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Klinische Forschung
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Publications Siegemund Martin

A bedside swallowing screen for the identification of post-extubation dysphagia on the intensive care unit - validation of the Gugging Swallowing Screen (GUSS)-ICU.

Troll C; Trapl-Grundschober M; Teuschl Y; Cerrito A; Compte MG; Siegemund M. BMC anesthesiology. 2023.

Atrial Fibrillation (AFIB) in the ICU: Incidence, Risk Factors, and Outcomes: The International AFIB-ICU Cohort Study.

Wetterslev M; Hylander Møller M; Granholm A; Hassager C; Haase N; Lange T; Myatra SN; Hästbacka J; Arabi YM; Shen J; Cronhjort M; Lindqvist E; Aneman A; Young PJ; Szczeklik W; Siegemund M; Koster T; Aslam TN; Bestle MH; Girkov MS; Kalvit K; Mohanty R; Mascarenhas J; Pattnaik M; Vergis S; Haranath SP; Shah M; Joshi Z; Wilkman E; Reinikainen M; Lehto P; Jalkanen V; Pulkkinen A; An Y; Wang G; Huang L; Huang B; Liu W; Gao H; Dou L; Li S; Yang W; Tegnell E; Knight A; Czuczwar M; Czarnik T; Perner A; AFIB-ICU Collaborators. Critical care medicine. 2023.

Comment on 'Effect of intraoperative haemoadsorption therapy on cardiac surgery for active infective endocarditis with confirmed Staphylococcus aureus bacteraemia'.

Amacher SA; Miazza J; Siegemund M; Santer D. Interdisciplinary cardiovascular and thoracic surgery. 2023.

Does the age of packed red blood cells, donor sex or sex mismatch affect the sublingual microcirculation in critically ill intensive care unit patients? A secondary interpretation of a retrospective analysis.

Knobel D; Scheuzger J; Buser A; Hollinger A; Gebhard CE; Achermann R; Zaiser A; Bovey Y; Nuciforo C; Netzer JN; Räber A; Singh J; Siegemund M. Journal of clinical monitoring and computing. 2023.

Early Target Attainment With Continuous Infusion Meropenem and Piperacillin/Tazobactam and Utilization of Therapeutic Drug Monitoring in Critically Ill Patients: A Retrospective Cohort Study From 2017 to 2020.

Dräger S; von Rotz M; Labhardt ND; Siegemund M; Rentsch KM; Osthoff M; Franzeck FC. Open Forum Infectious Diseases. 2023.

Enhancement of the haemostatic effect of platelets in the presence of high normal concentrations of von Willebrand factor for critically ill patients needing platelet transfusion-a protocol for the will-plate randomised controlled trial.

Herrmann G; Blum A; Bolliger D; Achermann R; Estermann A; Gebhard CE; Henn A; Huber J; Singh J; Todorov A; Zehnder T; Zellweger N; Buser A; Tsakiris DA; Hollinger A; Siegemund M. Trials. 2023.

Factors impacting the pre-analytical quality of blood cultures-Analysis at a tertiary medical center.

Romann L; Werlen L; Rommers N; Hermann A; Gisler I; Bassetti S; Bingisser R; Siegemund M; Roloff T; Weisser M; Muigg V; Hinic V; Osthoff M; Franzeck FC; Egli A. PLoS ONE. 2023.

Higher risk for influenza-associated pulmonary aspergillosis (IAPA) in asthmatic patients: A Swiss multicenter cohort study on IAPA in critically ill influenza patients.

Waldeck F; Boroli F; Zingg S; Walti LN; Wendel-Garcia PD; Conen A; Pagani JL; Boggian K; Schnorf M; Siegemund M; Abed-Maillard S; Michot M; Que YA; Bättig V; Suh N; Kleger GR; Albrich WC. Influenza and other respiratory viruses. 2023.

How to Mitigate the Risk of Postoperative Thromboembolism in Thoracic Cancer Surgery: Comments on the Joint 2022 European Society of Thoracic Surgery and American Association of Thoracic Surgery Guidelines for the Prevention of Cancer-Associated Venous Thromboembolism in Thoracic Surgery.

Bolliger D; Hojski A; Siegemund M. . 2023.

PorinPredict: In Silico Identification of OprD Loss from WGS Data for Improved Genotype-Phenotype Predictions of P. aeruginosa Carbapenem Resistance.

Biggel M; Johler S; Roloff T; Tschudin-Sutter S; Bassetti S; Siegemund M; Egli A; Stephan R; Seth-Smith HMB. Microbiology Spectrum. 2023.

Pulmonary Surfactant Proteins Are Inhibited by Immunoglobulin A Autoantibodies in Severe COVID-19.

Sinnberg T; Lichtensteiger C; Ali OH; Pop OT; Jochum AK; Risch L; Brugger SD; Velic A; Bomze D; Kohler P; Vernazza P; Albrich WC; Kahlert CR; Abdou MT; Wyss N; Hofmeister K; Niessner H; Zinner C; Gilardi M; Tzankov A; Röcken M; Dulovic A; Shambat SM; Ruetalo N; Buehler PK; Scheier TC; Jochum W; Kern L; Henz S; Schneider T; Kuster GM; Lampart M; Siegemund M; Bingisser R; Schindler M; Schneiderhan-Marra N; Kalbacher H; McCoy KD; Spengler W; Brutsche MH; Maček B; Twerenbold R; Penninger JM; Matter MS; Flatz L. American Journal of Respiratory and Critical Care Medicine. 2023.

Subjective and objective survival prediction in mechanically ventilated critically ill patients: a prospective cohort study

Boeck L.; Pargger H.; Schellongowski P.; Luyt C.-E.; Maggiorini M.; Jahn K.; Muller G.; Lotscher R.; Bucher E.; Cueni N.; Staudinger T.; Chastre J.; Siegemund M.; Tamm M.; Stolz D.. Critical Care. 2023.

Temporal trends in mortality and provision of intensive care in younger women and men with acute myocardial infarction or stroke.

Arslani K; Tontsch J; Todorov A; Gysi B; Kaufmann M; Kaufmann F; Hollinger A; Wildi K; Merdji H; Helms J; Siegemund M; Gebhard C; Gebhard CE; Swiss Society of Intensive Care Medicine. Critical Care. 2023.

Acute and Long-Term Cardiovascular Complications among Patients with Sepsis and Septic Shock.

Merdji H; Siegemund M; Meziani F. . 2022.

A new high protein-to-energy enteral formula with a whey protein hydrolysate to achieve protein targets in critically ill patients: a prospective observational tolerability study.

Tedeschi-Jockers F; Reinhold S; Hollinger A; Tuchscherer D; Kiss C; Gantner L; Ledergerber K; Zimmermann S; Scheuzger J; Huber J; Siegemund M. European journal of clinical nutrition. 2022.

A review of European guidelines for patient blood management with a particular emphasis on antifibrinolytic drug administration for cardiac surgery.

Klein A; Agarwal S; Cholley B; Fassl J; Griffin M; Kaakinen T; Paulus P; Rex S; Siegemund M; van Saet A. Journal of Clinical Anesthesia. 2022.

Cardiogenic shock among cancer patients.

Curtiaud A; Delmas C; Gantzer J; Zafrani L; Siegemund M; Meziani F; Merdji H. Frontiers in Cardiovascular Medicine. 2022.

Clinical utility of inflammatory biomarkers in COVID-19 in direct comparison to other respiratory infections-A prospective cohort study.

Lampart M; Zellweger N; Bassetti S; Tschudin-Sutter S; Rentsch KM; Siegemund M; Bingisser R; Osswald S; Kuster GM; Twerenbold R. PLoS ONE. 2022.

Complement and endothelial cell activation in COVID-19 patients compared to controls with suspected SARS-CoV-2 infection: A prospective cohort study.

Bruni F; Charitos P; Lampart M; Moser S; Siegemund M; Bingisser R; Osswald S; Bassetti S; Twerenbold R; Trendelenburg M; Rentsch KM; Osthoff M. Frontiers in Immunology. 2022.

Critical care staffing ratio and outcome of COVID-19 patients requiring intensive care unit admission during the first pandemic wave: a retrospective analysis across Switzerland from the RISC-19-ICU observational cohort.

Jeitziner MM; Moser A; Wendel-Garcia PD; Exl MT; Keiser S; Schuepbach RA; Pietsch U; Cereghetti S; Boroli F; Marrel J; Sigg AA; Ksouri H; Schott P; Dullenkopf A; Fleisch I; Heise A; Laurent JC; Jakob SM; Hilty MP; Que YA; RISC-19-ICU Investigators for Switzerland. Swiss medical weekly. 2022.

Determinants of SARS-CoV-2 transmission to guide vaccination strategy in an urban area.

Brüningk SC; Klatt J; Stange M; Mari A; Brunner M; Roloff TC; Seth-Smith HMB; Schweitzer M; Leuzinger K; Søgaard KK; Albertos Torres D; Gensch A; Schlotterbeck AK; Nickel CH; Ritz N; Heininger U; Bielicki J; Rentsch K; Fuchs S; Bingisser R; Siegemund M; Pargger H; Ciardo D; Dubuis O; Buser A; Tschudin-Sutter S; Battegay M; Schneider-Sliwa R; Borgwardt KM; Hirsch HH; Egli A. Virus Evolution. 2022.

Development and validation of a prognostic model for the early identification of COVID-19 patients at risk of developing common long COVID symptoms.

