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Publications Huwyler Jörg

[Abuse deterrent drug formulations for opioids].

Matter M; Mühlebach S; Puchkov M; Huwyler J. Therapeutische Umschau. Revue therapeutique. 2020.

Assessment of Sensor Concepts for 100% In-Process Control of Low-Volume Aseptic Fill-Finish Processes.

Dreckmann T; Aipperspach W; Pfleghar K; TrÖndle J; Ernst A; Huwyler J; Ludwig IS; Luemkemann J. PDA journal of pharmaceutical science and technology. 2020.

Bioinspired Molecular Factories with Architecture and In Vivo Functionalities as Cell Mimics.

Einfalt T; Garni M; Witzigmann D; Sieber S; Baltisberger N; Huwyler J; Meier W; Palivan CG. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2020.

Controlled Tyrosine Kinase Inhibitor Delivery to Liver Cancer Cells by Gate-Capped Mesoporous Silica Nanoparticles

Mahsa Sedighi; Fereshteh Rahimi; Mohammad-Ali Shahbazi; Ali Hossein; Rezayan; Helene Kettiger; Tomaz Einfalt; Jörg Huwyler; Dominik Witzigmann. . 2020.

Correction to: In Vivo Stability of Therapeutic Proteins.

Schuster J; Koulov A; Mahler HC; Detampel P; Huwyler J; Singh S; Mathaes R. . 2020.

Design, Synthesis, and Characterization of a Paclitaxel Formulation Activated by Extracellular MMP9.

Ehrsam D; Sieber S; Oufir M; Porta F; Hamburger M; Huwyler J; Meyer Zu Schwabedissen HE. BIOCONJUGATE CHEMISTRY. 2020.

Design and in vivo evaluation of a microparticulate depot formulation of buprenorphine for veterinary use.

Schreiner V; Durst M; Arras M; Detampel P; Jirkof P; Huwyler J. Scientific Reports. 2020.

DNA-directed arrangement of soft synthetic compartments and their behavior in vitro and in vivo.

Liu J; Craciun I; Belluati A; Wu D; Sieber S; Einfalt T; Witzigmann D; Chami M; Huwyler J; Palivan CG. Nanoscale. 2020.

Efficacy and Safety of Ascending Dosages of Moxidectin and Moxidectin-albendazole Against Trichuris trichiura in Adolescents: A Randomized Controlled Trial.

Keller L; Palmeirim MS; Ame SM; Ali SM; Puchkov M; Huwyler J; Hattendorf J; Keiser J. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2020.

Excipients for Room Temperature Stable Freeze-Dried Monoclonal Antibody Formulations.

Haeuser C; Goldbach P; Huwyler J; Friess W; Allmendinger A. JOURNAL OF PHARMACEUTICAL SCIENCES. 2020.

Impact of dextran on thermal properties, product quality attributes, and monoclonal antibody stability in freeze-dried formulations.

Haeuser C; Goldbach P; Huwyler J; Friess W; Allmendinger A. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 2020.

Impact of Insoluble Separation Layer Mechanical Properties on Disintegration and Dissolution Kinetics of Multilayer Tablets.

Yokoyama R; Kimura G; Huwyler J; Hosoya KI; Puchkov M. Pharmaceutics. 2020.

Improvement of DNA Vector Delivery of DOTAP Lipoplexes by Short-Chain Aminolipids.

Buck J; Mueller D; Mettal U; Ackermann M; Grisch-Chan HM; Thöny B; Zumbuehl A; Huwyler J; Witzigmann D. ACS Omega. 2020.

In Vivo Stability of Therapeutic Proteins.

Schuster J; Koulov A; Mahler HC; Detampel P; Huwyler J; Singh S; Mathaes R. PHARMACEUTICAL RESEARCH. 2020.

Low volume aseptic filling: Impact of pump systems on shear stress.

Dreckmann T; Boeuf J; Ludwig IS; Lümkemann J; Huwyler J. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 2020.

Low-Volume Aseptic Filling Using a Linear Peristaltic Pump.

