Klinische Forschung
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Publications Sinues Pablo

Ambient prenatal air pollution exposure is associated with low cord blood IL-17a in infants.

Gorlanova O; Oller H; Marten A; Müller L; Laine-Carmelli J; Decrue F; Salem Y; Vienneau D; Hoogh K; Gisler A; Usemann J; Korten I; Yammine S; Nahum U; Künstle N; Sinues P; Schulzke S; Latzin P; Fuchs O; Röösli M; Schaub B; Frey U; BILD study group. Pediatric Allergy and Immunology. 2023.

UHPLC-MS/MS-Based Identity Confirmation of Amino Acids Involved in Response to and Side Effects from Antiseizure Medications.

Awchi M; Sinues P; Datta AN; García-Gómez D; Singh KD. Journal of Proteome Research. 2023.

An interoperability framework for multicentric breath metabolomic studies

Gisler A.; Singh K.D.; Zeng J.; Osswald M.; Awchi M.; Decrue F.; Schmidt F.; Sievi N.A.; Chen X.; Usemann J.; Frey U.; Kohler M.; Li X.; Sinues P.. iScience. 2022.

An Interoperability Framework for Multicentric Breath Metabolomic Studies

Amanda Gisler; Kapil Dev Singh; Jiafa Zeng; Martin Osswald; Mo Awchi; Fabienne Decrue; Felix Schmidt; Noriane Sievi; Xing Chen; Jakob Usemann; Urs Frey; Malcolm Kohler; Xue Li; Pablo Sinues. . 2022.

Comparison of Plasma Ionization- and Secondary Electrospray IonizationHigh-resolution Mass Spectrometry for Real-time Breath Analysis

Zeng J.; Christen A.; Singh K.D.; Frey U.; Sinues P.. Chimia. 2022.

Increased Impact of Air Pollution on Lung Function in Preterm versus Term Infants: The BILD Study.

Decrue F; Gorlanova O; Salem Y; Vienneau D; de Hoogh K; Gisler A; Usemann J; Korten I; Nahum U; Sinues P; Schulzke S; Fuchs O; Latzin P; Röösli M; Frey U; BILD study group. American Journal of Respiratory and Critical Care Medicine. 2022.

In vivo detection of metabolic <sup>2</sup>H-incorporation upon ingestion of <sup>2</sup>H<inf>2</inf>O

Arnold K.; Chen X.; Zhang H.; Singh K.D.; Yin Z.; Yao Y.; Luan T.; Sinues P.; Li X.. Journal of Bio-X Research. 2022.

Rapid detection of Staphylococcus aureus and Streptococcus pneumoniae by real-time analysis of volatile metabolites

Gomez-Mejia A.; Arnold K.; Bar J.; Singh K.D.; Scheier T.C.; Brugger S.D.; Zinkernagel A.S.; Sinues P.. iScience. 2022.

Circadian Metabolomics from Breath.

Brown SA; Sinues P. Methods in Molecular Biology. 2021.

Combination of Exhaled Breath Analysis with Parallel Lung Function and FeNO Measurements in Infants.

Decrue F; Singh KD; Gisler A; Awchi M; Zeng J; Usemann J; Frey U; Sinues P. Analytical Chemistry. 2021.

In vivo monitoring of volatile metabolic trajectories enables rapid diagnosis of influenza A infection.

Yin Z ; Huang W ; Singh KD ; Chen Z ; Chen X ; Zhou Z ; Yang Z ; Sinues P ; Li X . Chemical Communications. 2021.

Monitoring peppermint washout in the breath metabolome by secondary electrospray ionization-high resolution mass spectrometry.

Lan J; Gisler A; Bruderer T; Sinues P; Zenobi R. Journal of Breath Research. 2021.

Online Real-Time Monitoring of Exhaled Breath Particles Reveals Unnoticed Transport of Nonvolatile Drugs from Blood to Breath.

Chen X; Zhang K; Yin Z; Fang M; Pu W; Liu Z; Li L; Sinues P; Dallmann R; Zhou Z; Li X. Analytical Chemistry. 2021.

Personalised therapeutic management of epileptic patients guided by pathway-driven breath metabolomics.

Singh KD; Osswald M; Ziesenitz VC; Awchi M; Usemann J; Imbach LL; Kohler M; García-Gómez D; van den Anker J; Frey U; Datta AN; Sinues P. Communications medicine. 2021.

Quantification of volatile organic compounds by secondary electrospray ionization-high resolution mass spectrometry.

Liu C; Zeng J; Sinues P; Fang M; Zhou Z; Li X. Analytica Chimica Acta. 2021.

Rapid and reversible control of human metabolism by individual sleep states.

