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Klinische Forschung
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Publications Winzeler Bettina

Approach to the Patient: "Utility of the Copeptin Assay".

Christ-Crain M; Refardt J; Winzeler B. Journal of Clinical Endocrinology and Metabolism. 2022.

Central diabetes insipidus from a patient's perspective: management, psychological co-morbidities, and renaming of the condition: results from an international web-based survey

Atila C.; Loughrey P.B.; Garrahy A.; Winzeler B.; Refardt J.; Gildroy P.; Hamza M.; Pal A.; Verbalis J.G.; Thompson C.J.; Hemkens L.G.; Hunter S.J.; Sherlock M.; Levy M.J.; Karavitaki N.; Newell-Price J.; Wass J.A.H.; Christ-Crain M.. The lancet. Diabetes & endocrinology. 2022.

Effect of a 3-Week Treatment with GLP-1 Receptor Agonists on Vasoactive Hormones in Euvolemic Participants.

Vukajlovic T; Sailer CO; Asmar A; Jensen BL; Vogt DR; Christ-Crain M; Winzeler B. Journal of Clinical Endocrinology and Metabolism. 2022.

Hypothalamic-pituitary-adrenal axis activity in patients with primary polydipsia compared to healthy controls.

Sailer CO; Kuehne JM; da Conceição I; Refardt J; Christ-Crain M; Winzeler B. Clinical endocrinology. 2022.

Investigating the role of somatic sequencing platforms for phaeochromocytoma and paraganglioma in a large UK cohort.

Winzeler B; Tufton N; S Lim E; Challis BG; Park SM; Izatt L; Carroll PV; Velusamy A; Hulse T; Whitelaw BC; Martin E; Rodger F; Maranian M; Clark GR; A Akker S; Maher ER; Casey RT. Clinical endocrinology. 2022.

The effect of glucose dynamics on plasma copeptin levels upon glucagon, arginine, and macimorelin stimulation in healthy adults : Data from: Glucacop, Macicop, and CARGO study.

Atila C; Monnerat S; Urwyler SA; Refardt J; Winzeler B; Christ-Crain M. Pituitary. 2022.

Treatment Effect of the SGLT2 Inhibitor Empagliflozin on Chronic Syndrome of Inappropriate Antidiuresis: Results of a Randomized, Double-Blind, Placebo-Controlled, Crossover Trial.

Refardt J; Imber C; Nobbenhuis R; Sailer CO; Haslbauer A; Monnerat S; Bathelt C; Vogt DR; Berres M; Winzeler B; Bridenbaugh SA; Christ-Crain M. Journal of the American Society of Nephrology : JASN. 2022.

A randomized controlled trial of the GLP-1 receptor agonist dulaglutide in primary polydipsia

Winzeler B.; Sailer C.O.; Coynel D.; Zanchi D.; Vogt D.R.; Urwyler S.A.; Refardt J.; Christ-Crain M.. The Journal of clinical investigation. 2021.

Can treatment response to SGLT2-inhibitors in syndrome of inappropriate antidiuresis be predicted by copeptin, natriuretic peptides and inflammatory markers?

Nobbenhuis R; Refardt J; Vogt D; Sailer CO; Winzeler B; Christ-Crain M. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 2021.

Diagnosis and management of diabetes insipidus for the internist: an update.

Christ-Crain M; Winzeler B; Refardt J. Journal of internal medicine. 2021.

Influence of Prednisone on Inflammatory Biomarkers in Community-Acquired Pneumonia: Secondary Analysis of a Randomized Trial

Raess N.; Schuetz P.; Cesana-Nigro N.; Winzeler B.; Urwyler S.A.; Schaedelin S.; Rodondi N.; Blum M.R.; Briel M.; Mueller B.; Christ-Crain M.; Blum C.A.. Journal of Clinical Pharmacology. 2021.

Oxytocin levels in response to pituitary provocation tests in healthy volunteers.

Sailer CO; Winzeler B; Urwyler SA; Schnyder I; Refardt J; Eckert A; Varghese N; Fassnacht M; Chifu I; Lawson EA; Verbalis JG; Fenske W; Christ-Crain M. European journal of endocrinology. 2021.

Precision Medicine in Phaeochromocytoma and Paraganglioma.

Winzeler B; Challis BG; Casey RT. Journal of personalized medicine. 2021.