Dreckmann T; Ludwig IS; Luemkemann J; Huwyler J. PDA journal of pharmaceutical science and technology. 2020.

Mechanisms of increased bioavailability through amorphous solid dispersions: a review.

Schittny A; Huwyler J; Puchkov M. DRUG DELIVERY. 2020.

Mechanistic insights into effect of surfactants on oral bioavailability of amorphous solid dispersions.

Schittny A; Philipp-Bauer S; Detampel P; Huwyler J; Puchkov M. JOURNAL OF CONTROLLED RELEASE. 2020.

Particle Analysis of Biotherapeutics in Human Serum Using Machine Learning.

Schuster J; Koulov A; Mahler HC; Joerg S; Huwyler J; Schleicher K; Detampel P; Mathaes R. JOURNAL OF PHARMACEUTICAL SCIENCES. 2020.

Pharmacokinetics and phenotyping properties of the Basel phenotyping cocktail combination capsule in healthy male adults.

Suenderhauf C; Berger B; Puchkov M; Schmid Y; Müller S; Huwyler J; Haschke M; Krähenbühl S; Duthaler U. British journal of clinical pharmacology. 2020.

Protein-Polydimethylsiloxane Particles in Liquid Vial Monoclonal Antibody Formulations Containing Poloxamer 188.

Grapentin C; Müller C; Kishore RSK; Adler M; ElBialy I; Friess W; Huwyler J; Khan TA. JOURNAL OF PHARMACEUTICAL SCIENCES. 2020.

Shedding Light on Metal-Based Nanoparticles in Zebrafish by Computed Tomography with Micrometer Resolution

Corek E.; Rodgers G.; Siegrist S.; Einfalt T.; Detampel P.; Schleputz C.M.; Sieber S.; Fluder P.; Schulz G.; Unterweger H.; Alexiou C.; Muller B.; Puchkov M.; Huwyler J.. Small. 2020.

Spontaneous In Situ Formation of Liposomes from Inert Porous Microparticles for Oral Drug Delivery.

Farzan M; Québatte G; Strittmatter K; Hilty FM; Schoelkopf J; Huwyler J; Puchkov M. Pharmaceutics. 2020.

Stabilizing Polysorbate 20 and 80 Against Oxidative Degradation.

Schmidt A; Koulov A; Huwyler J; Mahler HC; Jahn M. JOURNAL OF PHARMACEUTICAL SCIENCES. 2020.

Study of drug particle distributions within mini-tablets using synchrotron X-ray microtomography and superpixel image clustering.

Wagner-Hattler L; Québatte G; Keiser J; Schoelkopf J; Schlepütz CM; Huwyler J; Puchkov M. INTERNATIONAL JOURNAL OF PHARMACEUTICS. 2020.

Subvisible Particulate Contamination in Cell Therapy Products-Can We Distinguish?

Vollrath I; Mathaes R; Sediq AS; Jere D; Jörg S; Huwyler J; Mahler HC. JOURNAL OF PHARMACEUTICAL SCIENCES. 2020.

The use of 4-Hexylresorcinol as antibiotic adjuvant.

Nikolaev YA; Tutel'yan AV; Loiko NG; Buck J; Sidorenko SV; Lazareva I; Gostev V; Manzen'yuk OY; Shemyakin IG; Abramovich RA; Huwyler J; El'-Registan GI. PLoS One. 2020.

Tracking the physical stability of fluorescent-labeled mAbs under physiologic in vitro conditions in human serum and PBS.

Schuster J; Mahler HC; Koulov A; Joerg S; Racher A; Huwyler J; Detampel P; Mathaes R. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 2020.

<i>In Vitro</i> and <i>In Vivo</i> Drug-Drug Interaction Study of the Effects of Ivermectin and Oxantel Pamoate on Tribendimidine.

Neodo A; Schulz JD; Huwyler J; Keiser J. Antimicrobial agents and chemotherapy. 2019.

Be Aggressive! Amorphous Excipients Enabling Single-Step Freeze-Drying of Monoclonal Antibody Formulations.