Nowak N; Gaisl T; Miladinovic D; Marcinkevics R; Osswald M; Bauer S; Buhmann J; Zenobi R; Sinues P; Brown SA; Kohler M. Cell Reports. 2021.

Real-Time Monitoring of Metabolism during Exercise by Exhaled Breath.

Osswald M; Kohlbrenner D; Nowak N; Spörri J; Sinues P; Nieman D; Sievi NA; Scherr J; Kohler M. Metabolites. 2021.

Real-time pharmacokinetics via online analysis of exhaled breath.

López-Lorente CI; Awchi M; Sinues P; García-Gómez D. Journal of Pharmaceutical and Biomedical Analysis. 2021.

The peppermint breath test: A benchmarking protocol for breath sampling and analysis using GC-MS

Wilkinson M.; White I.; Hamshere K.; Holz O.; Schuchardt S.; Bellagambi F.G.; Lomonaco T.; Biagini D.; Di F.F.; Fowler S.J.; Beauchamp J.D.; Cristescu S.M.; Focant J.-F.; Franchina F.A.; Grassin-Delyle S.; Hadjithekli A.; Henderson B.; Koppen G.F.; Langejurgen J.; Malaskova M.; Mayhew C.; Moreno S.; Pedrotti M.; Pugliese G.; Ruszkiewicz D.M.; Salman D.; Sinues P.; Slingers G.F.; Stefanuto P.-H.; Thomas C.L.P.; Wilde M.; Zanella D.; Zenobi R.. Journal of Breath Research. 2021.

Validation of breath biomarkers for obstructive sleep apnea.

Nowak N; Engler A; Thiel S; Stöberl AS; Sinues P; Zenobi R; Kohler M. . 2021.

A benchmarking protocol for breath analysis: the peppermint experiment.

Henderson B; Ruszkiewicz DM; Wilkinson M; Beauchamp JD; Cristescu SM; Fowler SJ; Salman D; Francesco FD; Koppen G; Langejürgen J; Holz O; Hadjithekli A; Moreno S; Pedrotti M; Sinues P; Slingers G; Wilde M; Lomonaco T; Zanella D; Zenobi R; Focant JF; Grassin-Delyle S; Franchina FA; Malásková M; Stefanuto PH; Pugliese G; Mayhew C; Thomas CLP. Journal of Breath Research. 2020.

Real-time breath analysis of exhaled compounds upon peppermint oil ingestion by secondary electrospray ionization-high resolution mass spectrometry: technical aspects.

Gisler A; Lan J; Singh KD; Usemann J; Frey U; Zenobi R; Sinues P. Journal of Breath Research. 2020.

Molecular breath analysis supports altered amino acid metabolism in idiopathic pulmonary fibrosis.

Gaugg MT; Engler A; Bregy L; Nussbaumer-Ochsner Y; Eiffert L; Bruderer T; Zenobi R; Sinues P; Kohler M. Respirology (Carlton, Vic.). 2019.

Real-Time Breath Analysis Reveals Specific Metabolic Signatures of COPD Exacerbations.

Gaugg MT; Nussbaumer-Ochsner Y; Bregy L; Engler A; Stebler N; Gaisl T; Bruderer T; Nowak N; Sinues P; Zenobi R; Kohler M. Chest. 2019.

Standardization procedures for real-time breath analysis by secondary electrospray ionization high-resolution mass spectrometry.

Singh KD; Tancev G; Decrue F; Usemann J; Appenzeller R; Barreiro P; Jaumà G; Macia Santiago M; Vidal de Miguel G; Frey U; Sinues P. Analytical and Bioanalytical Chemistry. 2019.

Real-time exhaled breath analysis in patients with cystic fibrosis and controls.

Gaisl T; Bregy L; Stebler N; Gaugg MT; Bruderer T; García-Gómez D; Moeller A; Singer F; Schwarz EI; Benden C; M-L Sinues P; Zenobi R; Kohler M. Journal of Breath Research. 2018.

Real-time mass spectrometric identification of metabolites characteristic of chronic obstructive pulmonary disease in exhaled breath

Bregy, Lukas; Nussbaumer-Ochsner, Yvonne; Martinez-Lozano Sinues, Pablo; García-Gómez, Diego; Suter, Yannick; Gaisl, Thomas; Stebler, Nina; Gaugg, Martin Thomas; Kohler, Malcolm; Zenobi, Renato. Clinical Mass Spectrometry. 2018.

Real-Time Monitoring of Tricarboxylic Acid Metabolites in Exhaled Breath.

Tejero Rioseras A; Singh KD; Nowak N; Gaugg MT; Bruderer T; Zenobi R; Sinues PM. Analytical Chemistry. 2018.