Deforth M; Gebhard CE; Bengs S; Buehler PK; Schuepbach RA; Zinkernagel AS; Brugger SD; Acevedo CT; Patriki D; Wiggli B; Twerenbold R; Kuster GM; Pargger H; Schefold JC; Spinetti T; Wendel-Garcia PD; Hofmaenner DA; Gysi B; Siegemund M; Heinze G; Regitz-Zagrosek V; Gebhard C; Held U. Diagnostic and prognostic research. 2022.

Diagnostic challenges within the Bacillus cereus-group: finding the beast without teeth.

Muigg V; Cuénod A; Purushothaman S; Siegemund M; Wittwer M; Pflüger V; Schmidt KM; Weisser M; Ritz N; Widmer A; Goldenberger D; Hinic V; Roloff T; Søgaard KK; Egli A; Seth-Smith HMB. New microbes and new infections. 2022.

Dynamics of disease characteristics and clinical management of critically ill COVID-19 patients over the time course of the pandemic: an analysis of the prospective, international, multicentre RISC-19-ICU registry.

Wendel-Garcia PD; Moser A; Jeitziner MM; Aguirre-Bermeo H; Arias-Sanchez P; Apolo J; Roche-Campo F; Franch-Llasat D; Kleger GR; Schrag C; Pietsch U; Filipovic M; David S; Stahl K; Bouaoud S; Ouyahia A; Fodor P; Locher P; Siegemund M; Zellweger N; Cereghetti S; Schott P; Gangitano G; Wu MA; Alfaro-Farias M; Vizmanos-Lamotte G; Ksouri H; Gehring N; Rezoagli E; Turrini F; Lozano-Gómez H; Carsetti A; Rodríguez-García R; Yuen B; Weber AB; Castro P; Escos-Orta JO; Dullenkopf A; Martín-Delgado MC; Aslanidis T; Perez MH; Hillgaertner F; Ceruti S; Franchitti Laurent M; Marrel J; Colombo R; Laube M; Fogagnolo A; Studhalter M; Wengenmayer T; Gamberini E; Buerkle C; Buehler PK; Keiser S; Elhadi M; Montomoli J; Guerci P; Fumeaux T; Schuepbach RA; Jakob SM; Que YA; Hilty MP; RISC-19-ICU Investigators. Critical Care. 2022.

Exercise capacity impairment after COVID-19 pneumonia is mainly caused by deconditioning.

Jahn K; Sava M; Sommer G; Schumann DM; Bassetti S; Siegemund M; Battegay M; Stolz D; Tamm M; Khanna N; Hostettler KE. . 2022.

Inpatient Specialist Palliative Care in Patients With Left Ventricular Assist Devices (LVAD): A Retrospective Case Series.

Tenge T; Santer D; Schlieper D; Schallenburger M; Schwartz J; Meier S; Akhyari P; Pfister O; Walter S; Eckstein S; Eckstein F; Siegemund M; Gaertner J; Neukirchen M. Frontiers in Cardiovascular Medicine. 2022.

Inverse relationship between IL-6 and sodium levels in patients with COVID-19 and other respiratory tract infections: data from the COVIVA study.

Atila C; Monnerat S; Bingisser R; Siegemund M; Lampart M; Rueegg M; Zellweger N; Osswald S; Rentsch K; Christ-Crain M; Twerenbold R. Endocrine connections. 2022.

Is sleep disordered breathing a risk factor for COVID-19 or vice versa?

Cardoso E; Herrmann MJ; Grize L; Hostettler KE; Bassetti S; Siegemund M; Khanna N; Sava M; Sommer G; Tamm M; Stolz D. ERJ Open Research. 2022.

Long-term mortality and health-related quality of life of lower versus higher oxygenation targets in ICU patients with severe hypoxaemia.

Crescioli E; Klitgaard TL; Poulsen LM; Brand BA; Siegemund M; Grøfte T; Keus F; Pedersen UG; Bäcklund M; Karttunen J; Morgan M; Ciubotariu A; Bunzel AG; Vestergaard SR; Jensen NM; Jensen TS; Kjær MN; Jensen AKG; Lange T; Wetterslev J; Perner A; Schjørring OL; Rasmussen BS. Intensive Care Medicine. 2022.

Management of acute atrial fibrillation in the intensive care unit: An international survey.

Wetterslev M; Møller MH; Granholm A; Hassager C; Haase N; Aslam TN; Shen J; Young PJ; Aneman A; Hästbacka J; Siegemund M; Cronhjort M; Lindqvist E; Myatra SN; Kalvit K; Arabi YM; Szczeklik W; Sigurdsson MI; Balik M; Keus F; Perner A; AFIB-ICU collaborators. Acta anaesthesiologica Scandinavica. 2022.

Non-invasive evaluation of new-onset atrial fibrillation after cardiac surgery: a protocol for the BigMap study.

Mork C; Amacher SA; Gahl B; Koechlin L; Miazza J; Schaeffer T; Schmuelling L; Bremerich J; Berdajs D; Cueni N; Kühne M; Mueller C; Osswald S; Reuthebuch O; Schurr U; Sticherling C; Kopp Lugli A; Marsch S; Pargger H; Siegemund M; Eckstein F; Hollinger A; Santer D. ESC Heart Failure. 2022.

Restriction of Intravenous Fluid in ICU Patients with Septic Shock.

Meyhoff TS; Hjortrup PB; Wetterslev J; Sivapalan P; Laake JH; Cronhjort M; Jakob SM; Cecconi M; Nalos M; Ostermann M; Malbrain M; Pettilä V; Møller MH; Kjær MN; Lange T; Overgaard-Steensen C; Brand BA; Winther-Olesen M; White JO; Quist L; Westergaard B; Jonsson AB; Hjortsø CJS; Meier N; Jensen TS; Engstrøm J; Nebrich L; Andersen-Ranberg NC; Jensen JV; Joseph NA; Poulsen LM; Herløv LS; Sølling CG; Pedersen SK; Knudsen KK; Straarup TS; Vang ML; Bundgaard H; Rasmussen BS; Aagaard SR; Hildebrandt T; Russell L; Bestle MH; Schønemann-Lund M; Brøchner AC; Elvander CF; Hoffmann SKL; Rasmussen ML; Martin YK; Friberg FF; Seter H; Aslam TN; Ådnøy S; Seidel P; Strand K; Johnstad B; Joelsson-Alm E; Christensen J; Ahlstedt C; Pfortmueller CA; Siegemund M; Greco M; Raděj J; Kříž M; Gould DW; Rowan KM; Mouncey PR; Perner A; CLASSIC Trial Group. New England Journal of Medicine. 2022.

SARS-CoV-2 Vaccine Alpha and Delta Variant Breakthrough Infections Are Rare and Mild but Can Happen Relatively Early after Vaccination.

Peter JK; Wegner F; Gsponer S; Helfenstein F; Roloff T; Tarnutzer R; Grosheintz K; Back M; Schaubhut C; Wagner S; Seth-Smith HMB; Scotton P; Redondo M; Beckmann C; Stadler T; Salzmann A; Kurth H; Leuzinger K; Bassetti S; Bingisser R; Siegemund M; Weisser M; Battegay M; Sutter ST; Lebrand A; Hirsch HH; Fuchs S; Egli A. Microorganisms. 2022.

Severe acute respiratory syndrome coronavirus 2, primary varicella zoster virus coinfection, and a polymicrobial ventilator-associated tracheobronchitis in an adult immunocompetent male: a case report.

Bruno J; Ragozzino S; Quitt J; Siegemund M; Labhardt N. Journal of medical case reports. 2022.

Severe Neuro-COVID is associated with peripheral immune signatures, autoimmunity and neurodegeneration: a prospective cross-sectional study.

Etter MM; Martins TA; Kulsvehagen L; Pössnecker E; Duchemin W; Hogan S; Sanabria-Diaz G; Müller J; Chiappini A; Rychen J; Eberhard N; Guzman R; Mariani L; Melie-Garcia L; Keller E; Jelcic I; Pargger H; Siegemund M; Kuhle J; Oechtering J; Eich C; Tzankov A; Matter MS; Uzun S; Yaldizli Ö; Lieb JM; Psychogios MN; Leuzinger K; Hirsch HH; Granziera C; Pröbstel AK; Hutter G. Nature Communications. 2022.

Sex versus gender-related characteristics: which predicts clinical outcomes of acute COVID-19?

Gebhard C.E.; Hamouda N.; Gebert P.; Regitz-Zagrosek V.; Gebhard C.; Bengs S.; Gysi B.; Dussault-Cloutier A.; Buehler K.P.; Schuepbach R.A.; Zinkernagel A.S.; Brugger S.D.; Acevedo C.; Patriki D.; Wiggli B.; Beer J.H.; Friedl A.; Twerenbold R.; Kuster G.M.; Pargger H.; Tschudin-Sutter S.; Schefold J.C.; Spinetti T.; Wendel-Garcia P.D.; Hofmaenner D.A.; Scheier T.; Todorov A.; Merdji H.; Siegemund M.. Intensive Care Medicine. 2022.

Temporary Extracorporeal Femoro-Femoral Crossover Bypass to Treat Acute Limb Ischemia due to Occlusive Femoral Transaortic Microaxial Left Ventricular Assist Device - A Novel Technique and Case Series.

Richarz S; Siegemund M; d'Amico R; Bachofen B; Döbele T; Gürke L; Mujagic E. Annals of Vascular Surgery. 2022.

