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Klinische Forschung
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Publications D'Souza Marcus

Optical coherence tomography reflects clinically relevant gray matter damage in patients with multiple sclerosis.

Cagol A; Fuertes NC; Stoessel M; Barakovic M; Schaedelin S; D'Souza M; Würfel J; Brandt AU; Kappos L; Sprenger T; Naegelin Y; Kuhle J; Granziera C; Papadopoulou A. Journal of Neurology. 2023.

Serum Glial Fibrillary Acidic Protein Compared With Neurofilament Light Chain as a Biomarker for Disease Progression in Multiple Sclerosis

Meier S.; Willemse E.A.J.; Schaedelin S.; Oechtering J.; Lorscheider J.; Melie-Garcia L.; Cagol A.; Barakovic M.; Galbusera R.; Subramaniam S.; Barro C.; Abdelhak A.; Thebault S.; Achtnichts L.; Lalive P.; Muller S.; Pot C.; Salmen A.; Disanto G.; Zecca C.; D'souza M.; Orleth A.; Khalil M.; Buchmann A.; Du Pasquier R.; Yaldizli O.; Derfuss T.; Berger K.; Hermesdorf M.; Wiendl H.; Piehl F.; Battaglini M.; Fischer U.; Kappos L.; Gobbi C.; Granziera C.; Bridel C.; Leppert D.; Maleska Maceski A.; Benkert P.; Kuhle J.. JAMA neurology. 2023.

Improving Detection of Change in Motor Functioning in Multiple Sclerosis Using Video-Assisted Composite Measures.

Lam KH; van Munster CEP; D'Souza M; Steinheimer S; Kamm CP; Burggraaff J; Johnson M; Zaykov Y; Dorn J; Dahlke F; Kappos L; Killestein J; Uitdehaag B. International journal of MS care. 2022.

Lateral geniculate nucleus volume changes after optic neuritis in neuromyelitis optica: A longitudinal study.

Papadopoulou A; Oertel FC; Chien C; Kuchling J; Zimmermann HG; Siebert N; Motamedi S; Souza M; Asseyer S; Bellmann-Strobl J; Ruprecht K; Chakravarty MM; Scheel M; Magon S; Wuerfel J; Paul F; Brandt AU. NeuroImage. Clinical. 2021.

Standardization and digitization of clinical data in multiple sclerosis.

D'Souza M; Papadopoulou A; Girardey C; Kappos L. Nature reviews. Neurology. 2021.

Autoencoder as a New Method for Maintaining Data Privacy While Analyzing Videos of Patients With Motor Dysfunction: Proof-of-Concept Study.

D'Souza M; Van Munster CEP; Dorn JF; Dorier A; Kamm CP; Steinheimer S; Dahlke F; Uitdehaag BMJ; Kappos L; Johnson M. Journal of Medical Internet Research. 2020.

Development and validation of the self-reported disability status scale (SRDSS) to estimate EDSS-categories.

Kaufmann M; Salmen A; Barin L; Puhan MA; Calabrese P; Kamm CP; Gobbi C; Kuhle J; Manjaly ZM; Ajdacic-Gross V; Schafroth S; Bottignole B; Ammann S; Zecca C; D'Souza M; von Wyl V; Swiss Multiple Sclerosis Registry (SMSR). Multiple Sclerosis and Related Disorders. 2020.

Diagnostic procedures in suspected attacks in patients with neuromyelitis optica spectrum disorders: Results of an international survey.

D'Souza M; Papadopoulou A; Levy M; Jacob A; Yeaman MR; Kümpfel T; Marignier R; Paul F; Brandt AU. Multiple Sclerosis and Related Disorders. 2020.

Electronic Neurostatus-EDSS increases the quality of expanded disability status scale assessments: Experience from two phase 3 clinical trials.

D'Souza M; Heikkilä A; Lorscheider J; Haller V; Kravalis K; Gysin S; Fuertes NAC; Fricker E; Lam E; Higgins P; Tomic D; Papadopoulou A; Kappos L. Multiple Sclerosis Journal. 2020.

Setwise comparison: efficient fine-grained rating of movement videos using algorithmic support - a proof of concept study.

Steinheimer S; Dorn JF; Morrison C; Sarkar A; D'Souza M; Boisvert J; Bedi R; Burggraaff J; Kontschieder P; Dahlke F; Sellen A; Uitdehaag BMJ; Kappos L; Kamm CP. Disability and rehabilitation. 2020.