Syndrome of inappropriate antidiuretic hormone secretion and hypothalamic hypocortisolism in neuromyelitis optica

Tsagkas C.; Schafer S.; Baumgartner A.; Muller J.; Sinnecker T.; Mehling M.; van der Stouwe J.G.; Felder S.; Panagiotou A.; Potlukova E.; Winzeler B.; Scholz M.C.; Timper K.; Blackham K.; Nickel C.H.; Christ-Crain M.; Bingisser R.; Lyrer P.; Kappos L.; Yaldizli O.. Lancet (London, England). 2021.

A Randomized Trial of Empagliflozin to Increase Plasma Sodium Levels in Patients with the Syndrome of Inappropriate Antidiuresis.

Refardt J; Imber C; Sailer CO; Jeanloz N; Potasso L; Kutz A; Widmer A; Urwyler SA; Ebrahimi F; Vogt DR; Winzeler B; Christ-Crain M. Journal of the American Society of Nephrology : JASN. 2020.

Copeptin is not useful as a marker of malignant disease in the syndrome of inappropriate antidiuresis.

Winzeler B; Steinmetz M; Refardt J; Cesana-Nigro N; Popovic M; Fenske W; Christ-Crain M. Endocrine connections. 2020.

Diabetes Insipidus: An Update.

Refardt J; Winzeler B; Christ-Crain M. Endocrinology and metabolism clinics of North America. 2020.

Effectiveness of real-time continuous glucose monitoring to improve glycaemic control and pregnancy outcome in patients with gestational diabetes mellitus: a study protocol for a randomised controlled trial.

Huhn EA; Linder T; Eppel D; Weißhaupt K; Klapp C; Schellong K; Henrich W; Yerlikaya-Schatten G; Rosicky I; Husslein P; Chalubinski K; Mittlböck M; Rust P; Hoesli I; Winzeler B; Jendle J; Fehm T; Icks A; Vomhof M; Greiner GG; Szendrödi J; Roden M; Tura A; Göbl CS. BMJ Open. 2020.

Effect of Arginine on the Hypothalamic-Pituitary-Adrenal Axis in Individuals With and Without Vasopressin Deficiency.

Bologna K; Cesana-Nigro N; Refardt J; Imber C; Vogt DR; Christ-Crain M; Winzeler B. Journal of Clinical Endocrinology and Metabolism. 2020.

Effects of glucagon-like peptide-1 receptor agonists on fluid intake in healthy volunteers.

Winzeler B; da Conceição I; Refardt J; Sailer CO; Dutilh G; Christ-Crain M. Endocrine. 2020.

Low arginine vasopressin levels in patients with diabetes insipidus are not associated with anaemia.

Winzeler B; Morin B; Refardt J; Imber C; Fenske W; Sailer CO; Holbro A; Christ-Crain M. Clinical endocrinology. 2020.

Use of copeptin in the diagnosis of polyuria-polydipsia syndrome - Authors' reply.

Winzeler B; Christ-Crain M. . 2020.

Arginine-stimulated copeptin measurements in the differential diagnosis of diabetes insipidus: a prospective diagnostic study.

Winzeler B; Cesana-Nigro N; Refardt J; Vogt DR; Imber C; Morin B; Popovic M; Steinmetz M; Sailer CO; Szinnai G; Chifu I; Fassnacht M; Christ-Crain M. Lancet (London, England). 2019.

Copeptin and its role in the diagnosis of diabetes insipidus and the syndrome of inappropriate antidiuresis.

Refardt J; Winzeler B; Christ-Crain M. Clinical endocrinology. 2019.

Cosyntropin testing does not predict response to glucocorticoids in community-acquired pneumonia in a randomized controlled trial.

Blum CA; Schuetz P; Nigro N; Winzeler B; Arici B; Refardt J; Urwyler SA; Rodondi N; Blum MR; Briel M; Mueller B; Christ-Crain M. Clinical endocrinology. 2019.

Effects of Glucagon-Like Peptide-1 Receptor Agonists on Hypothalamic-Pituitary-Adrenal Axis in Healthy Volunteers.

Winzeler B; da Conceição I; Refardt J; Sailer CO; Dutilh G; Christ-Crain M. Journal of Clinical Endocrinology and Metabolism. 2019.

Estimation of treatment allocation in a randomised, double-blinded, placebo-controlled trial.

Popovic M; Cesana-Nigro N; Winzeler B; Thomann R; Schütz P; Müller B; Christ-Crain M; Blum CA. Swiss medical weekly. 2019.

High concentration of plasma methoxytyramine: dopamine-producing tumour or Parkinson's disease therapy?