5-year results of a newly implemented mechanical circulatory support program for terminal heart failure patients in a Swiss non-cardiac transplant university hospital

Schaeffer T.; Pfister O.; Mork C.; Mohacsi P.; Rueter F.; Scheifele S.; Morgen A.; Zenklusen U.; Doebele T.; Maurer M.; Erb J.; Fassl J.; Cueni N.; Siegemund M.; Pargger H.; Gahl B.; Osswald S.; Eckstein F.; Grapow M.. Journal of Cardiothoracic Surgery. 2021.

Adverse Events of Percutaneous Microaxial Left Ventricular Assist Devices-A Retrospective, Single-Centre Cohort Study.

Zaiser AS; Fahrni G; Hollinger A; Knobel DT; Bovey Y; Zellweger NM; Buser A; Santer D; Pargger H; Gebhard CE; Siegemund M. Journal of Clinical Medicine. 2021.

Aortic Root Thrombus Directly After Left Ventricular Assist Device Implantation.

Mork C; Pfister O; Koechlin L; Scheifele S; Morgen A; Altwegg L; Heppel D; Berdajs D; Darwisch A; Kuehne M; Reuthebuch O; Schurr U; Siegemund M; Eckstein F; Santer D; Zhou Q. CJC Open. 2021.

Association of Frailty with Adverse Outcomes in Patients with Suspected COVID-19 Infection.

Simon NR; Jauslin AS; Rueegg M; Twerenbold R; Lampart M; Osswald S; Bassetti S; Tschudin-Sutter S; Siegemund M; Nickel CH; Bingisser R. Journal of Clinical Medicine. 2021.

A survey of patient blood management for patients undergoing cardiac surgery in nine European countries.

Klein A; Agarwal S; Cholley B; Fassl J; Griffin M; Kaakinen T; Mzallassi Z; Paulus P; Rex S; Siegemund M; van Saet A. Journal of Clinical Anesthesia. 2021.

Bilateral acute renal cortical necrosis after a dog bite: case report.

Amacher SA; Søgaard KK; Nkoulou C; Sutter R; Weisser M; Zingg SS; Egli A; Hollinger A; Siegemund M. BMC Infectious Diseases. 2021.

Case Report: Left Ventricular Unloading Using a Mechanical CPR Device in a Prolonged Accidental Hypothermic Cardiac Arrest Treated by VA-ECMO - a Novel Approach.

Amacher SA; Quitt J; Hammel E; Zenklusen U; Darwisch A; Siegemund M. . 2021.

Community-acquired and hospital-acquired respiratory tract infection and bloodstream infection in patients hospitalized with COVID-19 pneumonia.

Søgaard KK; Baettig V; Osthoff M; Marsch S; Leuzinger K; Schweitzer M; Meier J; Bassetti S; Bingisser R; Nickel CH; Khanna N; Tschudin-Sutter S; Weisser M; Battegay M; Hirsch HH; Pargger H; Siegemund M; Egli A. Journal of intensive care. 2021.

Comparing Immunoassays for SARS-CoV-2 Antibody Detection in Patients with and without Laboratory-Confirmed SARS-CoV-2 Infection.

Leuzinger K; Osthoff M; Dräger S; Pargger H; Siegemund M; Bassetti S; Bingisser R; Nickel CH; Tschudin-Sutter S; Khanna N; Rentsch K; Battegay M; Egli A; Hirsch HH. Journal of Clinical Microbiology. 2021.

Comparison of Acute Kidney Injury in Patients with COVID-19 and Other Respiratory Infections: A Prospective Cohort Study.

Diebold M; Zimmermann T; Dickenmann M; Schaub S; Bassetti S; Tschudin-Sutter S; Bingisser R; Heim C; Siegemund M; Osswald S; Kuster GM; Rentsch KM; Breidthardt T; Twerenbold R. Journal of Clinical Medicine. 2021.

D-dimer levels for risk stratification in patients with suspected covid-19 - a prospective observational study

Jauslin A.S.; Kellett J.; Brabrand M.; Simon N.R.; Rueegg M.; Twerenbold R.; Osswald S.; Bassetti S.; Tschudin-Sutter S.; Siegemund M.; Rentsch K.; Bingisser R.; Nickel C.H.. Acute medicine. 2021.

D-dimer levels for Risk Stratification in Patients with Suspected COVID-19 - A Prospective Observational Study.

Jauslin AS; Kellett J; Brabrand M; Simon NR; Rueegg M; Twerenbold R; Osswald S; Bassetti S; Tschudin-Sutter S; Siegemund M; Rentsch K; Bingisser R; Nickel CH. Acute medicine. 2021.

Direct Comparison of Clinical Characteristics, Outcomes, and Risk Prediction in Patients with COVID-19 and Controls-A Prospective Cohort Study.

Lampart M; Rüegg M; Jauslin AS; Simon NR; Zellweger N; Eken C; Tschudin-Sutter S; Bassetti S; Rentsch KM; Siegemund M; Bingisser R; Nickel CH; Osswald S; Kuster GM; Twerenbold R. Journal of Clinical Medicine. 2021.

Epidemiology and precision of SARS-CoV-2 detection following lockdown and relaxation measures.

Leuzinger K; Gosert R; Søgaard KK; Naegele K; Bielicki J; Roloff T; Bingisser R; Nickel CH; Khanna N; Sutter ST; Widmer AF; Rentsch K; Pargger H; Siegemund M; Stolz D; Tamm M; Bassetti S; Osthoff M; Battegay M; Egli A; Hirsch HH. Journal of Medical Virology. 2021.

Femoral and popliteal venous Doppler during prone and supine position in COVID-19 patients: a potential diagnostic tool to detect abnormal right ventricular function.

Malinovska A; Arslani K; Zellweger N; Gebhard C; Beaubien-Souligny W; Calderone A; Siegemund M; Aschwanden M; Denault A; Gebhard CE. . 2021.

Gender differences in the provision of intensive care: a Bayesian approach.

Todorov A; Kaufmann F; Arslani K; Haider A; Bengs S; Goliasch G; Zellweger N; Tontsch J; Sutter R; Buddeberg B; Hollinger A; Zemp E; Kaufmann M; Siegemund M; Gebhard C; Gebhard CE; Swiss Society of Intensive Care Medicine. Intensive Care Medicine. 2021.

Global Genomic Analysis of SARS-CoV-2 RNA Dependent RNA Polymerase Evolution and Antiviral Drug Resistance.

Mari A; Roloff T; Stange M; Søgaard KK; Asllanaj E; Tauriello G; Alexander LT; Schweitzer M; Leuzinger K; Gensch A; Martinez AE; Bielicki J; Pargger H; Siegemund M; Nickel CH; Bingisser R; Osthoff M; Bassetti S; Sendi P; Battegay M; Marzolini C; Seth-Smith HMB; Schwede T; Hirsch HH; Egli A. Microorganisms. 2021.

Haemophagocytic lymphohistiocytosis and liver failure-induced massive hyperferritinaemia in a male COVID-19 patient.

Zellweger NM; Huber J; Tsakiris DA; Tzankov A; Gebhard CE; Siegemund M. Swiss medical weekly. 2021.

Handling oxygenation targets in ICU patients with COVID-19-Protocol and statistical analysis plan in the HOT-COVID trial.

Mølgaard Nielsen F; Lass Klitgaard T; Crescioli E; Rosborg Aagaard S; Andreasen AS; Musaeus Poulsen L; Siegemund M; Craveiro Brøchner A; Bestle MH; Andi Iversen S; Brand BA; Laake JH; Grøfte T; Hildebrandt T; Lange T; Perner A; Lilleholt Schjørring O; Steen Rasmussen B. Acta anaesthesiologica Scandinavica. 2021.

Hemoadsorption during Cardiopulmonary Bypass in Patients with Endocarditis Undergoing Valve Surgery: A Retrospective Single-Center Study.

Santer D; Miazza J; Koechlin L; Gahl B; Rrahmani B; Hollinger A; Eckstein FS; Siegemund M; Reuthebuch OT. Journal of Clinical Medicine. 2021.

Implications of early respiratory support strategies on disease progression in critical COVID-19: a matched subanalysis of the prospective RISC-19-ICU cohort.

Wendel Garcia PD; Aguirre-Bermeo H; Buehler PK; Alfaro-Farias M; Yuen B; David S; Tschoellitsch T; Wengenmayer T; Korsos A; Fogagnolo A; Kleger GR; Wu MA; Colombo R; Turrini F; Potalivo A; Rezoagli E; Rodríguez-García R; Castro P; Lander-Azcona A; Martín-Delgado MC; Lozano-Gómez H; Ensner R; Michot MP; Gehring N; Schott P; Siegemund M; Merki L; Wiegand J; Jeitziner MM; Laube M; Salomon P; Hillgaertner F; Dullenkopf A; Ksouri H; Cereghetti S; Grazioli S; Bürkle C; Marrel J; Fleisch I; Perez MH; Baltussen Weber A; Ceruti S; Marquardt K; Hübner T; Redecker H; Studhalter M; Stephan M; Selz D; Pietsch U; Ristic A; Heise A; Meyer Zu Bentrup F; Franchitti Laurent M; Fodor P; Gaspert T; Haberthuer C; Colak E; Heuberger DM; Fumeaux T; Montomoli J; Guerci P; Schuepbach RA; Hilty MP; Roche-Campo F; RISC-19-ICU Investigators. Critical Care. 2021.

