Klinische Forschung
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Publications Mehling Matthias

The risk of infections for multiple sclerosis and neuromyelitis optica spectrum disorder disease-modifying treatments: Eighth European Committee for Treatment and Research in Multiple Sclerosis Focused Workshop Review. April 2021.

Tur C; Dubessy AL; Otero-Romero S; Amato MP; Derfuss T; Di Pauli F; Iacobaeus E; Mycko M; Abboud H; Achiron A; Bellinvia A; Boyko A; Casanova JL; Clifford D; Dobson R; Farez MF; Filippi M; Fitzgerald KC; Fonderico M; Gouider R; Hacohen Y; Hellwig K; Hemmer B; Kappos L; Ladeira F; Lebrun-Frénay C; Louapre C; Magyari M; Mehling M; Oreja-Guevara C; Pandit L; Papeix C; Piehl F; Portaccio E; Ruiz-Camps I; Selmaj K; Simpson-Yap S; Siva A; Sorensen PS; Sormani MP; Trojano M; Vaknin-Dembinsky A; Vukusic S; Weinshenker B; Wiendl H; Winkelmann A; Zuluaga Rodas MI; Tintoré M; Stankoff B. Multiple Sclerosis Journal. 2022.

Acute Polyradiculomyelitis With Spinal Cord Gray Matter Lesions: A Report of Two Cases.

Tsagkas C; Wendebourg MJ; Mehling M; Lorscheider J; Lyrer P; Décard BF. Frontiers in Neurology. 2021.

Smartphone-based active vaccine safety surveillance (SmartVax) at a Swiss adult vaccination clinic - a pilot study.

Guedel DS; Peters IJ; Banderet F; Epple V; Egli S; Mehling M; Mayr M; Leeb A; Berger CT. Swiss medical weekly. 2021.

Syndrome of inappropriate antidiuretic hormone secretion and hypothalamic hypocortisolism in neuromyelitis optica.

Tsagkas C; Schäfer S; Baumgartner A; Müller J; Sinnecker T; Mehling M; van der Stouwe JG; Felder S; Panagiotou A; Potlukova E; Winzeler B; Scholz MC; Timper K; Blackham K; Nickel CH; Christ-Crain M; Bingisser R; Lyrer P; Kappos L; Yaldizli Ö. The Lancet. 2021.

Advances in oral immunomodulating therapies in relapsing multiple sclerosis.

Derfuss T; Mehling M; Papadopoulou A; Bar-Or A; Cohen JA; Kappos L. The Lancet Neurology. 2020.

Growth differentiation factor 15 is increased in stable MS.

Amstad A; Coray M; Frick C; Barro C; Oechtering J; Amann M; Wischhusen J; Kappos L; Naegelin Y; Kuhle J; Mehling M. Neurology(R) neuroimmunology & neuroinflammation. 2020.

Nano-scale microfluidics to study 3D chemotaxis at the single cell level.

Frick C; Dettinger P; Renkawitz J; Jauch A; Berger CT; Recher M; Schroeder T; Mehling M. PLoS ONE. 2018.

Shortening the washout to 4 weeks when switching from natalizumab to fingolimod and risk of disease reactivation in multiple sclerosis.

Naegelin Y; Rasenack M; Andelova M; Von Felten S; Fischer-Barnicol B; Amann M; Mehling M; Kappos L; Sprenger T; Derfuss T. Multiple Sclerosis and Related Disorders. 2018.

Varicella zoster virus-specific T cell responses in untreated giant cell arteritis: comment on the article by England et al.

Bigler MB; Hirsiger JR; Recher M; Mehling M; Daikeler T; Berger CT. Arthritis and Rheumatology. 2018.

Characteristics of autoantibodies targeting 14-3-3 proteins and their association with clinical features in newly diagnosed giant cell arteritis.

Kistner A; Bigler MB; Glatz K; Egli SB; Baldin FS; Marquardsen FA; Mehling M; Rentsch KM; Staub D; Aschwanden M; Recher M; Daikeler T; Berger CT. Rheumatology (United Kingdom). 2017.

