow-up data.

Bischof M; Briel M; Bucher HC; Nordmann A. Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research. 2009.

LOST to follow-up Information in Trials (LOST-IT): a protocol on the potential impact.

Akl EA; Briel M; You JJ; Lamontagne F; Gangji A; Cukierman-Yaffe T; Alshurafa M; Sun X; Nerenberg KA; Johnston BC; Vera C; Mills EJ; Bassler D; Salazar A; Bhatnagar N; Busse JW; Khalid Z; Walter S; Cook DJ; Schünemann HJ; Altman DG; Guyatt GH. Trials. 2009.

Prescribed medications and pharmacy interventions for acute respiratory tract infections in Swiss primary care.

Hersberger KE; Botomino A; Sarkar R; Tschudi P; Bucher HC; Briel M. Journal of clinical pharmacy and therapeutics. 2009.

Stopping randomized trials early for benefit: a protocol of the Study Of Trial Policy Of Interim Truncation-2 (STOPIT-2).

Briel M; Lane M; Montori VM; Bassler D; Glasziou P; Malaga G; Akl EA; Ferreira-Gonzalez I; Alonso-Coello P; Urrutia G; Kunz R; Culebro CR; da Silva SA; Flynn DN; Elamin MB; Strahm B; Murad MH; Djulbegovic B; Adhikari NK; Mills EJ; Gwadry-Sridhar F; Kirpalani H; Soares HP; Abu Elnour NO; You JJ; Karanicolas PJ; Bucher HC; Lampropulos JF; Nordmann AJ; Burns KE; Mulla SM; Raatz H; Sood A; Kaur J; Bankhead CR; Mullan RJ; Nerenberg KA; Vandvik PO; Coto-Yglesias F; Schünemann H; Tuche F; Chrispim PP; Cook DJ; Lutz K; Ribic CM; Vale N; Erwin PJ; Perera R; Zhou Q; Heels-Ansdell D; Ramsay T; Walter SD; Guyatt GH. Trials. 2009.

Subgroup Analysis of Trials Is Rarely Easy (SATIRE): a study protocol for a systematic review to characterize the analysis, reporting, and claim of subgroup effects in randomized trials.

Sun X; Briel M; Busse JW; Akl EA; You JJ; Mejza F; Bala M; Diaz-Granados N; Bassler D; Mertz D; Srinathan SK; Vandvik PO; Malaga G; Alshurafa M; Dahm P; Alonso-Coello P; Heels-Ansdell DM; Bhatnagar N; Johnston BC; Wang L; Walter SD; Altman DG; Guyatt GH. Trials. 2009.

Drug-eluting stents from a Medicare payer perspective: Cost-utility analysis with 4-year clinical meta-analysis data

Bischof, M.; Briel, M.; Bucher, H. C.; Nordmann, A.. Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research. 2008.

Early stopping of randomized clinical trials for overt efficacy is problematic.

Bassler D; Montori VM; Briel M; Glasziou P; Guyatt G. Journal of clinical epidemiology. 2008.

Hemodynamic performance of stentless versus stented valves: a systematic review and meta-analysis.

Payne DM; Koka HP; Karanicolas PJ; Chu MW; Nagpal AD; Briel M; Schünemann HJ; Lonn EM. JOURNAL OF CARDIAC SURGERY. 2008.

Procalcitonin-guided antibiotic use vs a standard approach for acute respiratory tract infections in primary care.

Briel M; Schuetz P; Mueller B; Young J; Schild U; Nusbaumer C; Périat P; Bucher HC; Christ-Crain M. Archives of internal medicine. 2008.

Procalcitonin to initiate or withhold antibiotics in acute respiratory tract infections

Schuetz P.; Briel M.; Christ-Crain M.; Wolbers M.; Stolz D.; Tamm M.; Bucher H.; Muller B.. Cochrane Database of Systematic Reviews. 2008.

The master-question: meta-analyses and stopped-early randomized trials - a problem? - Reply

Bassler, Dirk; Ferreira-Gonzalez, Ignacio; Briel, Matthias; Cook, Deborah J.; Devereaux, P. J.; Heels-Ansdell, Diane; Kirpalani, Haresh; Meade, Maureen O.; Montori, Victor M.; Rozenberg, Anna; Schunemann, Holger J.; Guyatt, Gordon H.. Journal of clinical epidemiology. 2008.

Cost-effectiveness of drug eluting stents in a US setting: cost-utility analysis with a decision analytic model using meta-analysis data with 3 year follow-up

Nordmann, A. J.; Bischof, M.; Briel, M.; Bucher, H. C.. European Heart Journal. 2007.

Effects of antithyroid drugs on radioiodine treatment: systematic review and meta-analysis of randomised controlled trials.

Walter MA; Briel M; Christ-Crain M; Bonnema SJ; Connell J; Cooper DS; Bucher HC; Müller-Brand J; Müller B. BMJ (Clinical research ed.). 2007.

Shared-decision making in general practice: do patients with respiratory tract infections actually want it?

Briel M; Young J; Tschudi P; Hugenschmidt C; Bucher HC; Langewitz W. Swiss medical weekly. 2007.

Systematic reviewers neglect bias that results from trials stopped early for benefit.

Bassler D; Ferreira-Gonzalez I; Briel M; Cook DJ; Devereaux PJ; Heels-Ansdell D; Kirpalani H; Meade MO; Montori VM; Rozenberg A; Schünemann HJ; Guyatt GH. Journal of clinical epidemiology. 2007.

The pylorus: take it or leave it? Systematic review and meta-analysis of pylorus-preserving versus standard whipple pancreaticoduodenectomy for pancreatic or periampullary cancer.