Chtioui H; Sadowski SM; Winzeler B; Tschopp O; Grouzmann E; Abid K. ANNALS OF CLINICAL BIOCHEMISTRY. 2019.

Influence of Outdoor Temperature and Relative Humidity on Incidence and Etiology of Hyponatremia.

Sailer CO; Winzeler B; Nigro N; Bernasconi L; Mueller B; Christ-Crain M. Journal of Clinical Endocrinology and Metabolism. 2019.

The challenges of sodium measurements: indirect versus direct ion-selective method.

Refardt J; Sailer CO; Chifu I; Winzeler B; Schnyder I; Fassnacht M; Fenske W; Christ-Crain M. . 2019.

A Copeptin-Based Approach in the Diagnosis of Diabetes Insipidus.

Fenske W; Refardt J; Chifu I; Schnyder I; Winzeler B; Drummond J; Ribeiro-Oliveira A Jr; Drescher T; Bilz S; Vogt DR; Malzahn U; Kroiss M; Christ E; Henzen C; Fischli S; Tönjes A; Mueller B; Schopohl J; Flitsch J; Brabant G; Fassnacht M; Christ-Crain M. The New England journal of medicine. 2018.

Copeptin levels and commonly used laboratory parameters in hospitalised patients with severe hypernatraemia - the "Co-MED study".

Nigro N; Winzeler B; Suter-Widmer I; Schuetz P; Arici B; Bally M; Refardt J; Betz M; Gashi G; Urwyler SA; Burget L; Blum CA; Bock A; Huber A; Müller B; Christ-Crain M. Critical care (London, England). 2018.

FGF-21 levels in polyuria-polydipsia syndrome.

Refardt J; Sailer CO; Winzeler B; Betz MJ; Chifu I; Schnyder I; Fassnacht M; Fenske W; Christ-Crain M. Endocrine connections. 2018.

Hypothyroidism, subclinical

Winzeler B.F.; Christ-Crain M.; Muller B.; Meier C.. . 2018.

Reply to comment on: Sailer CO, et al. Primary polydipsia in the medical and psychiatric patient: characteristics, complications and therapy.

Sailer CO; Winzeler B; Christ-Crain M. Swiss medical weekly. 2018.

Artificial Syndrome of Inappropriate Antidiuresis Model as Potential Use for Diagnostic and Therapeutic Strategies.

Refardt J; Winzeler B; Meienberg F; Christ-Crain M. HORMONE AND METABOLIC RESEARCH. 2017.

Characteristics and outcomes of patients with profound hyponatraemia due to primary polydipsia.

Sailer CO; Winzeler B; Nigro N; Suter-Widmer I; Arici B; Bally M; Schuetz P; Mueller B; Christ-Crain M. Clinical endocrinology. 2017.

Copeptin for risk stratification in non-traumatic headache in the emergency setting: a prospective multicenter observational cohort study

Blum C.A.; Winzeler B.; Nigro N.; Schuetz P.; Biethahn S.; Kahles T.; Mueller C.; Timper K.; Haaf K.; Tepperberg J.; Amort M.; Huber A.; Bingisser R.; Sandor P.S.; Nedeltchev K.; Muller B.; Katan M.; Christ-Crain M.. Journal of Headache and Pain. 2017.

Empagliflozin Increases Short-Term Urinary Volume Output in Artificially Induced Syndrome of Inappropriate Antidiuresis.

Refardt J; Winzeler B; Meienberg F; Vogt DR; Christ-Crain M. International journal of endocrinology. 2017.

Evaluation of copeptin and commonly used laboratory parameters for the differential diagnosis of profound hyponatraemia in hospitalized patients: ‘The Co-MED Study'

Nigro N.; Winzeler B.; Suter-Widmer I.; Schuetz P.; Arici B.; Bally M.; Blum C.A.; Nickel C.H.; Bingisser R.; Bock A.; Huber A.; Muller B.; Christ-Crain M.. Clinical endocrinology. 2017.

Fourfold increase in prevalence of gestational diabetes mellitus after adoption of the new International Association of Diabetes and Pregnancy Study Groups (IADPSG) criteria.

Huhn EA; Massaro N; Streckeisen S; Manegold-Brauer G; Schoetzau A; Schulzke SM; Winzeler B; Hoesli I; Lapaire O. Journal of perinatal medicine. 2017.

Primary polydipsia in the medical and psychiatric patient: characteristics, complications and therapy.

Sailer C; Winzeler B; Christ-Crain M. Swiss medical weekly. 2017.