Haeuser C; Goldbach P; Huwyler J; Friess W; Allmendinger A. Pharmaceutics. 2019.

Insights into possibilities for grouping and read-across for nanomaterials in EU chemicals legislation.

Mech A; Rasmussen K; Jantunen P; Aicher L; Alessandrelli M; Bernauer U; Bleeker EAJ; Bouillard J; Di Prospero Fanghella P; Draisci R; Dusinska M; Encheva G; Flament G; Haase A; Handzhiyski Y; Herzberg F; Huwyler J; Jacobsen NR; Jeliazkov V; Jeliazkova N; Nymark P; Grafström R; Oomen AG; Polci ML; Riebeling C; Sandström J; Shivachev B; Stateva S; Tanasescu S; Tsekovska R; Wallin H; Wilks MF; Zellmer S; Apostolova MD. Nanotoxicology. 2019.

Lipid-Based DNA Therapeutics: Hallmarks of Non-Viral Gene Delivery.

Buck J; Grossen P; Cullis PR; Huwyler J; Witzigmann D. ACS nano. 2019.

Loading of Porous Functionalized Calcium Carbonate Microparticles: Distribution Analysis with Focused Ion Beam Electron Microscopy and Mercury Porosimetry.

Farzan M; Roth R; Québatte G; Schoelkopf J; Huwyler J; Puchkov M. Pharmaceutics. 2019.

Microdosed midazolam for the determination of cytochrome P450 3A activity: Development and clinical evaluation of a buccal film.

Kiene K; Hayasi N; Burhenne J; Uchitomi R; Sünderhauf C; Schmid Y; Haschke M; Haefeli WE; Krähenbühl S; Mikus G; Inada H; Huwyler J. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. 2019.

Optimization-by-design of hepatotropic lipid nanoparticles targeting the sodium-taurocholate cotransporting polypeptide.

Witzigmann D; Uhl P; Sieber S; Kaufman C; Einfalt T; Schöneweis K; Grossen P; Buck J; Ni Y; Schenk SH; Hussner J; Meyer Zu Schwabedissen HE; Québatte G; Mier W; Urban S; Huwyler J. Elife. 2019.

Poly(Sarcosine) Surface Modification Imparts Stealth-Like Properties to Liposomes.

Bleher S; Buck J; Muhl C; Sieber S; Barnert S; Witzigmann D; Huwyler J; Barz M; Süss R. Small. 2019.

Pooled Population Pharmacokinetic Analysis of Tribendimidine for the Treatment of <i>Opisthorchis viverrini</i> Infections.

Meister I; Assawasuwannakit P; Vanobberghen F; Penny MA; Odermatt P; Sayasone S; Huwyler J; Tarning J; Keiser J. Antimicrobial agents and chemotherapy. 2019.

Preclinical hazard evaluation strategy for nanomedicines.

Siegrist S; Cörek E; Detampel P; Sandström J; Wick P; Huwyler J. Nanotoxicology. 2019.

Rapid optimization of liposome characteristics using a combined microfluidics and design-of-experiment approach.

Sedighi M; Sieber S; Rahimi F; Shahbazi MA; Rezayan AH; Huwyler J; Witzigmann D. Drug Delivery and Translational Research. 2019.

Stability investigation of FCC-based tablets for oral suspension with caffeine and oxantel pamoate as model drugs.

Wagner-Hattler L; Schoelkopf J; Huwyler J; Puchkov M. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY. 2019.

Zebrafish as a preclinical in vivo screening model for nanomedicines.

Sieber S; Grossen P; Bussmann J; Campbell F; Kros A; Witzigmann D; Huwyler J. ADVANCED DRUG DELIVERY REVIEWS. 2019.

Zebrafish as a predictive screening model to assess macrophage clearance of liposomes in vivo.

Sieber S; Grossen P; Uhl P; Detampel P; Mier W; Witzigmann D; Huwyler J. Nanomedicine-Nanotechnology Biology and Medicine. 2019.