Locally Triggered Release of the Chemokine CCL21 Promotes Dendritic Cell Transmigration across Lymphatic Endothelia.

Vaahtomeri K; Brown M; Hauschild R; De Vries I; Leithner AF; Mehling M; Kaufmann WA; Sixt M. Cell Reports. 2017.

Vedolizumab as a successful treatment of CTLA-4-associated autoimmune enterocolitis.

Navarini AA; Hruz P; Berger CT; Hou TZ; Schwab C; Gabrysch A; Higgins R; Frede N; Padberg Sgier BC; Kämpe O; Burgener AV; Marquardsen F; Baldin F; Bigler M; Kistner A; Jauch A; Bignucolo O; Meyer B; Meienberg F; Mehling M; Jeker LT; Heijnen I; Daikeler TD; Gebbers JO; Grimbacher B; Sansom DM; Jeker R; Hess C; Recher M. Journal of Allergy and Clinical Immunology. 2017.

A microfluidic device for measuring cell migration towards substrate-bound and soluble chemokine gradients.

Schwarz J; Bierbaum V; Merrin J; Frank T; Hauschild R; Bollenbach T; Tay S; Sixt M; Mehling M. Scientific Reports. 2016.

Cytokine profiles show heterogeneity of interferon-β response in multiple sclerosis patients.

Hegen H; Adrianto I; Lessard CJ; Millonig A; Bertolotto A; Comabella M; Giovannoni G; Guger M; Hoelzl M; Khalil M; Fazekas F; Killestein J; Lindberg RL; Malucchi S; Mehling M; Montalban X; Rudzki D; Schautzer F; Sellebjerg F; Sorensen PS; Deisenhammer F; Steinman L; Axtell RC. Neurology(R) neuroimmunology & neuroinflammation. 2016.

Cytokine profiles show heterogeneity of interferon-β response in multiple sclerosis patients.

Hegen H; Adrianto I; Lessard CJ; Millonig A; Bertolotto A; Comabella M; Giovannoni G; Guger M; Hoelzl M; Khalil M; Fazekas F; Killestein J; Lindberg RL; Malucchi S; Mehling M; Montalban X; Rudzki D; Schautzer F; Sellebjerg F; Sorensen PS; Deisenhammer F; Steinman L; Axtell RC. Neurology(R) neuroimmunology & neuroinflammation. 2016.

The Immune-Metabolic Basis of Effector Memory CD4+ T Cell Function under Hypoxic Conditions.

Dimeloe S; Mehling M; Frick C; Loeliger J; Bantug GR; Sauder U; Fischer M; Belle R; Develioglu L; Tay S; Langenkamp A; Hess C. Journal of Immunology. 2016.

Influenza vaccine response profiles are affected by vaccine preparation and preexisting immunity, but not HIV infection.

Berger CT; Greiff V; Mehling M; Fritz S; Meier MA; Hoenger G; Conen A; Recher M; Battegay M; Reddy ST; Hess C. Human Vaccines and Immunotherapeutics. 2015.

Randomized trial of vaccination in fingolimod-treated patients with multiple sclerosis.

Kappos L; Mehling M; Arroyo R; Izquierdo G; Selmaj K; Curovic-Perisic V; Keil A; Bijarnia M; Singh A; von Rosenstiel P. Neurology. 2015.

Real-time tracking, retrieval and gene expression analysis of migrating human T cells.

Mehling M; Frank T; Albayrak C; Tay S. Lab on a Chip. 2015.

Tissue Distribution Dynamics of Human NK Cells Inferred from Peripheral Blood Depletion Kinetics after Sphingosine-1-Phosphate Receptor Blockade.

Mehling M; Burgener AV; Brinkmann V; Bantug GR; Dimeloe S; Hoenger G; Kappos L; Hess C. SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2015.

Avidity of vaccine-induced influenza IgG fails to increase in fingolimod-treated patients with MS.

Mehling M; Eichin D; Hafner P; Hönger G; Kappos L; Hess C. Neurology(R) neuroimmunology & neuroinflammation. 2014.