Translating secondary electrospray ionization-high-resolution mass spectrometry to the clinical environment.

Singh KD; Del Miguel GV; Gaugg MT; Ibañez AJ; Zenobi R; Kohler M; Frey U; Sinues PM. Journal of Breath Research. 2018.

Comprehensive Real-Time Analysis of the Yeast Volatilome.

Tejero Rioseras A; Garcia Gomez D; Ebert BE; Blank LM; Ibáñez AJ; Sinues PM. Scientific Reports. 2017.

Gauging circadian variation in ketamine metabolism by real-time breath analysis.

Martinez-Lozano Sinues P; Kohler M; Brown SA; Zenobi R; Dallmann R. Chemical Communications. 2017.

Mass-Spectrometric Detection of Omega-Oxidation Products of Aliphatic Fatty Acids in Exhaled Breath.

Gaugg MT; Bruderer T; Nowak N; Eiffert L; Martinez-Lozano Sinues P; Kohler M; Zenobi R. Analytical Chemistry. 2017.

Metabolic effects of inhaled salbutamol determined by exhaled breath analysis.

Gaugg MT; Engler A; Nussbaumer-Ochsner Y; Bregy L; Stöberl AS; Gaisl T; Bruderer T; Zenobi R; Kohler M; Martinez-Lozano Sinues P. Journal of Breath Research. 2017.

Rapid fingerprinting of grape volatile composition using secondary electrospray ionization orbitrap mass spectrometry: A preliminary study of grape ripening

Farrell, Ross R.; Fahrentrapp, Johannes; Garcia-Gomez, Diego; Martinez-Lozano Sinues, Pablo; Zenobi, Renato. Food Control. 2017.

Secondary electrospray ionization proceeds via gas-phase chemical ionization

Tejero Rioseras, Alberto; Thomas Gaugg, Martin; Martinez-Lozano Sinues, Pablo. Analytical Methods. 2017.

Capturing in Vivo Plant Metabolism by Real-Time Analysis of Low to High Molecular Weight Volatiles.

Barrios-Collado C; García-Gómez D; Zenobi R; Vidal-de-Miguel G; Ibáñez AJ; Martinez-Lozano Sinues P. Analytical Chemistry. 2016.

Effects of CPAP therapy withdrawal on exhaled breath pattern in obstructive sleep apnoea.

Schwarz EI; Martinez-Lozano Sinues P; Bregy L; Gaisl T; Garcia Gomez D; Gaugg MT; Suter Y; Stebler N; Nussbaumer-Ochsner Y; Bloch KE; Stradling JR; Zenobi R; Kohler M. Thorax. 2016.

Expanding metabolite coverage of real-time breath analysis by coupling a universal secondary electrospray ionization source and high resolution mass spectrometry - A pilot study on tobacco smokers

Gaugg M.T.; Gomez D.G.; Barrios-Collado C.; Vidal-De-Miguel G.; Kohler M.; Zenobi R.; Martinez-Lozano Sinues P.. Journal of Breath Research. 2016.

Noninvasive strategies for breast cancer early detection

Trecate G.; Sinues P.M.-L.; Orlandi R.. Future Oncology. 2016.

Numerical modeling and experimental validation of a universal secondary electrospray ionization source for mass spectrometric gas analysis in real-time

Barrios-Collado C.; Vidal-De-Miguel G.; Martinez-Lozano Sinues P.. Sensors and Actuators, B: Chemical. 2016.

Real-time quantification of amino acids in the exhalome by secondary electrospray ionization-mass spectrometry: A proof-of-principle study

Garcia-Gomez D.; Gaisl T.; Bregy L.; Cremonesi A.; Sinues P.M.-L.; Kohler M.; Zenobi R.. Clinical chemistry. 2016.

Real time read-out of plant metabolism

Barrios-Collado C.; Garcia-Gomez D.; Zenobi R.; Vidal-De-Miguel G.; Ibanez A.J.; Sinues P.M.-L.. Chimia. 2016.

Secondary electrospray ionization coupled to high-resolution mass spectrometry reveals tryptophan pathway metabolites in exhaled human breath.

García-Gómez D; Gaisl T; Bregy L; Martínez-Lozano Sinues P; Kohler M; Zenobi R. Chemical Communications. 2016.

Differentiation of oral bacteria in in vitro cultures and human saliva by secondary electrospray ionization - mass spectrometry.

Bregy L; Müggler AR; Martinez-Lozano Sinues P; García-Gómez D; Suter Y; Belibasakis GN; Kohler M; Schmidlin PR; Zenobi R. Scientific Reports. 2015.