Long-Term outcome of profound hyponatremia: A prospective 12 months follow-up study

Winzeler B.; Jeanloz N.; Nigro N.; Suter-Widmer I.; Schuetz P.; Arici B.; Bally M.; Blum C.; Bock A.; Huber A.; Mueller B.; Christ-Crain M.. European journal of endocrinology. 2016.

Pathogen- and antibiotic-specific effects of prednisone in community-acquired pneumonia

Wirz S.A.; Blum C.A.; Schuetz P.; Albrich W.C.; Noppen C.; Mueller B.; Christ-Crain M.; Tarr P.E.; Blum C.A.; Nigro N.; Briel M.; Ullmer E.; Suter-Widmer I.; Winzeler B.; Bingisser R.; Elsaesser H.; Drozdov D.; Arici B.; Urwyler S.A.; Refardt J.; Thomann R.; Baumgartner C.; Duplain H.; Burki D.; Zimmerli W.; Rodondi N.. The European respiratory journal. 2016.

Predictors of nonresponse to fluid restriction in hyponatraemia due to the syndrome of inappropriate antidiuresis

Winzeler B.; Lengsfeld S.; Nigro N.; Suter-Widmer I.; Schutz P.; Arici B.; Bally M.; Blum C.; Bock A.; Huber A.; Muller B.; Christ-Crain M.. Journal of internal medicine. 2016.

Adjunct prednisone therapy for patients with community-acquired pneumonia: a multicentre, double-blind, randomised, placebo-controlled trial.

Blum CA; Nigro N; Briel M; Schuetz P; Ullmer E; Suter-Widmer I; Winzeler B; Bingisser R; Elsaesser H; Drozdov D; Arici B; Urwyler SA; Refardt J; Tarr P; Wirz S; Thomann R; Baumgartner C; Duplain H; Burki D; Zimmerli W; Rodondi N; Mueller B; Christ-Crain M. Lancet (London, England). 2015.

Diabetische Nephropathie und Anpassung der antidiabetischen Therapie bei Niereninsuffizienz.

Winzeler B; Dickenmann M; Jehle AW. Therapeutische Umschau. Revue therapeutique. 2015.

Hypothyroidism Subclinical: Encyclopedia of Endocrinology and Endocrine Diseases

Winzeler,BF; Christ-Crain,M; Staub,J-J; Müller,B; Meier,C. . 2015.

Mid-regional pro-atrial natriuretic peptide and the assessment of volaemic status and differential diagnosis of profound hyponatraemia.

Nigro N; Winzeler B; Suter-Widmer I; Schuetz P; Arici B; Bally M; Blum CA; Nickel CH; Bingisser R; Bock A; Rentsch Savoca K; Huber A; Müller B; Christ-Crain M. Journal of internal medicine. 2015.

Postoperative Copeptin Concentration Predicts Diabetes Insipidus After Pituitary Surgery.

Winzeler B; Zweifel C; Nigro N; Arici B; Bally M; Schuetz P; Blum CA; Kelly C; Berkmann S; Huber A; Gentili F; Zadeh G; Landolt H; Mariani L; Müller B; Christ-Crain M. Journal of Clinical Endocrinology and Metabolism. 2015.

Symptoms and characteristics of individuals with profound hyponatremia: a prospective multicenter observational study.

Nigro N; Winzeler B; Suter-Widmer I; Schuetz P; Arici B; Bally M; Blum C; Bingisser R; Bock A; Huber A; Müller B; Nickel CH; Christ-Crain M. Journal of the American Geriatrics Society. 2015.

Corticosteroid treatment for community-acquired pneumonia--the STEP trial: study protocol for a randomized controlled trial.

Blum CA; Nigro N; Winzeler B; Suter-Widmer I; Schuetz P; Briel M; Bingisser R; Zimmerli W; Ullmer E; Elsaesser H; Tarr P; Wirz S; Thomann R; Hofmann E; Rodondi N; Duplain H; Burki D; Mueller B; Christ-Crain M. Trials. 2014.

Systemic Allergic Reaction to the GLP-1 Receptor Agonist Exenatide.

Steveling EH; Winzeler B; Bircher AJ. Journal of Pharmacy Technology. 2014.

Hyponatriämie als Zufallsbefund.

Winzeler B; Nigro N; Walti C; Bock A; Christ-Crain M. Therapeutische Umschau. Revue therapeutique. 2013.

[Hormones as biomarkers for diagnosis and prognosis].

Winzeler BF; Christ-Crain M. Praxis. 2012.