Klinische Forschung
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Publications Marsano Anna

Versatile electrical stimulator for cardiac tissue engineering—Investigation of charge-balanced monophasic and biphasic electrical stimulations

Stefano Gabetti; Antonio Sileo; Federica Montrone; Giovanni Putame; Alberto L. Audenino: Anna Marsano; Diana Massai. . 2023.

Bizonal cardiac engineered tissues with differential maturation features in a mid-throughput multimodal bioreactor

Pisanu A.; Reid G.; Fusco D.; Sileo A.; Robles Diaz D.; Tarhini H.; Putame G.; Massai D.; Isu G.; Marsano A.. iScience. 2022.

Small-diameter bacterial cellulose-based vascular grafts for coronary artery bypass grafting in a pig model.

Fusco D; Meissner F; Podesser BK; Marsano A; Grapow M; Eckstein F; Winkler B. Frontiers in Cardiovascular Medicine. 2022.

A dynamic microscale mid-throughput fibrosis model to investigate the effects of different ratios of cardiomyocytes and fibroblasts.

Mainardi A; Carminati F; Ugolini GS; Occhetta P; Isu G; Robles Diaz D; Reid G; Visone R; Rasponi M; Marsano A. Lab on a Chip. 2021.

Impact on Mechanical Properties of 10 versus 20 Minute Treatment of Human Pericardium with Glutaraldehyde in OZAKI Procedure.

Koechlin L; Isu G; Borisov V; Robles Diaz D; Eckstein FS; Marsano A; Reuthebuch O. Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia. 2021.

Long-term severe in vitro hypoxia exposure enhances the vascularization potential of human adipose tissue-derived stromal vascular fraction cell engineered tissues

Mytsyk M.; Cerino G.; Reid G.; Sole L.G.; Eckstein F.S.; Santer D.; Marsano A.. International Journal of Molecular Sciences. 2021.

Bioreactor Platform for Biomimetic Culture and in situ Monitoring of the Mechanical Response of in vitro Engineered Models of Cardiac Tissue.

Massai D; Pisani G; Isu G; Rodriguez Ruiz A; Cerino G; Galluzzi R; Pisanu A; Tonoli A; Bignardi C; Audenino AL; Marsano A; Morbiducci U. Frontiers in Bioengineering and Biotechnology. 2020.

Fatty acid-based monolayer culture to promote in vitro neonatal rat cardiomyocyte maturation

Isu G.; Robles Diaz D.; Grussenmeyer T.; Gaudiello E.; Eckstein F.; Brink M.; Marsano A.. Biochimica et Biophysica Acta - Molecular Cell Research. 2020.

Fibrin hydrogels promote scar formation and prevent therapeutic angiogenesis in the heart.

Melly L; Grosso A; Stanciu Pop C; Yu-Hsuan C; Nollevaux MC; Schachtrup C; Marsano A; Di Maggio N; Rondelet B; Banfi A. Journal of Tissue Engineering and Regenerative Medicine. 2020.

Impact on mechanical properties of 10 versus 20 minutes treatment of human pericardium with gluteraldehde in OZAKY procedure

Luca Koechlin; Giuseppe Isu; Vladislav Borisov; Diana Robles Diaz; Friedrich Eckstein; Anna Marsano; Oliver Reuthebuch. . 2020.

Next Stage Approach to Tissue Engineering Skeletal Muscle.

Reid G; Magarotto F; Marsano A; Pozzobon M. Bioengineering. 2020.

Modeling methodology for defining a priori the hydrodynamics of a dynamic suspension bioreactor. Application to human induced pluripotent stem cell culture.

Isu G; Morbiducci U; De Nisco G; Kropp C; Marsano A; Deriu MA; Zweigerdt R; Audenino A; Massai D. Journal of Biomechanics. 2019.

Paracrine potential of adipose stromal vascular fraction cells to recover hypoxia-induced loss of cardiomyocyte function.

Mytsyk M; Isu G; Cerino G; Grapow MTR; Eckstein FS; Marsano A. Biotechnology and Bioengineering. 2019.