A combined mathematical model linking the formation of amorphous solid dispersions with hot-melt-extrusion process parameters.

Schittny A; Ogawa H; Huwyler J; Puchkov M. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 2018.

Biomimetic artificial organelles with in vitro and in vivo activity triggered by reduction in microenvironment.

Einfalt T; Witzigmann D; Edlinger C; Sieber S; Goers R; Najer A; Spulber M; Onaca-Fischer O; Huwyler J; Palivan CG. Nature Communications. 2018.

Characterization of surface properties of glass vials used as primary packaging material for parenterals.

Ditter D; Mahler HC; Roehl H; Wahl M; Huwyler J; Nieto A; Allmendinger A. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 2018.

Directing Nanoparticle Biodistribution through Evasion and Exploitation of Stab2-Dependent Nanoparticle Uptake.

Campbell F; Bos FL; Sieber S; Arias-Alpizar G; Koch BE; Huwyler J; Kros A; Bussmann J. ACS nano. 2018.

Efficacy and Safety of Ivermectin Against Trichuris trichiura in Preschool-aged and School-aged Children: A Randomized Controlled Dose-finding Trial.

Wimmersberger D; Coulibaly JT; Schulz JD; Puchkow M; Huwyler J; N'Gbesso Y; Hattendorf J; Keiser J. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2018.

Efficacy and tolerability of moxidectin alone and in co-administration with albendazole and tribendimidine versus albendazole plus oxantel pamoate against Trichuris trichiura infections: a randomised, non-inferiority, single-blind trial.

Barda B; Ame SM; Ali SM; Albonico M; Puchkov M; Huwyler J; Hattendorf J; Keiser J. The Lancet. Infectious diseases. 2018.

Efficacy and tolerability of triple drug therapy with albendazole, pyrantel pamoate, and oxantel pamoate compared with albendazole plus oxantel pamoate, pyrantel pamoate plus oxantel pamoate, and mebendazole plus pyrantel pamoate and oxantel pamoate against hookworm infections in school-aged children in Laos: a randomised, single-blind trial.

Moser W; Sayasone S; Xayavong S; Bounheuang B; Puchkov M; Huwyler J; Hattendorf J; Keiser J. The Lancet. Infectious diseases. 2018.

Evaluation of Glass Delamination Risk in Pharmaceutical 10 mL/10R Vials.

Ditter D; Nieto A; Mahler HC; Roehl H; Wahl M; Huwyler J; Allmendinger A. JOURNAL OF PHARMACEUTICAL SCIENCES. 2018.

Functionalized calcium carbonate microparticles for the delivery of proteins.

Roth R; Schoelkopf J; Huwyler J; Puchkov M. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 2018.

Imaging Techniques to Characterize Cake Appearance of Freeze-Dried Products.

Haeuser C; Goldbach P; Huwyler J; Friess W; Allmendinger A. JOURNAL OF PHARMACEUTICAL SCIENCES. 2018.

Impact of non-ideal analyte behavior on the separation of protein aggregates by asymmetric flow field-flow fractionation.

Boll B; Josse L; Heubach A; Hochenauer S; Finkler C; Huwyler J; Koulov AV. JOURNAL OF SEPARATION SCIENCE. 2018.

Impact of Vial Washing and Depyrogenation on Surface Properties and Delamination Risk of Glass Vials.

Ditter D; Mahler HC; Gohlke L; Nieto A; Roehl H; Huwyler J; Wahl M; Allmendinger A. PHARMACEUTICAL RESEARCH. 2018.

Modeling of Disintegration and Dissolution Behavior of Mefenamic Acid Formulation Using Numeric Solution of Noyes-Whitney Equation with Cellular Automata on Microtomographic and Algorithmically Generated Surfaces.

Yokoyama R; Kimura G; Schlepütz CM; Huwyler J; Puchkov M. Pharmaceutics. 2018.

Pharmacokinetics of a Pediatric Tribendimidine Dose-Finding Study To Treat Hookworm Infection in African Children.