Drug Pharmacokinetics Determined by Real-Time Analysis of Mouse Breath.

Li X; Martinez-Lozano Sinues P; Dallmann R; Bregy L; Hollmén M; Proulx S; Brown SA; Detmar M; Kohler M; Zenobi R. Angewandte Chemie - International Edition. 2015.

Identification of 2-alkenals, 4-hydroxy-2-alkenals, and 4-hydroxy-2,6-alkadienals in exhaled breath condensate by UHPLC-HRMS and in breath by real-time HRMS.

García-Gómez D; Martínez-Lozano Sinues P; Barrios-Collado C; Vidal-de-Miguel G; Gaugg M; Zenobi R. Analytical Chemistry. 2015.

Secondary electrospray ionization-mass spectrometry and a novel statistical bioinformatic approach identifies a cancer-related profile in exhaled breath of breast cancer patients: a pilot study.

Martinez-Lozano Sinues P; Landoni E; Miceli R; Dibari VF; Dugo M; Agresti R; Tagliabue E; Cristoni S; Orlandi R. Journal of Breath Research. 2015.

Breath analysis in real time by mass spectrometry in chronic obstructive pulmonary disease.

Martinez-Lozano Sinues P; Meier L; Berchtold C; Ivanov M; Sievi N; Camen G; Kohler M; Zenobi R. Respiration. 2014.

Circadian variation of the human metabolome captured by real-time breath analysis.

Martinez-Lozano Sinues P; Tarokh L; Li X; Kohler M; Brown SA; Zenobi R; Dallmann R. PLoS ONE. 2014.

Fingerprinting breast cancer vs. normal mammary cells by mass spectrometric analysis of volatiles

He J.; Sinues P.M.-L.; Hollmen M.; Li X.; Detmar M.; Zenobi R.. Scientific Reports. 2014.

Ion mobility spectrometry coupled to laser-induced fluorescence for probing the electronic structure and conformation of gas-phase ions

Frankevich V.E.; Barylyuk K.V.; Martinez-Lozano Sinues P.; Zenobi R.. JOURNAL OF ANALYTICAL CHEMISTRY. 2014.

Mass spectrometry research at the laboratory for organic chemistry, eth zurich

Barylyuk K.; Frankevich V.; Ibanez A.J.; Sinues P.M.-L.; Zenobi R.. Chimia. 2014.

Rapid identification of bacteria in blood cultures by mass-spectrometric analysis of volatiles.

Ballabio C; Cristoni S; Puccio G; Kohler M; Sala MR; Brambilla P; Martinez-Lozano Sinues P. Journal of clinical pathology. 2014.

Real-time breath analysis with active capillary plasma ionization-ambient mass spectrometry

Bregy L.; Sinues P.M.-L.; Nudnova M.M.; Zenobi R.. Journal of Breath Research. 2014.

Real-time detection of chemical warfare agent simulants in forensic samples using active capillary plasma ionization with benchtop and field-deployable mass spectrometers

Dumlao M.; Sinues P.M.-L.; Nudnova M.; Zenobi R.. Analytical Methods. 2014.

Analysis of the exhalome: A diagnostic tool of the future

Sinues P.M.-L.; Zenobi R.; Kohler M.. Chest. 2013.

Human Breath Analysis May Support the Existence of Individual Metabolic Phenotypes

Martinez-Lozano Sinues P.; Kohler M.; Zenobi R.. PLoS ONE. 2013.

Ion mobility spectrometry coupled to laser-induced fluorescence

Frankevich V.; Martinez-Lozano Sinues P.; Barylyuk K.; Zenobi R.. Analytical Chemistry. 2013.

Monitoring diurnal changes in exhaled human breath

Sinues P.M.-L.; Kohler M.; Zenobi R.. Analytical Chemistry. 2013.

Mass spectrometry fingerprinting coupled to National Institute of Standards and Technology Mass Spectral search algorithm for pattern recognition

Martinez-Lozano Sinues P.; Alonso-Salces R.M.; Zingaro L.; Finiguerra A.; Holland M.V.; Guillou C.; Cristoni S.. Analytica Chimica Acta. 2012.

Mechanistic study on the ionization of trace gases by an electrospray plume

Martinez-Lozano Sinues P.; Criado E.; Vidal G.. International Journal of Mass Spectrometry. 2012.

Letter to the editor

Cristoni S.; Molin L.; Lai A.; Bernardi L.R.; Pucciarelli S.; Agostini M.; Bedin C.; Nitti D.; Seraglia R.; Repetto O.; Dibari V.F.; Orlandi R.; Sinues P.M.-L.; Traldi P.. Rapid Communications in Mass Spectrometry. 2009.