In Reply to Bevelacqua et al.

Finazzi T; Papachristofilou A; Siegemund M. International journal of radiation oncology, biology, physics. 2021.

Ketamine vs. haloperidol for prevention of cognitive dysfunction and postoperative delirium: A phase IV multicentre randomised placebo-controlled double-blind clinical trial.

Hollinger A; Rüst CA; Riegger H; Gysi B; Tran F; Brügger J; Huber J; Toft K; Surbeck M; Schmid HR; Rentsch K; Steiner L; Siegemund M. Journal of Clinical Anesthesia. 2021.

Lactic acidosis and hyperlactatemia associated with lamivudine accumulation and sepsis in a kidney transplant recipient-a case report and review of the literature.

Hollinger A; Cueni N; Marzolini C; Dickenmann M; Landmann E; Battegay M; Martinez AE; Siegemund M; Leuppi-Taegtmeyer A. AIDS Research and Therapy. 2021.

Low dose radiation therapy for severe COVID-19 pneumonia: a randomized double-blind study.

Papachristofilou A; Finazzi T; Blum A; Zehnder T; Zellweger N; Lustenberger J; Bauer T; Dott C; Avcu Y; Kohler G; Zimmermann F; Pargger H; Siegemund M. International journal of radiation oncology, biology, physics. 2021.

Low-Dose Radiation Therapy for Severe COVID-19 Pneumonia: A Randomized Double-Blind Study.

Papachristofilou A; Finazzi T; Blum A; Zehnder T; Zellweger N; Lustenberger J; Bauer T; Dott C; Avcu Y; Kohler G; Zimmermann F; Pargger H; Siegemund M. International journal of radiation oncology, biology, physics. 2021.

Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure.

Schjørring OL; Klitgaard TL; Perner A; Wetterslev J; Lange T; Siegemund M; Bäcklund M; Keus F; Laake JH; Morgan M; Thormar KM; Rosborg SA; Bisgaard J; Erntgaard AES; Lynnerup AH; Pedersen RL; Crescioli E; Gielstrup TC; Behzadi MT; Poulsen LM; Estrup S; Laigaard JP; Andersen C; Mortensen CB; Brand BA; White J; Jarnvig IL; Møller MH; Quist L; Bestle MH; Schønemann-Lund M; Kamper MK; Hindborg M; Hollinger A; Gebhard CE; Zellweger N; Meyhoff CS; Hjort M; Bech LK; Grøfte T; Bundgaard H; Østergaard LHM; Thyø MA; Hildebrandt T; Uslu B; Sølling CG; Møller-Nielsen N; Brøchner AC; Borup M; Okkonen M; Dieperink W; Pedersen UG; Andreasen AS; Buus L; Aslam TN; Winding RR; Schefold JC; Thorup SB; Iversen SA; Engstrøm J; Kjær MN; Rasmussen BS; HOT-ICU Investigators. New England Journal of Medicine. 2021.

New-onset atrial fibrillation in the intensive care unit: Protocol for an international inception cohort study (AFIB-ICU).

Wetterslev M; Møller MH; Granholm A; Haase N; Hassager C; Lange T; Hästbacka J; Wilkman E; Myatra SN; Shen J; An Y; Siegemund M; Young PJ; Aslam TN; Szczeklik W; Aneman A; Arabi YM; Cronhjort M; Keus F; Perner A. Acta anaesthesiologica Scandinavica. 2021.

Ninety-day outcome of patients with severe COVID-19 treated with tocilizumab - a single centre cohort study.

Sava M; Sommer G; Daikeler T; Woischnig AK; Martinez AE; Leuzinger K; Hirsch HH; Erlanger T; Wiencierz A; Bassetti S; Tamm M; Tschudin-Sutter S; Stoeckle M; Pargger H; Siegemund M; Boss R; Zimmer G; Vu DL; Kaiser L; Dell-Kuster S; Weisser M; Battegay M; Hostettler K; Khanna N. Swiss medical weekly. 2021.

Oxygenation targets in ICU patients with COVID-19: A post hoc subgroup analysis of the HOT-ICU trial

Rasmussen B.S.; Klitgaard T.L.; Perner A.; Brand B.A.; Hildebrandt T.; Siegemund M.; Hollinger A.; Aagaard S.R.; Bestle M.H.; Marcussen K.V.; Brochner A.C.; Solling C.G.; Poulsen L.M.; Laake J.H.; Aslam T.N.; Backlund M.; Okkonen M.; Morgan M.; Sharman M.; Lange T.; Wetterslev J.; Schjorring O.L.. Acta anaesthesiologica Scandinavica. 2021.

Point-of-Care Platelet Function Monitoring: Implications for Patients With Platelet Inhibitors in Cardiac Surgery.

Bolliger D; Lancé MD; Siegemund M. Journal of cardiothoracic and vascular anesthesia. 2021.

Preoperative Noninvasive Mapping Allowed Targeted Concomitant Surgical Ablation and Revealed COVID-19 Infection.

Mork C; Koechlin L; Streif M; Hollinger A; Siegemund M; Eckstein F; Santer D. . 2021.

Prevalence and outcome of dysnatremia in patients with COVID-19 compared to controls.

Atila C; Sailer CO; Bassetti S; Tschudin-Sutter S; Bingisser R; Siegemund M; Osswald S; Rentsch K; Rueegg M; Schaerli S; Kuster GM; Twerenbold R; Christ-Crain M. European journal of endocrinology. 2021.

Prevalence and risk factors for delirium in critically ill patients with COVID-19 (COVID-D): a multicentre cohort study

Pun B.T.; Badenes R.; Heras La Calle G.; Orun O.M.; Chen W.; Raman R.; Simpson B.-G.K.; Wilson-Linville S.; Hinojal Olmedillo B.; Vallejo de la Cueva A.; van der Jagt M.; Navarro Casado R.; Leal Sanz P.; Orhun G.; Ferrer Gomez C.; Nunez Vazquez K.; Pineiro Otero P.; Taccone F.S.; Gallego Curto E.; Caricato A.; Woien H.; Lacave G.; O'Neal H.R.; Peterson S.J.; Brummel N.E.; Girard T.D.; Ely E.W.; Pandharipande P.P.; Creteur J.; Bogossian E.G.; Peluso L.; Gonzalez-Seguel F.; Hidalgo-Cabalin V.; Carreno-Montenegro P.; Rojas V.; Tobar E.; Ramirez-Palma A.; Herrera-Davis K.; Ferre A.; Legriel S.; Godet T.; Fraisse U.; Goncalves B.; Mazeraud A.; Tzimou M.; Rasulo F.; Beretta S.; Marchesi M.; Robba C.; Battaglini D.; Pelosi P.; Mazzeo A.T.; Noto A.; Servillo G.; Marra A.; Cutuli S.L.; Pintaudi G.; Stival E.; Tanzarella E.S.; Roman-Pognuz E.; Concetta Massaro C.M.; Elhadi M.; Smit L.; Olasveengen T.; Pereira I.J.; Teixeira C.M.; Santos A.; Valente M.; Granja C.; Pereia R.; Silva J.; Furquet B.; Garcia Simon M.; Godoy Torres D.A.; Monleon B.; Morcillo E.; Romero N.; Serrano A.; Torrico Sanchez S.; Perez Caballero F.L.; Pena Luna I.; Baeza Gomez I.; Calizaya Vargas M.; Morillas Perez J.; Carrasco Gomez G.; Molina Latorre R.; Moya Gutierrez S.; Baron Barrera I.P.; Delgado Palacios C.; Garcia Gongora B.; Labrador Romero L.; Galarza L.; Catalan-Monzon I.; Rodriguez-Martinez E.; Murcia Gubianas C.; Belles A.; Rodriguez Delgado M.E.; Caballero J.; Morales D.; Pujol A.; Rubio J.; Alvarez Torres E.; Carvajal Revuelta E.; de la Calle Gil I.; Fernandez Tomas B.; Gallego Rodriguez B.; Gonzalez Serrano M.; LaTorre Andreu P.; Perez Lucendo A.; Abril Palomares E.; Gonzalez Gonzalez E.; Martin Delgado M.C.; Munoz De Cabo C.; Aznar P.T.; Calvo C.A.; Garutti I.; Higuero F.; Martinez-Gascuena D.; Maseda E.; Insausti I.; Montero Feijoo A.; Suarez-de-la-Rica A.; Del Moral Barbudo B.; Garcia Blanco-Traba Y.; Gimenez Santamarina M.C.; Gonzalo Millan A.; Llorente Damas S.; Pestana Lagunas D.; Reyes Garcia I.; Ruiz Perea A.; Ortega Guerrero A.; Marmol Cubillo M.J.; Diaz Munoz D.; Garcia de Castrillon i Ramal S.; Andorra Sunyer X.; Noci Moreno M.D.L.N.; Perez Manrique R.M.; del Campo Molina E.; Martinez Quintana M.E.; Fernandez-Gonzalo S.; Goma Fernandez G.; Navarra-Ventura G.; Baro Serra A.; Fuster C.; Plans Galvan O.; Gil-Castillejos D.; Dalorzo Gonzalez M.; Moran Gallego F.J.; Paredes Borrachero I.; Rodriguez Villamizar P.; Romeu Prieto J.; Sanchez Carretero M.J.; Gallardo Sanchez S.; Bustos Molina F.; Garcia Perez M.L.; Castello-Mora P.; Puig J.; Sanchis-Martin M.R.; Sanchis-Veryser C.A.; Vicente-Fernandez M.P.; Zaragoza R.; Lizama L.; Torres I.; Alvarez C.; Ramirez P.; Martin Cerezuela M.; Montero M.J.; Garcia Cantos J.; Valls P.; Aretxabala Cortajarena N.; Garcia Domelo P.; Gonzalez Cubillo L.; Martin Martinez M.; Perez Francisco I.; Poveda Hernandez Y.; Quintano Rodero A.; Rodriguez Nunez C.; Siegemund M.; Estermann A.; Zellweger N.; Ben Saida I.; Boussarsar M.; Esen F.; Ergin Ozcan P.; Berkey C.; Harb C.; Tandy M.H.; Morgan E.; Shephard K.; Hyzy R.C.; Kenes M.; Nelson K.; Hosse R.E.; Vance K.M.; Austin C.A.; Lerner A.; Sanders E.; Balk R.A.; Bennett D.A.; Vogel A.R.; Chowdhury L.; Devulapally K.; Woodham M.; Cohen S.; Patel N.; Kuza C.M.; Sing M.; Roberson S.; Drumright K.; Sehgal S.; LaHue S.C.; Douglas V.C.; Sarwal A.. The Lancet Respiratory Medicine. 2021.