A three-dimensional in vitro dynamic micro-tissue model of cardiac scar formation.

Occhetta P; Isu G; Lemme M; Conficconi C; Oertle P; Räz C; Visone R; Cerino G; Plodinec M; Rasponi M; Marsano A. Integrative Biology. 2018.

Myocardial infarction stabilization by cell-based expression of controlled Vascular Endothelial Growth Factor levels.

Melly L; Cerino G; Frobert A; Cook S; Giraud MN; Carrel T; Tevaearai Stahel HT; Eckstein F; Rondelet B; Marsano A; Banfi A. Journal of cellular and molecular medicine. 2018.

Control of angiogenesis and host response by modulating the cell adhesion properties of an Elastin-Like Recombinamer-based hydrogel.

Staubli SM; Cerino G; Gonzalez De Torre I; Alonso M; Oertli D; Eckstein F; Glatz K; Rodríguez Cabello JC; Marsano A. Biomaterials. 2017.

Engineering of an angiogenic niche by perfusion culture of adipose-derived stromal vascular fraction cells.

Cerino G; Gaudiello E; Muraro MG; Eckstein F; Martin I; Scherberich A; Marsano A. Scientific Reports. 2017.

Polo-Like Kinase 2 is Dynamically Regulated to Coordinate Proliferation and Early Lineage Specification Downstream of Yes-Associated Protein 1 in Cardiac Progenitor Cells.

Mochizuki M; Lorenz V; Ivanek R; Della Verde G; Gaudiello E; Marsano A; Pfister O; Kuster GM. Journal of the American Heart Association. 2017.

Scaffold Composition Determines the Angiogenic Outcome of Cell-Based Vascular Endothelial Growth Factor Expression by Modulating Its Microenvironmental Distribution.

Gaudiello E; Melly L; Cerino G; Boccardo S; Jalili-Firoozinezhad S; Xu L; Eckstein F; Martin I; Kaufmann BA; Banfi A; Marsano A. Advanced Healthcare Materials. 2017.

Vascular endothelial growth factor sequestration enhances in vivo cartilage formation

Medeiros Da Cunha C.M.; Perugini V.; Bernegger P.; Centola M.; Barbero A.; Guildford A.L.; Santin M.; Banfi A.; Martin I.; Marsano A.. International Journal of Molecular Sciences. 2017.

Beating heart on a chip: a novel microfluidic platform to generate functional 3D cardiac microtissues.

Marsano A; Conficconi C; Lemme M; Occhetta P; Gaudiello E; Votta E; Cerino G; Redaelli A; Rasponi M. Lab on a Chip. 2016.

Cardiac Meets Skeletal: What's New in Microfluidic Models for Muscle Tissue Engineering.

Visone R; Gilardi M; Marsano A; Rasponi M; Bersini S; Moretti M. Molecules. 2016.

Engineered mesenchymal cell-based patches as controlled VEGF delivery systems to induce extrinsic angiogenesis.

Boccardo S; Gaudiello E; Melly L; Cerino G; Ricci D; Martin I; Eckstein F; Banfi A; Marsano A. Acta Biomaterialia. 2016.

Influence of decellularized pericardium matrix on the behavior of cardiac progenitors

Jalili-Firoozinezhad, Sasan; Rajabi-Zeleti, Sareh; Marsano, Anna; Aghdami, Nasser; Baharvand, Hossein. Journal of Applied Polymer Science. 2016.

Spontaneous in vivo chondrogenesis of bone marrow-derived mesenchymal progenitor cells by blocking vascular endothelial growth factor signaling

Marsano A.; Medeiros Da Cunha C.M.; Ghanaati S.; Gueven S.; Centola M.; Tsaryk R.; Barbeck M.; Stuedle C.; Barbero A.; Helmrich U.; Schaeren S.; Kirkpatrick J.C.; Banfi A.; Martin I.. Stem Cells Translational Medicine. 2016.

