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Klinische Forschung
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Publications Pröbstel Anne-Katrin

Age-dependent gray matter demyelination is associated with leptomeningeal neutrophil accumulation.

Zuo M; Fettig NM; Bernier LP; Pössnecker E; Spring S; Pu A; Ma XI; Lee DS; Ward LA; Sharma A; Kuhle J; Sled JG; Pröbstel AK; MacVicar BA; Osborne LC; Gommerman JL; Ramaglia V. JCI Insight. 2022.

Choroid Plexus Volume in Multiple Sclerosis vs Neuromyelitis Optica Spectrum Disorder: A Retrospective, Cross-sectional Analysis.

Müller J; Sinnecker T; Wendebourg MJ; Schläger R; Kuhle J; Schädelin S; Benkert P; Derfuss T; Cattin P; Jud C; Spiess F; Amann M; Lincke T; Barakovic M; Cagol A; Tsagkas C; Parmar K; Pröbstel AK; Reimann S; Asseyer S; Duchow A; Brandt A; Ruprecht K; Hadjikhani N; Fukumoto S; Watanabe M; Masaki K; Matsushita T; Isobe N; Kira JI; Kappos L; Würfel J; Granziera C; Paul F; Yaldizli Ö. Neurology(R) neuroimmunology & neuroinflammation. 2022.

Gut microbiota composition as a candidate risk factor for dimethyl fumarate-induced lymphopenia in multiple sclerosis.

Diebold M; Meola M; Purushothaman S; Siewert LK; Pössnecker E; Roloff T; Lindberg RL; Kuhle J; Kappos L; Derfuss T; Egli A; Pröbstel AK. Gut microbes. 2022.

Severe Neuro-COVID is associated with peripheral immune signatures, autoimmunity and neurodegeneration: a prospective cross-sectional study.

Etter MM; Martins TA; Kulsvehagen L; Pössnecker E; Duchemin W; Hogan S; Sanabria-Diaz G; Müller J; Chiappini A; Rychen J; Eberhard N; Guzman R; Mariani L; Melie-Garcia L; Keller E; Jelcic I; Pargger H; Siegemund M; Kuhle J; Oechtering J; Eich C; Tzankov A; Matter MS; Uzun S; Yaldizli Ö; Lieb JM; Psychogios MN; Leuzinger K; Hirsch HH; Granziera C; Pröbstel AK; Hutter G. Nature Communications. 2022.

Cell type-specific transcriptomics identifies neddylation as a novel therapeutic target in multiple sclerosis.

Kim K; Pröbstel AK; Baumann R; Dyckow J; Landefeld J; Kogl E; Madireddy L; Loudermilk R; Eggers EL; Singh S; Caillier SJ; Hauser SL; Cree BAC; UCSF MS-EPIC Team; Schirmer L; Wilson MR; Baranzini SE. Brain. 2021.

CSF Findings in Acute NMDAR and LGI1 Antibody-Associated Autoimmune Encephalitis.

Dürr M; Nissen G; Sühs KW; Schwenkenbecher P; Geis C; Ringelstein M; Hartung HP; Friese MA; Kaufmann M; Malter MP; Madlener M; Thaler FS; Kümpfel T; Senel M; Häusler MG; Schneider H; Bergh FT; Kellinghaus C; Zettl UK; Wandinger KP; Melzer N; Gross CC; Lange P; Dreyhaupt J; Tumani H; Leypoldt F; Lewerenz J; German Network for Research on Autoimmune Encephalitis.. Neurology(R) neuroimmunology & neuroinflammation. 2021.

Genome-wide Association Study Identifies 2 New Loci Associated With Anti-NMDAR Encephalitis

Tietz A.K.; Angstwurm K.; Baumgartner T.; Doppler K.; Eisenhut K.; Elisak M.; Franke A.; Golombeck K.S.; Handreka R.; Kaufmann M.; Kraemer M.; Kraft A.; Lewerenz J.; Lieb W.; Madlener M.; Melzer N.; Mojzisova H.; Moller P.; Pfefferkorn T.; Pruss H.; Rostasy K.; Schnegelsberg M.; Schroder I.; Siebenbrodt K.; Suhs K.-W.; Wickel J.; Wandinger K.-P.; Leypoldt F.; Kuhlenbaumer G.. Neurology(R) neuroimmunology & neuroinflammation. 2021.