Hiroshige N; Coulibaly J; Huwyler J; Bonate PL; Keiser J. Antimicrobial agents and chemotherapy. 2018.

A Method To Determine the Kinetics of Solute Mixing in Liquid/Liquid Formulation Dual-Chamber Syringes.

Werk T; Mahler HC; Ludwig IS; Luemkemann J; Huwyler J; Hafner M. PDA JOURNAL OF PHARMACEUTICAL SCIENCE AND TECHNOLOGY. 2017.

Assessing the Risk of Drug-Induced Cholestasis Using Unbound Intrahepatic Concentrations.

Riede J; Poller B; Huwyler J; Camenisch G. DRUG METABOLISM AND DISPOSITION. 2017.

Characterization of new functionalized calcium carbonate-polycaprolactone composite material for application in geometry-constrained drug release formulation development.

Wagner-Hattler L; Schoelkopf J; Huwyler J; Puchkov M. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY. 2017.

Current In Vitro Methods to Determine Hepatic Kp<sub>uu</sub>: A Comparison of Their Usefulness and Limitations.

Riede J; Camenisch G; Huwyler J; Poller B. JOURNAL OF PHARMACEUTICAL SCIENCES. 2017.

Efficacy and safety of tribendimidine, tribendimidine plus ivermectin, tribendimidine plus oxantel pamoate, and albendazole plus oxantel pamoate against hookworm and concomitant soil-transmitted helminth infections in Tanzania and Côte d'Ivoire: a randomised, controlled, single-blinded, non-inferiority trial.

Moser W; Coulibaly JT; Ali SM; Ame SM; Amour AK; Yapi RB; Albonico M; Puchkov M; Huwyler J; Hattendorf J; Keiser J. The Lancet. Infectious diseases. 2017.

Efficacy of Moxidectin Versus Ivermectin Against Strongyloides stercoralis Infections: A Randomized, Controlled Noninferiority Trial.

Barda B; Sayasone S; Phongluxa K; Xayavong S; Keoduangsy K; Odermatt P; Puchkov M; Huwyler J; Hattendorf J; Keiser J. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2017.

Extensive Chemical Modifications in the Primary Protein Structure of IgG1 Subvisible Particles Are Necessary for Breaking Immune Tolerance.

Boll B; Bessa J; Folzer E; Ríos Quiroz A; Schmidt R; Bulau P; Finkler C; Mahler HC; Huwyler J; Iglesias A; Koulov AV. MOLECULAR PHARMACEUTICS. 2017.

Immobilization of Enzymes on PLGA Sub-Micrometer Particles by Crosslinked Layer-by-Layer Deposition.

Sieber S; Siegrist S; Schwarz S; Porta F; Schenk SH; Huwyler J. MACROMOLECULAR BIOSCIENCE. 2017.

In vitro characterization and mouthfeel study of functionalized calcium carbonate in orally disintegrating tablets.

Wagner-Hattler L; Wyss K; Schoelkopf J; Huwyler J; Puchkov M. INTERNATIONAL JOURNAL OF PHARMACEUTICS. 2017.

Oral delivery of vancomycin by tetraether lipid liposomes.

Uhl P; Pantze S; Storck P; Parmentier J; Witzigmann D; Hofhaus G; Huwyler J; Mier W; Fricker G. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. 2017.

PDMS-b-PMOXA polymersomes for hepatocyte targeting and assessment of toxicity.

Kiene K; Schenk SH; Porta F; Ernst A; Witzigmann D; Grossen P; Huwyler J. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 2017.

PEG-PCL-based nanomedicines: A biodegradable drug delivery system and its application.

Grossen P; Witzigmann D; Sieber S; Huwyler J. JOURNAL OF CONTROLLED RELEASE. 2017.

Selective stimulation of the JAK/STAT signaling pathway by silica nanoparticles in human endothelial cells.

Siegrist S; Kettiger H; Fasler-Kan E; Huwyler J. TOXICOLOGY IN VITRO. 2017.

Zebrafish as an early stage screening tool to study the systemic circulation of nanoparticulate drug delivery systems in vivo.