Three dimensional multi-cellular muscle-like tissue engineering in perfusion-based bioreactors

Cerino G.; Gaudiello E.; Grussenmeyer T.; Melly L.; Massai D.; Banfi A.; Martin I.; Eckstein F.; Grapow M.; Marsano A.. Biotechnology and Bioengineering. 2016.

Facile fabrication of egg white macroporous sponges for tissue regeneration.

Jalili-Firoozinezhad S; Rajabi-Zeleti S; Mohammadi P; Gaudiello E; Bonakdar S; Solati-Hashjin M; Marsano A; Aghdami N; Scherberich A; Baharvand H; Martin I. Advanced Healthcare Materials. 2015.

Engineered autologous cartilage tissue for nasal reconstruction after tumour resection: an observational first-in-human trial.

Fulco I; Miot S; Haug MD; Barbero A; Wixmerten A; Feliciano S; Wolf F; Jundt G; Marsano A; Farhadi J; Heberer M; Jakob M; Schaefer DJ; Martin I. The Lancet. 2014.

Macrophage-mediated angiogenic activation of outgrowth endothelial cells in co-culture with primary osteoblasts.

Dohle E; Bischoff I; Böse T; Marsano A; Banfi A; Unger RE; Kirkpatrick CJ. European cells & materials. 2014.

In vitro mesenchymal trilineage differentiation and extracellular matrix production by adipose and bone marrow derived adult equine multipotent stromal cells on a collagen scaffold.

Xie L; Zhang N; Marsano A; Vunjak-Novakovic G; Zhang Y; Lopez MJ. Stem Cell Reviews and Reports. 2013.

Scaffold-based delivery of a clinically relevant anti-angiogenic drug promotes the formation of in vivo stable cartilage

Centola M.; Abbruzzese F.; Scotti C.; Barbero A.; Vadala G.; Denaro V.; Martin I.; Trombetta M.; Rainer A.; Marsano A.. Tissue Engineering - Part A. 2013.

The effect of controlled expression of VEGF by transduced myoblasts in a cardiac patch on vascularization in a mouse model of myocardial infarction

Marsano A.; Maidhof R.; Luo J.; Fujikara K.; Konofagou E.E.; Banfi A.; Vunjak-Novakovic G.. Biomaterials. 2013.

Cell and gene therapy approaches for cardiac vascularization.

Melly L; Boccardo S; Eckstein F; Banfi A; Marsano A. Cells. 2012.

Cell-based tissue engineering approaches for disc regeneration

Miot S.; Marsano A.; Martin I.. . 2012.

Controlled angiogenesis in the heart by cell-based expression of specific vascular endothelial growth factor levels.

Melly LF; Marsano A; Frobert A; Boccardo S; Helmrich U; Heberer M; Eckstein FS; Carrel TP; Giraud MN; Tevaearai HT; Banfi A. Human Gene Therapy Methods. 2012.

Generation of human adult mesenchymal stromal/stem cells expressing defined xenogenic vascular endothelial growth factor levels by optimized transduction and flow cytometry purification.

Helmrich U; Marsano A; Melly L; Wolff T; Christ L; Heberer M; Scherberich A; Martin I; Banfi A. Tissue engineering. Part C, Methods. 2012.

In vivo chondrogenesis by using anti-angiogenic peptides

Marsano A.; Perugini V.; Centola M.; Guven S.; Banfi A.; Meikle S.T.; Guildford A.L.; Santin M.; Martin I.. . 2011.

Optimization of electrical stimulation parameters for cardiac tissue engineering.

Tandon N; Marsano A; Maidhof R; Wan L; Park H; Vunjak-Novakovic G. Journal of Tissue Engineering and Regenerative Medicine. 2011.

Challenges in Cardiac Tissue Engineering

Vunjak-Novakovic, Gordana; Tandon, Nina; Godier, Amandine; Maidhof, Robert; Marsano, Anna; Martens, Timothy P.; Radisic, Milica. Tissue Engineering Part B-Reviews. 2010.

Generation of human nasal chondrocytes engineered to express soluble VEGF receptor-2 for cartilage tissue engineering

Marsano A.; Bernegger P.; Helmrich U.; Schaeren S.; Miot S.; Barbero A.; Martin I.; Banfi A.. European Cells and Materials. 2010.