Karanicolas PJ; Davies E; Kunz R; Briel M; Koka HP; Payne DM; Smith SE; Hsu HP; Lin PW; Bloechle C; Paquet KJ; Guyatt GH. Annals of surgical oncology. 2007.

Adjunctive corticosteroids for Pneumocystis jiroveci pneumonia in patients with HIV-infection.

Briel M; Bucher HC; Boscacci R; Furrer H. Cochrane Database of Systematic Reviews. 2006.

Communication training and antibiotic use in acute respiratory tract infections. A cluster randomised controlled trial in general practice.

Briel M; Langewitz W; Tschudi P; Young J; Hugenschmidt C; Bucher HC. Swiss medical weekly. 2006.

Definition of low-fat diets - In reply

Nordmann, Alain J.; Yancy, William S., Jr.; Keller, Ulrich; Briel, Matthias; Bucher, Heiner C.. Archives of internal medicine. 2006.

Economic evaluation of drug eluting stents: Cost-utility analysis

Bischof, M.; Briel, M.; Bucher, H. C.; Nordmann, A.. Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research. 2006.

Effects of early treatment with statins on short-term clinical outcomes in acute coronary syndromes: a meta-analysis of randomized controlled trials.

Briel M; Schwartz GG; Thompson PL; de Lemos JA; Blazing MA; van Es GA; Kayikçioglu M; Arntz HR; den Hartog FR; Veeger NJ; Colivicchi F; Dupuis J; Okazaki S; Wright RS; Bucher HC; Nordmann AJ. JAMA. 2006.

Effects of early treatment with statins on short-term clinical outcomes in acute coronary syndromes: a systematic review and collaborative meta-analysis of randomized trials

Briel, M.; Schwartz, G. G.; Bucher, H. C.; Nordmann, A. J.. European Heart Journal. 2006.

Effects of low-carbohydrate vs low-fat diets on weight loss and cardiovascular risk factors: a meta-analysis of randomized controlled trials.

Nordmann AJ; Nordmann A; Briel M; Keller U; Yancy WS Jr; Brehm BJ; Bucher HC. Archives of internal medicine. 2006.

Lack of efficacy and cost-effectiveness of drug-eluting stents: reply

Nordmann, Alain J.; Briel, Matthias; Bucher, Heiner C.. European Heart Journal. 2006.

Mortality in randomized controlled trials comparing drug-eluting vs. bare metal stents in coronary artery disease: a meta-analysis.

Nordmann AJ; Briel M; Bucher HC. European Heart Journal. 2006.

Prevalence and influence of diagnostic tests for acute respiratory tract infections in primary care.

Briel M; Young J; Tschudi P; Hersberger KE; Hugenschmidt C; Langewitz W; Bucher HC. Swiss medical weekly. 2006.

Adjunctive corticosteroids for Pneumocystis jiroveci pneumonia in patients with HIV infection: a meta-analysis of randomised controlled trials.

Briel M; Boscacci R; Furrer H; Bucher HC. BMC Infectious Diseases. 2005.

Effect of different antilipidemic agents and diets on mortality: a systematic review.

Studer M; Briel M; Leimenstoll B; Glass TR; Bucher HC. Archives of internal medicine. 2005.

Procalcitonin-guided antibiotic use versus a standard approach for acute respiratory tract infections in primary care: study protocol for a randomised controlled trial and baseline characteristics of participating general practitioners [ISRCTN73182671].

Briel M; Christ-Crain M; Young J; Schuetz P; Huber P; Périat P; Bucher HC; Müller B. BMC family practice. 2005.

Randomized trials stopped early for benefit: a systematic review.

Montori VM; Devereaux PJ; Adhikari NK; Burns KE; Eggert CH; Briel M; Lacchetti C; Leung TW; Darling E; Bryant DM; Bucher HC; Schünemann HJ; Meade MO; Cook DJ; Erwin PJ; Sood A; Sood R; Lo B; Thompson CA; Zhou Q; Mills E; Guyatt GH. JAMA. 2005.

Statin therapy for prevention and treatment of acute and chronic cardiovascular disease: update on recent trials and metaanalyses.

Briel M; Nordmann AJ; Bucher HC. CURRENT OPINION IN LIPIDOLOGY. 2005.

Effects of statins on stroke prevention in patients with and without coronary heart disease: a meta-analysis of randomized controlled trials.

Briel M; Studer M; Glass TR; Bucher HC. The American journal of medicine. 2004.

Cystic fibrosis and CFTR.

Greger R; Schreiber R; Mall M; Wissner A; Hopf A; Briel M; Bleich M; Warth R; Kunzelmann K. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY. 2001.

Cl- transport by cystic fibrosis transmembrane conductance regulator (CFTR) contributes to the inhibition of epithelial Na+ channels (ENaCs) in Xenopus oocytes co-expressing CFTR and ENaC.

Briel M; Greger R; Kunzelmann K. JOURNAL OF PHYSIOLOGY-LONDON. 1998.

No evidence for direct activation of the cystic fibrosis transmembrane conductance regulator by 8-cyclopentyl-1,3-dipropylxanthine.

Kunzelmann K; Briel M; Schreiber R; Ricken S; Nitschke R; Greger R. Cellular Physiology and Biochemistry. 1998.

KVLQT channels are inhibited by the K+ channel blocker 293B.

Bleich M; Briel M; Busch AE; Lang HJ; Gerlach U; Gögelein H; Greger R; Kunzelmann K. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY. 1997.

The cystic fibrosis transmembrane conductance regulator attenuates the endogenous Ca2+ activated Cl- conductance of Xenopus oocytes.

Kunzelmann K; Mall M; Briel M; Hipper A; Nitschke R; Ricken S; Greger R. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY. 1997.