Video-Based Pairwise Comparison: Enabling the Development of Automated Rating of Motor Dysfunction in Multiple Sclerosis.

Burggraaff J; Dorn J; D'Souza M; Morrison C; Kamm CP; Kontschieder P; Tewarie P; Steinheimer S; Sellen A; Dahlke F; Kappos L; Uitdehaag B. Archives of physical medicine and rehabilitation. 2020.

Tasks of activities of daily living (ADL) are more valuable than the classical neurological examination to assess upper extremity function and mobility in multiple sclerosis.

van Munster CE; D'Souza M; Steinheimer S; Kamm CP; Burggraaff J; Diederich M; Kravalis K; Dorn J; Walsh L; Dahlke F; Kappos L; Uitdehaag BM. Multiple Sclerosis Journal. 2019.

Reference videos reduce variability of motor dysfunction assessments in multiple sclerosis.

D'Souza M; Steinheimer S; Dorn J; Morrison C; Boisvert J; Kravalis K; Burggraaff J; van Munster CE; Diederich M; Sellen A; Kamm CP; Dahlke F; Uitdehaag BM; Kappos L. Multiple sclerosis journal - experimental, translational and clinical. 2018.

The role of the cerebellum in multiple sclerosis-150 years after Charcot.

Parmar K; Stadelmann C; Rocca MA; Langdon D; D'Angelo E; D'Souza M; Burggraaff J; Wegner C; Sastre-Garriga J; Barrantes-Freer A; Dorn J; Uitdehaag BMJ; Montalban X; Wuerfel J; Enzinger C; Rovira A; Tintore M; Filippi M; Kappos L; Sprenger T; MAGNIMS study group. Neuroscience and biobehavioral reviews. 2018.

Neurostatus e-Scoring improves consistency of Expanded Disability Status Scale assessments: A proof of concept study.

D'Souza M; Yaldizli Ö; John R; Vogt DR; Papadopoulou A; Lucassen E; Menegola M; Andelova M; Dahlke F; Schnyder F; Kappos L. Multiple Sclerosis Journal. 2017.

Ocrelizumab versus Interferon Beta-1a in Relapsing Multiple Sclerosis.

Hauser SL; Bar-Or A; Comi G; Giovannoni G; Hartung HP; Hemmer B; Lublin F; Montalban X; Rammohan KW; Selmaj K; Traboulsee A; Wolinsky JS; Arnold DL; Klingelschmitt G; Masterman D; Fontoura P; Belachew S; Chin P; Mairon N; Garren H; Kappos L; OPERA I and OPERA II Clinical Investigators. New England Journal of Medicine. 2017.

Ocrelizumab versus Placebo in Primary Progressive Multiple Sclerosis.

Montalban X; Hauser SL; Kappos L; Arnold DL; Bar-Or A; Comi G; de Seze J; Giovannoni G; Hartung HP; Hemmer B; Lublin F; Rammohan KW; Selmaj K; Traboulsee A; Sauter A; Masterman D; Fontoura P; Belachew S; Garren H; Mairon N; Chin P; Wolinsky JS; ORATORIO Clinical Investigators.. New England Journal of Medicine. 2017.

Monitoring multiple sclerosis by multimodal evoked potentials: Numerically versus ordinally scaled scoring systems.

Schlaeger R; Hardmeier M; D'Souza M; Grize L; Schindler C; Kappos L; Fuhr P. Clinical Neurophysiology. 2016.

Setwise comparison: Consistent, scalable, continuum labels for computer vision

Sarkar A.; Morrison C.; Dorn J.F.; Bedi R.; Steinheimer S.; Boisvert J.; Burggra J.; D'Souza M.; Kontschieder P.; Bulo S.R.; Walsh L.; Kamm C.P.; Zaykov Y.; Sellen A.; Lindley S.. . 2016.

MS tracking: basic and new tools/exergaming.

D'Souza M. Neurodegenerative disease management. 2015.

On the origin of Neurostatus.

Kappos L; D'Souza M; Lechner-Scott J; Lienert C. Multiple Sclerosis and Related Disorders. 2015.

Usability and Acceptability of ASSESS MS: Assessment of Motor Dysfunction in Multiple Sclerosis Using Depth-Sensing Computer Vision.

