Klinische Forschung
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Publications Betz Matthias

Effect of high-dose glucocorticoid treatment on human brown adipose tissue activity: a randomised, double-blinded, placebo-controlled cross-over trial in healthy men.

Maushart CI; Sun W; Othman A; Ghosh A; Senn JR; Fischer JGW; Madoerin P; Loeliger RC; Benz RM; Takes M; Zech CJ; Chirindel A; Beuschlein F; Reincke M; Wild D; Bieri O; Zamboni N; Wolfrum C; Betz MJ. eBioMedicine. 2023.

Acute effect of propranolol on resting energy expenditure in hyperthyroid patients.

Senn JR; Löliger RC; Fischer JGW; Bur F; Maushart CI; Betz MJ. . 2022.

Adrenal venous sampling in the diagnostic workup of primary aldosteronism.

Betz MJ; Zech CJ. British Journal of Radiology. 2022.

Resting Energy Expenditure and Cold-induced Thermogenesis in Patients With Overt Hyperthyroidism.

Maushart CI; Senn JR; Loeliger RC; Siegenthaler J; Bur F; Fischer JGW; Betz MJ. Journal of Clinical Endocrinology and Metabolism. 2022.

Challenges in tackling energy expenditure as obesity therapy: From preclinical models to clinical application.

Löffler MC; Betz MJ; Blondin DP; Augustin R; Sharma AK; Tseng YH; Scheele C; Zimdahl H; Mark M; Hennige AM; Wolfrum C; Langhans W; Hamilton BS; Neubauer H. Molecular Metabolism. 2021.

Effects of interleukin-1 antagonism and corticosteroids on fibroblast growth factor-21 in patients with metabolic syndrome

Ebrahimi F.; Urwyler S.A.; Betz M.J.; Christ E.R.; Schuetz P.; Mueller B.; Donath M.Y.; Christ-Crain M.. Scientific Reports. 2021.

Fluvastatin Reduces Glucose Tolerance in Healthy Young Individuals Independently of Cold Induced BAT Activity.

Felder M; Maushart CI; Gashi G; Senn JR; Becker AS; Müller J; Balaz M; Wolfrum C; Burger IA; Betz MJ. Frontiers in endocrinology. 2021.

Free Thyroxine Levels are Associated with Cold Induced Thermogenesis in Healthy Euthyroid Individuals.

Maushart CI; Senn JR; Loeliger RC; Kraenzlin ME; Müller J; Becker AS; Balaz M; Wolfrum C; Burger IA; Betz MJ. Frontiers in endocrinology. 2021.

Relation of diet-induced thermogenesis to brown adipose tissue activity in healthy men.

Loeliger RC; Maushart CI; Gashi G; Senn JR; Felder M; Becker AS; Müller J; Balaz M; Wolfrum C; Burger IA; Betz MJ. American Journal of Physiology - Endocrinology and Metabolism. 2021.

Cold Exposure Distinctively Modulates Parathyroid and Thyroid Hormones in Cold-Acclimatized and Non-Acclimatized Humans.

Kovaničová Z; Kurdiová T; Baláž M; Štefanička P; Varga L; Kulterer OC; Betz MJ; Haug AR; Burger IA; Kiefer FW; Wolfrum C; Ukropcová B; Ukropec J. Endocrinology. 2020.

Comparison of [(18)F]FDG PET/CT with magnetic resonance imaging for the assessment of human brown adipose tissue activity.

Fischer JGW; Maushart CI; Becker AS; Müller J; Madoerin P; Chirindel A; Wild D; Ter Voert EEGW; Bieri O; Burger I; Betz MJ. EJNMMI Research. 2020.

Editorial: Current Challenges for Targeting Brown Fat Thermogenesis to Combat Obesity.

Yoneshiro T; Rodríguez-Rodríguez R; Betz MJ; Rensen PCN. . 2020.

Low-dose (18)F-FDG TOF-PET/MR for accurate quantification of brown adipose tissue in healthy volunteers.

Ter Voert EEGW; Svirydenka H; Müller J; Becker AS; Balaz M; Efthymiou V; Maushart CI; Gashi G; Wolfrum C; Betz MJ; Burger IA. EJNMMI Research. 2020.

Fibroblast growth factor 21 predicts outcome in community-acquired pneumonia: secondary analysis of two randomised controlled trials.

Ebrahimi F; Wolffenbuttel C; Blum CA; Baumgartner C; Mueller B; Schuetz P; Meier C; Kraenzlin M; Christ-Crain M; Betz MJ. European Respiratory Journal. 2019.