Myelin-oligodendrocyte glycoprotein antibody-associated disease

Marignier R.; Hacohen Y.; Cobo-Calvo A.; Probstel A.-K.; Aktas O.; Alexopoulos H.; Amato M.-P.; Asgari N.; Banwell B.; Bennett J.; Brilot F.; Capobianco M.; Chitnis T.; Ciccarelli O.; Deiva K.; De Seze J.; Fujihara K.; Jacob A.; Kim H.J.; Kleiter I.; Lassmann H.; Leite M.-I.; Linington C.; Meinl E.; Palace J.; Paul F.; Petzold A.; Pittock S.; Reindl M.; Sato D.K.; Selmaj K.; Siva A.; Stankoff B.; Tintore M.; Traboulsee A.; Waters P.; Waubant E.; Weinshenker B.; Derfuss T.; Vukusic S.; Hemmer B.. The Lancet Neurology. 2021.

Neuro-psychiatric manifestations in patients with systemic lupus erythematosus: A systematic review and results from the Swiss lupus cohort study.

Meier AL; Bodmer NS; Wirth C; Bachmann LM; Ribi C; Pröbstel AK; Waeber D; Jelcic I; Steiner UC; Swiss SLE Cohort Study (SSCS). LUPUS. 2021.

Presence of SARS-CoV-2 Transcripts in the Choroid Plexus of MS and Non-MS Patients With COVID-19.

Fuchs V; Kutza M; Wischnewski S; Deigendesch N; Lutz L; Kulsvehagen L; Ricken G; Kappos L; Tzankov A; Hametner S; Frank S; Schirmer L; Pröbstel AK. Neurology(R) neuroimmunology & neuroinflammation. 2021.

Rituximab Treatment and Long-term Outcome of Patients With Autoimmune Encephalitis: Real-world Evidence From the GENERATE Registry

Thaler F.S.; Zimmermann L.; Kammermeier S.; Strippel C.; Ringelstein M.; Kraft A.; Suhs K.-W.; Wickel J.; Geis C.; Markewitz R.; Urbanek C.; Sommer C.; Doppler K.; Penner L.; Lewerenz J.; Rossling R.; Finke C.; Pruss H.; Melzer N.; Wandinger K.-P.; Leypoldt F.; Kumpfel T.. Neurology(R) neuroimmunology & neuroinflammation. 2021.

SARS-CoV-2-specific neuropathology: fact or fiction?

Probstel A.-K.; Schirmer L.. Trends in Neurosciences. 2021.

Symptomatic and restorative therapies in neuromyelitis optica spectrum disorders

Abboud H.; Salazar-Camelo A.; George N.; Planchon S.M.; Matiello M.; Mealy M.A.; Goodman A.; Alroughani R.; Altintas A.; Apiwattanakul M.; Asgari N.; Paolilo R.B.; Bennett J.; Bichuetti D.B.; Blaschke T.F.; Boyko A.; Broadley S.; Contentti E.C.; Cohen J.A.; Delgado-Garcia G.; Basuroski I.D.; Flores-Rivera J.; Fujihara K.; Havla J.; Hellwig K.; Hor J.Y.; Huda S.; Iorio R.; Jarius S.; Kimbrough D.; Kister I.; Kleiter I.; Kissani N.; Lana-Peixoto M.; Leite M.I.; Levy M.; Maiga Y.; Mao-Draayer Y.; Mariotto S.; Melamed E.; Neubrand V.E.; Oreja-Guevara C.; Palace J.; Probstel A.-K.; Qian P.; Quan C.; Riley C.; Ringelstein M.; Sa M.J.; Siritho S.; Smith T.J.; de Castillo I.S.; Tenembaum S.; Villoslada P.; Wuerfel J.; Wingerchuk D.; Yamout B.; Yeaman M.. Journal of Neurology. 2021.

A pathogenic and clonally expanded B cell transcriptome in active multiple sclerosis.

Ramesh A; Schubert RD; Greenfield AL; Dandekar R; Loudermilk R; Sabatino JJ Jr; Koelzer MT; Tran EB; Koshal K; Kim K; Pröbstel AK; Banerji D; University of California, San Francisco MS-EPIC Team; Guo CY; Green AJ; Bove RM; DeRisi JL; Gelfand JM; Cree BAC; Zamvil SS; Baranzini SE; Hauser SL; Wilson MR. Proceedings of the National Academy of Sciences of the United States of America. 2020.

Correlates of critical illness-related encephalopathy predominate postmortem COVID-19 neuropathology

Deigendesch N.; Sironi L.; Kutza M.; Wischnewski S.; Fuchs V.; Hench J.; Frank A.; Nienhold R.; Mertz K.D.; Cathomas G.; Matter M.S.; Siegemund M.; Tolnay M.; Schirmer L.; Probstel A.-K.; Tzankov A.; Frank S.. Acta neuropathologica. 2020.

Gut microbiota-specific IgA(+) B cells traffic to the CNS in active multiple sclerosis.