Probabilistic analysis of COVID-19 patients' individual length of stay in Swiss intensive care units

Henzi A.; Kleger G.-R.; Hilty M.P.; Wendel Garcia P.D.; Ziegel J.F.; Hilty Matthias P.; Wendel Garcia Pedro D.; Schupbach Reto A.; Fumeaux T.; Montomoli J.; Guerci P.; Ensner R.; Gehring N.; Schott P.; Urech S.; Siegemund M.; Zellweger N.; Lambert A.; Merki L.; Jeitziner M.-M.; Jenni-Moser B.; Laube M.; Yuen B.; Hillermann T.; Salomon P.; Drvaric I.; Hillgaertner F.; Sieber M.; Dullenkopf A.; Petersen L.; Ksouri H.; Sridharan G.O.; Cereghetti S.; Boroli F.; Pugin J.; Grazioli S.; Rimensberger P.C.; Burkle C.; Marrel J.; Brenni M.; Fleisch I.; Lavanchy J.; Weber A.B.; Gerecke P.; Christ A.; Mauri R.; Ceruti S.; Marquardt K.; Shaikh K.; Neff T.; Hubner T.; Redecker H.; Moret-Bochatay M.; Studhalter M.; Stephan M.; Brem J.; Selz D.; Naon D.; Filipovic M.; Pietsch U.; Rogdo B.; Birkenmaier A.; Ristic A.; Sepulcri M.; Heise A.; zu Bentrup F.M.; Laurent M.F.; Laurent J.-C.; Buhler P.; Brugger S.; Bartussek J.; Maibach M.; Zinkernagel A.; Heuberger D.; Shambat S.M.; Fodor P.; Locher P.; Camen G.; Gaspert T.; Jovic M.; Haberthuer C.; Lussman R.F.. PLoS ONE. 2021.

Prone Positioning as a Potential Risk Factor for Deep Vein Thrombosis in COVID-19 Patients: A Hypothesis Generating Observation.

Gebhard CE; Zellweger N; Gebhard C; Hollinger A; Chrobok L; Stähli D; Schönenberger CM; Todorov A; Aschwanden M; Siegemund M. Journal of Clinical Medicine. 2021.

SARS-CoV-2 outbreak in a tri-national urban area is dominated by a B.1 lineage variant linked to a mass gathering event.

Stange M; Mari A; Roloff T; Seth-Smith HM; Schweitzer M; Brunner M; Leuzinger K; Søgaard KK; Gensch A; Tschudin-Sutter S; Fuchs S; Bielicki J; Pargger H; Siegemund M; Nickel CH; Bingisser R; Osthoff M; Bassetti S; Schneider-Sliwa R; Battegay M; Hirsch HH; Egli A. PLoS Pathogens. 2021.

Serum Neurofilament Light Chain Levels in the Intensive Care Unit: Comparison between Severely Ill Patients with and without Coronavirus Disease 2019.

Sutter R; Hert L; De Marchis GM; Twerenbold R; Kappos L; Naegelin Y; Kuster GM; Benkert P; Jost J; Maceski AM; Rüegg S; Siegemund M; Leppert D; Tschudin-Sutter S; Kuhle J. Annals of Neurology. 2021.

Temporal trends of COVID-19 related in-hospital mortality and demographics in Switzerland - a retrospective single centre cohort study.

Diebold M; Martinez AE; Adam KM; Bassetti S; Osthoff M; Kassi E; Steiger J; Pargger H; Siegemund M; Battegay M; Khanna N; Schaub S; Wesch C; Dickenmann M; Weisser M. Swiss medical weekly. 2021.

Use of crystalloids and colloids in Europe per year from 2010 to 2019: Protocol for an international descriptive study.

Zellweger NM; Hylander Møller M; Ellekjaer KL; Jonsson AB; Bruun Svan K; Siegemund M; Perner A. Acta anaesthesiologica Scandinavica. 2021.

Bedside hand vein inspection for noninvasive central venous pressure assessment.

Vogel F; Staub D; Aschwanden M; Siegemund M; Imfeld S; Balestra G; Keo HH; Uthoff H. The American journal of emergency medicine. 2020.

Correlates of critical illness-related encephalopathy predominate postmortem COVID-19 neuropathology

Deigendesch N.; Sironi L.; Kutza M.; Wischnewski S.; Fuchs V.; Hench J.; Frank A.; Nienhold R.; Mertz K.D.; Cathomas G.; Matter M.S.; Siegemund M.; Tolnay M.; Schirmer L.; Probstel A.-K.; Tzankov A.; Frank S.. Acta Neuropathologica. 2020.

icumonitoring.ch: a platform for short-term forecasting of intensive care unit occupancy during the COVID-19 epidemic in Switzerland

Cheng Z.; Burcu T.; Criscuolo Nicola G.; Wendel Garcia Pedro D.; Hilty Matthias P.; Thierry F.; Van Boeckel Thomas P.; Schupbach R.; Buhler P.; Brugger S.; Bartussek J.; Moret-Bochatay M.; Yuen B.; Hillermann T.; Ksouri H.; Sridharan G.O.; Ristic A.; Sepulcri M.; Filipovic M.; Pietsch U.; Salomon P.; Drvaric I.; Schott P.; Urech S.; Lambert A.; Merki L.; Laube M.; Hillgaertner F.; Sieber M.; Dullenkopf A.; Petersen L.; Grazioli S.; Rimensberger P.C.; Fleisch I.; Lavanchy J.; Marquardt K.; Shaikh K.; Redecker H.; Stephan M.; Brem J.; Rogdo B.; Birkenmaier A.; zu Bentrup F.M.; Fodor P.; Locher P.; Siegemund M.; Zellweger N.; Jeitziner M.-M.; Jenni-Moser B.; Burkle C.; Kleger G.-R.; Laurent M.F.; Laurent J.-C.; Gaspert T.; Jovic M.; Studhalter M.; Haberthuer C.; Lussman R.F.; Selz D.; Naon D.; Mauri R.; Ceruti S.; Marrel J.; Brenni M.; Ensner R.; Gehring N.; Heise A.; Cereghetti S.; Boroli F.; Pugin J.. Swiss Medical Weekly. 2020.

Implementation of a multiprofessional, multicomponent delirium management guideline in two intensive care units, and its effect on patient outcomes and nurse workload: a pre-post design retrospective cohort study.

Schubert M; Bettex D; Steiger P; Schürch R; Haller A; Bogdanovic J; Garcia Nuñez D; Schwarz U; Siegemund M. Swiss medical weekly. 2020.

Performance of the T2Candida Panel for the Diagnosis of Intra-abdominal Candidiasis.

Lamoth F; Clancy CJ; Tissot F; Squires K; Eggimann P; Flückiger U; Siegemund M; Orasch C; Zimmerli S; Calandra T; Marchetti O; Nguyen MH; Bochud PY. Open Forum Infectious Diseases. 2020.

Protein delivery in intermittent and continuous enteral nutrition with a protein-rich formula in critically ill patients-a protocol for the prospective randomized controlled proof-of-concept Protein Bolus Nutrition (Pro BoNo) study.

Reinhold S; Yeginsoy D; Hollinger A; Todorov A; Tintignac L; Sinnreich M; Kiss C; Gebhard CE; Kovács B; Gysi B; Imwinkelried L; Siegemund M. Trials. 2020.

SPHN/PHRT: Forming a Swiss-Wide Infrastructure for Data-Driven Sepsis Research.

Egli A; Battegay M; Büchler AC; Bühlmann P; Calandra T; Eckert P; Furrer H; Greub G; Jakob SM; Kaiser L; Leib SL; Marsch S; Meinshausen N; Pagani JL; Pugin J; Rätsch G; Schrenzel J; Schüpbach R; Siegemund M; Zamboni N; Zbinden R; Zinkernagel A; Borgwardt K. Studies in health technology and informatics. 2020.

Study protocol for a prospective randomised double-blind placebo-controlled clinical trial investigating a Better Outcome with Melatonin compared to Placebo Administered to normalize sleep-wake cycle and treat hypoactive ICU Delirium: the Basel BOMP-AID study.