FOXK1 and FOXK2 regulate aerobic glycolysis.

Sukonina V; Ma H; Zhang W; Bartesaghi S; Subhash S; Heglind M; Foyn H; Betz MJ; Nilsson D; Lidell ME; Naumann J; Haufs-Brusberg S; Palmgren H; Mondal T; Beg M; Jedrychowski MP; Taskén K; Pfeifer A; Peng XR; Kanduri C; Enerbäck S. Nature. 2019.

Hypothyroidism manifesting as multiple cranial neuropathies: a case report.

Hepprich M; Lorscheider J; Peters N; Betz MJ. Journal of medical case reports. 2019.

Inhibition of Mevalonate Pathway Prevents Adipocyte Browning in Mice and Men by Affecting Protein Prenylation.

Balaz M; Becker AS; Balazova L; Straub L; Müller J; Gashi G; Maushart CI; Sun W; Dong H; Moser C; Horvath C; Efthymiou V; Rachamin Y; Modica S; Zellweger C; Bacanovic S; Stefanicka P; Varga L; Ukropcova B; Profant M; Opitz L; Amri EZ; Akula MK; Bergo M; Ukropec J; Falk C; Zamboni N; Betz MJ; Burger IA; Wolfrum C. Cell Metabolism. 2019.

MRI characteristics of supraclavicular brown adipose tissue in relation to cold-induced thermogenesis in healthy human adults.

Gashi G; Madoerin P; Maushart CI; Michel R; Senn JR; Bieri O; Betz MJ. Journal of Magnetic Resonance Imaging. 2019.

Proteomic Landscape of Aldosterone-Producing Adenoma.

Swierczynska MM; Betz MJ; Colombi M; Dazert E; Jenö P; Moes S; Pfaff C; Glatz K; Reincke M; Beuschlein F; Donath MY; Hall MN. Hypertension. 2019.

Resolution of Hypothyroidism Restores Cold-Induced Thermogenesis in Humans.

Maushart CI; Loeliger R; Gashi G; Christ-Crain M; Betz MJ. Thyroid. 2019.

The effect of exercise on intramyocellular acetylcarnitine (AcCtn) concentration in adult growth hormone deficiency (GHD).

Meienberg F; Loher H; Bucher J; Jenni S; Krüsi M; Kreis R; Boesch C; Betz MJ; Christ E. Scientific Reports. 2019.

Treatment of Primary Aldosteronism With mTORC1 Inhibitors.

Trinh B; Hepprich M; Betz MJ; Burkard T; Cavelti-Weder C; Seelig E; Meienberg F; Kratschmar DV; Beuschlein F; Reincke M; Odermatt A; Hall MN; Donath MY; Swierczynska MM. Journal of Clinical Endocrinology and Metabolism. 2019.

Copeptin levels and commonly used laboratory parameters in hospitalised patients with severe hypernatraemia - the "Co-MED study".

Nigro N; Winzeler B; Suter-Widmer I; Schuetz P; Arici B; Bally M; Refardt J; Betz M; Gashi G; Urwyler SA; Burget L; Blum CA; Bock A; Huber A; Müller B; Christ-Crain M. Critical Care. 2018.

FGF-21 levels in polyuria-polydipsia syndrome.

Refardt J; Sailer CO; Winzeler B; Betz MJ; Chifu I; Schnyder I; Fassnacht M; Fenske W; Christ-Crain M. Endocrine connections. 2018.

Outdoor Temperature Influences Cold Induced Thermogenesis in Humans.

Senn JR; Maushart CI; Gashi G; Michel R; Lalive d'Epinay M; Vogt R; Becker AS; Müller J; Baláz M; Wolfrum C; Burger IA; Betz MJ. Frontiers in Physiology. 2018.

Targeting thermogenesis in brown fat and muscle to treat obesity and metabolic disease

Betz, Matthias J.; Enerback, Sven. Nat Rev Endocrinol. 2018.

The Gq signalling pathway inhibits brown and beige adipose tissue.

Klepac K; Kilić A; Gnad T; Brown LM; Herrmann B; Wilderman A; Balkow A; Glöde A; Simon K; Lidell ME; Betz MJ; Enerbäck S; Wess J; Freichel M; Blüher M; König G; Kostenis E; Insel PA; Pfeifer A. Nature Communications. 2016.

Characterization of brown adipose tissue by water-fat separated magnetic resonance imaging.

Romu T; Elander L; Leinhard OD; Lidell ME; Betz MJ; Persson A; Enerbäck S; Borga M. Journal of Magnetic Resonance Imaging. 2015.