Morrison C; D'Souza M; Huckvale K; Dorn JF; Burggraaff J; Kamm CP; Steinheimer SM; Kontschieder P; Criminisi A; Uitdehaag B; Dahlke F; Kappos L; Sellen A. JMIR human factors. 2015.

Bedeutung des EDSS für die Therapie-indikation bei Multipler Sklerose

D`Souza,Marcus; Papadopoulou,A; Kappos,Ludwig. . 2014.

Electrophysiological markers and predictors of the disease course in primary progressive multiple sclerosis.

Schlaeger R; D'Souza M; Schindler C; Grize L; Kappos L; Fuhr P. Multiple Sclerosis Journal. 2014.

Lesion-to-ventricle distance and other risk factors for the persistence of newly formed black holes in relapsing-remitting multiple sclerosis.

Papadopoulou A; Menegola M; Kuhle J; Ramagopalan SV; D'Souza M; Sprenger T; Radue EW; Kappos L; Yaldizli Ö. Multiple Sclerosis Journal. 2014.

Prediction of MS disability by multimodal evoked potentials: investigation during relapse or in the relapse-free interval?

Schlaeger R; D'Souza M; Schindler C; Grize L; Kappos L; Fuhr P. Clinical Neurophysiology. 2014.

Quantifying progression of multiple sclerosis via classification of depth videos.

Kontschieder P; Dorn JF; Morrison C; Corish R; Zikic D; Sellen A; D'Souza M; Kamm CP; Burggraaff J; Tewarie P; Vogel T; Azzarito M; Glocker B; Chin P; Dahlke F; Polman C; Kappos L; Uitdehaag B; Criminisi A. Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention. 2014.

Combined evoked potentials as markers and predictors of disability in early multiple sclerosis.

Schlaeger R; D'Souza M; Schindler C; Grize L; Kappos L; Fuhr P. Clinical Neurophysiology. 2012.

Prediction of long-term disability in multiple sclerosis.

Schlaeger R; D'Souza M; Schindler C; Grize L; Dellas S; Radue EW; Kappos L; Fuhr P. Multiple Sclerosis Journal. 2012.

Dimethyl fumarate for multiple sclerosis.

Papadopoulou A; D'Souza M; Kappos L; Yaldizli O. Expert Opinion on Investigational Drugs. 2010.

MS quality of life, depression, and fatigue improve after mindfulness training: a randomized trial.

Grossman P; Kappos L; Gensicke H; D'Souza M; Mohr DC; Penner IK; Steiner C. Neurology. 2010.

Intravenous thrombolysis cancelled in acute right hemiparesis.

D'Souza M; Gass A; Lyrer P; Ott HW; Baumann T. Cerebrovascular Diseases. 2008.

Reconsidering clinical outcomes in Multiple Sclerosis: relapses, impairment, disability and beyond.

D'Souza M; Kappos L; Czaplinski A. Journal of the neurological sciences. 2008.

Regional gray matter volume abnormalities in the at risk mental state.

Borgwardt SJ; Riecher-Rössler A; Dazzan P; Chitnis X; Aston J; Drewe M; Gschwandtner U; Haller S; Pflüger M; Rechsteiner E; D'Souza M; Stieglitz RD; Radü EW; McGuire PK. Biological psychiatry. 2007.

Structural brain abnormalities in individuals with an at-risk mental state who later develop psychosis.

Borgwardt SJ; McGuire PK; Aston J; Berger G; Dazzan P; Gschwandtner U; Pflüger M; D'Souza M; Radue EW; Riecher-Rössler A. Br J Psychiatry Suppl. 2007.

Fabry disease: thirty-five mutations in the alpha-galactosidase A gene in patients with classic and variant phenotypes.

Eng CM; Ashley GA; Burgert TS; Enriquez AL; D'Souza M; Desnick RJ. MOLECULAR MEDICINE. 1997.

Genetic predisposition to multiple sclerosis as revealed by immunoprinting.

Epplen C; Jäckel S; Santos EJ; D'Souza M; Poehlau D; Dotzauer B; Sindern E; Haupts M; Rüde KP; Weber F; Stöver J; Poser S; Gehler W; Malin JP; Przuntek H; Epplen JT. Annals of Neurology. 1997.

Immunoprinting reveals different genetic bases for (auto)immuno diseases.

Epplen C; Buitkamp J; Rumpf H; D'Souza M; Epplen JT. Electrophoresis. 1995.