Hollinger A; von Felten S; Sutter R; Huber J; Tran F; Reinhold S; Abdelhamid S; Todorov A; Gebhard CE; Cajochen C; Steiner LA; Siegemund M. BMJ Open. 2020.

Sublingual microcirculation does not reflect red blood cell transfusion thresholds in the intensive care unit-a prospective observational study in the intensive care unit.

Scheuzger J; Zehnder A; Meier V; Yeginsoy D; Flükiger J; Siegemund M. Critical Care. 2020.

The handling oxygenation targets in the intensive care unit (HOT-ICU) trial: Detailed statistical analysis plan.

Schjørring OL; Klitgaard TL; Perner A; Wetterslev J; Lange T; Keus F; Laake JH; Morgan M; Bäcklund M; Siegemund M; Thormar KM; Rasmussen BS. Acta anaesthesiologica Scandinavica. 2020.

A preoperative single dose of methadone for moderate-to-severely painful surgery reduces postoperative morphine consumption.

Bastian K; Buehler PK; Slizyte D; Rüst CA; Toft K; Studer W; Lecheler L; Aguirre J; Siegemund M; Hollinger A. Minerva anestesiologica. 2019.

Between a Rock and a Hard Place: Coagulation Management in Venoarterial Extracorporeal Membrane Oxygenation Patients

Bolliger D.; Siegemund M.. Journal of cardiothoracic and vascular anesthesia. 2019.

Development and validation of a multivariable risk score for prolonged length of stay in the surgical intensive care unit.

Wesch C; Denhaerynck K; Barandun Schaefer U; Siegemund M; Wehrli M; Pargger H; Look S. Swiss medical weekly. 2019.

Discontinuation of dual antiplatelet therapy and bleeding in intensive care in patients undergoing urgent coronary artery bypass grafting: a retrospective analysis.

Vuilliomenet T; Gebhard C; Bizzozero C; Glauser S; Blum S; Buser A; Bolliger D; Grapow MTR; Siegemund M. Interactive Cardiovascular and Thoracic Surgery. 2019.

Handling Oxygenation Targets in the Intensive Care Unit (HOT-ICU)-Protocol for a randomised clinical trial comparing a lower vs a higher oxygenation target in adults with acute hypoxaemic respiratory failure.

Schjørring OL; Perner A; Wetterslev J; Lange T; Keus F; Laake JH; Okkonen M; Siegemund M; Morgan M; Thormar KM; Rasmussen BS; HOT-ICU Investigators. Acta anaesthesiologica Scandinavica. 2019.

High Mortality of Non-Fournier Necrotizing Fasciitis With Enterobacteriales: Time to Rethink Classification?

Kuehl R; Tschudin-Sutter S; Siegemund M; Marsch S; Battegay M; Wetterauer C; Seifert HH; Schaefer DJ; Erb S; Egli A. Clinical Infectious Diseases. 2019.

Prolonged respiratory failure due to pulmonary embolism in a young woman: a case report.

Tuchscherer D; Hollinger A; Bremerich J; Siegemund M. Journal of medical case reports. 2019.

Serum biomarkers of delirium in the elderly: a narrative review.

Toft K; Tontsch J; Abdelhamid S; Steiner L; Siegemund M; Hollinger A. Annals of intensive care. 2019.

Sublingual microcirculation: a case report.

Scheuzger JD; Zehnder A; Yeginsoy D; Siegemund M. Journal of medical case reports. 2019.

The value of volume substitution in patients with septic and haemorrhagic shock with respect to the microcirculation.

Siegemund M; Hollinger A; Gebhard EC; Scheuzger JD; Bolliger D. Swiss medical weekly. 2019.

Vasoactive agents to improve brain perfusion: pathophysiology and clinical utilization.

Steiner LA; Siegemund M. Current Opinion in Critical Care. 2019.

Association of social deprivation with 1-year outcome of ICU survivors: results from the FROG-ICU study.

Bastian K; Hollinger A; Mebazaa A; Azoulay E; Féliot E; Chevreul K; Fournier MC; Guidet B; Michel M; Montravers P; Pili-Floury S; Sonneville R; Siegemund M; Gayat E; FROG-ICU Study Investigators. Intensive Care Medicine. 2018.

Baden Prevention and Reduction of Incidence of Postoperative Delirium Trial (PRIDe): a phase IV multicenter, randomized, placebo-controlled, double-blind clinical trial of ketamine versus haloperidol for prevention of postoperative delirium.

Riegger H; Hollinger A; Seifert B; Toft K; Blum A; Zehnder T; Siegemund M. Trials. 2018.

Brain Tissue Oxygenation

Hollinger A.; Siegemund M.; Cueni N.; Steiner L.A.. . 2018.

Dexmedetomidine in prevention and treatment of postoperative and intensive care unit delirium: a systematic review and meta-analysis.

Flükiger J; Hollinger A; Speich B; Meier V; Tontsch J; Zehnder T; Siegemund M. Annals of intensive care. 2018.

Impact of amount of fluid for circulatory resuscitation on renal function in patients in shock: Evaluating the influence of intra-Abdominal pressure, renal resistive index, sublingual microcirculation and total body water measured by bio-impedance analysis on haemodynamic parameters for guidance of volume resuscitation in shock therapy: A protocol for the VoluKid pilot study-An observational clinical trial

Hollinger A.; Gantner L.; Jockers F.; Schweingruber T.; Ledergerber K.; Scheuzger J.D.; Aschwanden M.; Dickenmann M.; Knotzer J.; Van Bommel J.; Siegemund M.. Renal Replacement Therapy. 2018.

Pantoprazole in Patients at Risk for Gastrointestinal Bleeding in the ICU.

Krag M; Marker S; Perner A; Wetterslev J; Wise MP; Schefold JC; Keus F; Guttormsen AB; Bendel S; Borthwick M; Lange T; Rasmussen BS; Siegemund M; Bundgaard H; Elkmann T; Jensen JV; Nielsen RD; Liboriussen L; Bestle MH; Elkjær JM; Palmqvist DF; Bäcklund M; Laake JH; Bådstøløkken PM; Grönlund J; Breum O; Walli A; Winding R; Iversen S; Jarnvig IL; White JO; Brand B; Madsen MB; Quist L; Thornberg KJ; Møller A; Wiis J; Granholm A; Anthon CT; Meyhoff TS; Hjortrup PB; Aagaard SR; Andreasen JB; Sørensen CA; Haure P; Hauge J; Hollinger A; Scheuzger J; Tuchscherer D; Vuilliomenet T; Takala J; Jakob SM; Vang ML; Pælestik KB; Andersen KLD; van der Horst ICC; Dieperink W; Fjølner J; Kjer CKW; Sølling C; Sølling CG; Karttunen J; Morgan MPG; Sjøbø B; Engstrøm J; Agerholm-Larsen B; Møller MH; SUP-ICU trial group.. New England Journal of Medicine. 2018.

The More, the Merrier? - Urinary Biomarkers for Prediction of Acute Kidney Injury After Cardiac Surgery.

Bolliger D; Siegemund M. Journal of cardiothoracic and vascular anesthesia. 2018.

Anatomic changes after repair of traumatic bilateral diaphragmatic rupture impede bi-caval dual lumen catheter insertion for veno-venous extracorporeal membrane oxygenation treatment.

Hollinger A; Tuchscherer D; Bremerich J; Siegemund M. Critical Care. 2017.

Comparison of propofol and dexmedetomidine infused overnight to treat hyperactive and mixed ICU delirium: a protocol for the Basel ProDex clinical trial.

Hollinger A; Ledergerber K; von Felten S; Sutter R; Rüegg S; Gantner L; Zimmermann S; Blum A; Steiner LA; Marsch S; Siegemund M. BMJ Open. 2017.

Independent Predictors of the Duration and Overall Burden of Postoperative Delirium After Cardiac Surgery in Adults: An Observational Cohort Study.

Cereghetti C; Siegemund M; Schaedelin S; Fassl J; Seeberger MD; Eckstein FS; Steiner LA; Goettel N. Anesthesiology. 2017.

Modified frozen elephant trunk for acute type A aortic dissection: a comparative study with standard repair technique.

Matt P; Banerjee P; Grapow M; Rueter F; Schurr U; Siegemund M; Fassl J; Reuthebuch O; Eckstein F. European Journal of Cardio-thoracic Surgery. 2017.

The EMPIRICUS trial-the final nail in the coffin of empirical antifungal therapy in the intensive care unit?

Osthoff M; Khanna N; Siegemund M. Journal of Thoracic Disease. 2017.

Prolonged administration of β-lactam antibiotics - a comprehensive review and critical appraisal.

Osthoff M; Siegemund M; Balestra G; Abdul-Aziz MH; Roberts JA. Swiss medical weekly. 2016.

Postoperative care of the neurosurgical patient.

Siegemund M; Steiner LA. Current opinion in anaesthesiology. 2015.

Postoperative Delirium in Cardiac Surgery: An Unavoidable Menace?

Hollinger A.; Siegemund M.; Goettel N.; Steiner L.A.. Journal of cardiothoracic and vascular anesthesia. 2015.

Effect of n-3 fatty acids on markers of brain injury and incidence of sepsis-associated delirium in septic patients.

Burkhart CS; Dell-Kuster S; Siegemund M; Pargger H; Marsch S; Strebel SP; Steiner LA. Acta anaesthesiologica Scandinavica. 2014.

Polymorphisms in tumor necrosis factor-α increase susceptibility to intra-abdominal Candida infection in high-risk surgical ICU patients*.