CT mapping of the vertebral level of right adrenal vein.

Degenhart C; Strube H; Betz MJ; Pallauf A; Bidlingmaier M; Fischer E; Reincke M; Reiser MF; Wirth S. Diagnostic and interventional radiology (Ankara, Turkey). 2015.

Human Brown Adipose Tissue: What We Have Learned So Far.

Betz MJ; Enerbäck S. Diabetes. 2015.

Adenosine activates brown adipose tissue and recruits beige adipocytes via A2A receptors.

Gnad T; Scheibler S; von Kügelgen I; Scheele C; Kilić A; Glöde A; Hoffmann LS; Reverte-Salisa L; Horn P; Mutlu S; El-Tayeb A; Kranz M; Deuther-Conrad W; Brust P; Lidell ME; Betz MJ; Enerbäck S; Schrader J; Yegutkin GG; Müller CE; Pfeifer A. Nature. 2014.

Brown adipose tissue and its therapeutic potential.

Lidell ME; Betz MJ; Enerbäck S. Journal of Internal Medicine. 2014.

Two types of brown adipose tissue in humans.

Lidell ME; Betz MJ; Enerbäck S. Adipocyte. 2014.

Evidence for two types of brown adipose tissue in humans.

Lidell ME; Betz MJ; Dahlqvist Leinhard O; Heglind M; Elander L; Slawik M; Mussack T; Nilsson D; Romu T; Nuutila P; Virtanen KA; Beuschlein F; Persson A; Borga M; Enerbäck S. Nature Medicine. 2013.

Evidence for two types of brown adipose tissue in humans.

Lidell ME; Betz MJ; Dahlqvist Leinhard O; Heglind M; Elander L; Slawik M; Mussack T; Nilsson D; Romu T; Nuutila P; Virtanen KA; Beuschlein F; Persson A; Borga M; Enerbäck S. Nature Medicine. 2013.

Presence of brown adipocytes in retroperitoneal fat from patients with benign adrenal tumors: relationship with outdoor temperature.

Betz MJ; Slawik M; Lidell ME; Osswald A; Heglind M; Nilsson D; Lichtenauer UD; Mauracher B; Mussack T; Beuschlein F; Enerbäck S. Journal of Clinical Endocrinology and Metabolism. 2013.

Isoenergetic feeding of low carbohydrate-high fat diets does not increase brown adipose tissue thermogenic capacity in rats.

Betz MJ; Bielohuby M; Mauracher B; Abplanalp W; Müller HH; Pieper K; Ramisch J; Tschöp MH; Beuschlein F; Bidlingmaier M; Slawik M. PLoS ONE. 2012.

Mc2 receptor knockdown modulates differentiation and lipid composition in adipocytes.

Betz MJ; Hatiboglu N; Mauracher B; Hadaschik D; Sauter A; Demmelmair H; Koletzko B; Beuschlein F; Slawik M. Hormone and Metabolic Research. 2012.

What dietary modification best improves insulin sensitivity and why?

Weickert MO. Clinical Endocrinology. 2012.

Adrenal vein sampling using rapid cortisol assays in primary aldosteronism is useful in centers with low success rates.

Betz MJ; Degenhart C; Fischer E; Pallauf A; Brand V; Linsenmaier U; Beuschlein F; Bidlingmaier M; Reincke M. European journal of endocrinology. 2011.

Therapeutic prospects of metabolically active brown adipose tissue in humans.

Betz MJ; Enerbäck S. Frontiers in endocrinology. 2011.

Sepsis and cardiomyopathy as rare clinical manifestations of pheochromocytoma--two case report studies.

Tanriver Y; Betz MJ; Nibbe L; Pfluger T; Beuschlein F; Strowski MZ. Experimental and Clinical Endocrinology and Diabetes. 2010.

Diagnosis: Novel molecular signatures for adrenocortical carcinoma.

Betz MJ; Beuschlein F. Nat Rev Endocrinol. 2009.

Physical activity and obesity

. MMW Fortschritte der Medizin. 2008.

Images in cardiovascular medicine. Acute pneumopericardium due to intestino-pericardial fistula.

Müller AM; Betz MJ; Kromeier J; Ghanem NA; Geibel A; Imdahl A; Frydrychowicz AP. Circulation. 2006.

Peroxisome proliferator-activated receptor-gamma agonists suppress adrenocortical tumor cell proliferation and induce differentiation.

Betz MJ; Shapiro I; Fassnacht M; Hahner S; Reincke M; Beuschlein F; German and Austrian Adrenal Network. Journal of Clinical Endocrinology and Metabolism. 2005.