Early detection of neutralizing antibodies to interferon-beta in multiple sclerosis patients: binding antibodies predict neutralizing antibody development.

Hegen H; Millonig A; Bertolotto A; Comabella M; Giovanonni G; Guger M; Hoelzl M; Khalil M; Killestein J; Lindberg R; Malucchi S; Mehling M; Montalban X; Polman CH; Rudzki D; Schautzer F; Sellebjerg F; Sørensen PS; Deisenhammer F. Multiple Sclerosis Journal. 2014.

Microfluidic cell culture.

Mehling M; Tay S. Current Opinion in Biotechnology. 2014.

Homing frequency of human T cells inferred from peripheral blood depletion kinetics after sphingosine-1-phosphate receptor blockade

Mehling, Matthias; Brinkmann, Volker; Burgener, Anne-Valerie; Gubser, Patrick; Luster, Andrew D.; Kappos, Ludwig; Hess, Christoph. Journal of Allergy and Clinical Immunology. 2013.

Preserved antigen-specific immune response in patients with multiple sclerosis responding to IFNβ-therapy.

Mehling M; Fritz S; Hafner P; Eichin D; Yonekawa T; Klimkait T; Lindberg RL; Kappos L; Hess C. PLoS ONE. 2013.

Monoclonal antibodies and recombinant immunoglobulins for the treatment of multiple sclerosis.

Gensicke H; Leppert D; Yaldizli Ö; Lindberg RL; Mehling M; Kappos L; Kuhle J. CNS drugs. 2012.

Antigen-specific adaptive immune responses in fingolimod-treated multiple sclerosis patients.

Mehling M; Hilbert P; Fritz S; Durovic B; Eichin D; Gasser O; Kuhle J; Klimkait T; Lindberg RL; Kappos L; Hess C. Annals of Neurology. 2011.

Clinical immunology of the sphingosine 1-phosphate receptor modulator fingolimod (FTY720) in multiple sclerosis.

Mehling M; Johnson TA; Antel J; Kappos L; Bar-Or A. Neurology. 2011.

Fingolimod for multiple sclerosis: mechanism of action, clinical outcomes, and future directions.

Mehling M; Kappos L; Derfuss T. Current neurology and neuroscience reports. 2011.

Hodgkin's Lymphoma and Paraneoplastic Phenomena in the Central Nervous System: A Case Report and Review of the Literature.

Vetter M; Tzankov A; Engert A; Mehling M; Herrmann R; Rochlitz C. Case Rep Oncol (ONLINE-AUSGABE). 2011.

Neurofilament heavy chain in CSF correlates with relapses and disability in multiple sclerosis.

Kuhle J; Leppert D; Petzold A; Regeniter A; Schindler C; Mehling M; Anthony DC; Kappos L; Lindberg RL. Neurology. 2011.

Three cases of primary small vessel vasculitis of the skeletal muscle-an own entity.

Benz N; Daikeler T; Frank S; Mehling M; Tyndall A; Trendelenburg M. BMJ Case Reports. 2011.

A highly sensitive electrochemiluminescence immunoassay for the neurofilament heavy chain protein.

Kuhle J; Regeniter A; Leppert D; Mehling M; Kappos L; Lindberg RL; Petzold A. Journal of Neuroimmunology. 2010.

Altered expression of miR-17-5p in CD4+ lymphocytes of relapsing-remitting multiple sclerosis patients.

Lindberg RL; Hoffmann F; Mehling M; Kuhle J; Kappos L. European Journal of Immunology. 2010.

Images in clinical medicine. Dissociation of voluntary and emotional innervation after stroke.

Kappos L; Mehling M. New England Journal of Medicine. 2010.

Reduced cortisol levels in cerebrospinal fluid and differential distribution of 11beta-hydroxysteroid dehydrogenases in multiple sclerosis: implications for lesion pathogenesis.

Heidbrink C; Häusler SF; Buttmann M; Ossadnik M; Strik HM; Keller A; Buck D; Verbraak E; van Meurs M; Krockenberger M; Mehling M; Mittelbronn M; Laman JD; Wiendl H; Wischhusen J. Brain, Behavior, and Immunity. 2010.