Wójtowicz A; Tissot F; Lamoth F; Orasch C; Eggimann P; Siegemund M; Zimmerli S; Flueckiger UM; Bille J; Calandra T; Marchetti O; Bochud PY; Fungal Infection Network of Switzerland (FUNGINOS). Critical care medicine. 2014.

The PhysiologicPerspective in FluidManagement in VascularAnesthesiology.

Knotzer,Hans; Filipovic,Miodrag; Siegemund,Martin; Kleinsasser,Axel. Journal of cardiothoracic and vascular anesthesia. 2014.

The physiologic perspective in fluid management in vascular anesthesiology.

Knotzer H; Filipovic M; Siegemund M; Kleinsasser A. Journal of cardiothoracic and vascular anesthesia. 2014.

Hydroxyethyl starch 130/0.38-0.45 versus crystalloid or albumin in patients with sepsis: systematic review with meta-analysis and trial sequential analysis.

Haase N; Perner A; Hennings LI; Siegemund M; Lauridsen B; Wetterslev M; Wetterslev J. BMJ (Clinical research ed.). 2013.

Re-evaluating currently available data and suggestions for planning randomised controlled studies regarding the use of hydroxyethyl starch in critically ill patients - a multidisciplinary statement.

Meybohm P; Van Aken H; De Gasperi A; De Hert S; Della Rocca G; Girbes AR; Gombotz H; Guidet B; Hasibeder W; Hollmann MW; Ince C; Jacob M; Kranke P; Kozek-Langenecker S; Loer SA; Martin C; Siegemund M; Wunder C; Zacharowski K. Critical Care. 2013.

β-glucan antigenemia anticipates diagnosis of blood culture-negative intraabdominal candidiasis.

Tissot F; Lamoth F; Hauser PM; Orasch C; Flückiger U; Siegemund M; Zimmerli S; Calandra T; Bille J; Eggimann P; Marchetti O; Fungal Infection Network of Switzerland (FUNGINOS). American Journal of Respiratory and Critical Care Medicine. 2013.

Microcirculation follows macrocirculation in heart and gut in the acute phase of hemorrhagic shock and isovolemic autologous whole blood resuscitation in pigs.

van Iterson M; Bezemer R; Heger M; Siegemund M; Ince C. Transfusion. 2012.

New treatment concept in postnatal bleeding - An interdisciplinary challenge Neues behandlungskonzept bei postnataler blutung - Eine interdisziplinäre herausforderung

Girard Th.; Lapaire O.; Neeser E.; Siegemund M.. Journal fur Anasthesie und Intensivbehandlung. 2012.

Prospective comparison of noninvasive, bedside ultrasound methods for assessing central venous pressure.

Uthoff H; Siegemund M; Aschwanden M; Hunziker L; Fabbro T; Baumann U; Jaeger KA; Imfeld S; Staub D. Ultraschall in der Medizin. 2012.

The Sequential Organ Failure Assessment score and copeptin for predicting survival in ventilator-associated pneumonia.

Boeck L; Eggimann P; Smyrnios N; Pargger H; Thakkar N; Siegemund M; Morgenthaler NG; Rakic J; Tamm M; Stolz D. Journal of Critical Care. 2012.

[Thrombotic microangiopathy after extracorporeal circulation: important differential diagnosis].

Schmidt T; Tsakiris DA; Grapow M; Siegemund M. Anaesthesist. 2011.

Catheter related blood stream infections in critically ill patients with continuous haemo(dia)filtration and temporary non-tunnelled vascular access.

Schönenberger M; Forster C; Siegemund M; Woodtli S; Widmer AF; Dickenmann M. Swiss medical weekly. 2011.

Effect of age on intraoperative cerebrovascular autoregulation and near-infrared spectroscopy-derived cerebral oxygenation.

Burkhart CS; Rossi A; Dell-Kuster S; Gamberini M; Möckli A; Siegemund M; Czosnyka M; Strebel SP; Steiner LA. British Journal of Anaesthesia. 2011.

Midregional pro-atrial natriuretic peptide and procalcitonin improve survival prediction in VAP.

Boeck L; Eggimann P; Smyrnios N; Pargger H; Thakkar N; Siegemund M; Marsch S; Rakic J; Tamm M; Stolz D. European Respiratory Journal. 2011.

Pancreatic stone protein: A marker of organ failure and outcome in ventilator-associated pneumonia

Boeck L.; Graf R.; Eggimann P.; Pargger H.; Raptis D.A.; Smyrnios N.; Thakkar N.; Siegemund M.; Rakic J.; Tamm M.; Stolz D.. Chest. 2011.

Succinylcholine versus rocuronium for rapid sequence intubation in intensive care: a prospective, randomized controlled trial.

Marsch SC; Steiner L; Bucher E; Pargger H; Schumann M; Aebi T; Hunziker PR; Siegemund M. Critical Care. 2011.

Use of B-type natriuretic peptide in the management of hypoxaemic respiratory failure.

Noveanu M; Pargger H; Breidthardt T; Reichlin T; Schindler C; Heise A; Schoenenberger R; Manndorff P; Siegemund M; Mebazaa A; Marsch S; Mueller C. European Journal of Heart Failure. 2011.

[Seizure and non-cardiogenic pulmonary edema after intoxication].

Sawatzki M; Kummer O; Krähenbühl S; Siegemund M. Der Internist. 2010.

Aortic cross-clamping and reperfusion in pigs reduces microvascular oxygenation by altered systemic and regional blood flow distribution.

Siegemund M; van Bommel J; Stegenga ME; Studer W; van Iterson M; Annaheim S; Mebazaa A; Ince C. Anesthesia and Analgesia. 2010.

Cerebral perfusion in sepsis.

Burkhart CS; Siegemund M; Steiner LA. Critical Care. 2010.

Co-infection of Influenza B and Streptococci causing severe pneumonia and septic shock in healthy women.

Aebi T; Weisser M; Bucher E; Hirsch HH; Marsch S; Siegemund M. BMC Infectious Diseases. 2010.

Copeptin is associated with mortality and outcome in patients with acute intracerebral hemorrhage

Zweifel C.; Katan M.; Schuetz P.; Siegemund M.; Morgenthaler N.G.; Merlo A.; Mueller B.; Christ-Crain M.. BMC Neurology. 2010.

Iloprost-induced thrombocytopenia: a case proven by rechallenge.

Taegtmeyer AB; Zettler C; Siegemund M; Tsakiris DA; Rätz Bravo AE; Pargger H; Kraehenbuehl S; Haschke M. European Respiratory Journal. 2010.

10% Hydroxyethylstarch impairs renal function and induces interstitial proliferation, macrophage infiltration and tubular damage.

Siegemund M. Critical Care. 2009.

Non-invasive central venous pressure measurement by compression ultrasound--a step into real life.

Thalhammer C; Siegemund M; Aschwanden M; Gassmann M; Baumann UA; Jaeger KA; Imfeld S. Resuscitation. 2009.

Procalcitonin for reduced antibiotic exposure in ventilator-associated pneumonia: a randomised study.

Stolz D; Smyrnios N; Eggimann P; Pargger H; Thakkar N; Siegemund M; Marsch S; Azzola A; Rakic J; Mueller B; Tamm M. European Respiratory Journal. 2009.

Rivastigmine for the prevention of postoperative delirium in elderly patients undergoing elective cardiac surgery--a randomized controlled trial.

Gamberini M; Bolliger D; Lurati Buse GA; Burkhart CS; Grapow M; Gagneux A; Filipovic M; Seeberger MD; Pargger H; Siegemund M; Carrel T; Seiler WO; Berres M; Strebel SP; Monsch AU; Steiner LA. Critical care medicine. 2009.

Cerebral perfusion in sepsis-associated delirium.

Pfister D; Siegemund M; Dell-Kuster S; Smielewski P; Rüegg S; Strebel SP; Marsch SC; Pargger H; Steiner LA. Critical Care. 2008.

Emergency cesarean section after eclamptic seizure: Substandard care? Notsectio nach eklamptischem anfall: Substandard care?

Schneider M.C.; Lapaire O.; Hofmeister J.; Siegemund M.. Journal fur Anasthesie und Intensivbehandlung. 2008.

Heart, kidney, and intestine have different tolerances for anemia.

van Bommel J; Siegemund M; Henny ChP; Ince C. Translational Research. 2008.

Intracranial pressure in patients with sepsis.

Pfister D; Schmidt B; Smielewski P; Siegemund M; Strebel SP; Rüegg S; Marsch SC; Pargger H; Steiner LA. Acta neurochirurgica. Supplement. 2008.

Failure of recombinant factor VIIa in a patient with severe polymicrobial sepsis and postoperative uncontrolled intraabdominal bleeding.

Conen A; Weisser M; Tsakiris DA; Siegemund M. BMC Infectious Diseases. 2007.

The NO donor SIN-1 improves intestinal-arterial P(CO(2)) gap in experimental endotoxemia: an animal study.

Siegemund M; Van Bommel J; Sinaasappel M; Schwarte LA; Studer W; Girard T; Vollebregt K; Ince C. Acta anaesthesiologica Scandinavica. 2007.

[The use of ultrasound in intensive care medicine].

Christ M; Siegemund M. Anasthesiologie Intensivmedizin Notfallmedizin Schmerztherapie. 2006.

Effects of dopexamine in a rat model of supracoeliac aortic cross-clamping and declamping.