Pröbstel AK; Zhou X; Baumann R; Wischnewski S; Kutza M; Rojas OL; Sellrie K; Bischof A; Kim K; Ramesh A; Dandekar R; Greenfield AL; Schubert RD; Bisanz JE; Vistnes S; Khaleghi K; Landefeld J; Kirkish G; Liesche-Starnecker F; Ramaglia V; Singh S; Tran EB; Barba P; Zorn K; Oechtering J; Forsberg K; Shiow LR; Henry RG; Graves J; Cree BAC; Hauser SL; Kuhle J; Gelfand JM; Andersen PM; Schlegel J; Turnbaugh PJ; Seeberger PH; Gommerman JL; Wilson MR; Schirmer L; Baranzini SE. Science Immunology. 2020.

Publisher Correction: B cells in autoimmune and neurodegenerative central nervous system diseases.

Sabatino JJ Jr; Pröbstel AK; Zamvil SS. . 2020.

The future of microbiome research in neuroinflammatory disorders.

Waubant E; Pröbstel AK; Levy M; Hawkes CH; Giovannoni G; Lechner-Scott J; Tremlett H. . 2020.

Treatment of MOG antibody associated disorders: results of an international survey.

Whittam DH; Karthikeayan V; Gibbons E; Kneen R; Chandratre S; Ciccarelli O; Hacohen Y; de Seze J; Deiva K; Hintzen RQ; Wildemann B; Jarius S; Kleiter I; Rostasy K; Huppke P; Hemmer B; Paul F; Aktas O; Pröbstel AK; Arrambide G; Tintore M; Amato MP; Nosadini M; Mancardi MM; Capobianco M; Illes Z; Siva A; Altintas A; Akman-Demir G; Pandit L; Apiwattankul M; Hor JY; Viswanathan S; Qiu W; Kim HJ; Nakashima I; Fujihara K; Ramanathan S; Dale RC; Boggild M; Broadley S; Lana-Peixoto MA; Sato DK; Tenembaum S; Cabre P; Wingerchuk DM; Weinshenker BG; Greenberg B; Matiello M; Klawiter EC; Bennett JL; Wallach AI; Kister I; Banwell BL; Traboulsee A; Pohl D; Palace J; Leite MI; Levy M; Marignier R; Solomon T; Lim M; Huda S; Jacob A. Journal of Neurology. 2020.

Association of antibodies against myelin and neuronal antigens with neuroinflammation in systemic lupus erythematosus.

Pröbstel AK; Thanei M; Erni B; Lecourt AC; Branco L; André R; Roux-Lombard P; Koenig KF; Huynh-Do U; Ribi C; Chizzolini C; Kappos L; Trendelenburg M; Derfuss T; Swiss Systemic Lupus Erythematosus Cohort Study Group. Rheumatology (Oxford, England). 2019.

B cells in autoimmune and neurodegenerative central nervous system diseases.

Sabatino JJ Jr; Pröbstel AK; Zamvil SS. Nature reviews. Neuroscience. 2019.

Do maternal anti-N-methyl-D-aspartate receptor antibodies promote development of neuropsychiatric disease in children?

Pröbstel AK; Zamvil SS. . 2019.

Introducing the International Women in Multiple Sclerosis network.

Jokubaitis VG; Pröbstel AK; Arrambide G; Costello F; Waubant E. . 2019.

Peripheral neuropathy in antineutrophil cytoplasmic antibody-associated vasculitides: Insights from the DCVAS study.

Bischof A; Jaeger VK; Hadden RDM; Luqmani RA; Pröbstel AK; Merkel PA; Suppiah R; Craven A; Collins MP; Daikeler T. Neurology(R) neuroimmunology & neuroinflammation. 2019.

Recirculating Intestinal IgA-Producing Cells Regulate Neuroinflammation via IL-10.

Rojas OL; Pröbstel AK; Porfilio EA; Wang AA; Charabati M; Sun T; Lee DSW; Galicia G; Ramaglia V; Ward LA; Leung LYT; Najafi G; Khaleghi K; Garcillán B; Li A; Besla R; Naouar I; Cao EY; Chiaranunt P; Burrows K; Robinson HG; Allanach JR; Yam J; Luck H; Campbell DJ; Allman D; Brooks DG; Tomura M; Baumann R; Zamvil SS; Bar-Or A; Horwitz MS; Winer DA; Mortha A; Mackay F; Prat A; Osborne LC; Robbins C; Baranzini SE; Gommerman JL. . 2019.

Recirculating Intestinal IgA-Producing Cells Regulate Neuroinflammation via IL-10.