Th17 central memory T cells are reduced by FTY720 in patients with multiple sclerosis.

Mehling M; Lindberg R; Raulf F; Kuhle J; Hess C; Kappos L; Brinkmann V. Neurology. 2010.

A modern approach to CSF analysis: pathophysiology, clinical application, proof of concept and laboratory reporting.

Regeniter A; Kuhle J; Mehling M; Möller H; Wurster U; Freidank H; Siede WH. Clinical neurology and neurosurgery. 2009.

Increased levels of inflammatory chemokines in amyotrophic lateral sclerosis.

Kuhle J; Lindberg RL; Regeniter A; Mehling M; Steck AJ; Kappos L; Czaplinski A. European Journal of Neurology. 2009.

Retinal vessels in patients with multiple sclerosis: baseline diameter and response to flicker light stimulation.

Gugleta K; Kochkorov A; Kavroulaki D; Katamay R; Weier K; Mehling M; Kappos L; Flammer J; Orgül S. Klinische Monatsblatter fur Augenheilkunde. 2009.

Rigidity of retinal vessels in patients with multiple sclerosis.

Kochkorov A; Gugleta K; Kavroulaki D; Katamay R; Weier K; Mehling M; Kappos L; Flammer J; Orgül S. Klinische Monatsblatter fur Augenheilkunde. 2009.

10 most commonly asked questions about cerebrospinal fluid characteristics in demyelinating disorders of the central nervous system.

Mehling M; Kuhle J; Regeniter A. NEUROLOGIST. 2008.

Adaptation of antiretroviral therapy in human immunodeficiency virus infection with central nervous system involvement.

Mehling M; Drechsler H; Kuhle J; Hardmeier M; Doerries R; Ruegg S; Gass A. Journal of neurovirology. 2008.

FTY720 therapy exerts differential effects on T cell subsets in multiple sclerosis

Mehling M.; Brinkmann V.; Antel J.; Bar-Or A.; Goebels N.; Vedrine C.; Kristofic C.; Kuhle J.; Lindberg R.L.P.; Kappos L.. Neurology. 2008.

Immunopathogenesis of multiple sclerosis - Mechanisms in the development of multiple sclerosis lesions Immunpathogenese der multiplen sklerose - Mechanismen bei der entstehung von MS-läsionen

Mehling M.; Mittelbronn M.. PsychoNeuro. 2008.

Modern cerebrospinal fluid analysis of Multiple Sclerosis - Diagnosis and differential diagnosis Liquordiagnostik der multiplen sklerose - Diagnose und differenzialdiagnose

Schlager R.; Mehling M.; Gass A.; Kuhle J.. PsychoNeuro. 2008.

Pattern of macular thickness changes measured by ocular coherence tomography in patients with multiple sclerosis.

Gugleta K; Mehling M; Kochkorov A; Grieshaber M; Katamay R; Flammer J; Orgül S; Kappos L. Klinische Monatsblatter fur Augenheilkunde. 2008.

Antimyelin antibodies in clinically isolated syndromes correlate with inflammation in MRI and CSF.

Kuhle J; Lindberg RL; Regeniter A; Mehling M; Hoffmann F; Reindl M; Berger T; Radue EW; Leppert D; Kappos L. Journal of Neurology. 2007.

Lack of association between antimyelin antibodies and progression to multiple sclerosis.

Kuhle J; Pohl C; Mehling M; Edan G; Freedman MS; Hartung HP; Polman CH; Miller DH; Montalban X; Barkhof F; Bauer L; Dahms S; Lindberg R; Kappos L; Sandbrink R. New England Journal of Medicine. 2007.

WHO grade associated downregulation of MHC class I antigen-processing machinery components in human astrocytomas: does it reflect a potential immune escape mechanism?

Mehling M; Simon P; Mittelbronn M; Meyermann R; Ferrone S; Weller M; Wiendl H. Acta Neuropathologica. 2007.