Studer W; Wu X; Siegemund M; Seeberger M; Filipovic M. European Surgical Research. 2006.

Endocarditis as a possible cause for septicemia in the intensive care unit Sepsis auf der intensivstation: Endokarditis als differentialdiagnose!

Kessel-Schaefer A.; Siegemund M.; Buser P.; Linka A.. Intensivmedizin und Notfallmedizin. 2006.

Incidence, risk factors, and outcome of aspiration pneumonitis in ICU overdose patients.

Christ A; Arranto CA; Schindler C; Klima T; Hunziker PR; Siegemund M; Marsch SC; Eriksson U; Mueller C. Intensive Care Medicine. 2006.

In response [25]

Sluga M.; Ummenhofer W.; Studer W.; Siegemund M.; Marsch S.. Anesthesia and Analgesia. 2006.

Microcirculatory recruitment maneuvers correct tissue CO2 abnormalities in sepsis

Almac E.; Siegemund M.; Demirci C.; Ince C.. Minerva anestesiologica. 2006.

Microcirculatory recruitment maneuvers correct tissue CO2 abnormalities in sepsis.

Almac E; Siegemund M; Demirci C; Ince C. Minerva anestesiologica. 2006.

Patients with unexplained sepsis in the intensive care unit Patientin mit unklarer sepsis auf der intensivstation

Kessel-Schaefer A.; Buser P.; Linka A.; Siegemund M.. Intensivmedizin und Notfallmedizin. 2006.

Echocardiographic quantification of atherosclerosis leads to cost-effective treatment with statins: Data from a prospective study of 336 patients

Nietlispach F.; Hug B.; Jansen C.; Barbosa V.; Keller D.; Buser P.T.; Siegemund M.; Marsch S.; Hunziker P.R.. Swiss Medical Weekly. 2005.

Echocardiographic quantification of atherosclerosis leads to cost-effective treatment with statins.

Nietlispach F; Hug B; Jansen C; Barbosa V; Keller D; Buser PT; Siegemund M; Marsch S; Hunziker PR. Swiss Medical Weekly. 2005.

Genotyping the butyrylcholinesterase in patients with prolonged neuromuscular block after succinylcholine.

Levano S; Ginz H; Siegemund M; Filipovic M; Voronkov E; Urwyler A; Girard T. Anesthesiology. 2005.

Inducible nitric oxide synthase inhibition improves intestinal microcirculatory oxygenation and CO2 balance during endotoxemia in pigs.

Siegemund M; van Bommel J; Schwarte LA; Studer W; Girard T; Marsch S; Radermacher P; Ince C. Intensive Care Medicine. 2005.

Influence of dobutamine on the variables of systemic haemodynamics, metabolism, and intestinal perfusion after cardiopulmonary resuscitation in the rat.

Studer W; Wu X; Siegemund M; Marsch S; Seeberger M; Filipovic M. Resuscitation. 2005.

Intensive care treatment of pregnant women with preeclampsia and eclampsia Intensivmedizinische therapie von schwangeren mit präeklampsie und eklampsie

Siegemund M.. Journal fur Anasthesie und Intensivbehandlung. 2005.

Intensivmedizinische Therapie von Schwangeren mit Präeklampsie und Eklampsie

Siegemund,Martin. . 2005.

Rocuronium versus succinylcholine for rapid sequence induction of anesthesia and endotracheal intubation: a prospective, randomized trial in emergent cases.

Sluga M; Ummenhofer W; Studer W; Siegemund M; Marsch SC. Anesthesia and Analgesia. 2005.

B-Type natriuretic peptide for acute shortness of breath evaluation (BASEL) in patients with pulmonary disease: insights from a randomized comparison

Mueller,C; Scholer,A; Hunziker,P; Siegemund,M; Marsch,S. . 2004.

Frequency distribution of dibucaine numbers in 24,830 patients [1] (multiple letters) Verteilungsmuster der Dibucainzahl bei 24.830 Patientinnen und Patienten

Girard T.; Siegemund M.; Pestel G.. Anaesthesist. 2004.

Molecular genetic testing for malignant hyperthermia susceptibility.

Girard T; Treves S; Voronkov E; Siegemund M; Urwyler A. Anesthesiology. 2004.

Verteilungsmuster der Diubcainzahl bei 24830 Patientinnen und Patienten. Der Anästhesist (2003) 52:495-499

Girard,T; Siegemund,M. . 2004.

Hemoglobin-based oxygen carrier provides heterogeneous microvascular oxygenation in heart and gut after hemorrhage in pigs.

van Iterson M; Siegemund M; Burhop K; Ince C. The Journal of trauma. 2003.

How microcirculatory oxygenation of different organs reacts to resuscitation in experimental sepsis and reperfusion injury

Siegemund,M. . 2003.

[Obstetric analgesia and anesthesia in Switzerland in 1999].

Zwetsch-Rast G; Schneider MC; Siegemund M. Anaesthesist. 2002.

Ileocecal valve as substitute for the missing pyloric sphincter after partial distal gastrectomy.

Metzger J; Degen LP; Beglinger C; Siegemund M; Studer W; Heberer M; Harder F; von Flüe MO. Annals of Surgery. 2002.

Intestinal and cerebral oxygenation during severe isovolemic hemodilution and subsequent hyperoxic ventilation in a pig model.

van Bommel J; Trouwborst A; Schwarte L; Siegemund M; Ince C; Henny ChP. Anesthesiology. 2002.

Opening the microcirculation: can vasodilators be useful in sepsis?

Buwalda, M; Ince, C. Neth J Crit Care. 2002.

Resuscitation from cardiac arrest with adrenaline/epinephrine or vasopressin: effects on intestinal mucosal tonometer pCO(2) during the postresuscitation period in rats.

Studer W; Wu X; Siegemund M; Seeberger M. Resuscitation. 2002.

The rationale for vasodilator therapy in sepsis

Siegemund,M; Racovitza,I; Ince,C. . 2002.

Critical hematocrit in intestinal tissue oxygenation during severe normovolemic hemodilution.

van Bommel J; Siegemund M; Henny CP; Trouwborst A; Ince C. Anesthesiology. 2001.

Gastric emptying rates following different types of reconstruction after partial gastrectomy

Metzger,J; Degen,L; Siegemund,M; Studer,W; Harder,F; von Flüe,M. . 2001.

Selective blockade of iNOS by 1400W restores the gut oxygenation in a pig model of low-dose endotoxemia

Siegemund,M; van Bommel,J; Schwarte,LA; Emons,M; Ince,C. . 2001.

The effect of the transfusion of stored RBCs on intestinal microvascular oxygenation in the rat.

van Bommel J; de Korte D; Lind A; Siegemund M; Trouwborst A; Verhoeven AJ; Ince C; Henny CP. Transfusion. 2001.

Preservation of intestinal microvascular Po2 during normovolemic hemodilution in a rat model.

van Bommel J; Siegemund M; Henny CP; van den Heuvel DA; Trouwborst A; Ince C. J LAB CLIN MED. 2000.

Assessment of regional tissue oxygenation.

Siegemund M; van Bommel J; Ince C. Intensive Care Medicine. 1999.

Initiating extradural analgesia during labour: comparison of three different bupivacaine concentrations used as the loading dose.

Harms C; Siegemund M; Marsch SC; Surbek DV; Hösli I; Schneider MC. Fetal Diagnosis and Therapy. 1999.

Systemic and mesenteric hemodynamics, metabolism, and intestinal tonometry in a rat model of supraceliac aortic cross-clamping and declamping.

Wu X; Siegemund M; Seeberger M; Studer W. Journal of cardiothoracic and vascular anesthesia. 1999.

Oxygen electrodes, optode microsensing, near infrared spectroscopy and spectrophotometry.

Siegemund,M; van Iterson,M; Ince,C. . 1998.

Oral anti-hypertensive drugs and anaesthesia

Siegemund; Martin. . 1997.

Oral anti-hypertensive drugs and anaesthesia

Siegemund M.. Bailliere's Clinical Anaesthesiology. 1997.

Reperfusion after supracoeliac aortic cross-clamping in a rat model: Effects of dopexamine on mesenteric oxygen transport, lactate flux and jejunal luminal PCO2

Wu X.; Studer W.; Siegemund M.; Seeberger M.; Scheidegger D.. British Journal of Anaesthesia. 1997.

Reperfusion after supracoeliac aortic cross-clamping in a rat model: Effects of fluid-loading on mesenteric oxygen transport, lactate flux and jejunal luminal PCO2

Wu X.; Studer W.; Siegemund M.; Seeberger M.; Scheidegger D.. British Journal of Anaesthesia. 1997.

Sytemic arterial hypertension

Siegemund; Martin. . 1997.

Extradural abscess complicating lumbar extradural anaesthesia and analgesia in an obstetric patient.

Kindler C; Seeberger M; Siegemund M; Schneider M. Acta anaesthesiologica Scandinavica. 1996.

Optimal concentration for an initial bolus of bupivacaine for extradural analgesia during labour

Siegemund,M; Harms,C; Hampl,KF; Marsch,SC; Schneider,MC. British Journal of Anaesthesia. 1996.

Epidural clonidine for relief from intractable labour pain.

Siegemund M; Schneider MC; Hampl KF; Hösli I. Anaesthesia. 1995.

Epidural clonidine for relief from intractable labour pain [2]

Siegemund M.; Schneider M.C.; Hampl K.F.; Hosli I.. Anaesthesia. 1995.