Rojas OL; Pröbstel AK; Porfilio EA; Wang AA; Charabati M; Sun T; Lee DSW; Galicia G; Ramaglia V; Ward LA; Leung LYT; Najafi G; Khaleghi K; Garcillán B; Li A; Besla R; Naouar I; Cao EY; Chiaranunt P; Burrows K; Robinson HG; Allanach JR; Yam J; Luck H; Campbell DJ; Allman D; Brooks DG; Tomura M; Baumann R; Zamvil SS; Bar-Or A; Horwitz MS; Winer DA; Mortha A; Mackay F; Prat A; Osborne LC; Robbins C; Baranzini SE; Gommerman JL. Cell. 2019.

Single-Cell High-Throughput Technologies in Cerebrospinal Fluid Research and Diagnostics.

Lanz TV; Pröbstel AK; Mildenberger I; Platten M; Schirmer L. Frontiers in Immunology. 2019.

Multiple Sclerosis: B Cells Take Center Stage.

Pröbstel AK; Hauser SL. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society. 2018.

Multiple Sclerosis-Associated Changes in the Composition and Immune Functions of Spore-Forming Bacteria.

Cekanaviciute E; Pröbstel AK; Thomann A; Runia TF; Casaccia P; Katz Sand I; Crabtree E; Singh S; Morrissey J; Barba P; Gomez R; Knight R; Mazmanian S; Graves J; Cree BAC; Zamvil SS; Baranzini SE. mSystems. 2018.

Oligodendrocyte-encoded Kir4.1 function is required for axonal integrity.

Schirmer L; Möbius W; Zhao C; Cruz-Herranz A; Ben Haim L; Cordano C; Shiow LR; Kelley KW; Sadowski B; Timmons G; Pröbstel AK; Wright JN; Sin JH; Devereux M; Morrison DE; Chang SM; Sabeur K; Green AJ; Nave KA; Franklin RJ; Rowitch DH. Elife. 2018.

The Role of the Gut Microbiome in Multiple Sclerosis Risk and Progression: Towards Characterization of the "MS Microbiome".

Pröbstel AK; Baranzini SE. NEUROTHERAPEUTICS. 2018.

Mitochondrial cytopathy with common MELAS mutation presenting as multiple system atrophy mimic.

Pröbstel AK; Schaller A; Lieb J; Hench J; Frank S; Fuhr P; Kappos L; Sinnreich M. Neurology-Genetics. 2016.

Multiple Sclerosis and Antibodies against KIR4.1.

Pröbstel AK; Kuhle J; Lecourt AC; Vock I; Sanderson NS; Kappos L; Derfuss T. New England Journal of Medicine. 2016.

Nerve Hypertrophy in Primary Amyloidosis.

Rasenack M; Proebstel AK; Athanasopoulou IM; Décard BF; Grimm A. Muscle & Nerve. 2016.

Ultrasound and electrophysiologic findings in patients with Guillain-Barré syndrome at disease onset and over a period of six months.

Grimm A; Décard BF; Schramm A; Pröbstel AK; Rasenack M; Axer H; Fuhr P. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. 2016.

Anti-MOG antibodies are present in a subgroup of patients with a neuromyelitis optica phenotype.

Pröbstel AK; Rudolf G; Dornmair K; Collongues N; Chanson JB; Sanderson NS; Lindberg RL; Kappos L; de Seze J; Derfuss T. Journal of neuroinflammation. 2015.

B Cells and Autoantibodies in Multiple Sclerosis.

Pröbstel AK; Sanderson NS; Derfuss T. International Journal of Molecular Sciences. 2015.

Distinction and temporal stability of conformational epitopes on myelin oligodendrocyte glycoprotein recognized by patients with different inflammatory central nervous system diseases.

Mayer MC; Breithaupt C; Reindl M; Schanda K; Rostásy K; Berger T; Dale RC; Brilot F; Olsson T; Jenne D; Pröbstel AK; Dornmair K; Wekerle H; Hohlfeld R; Banwell B; Bar-Or A; Meinl E. Journal of Immunology. 2013.

Antibodies to MOG are transient in childhood acute disseminated encephalomyelitis.

Pröbstel AK; Dornmair K; Bittner R; Sperl P; Jenne D; Magalhaes S; Villalobos A; Breithaupt C; Weissert R; Jacob U; Krumbholz M; Kuempfel T; Blaschek A; Stark W; Gärtner J; Pohl D; Rostasy K; Weber F; Forne I; Khademi M; Olsson T; Brilot F; Tantsis E; Dale RC; Wekerle H; Hohlfeld R; Banwell B; Bar-Or A; Meinl E; Derfuss T. Neurology. 2011.

Humoral autoimmunity in multiple sclerosis.

Meinl E; Derfuss T; Krumbholz M; Pröbstel AK; Hohlfeld R. Journal of the neurological sciences. 2011.