Perfusion seeding of channeled elastomeric scaffolds with myocytes and endothelial cells for cardiac tissue engineering.

Maidhof R; Marsano A; Lee EJ; Vunjak-Novakovic G. BIOTECHNOLOGY PROGRESS. 2010.

Scaffold stiffness affects the contractile function of three-dimensional engineered cardiac constructs.

Marsano A; Maidhof R; Wan LQ; Wang Y; Gao J; Tandon N; Vunjak-Novakovic G. BIOTECHNOLOGY PROGRESS. 2010.

Surface-patterned electrode bioreactor for electrical stimulation.

Tandon N; Marsano A; Maidhof R; Numata K; Montouri-Sorrentino C; Cannizzaro C; Voldman J; Vunjak-Novakovic G. Lab on a Chip. 2010.

Alignment and elongation of human adipose-derived stem cells in response to direct-current electrical stimulation.

Tandon N; Goh B; Marsano A; Chao PH; Montouri-Sorrentino C; Gimble J; Vunjak-Novakovic G. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. 2009.

Efficacy and mechanisms of vacuum-assisted closure (VAC) therapy in promoting wound healing: a rodent model.

Jacobs S; Simhaee DA; Marsano A; Fomovsky GM; Niedt G; Wu JK. Journal of Plastic, Reconstructive and Aesthetic Surgery. 2009.

Electrical stimulation systems for cardiac tissue engineering.

Tandon N; Cannizzaro C; Chao PH; Maidhof R; Marsano A; Au HT; Radisic M; Vunjak-Novakovic G. Nature Protocols. 2009.

Cardiac tissue engineering using perfusion bioreactor systems.

Radisic M; Marsano A; Maidhof R; Wang Y; Vunjak-Novakovic G. Nature Protocols. 2008.

Design of Electrical Stimulation Bioreactors for Cardiac Tissue Engineering

Tandon, N.; Marsano, A.; Cannizzaro, C.; Voldman, J.; Vunjak-Novakovic, G.. Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. 2008.

Engineering of functional contractile cardiac tissues cultured in a perfusion system

Marsano, A.; Maidhof, R.; Tandon, N.; Gao, J.; Wang, Y.; Vunjak-Novakovic, G.. Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. 2008.

Differential cartilaginous tissue formation by human synovial membrane, fat pad, meniscus cells and articular chondrocytes

Marsano A.; Millward-Sadler S.J.; Salter D.M.; Adesida A.; Hardingham T.; Tognana E.; Kon E.; Chiari-Grisar C.; Nehrer S.; Jakob M.; Martin I.. Osteoarthritis and Cartilage. 2007.

Bi-zonal cartilaginous tissues engineered in a rotary cell culture system.

Marsano A; Wendt D; Quinn TM; Sims TJ; Farhadi J; Jakob M; Heberer M; Martin I. Biorheology. 2006.

Local compressive and tensile stiffness measured in tissues with regular patterns of hyaline-fibrocartilage regions

Marsano A.; Wendt D.; Raiteri R.; Gottardi R.; Dickinson S.; Hollander A.P.; Wirz D.; Daniels A.U.; Quinn T.M.; Stolz M.; Martin I.. European Cells and Materials. 2006.

Towards tissue engineering of meniscus substitutes: selection of cell source and culture environment.

Marsano A; Vunjak-Novakovic G; Martin I. Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. 2006.

Use of hydrodynamic forces to engineer cartilaginous tissues resembling the non-uniform structure and function of meniscus.

Marsano A; Wendt D; Raiteri R; Gottardi R; Stolz M; Wirz D; Daniels AU; Salter D; Jakob M; Quinn TM; Martin I. Biomaterials. 2006.

Oscillating perfusion of cell suspensions through three-dimensional scaffolds enhances cell seeding efficiency and uniformity.

Wendt D; Marsano A; Jakob M; Heberer M; Martin I. Biotechnology and Bioengineering. 2003.