Sieber S; Grossen P; Detampel P; Siegfried S; Witzigmann D; Huwyler J. JOURNAL OF CONTROLLED RELEASE. 2017.

CombiCap: A novel drug formulation for the basel phenotyping cocktail.

Camblin M; Berger B; Haschke M; Krähenbühl S; Huwyler J; Puchkov M. INTERNATIONAL JOURNAL OF PHARMACEUTICS. 2016.

Development and validation of an enantioselective LC-MS/MS method for the analysis of the anthelmintic drug praziquantel and its main metabolite in human plasma, blood and dried blood spots.

Meister I; Leonidova A; Kovač J; Duthaler U; Keiser J; Huwyler J. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. 2016.

Efficacy and Safety of Moxidectin, Synriam, Synriam-Praziquantel versus Praziquantel against Schistosoma haematobium and S. mansoni Infections: A Randomized, Exploratory Phase 2 Trial.

Barda B; Coulibaly JT; Puchkov M; Huwyler J; Hattendorf J; Keiser J. PLoS Neglected Tropical Diseases. 2016.

Efficacy and safety of oxantel pamoate in school-aged children infected with Trichuris trichiura on Pemba Island, Tanzania: a parallel, randomised, controlled, dose-ranging study.

Moser W; Ali SM; Ame SM; Speich B; Puchkov M; Huwyler J; Albonico M; Hattendorf J; Keiser J. The Lancet. Infectious diseases. 2016.

Factors Governing the Accuracy of Subvisible Particle Counting Methods.

Ríos Quiroz A; Finkler C; Huwyler J; Mahler HC; Schmidt R; Koulov AV. JOURNAL OF PHARMACEUTICAL SCIENCES. 2016.

Factors Governing the Precision of Subvisible Particle Measurement Methods - A Case Study with a Low-Concentration Therapeutic Protein Product in a Prefilled Syringe.

Ríos Quiroz A; Lamerz J; Da Cunha T; Boillon A; Adler M; Finkler C; Huwyler J; Schmidt R; Mahler HC; Koulov AV. PHARMACEUTICAL RESEARCH. 2016.

Impact of Vial Capping on Residual Seal Force and Container Closure Integrity.

Mathaes R; Mahler HC; Roggo Y; Ovadia R; Lam P; Stauch O; Vogt M; Roehl H; Huwyler J; Mohl S; Streubel A. PDA JOURNAL OF PHARMACEUTICAL SCIENCE AND TECHNOLOGY. 2016.

Influence of Different Container Closure Systems and Capping Process Parameters on Product Quality and Container Closure Integrity (CCI) in GMP Drug Product Manufacturing.

Mathaes R; Mahler HC; Roggo Y; Huwyler J; Eder J; Fritsch K; Posset T; Mohl S; Streubel A. PDA JOURNAL OF PHARMACEUTICAL SCIENCE AND TECHNOLOGY. 2016.

In silico and in vitro methods to optimize the performance of experimental gastroretentive floating mini-tablets.

Eberle VA; Häring A; Schoelkopf J; Gane PA; Huwyler J; Puchkov M. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY. 2016.

Interactions between silica nanoparticles and phospholipid membranes.

Kettiger H; Québatte G; Perrone B; Huwyler J. Biochimica et biophysica acta. 2016.

Mucoadhesive microparticles for local treatment of gastrointestinal diseases.

Preisig D; Roth R; Tognola S; Varum FJ; Bravo R; Cetinkaya Y; Huwyler J; Puchkov M. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 2016.

New IVIVE method for the prediction of total human clearance and relative elimination pathway contributions from in vitro hepatocyte and microsome data.

Riede J; Poller B; Umehara K; Huwyler J; Camenisch G. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. 2016.

New Processes for Freeze-Drying in Dual-Chamber Systems.

Werk T; Ludwig IS; Luemkemann J; Huwyler J; Mahler HC; Haeuser CR; Hafner M. PDA JOURNAL OF PHARMACEUTICAL SCIENCE AND TECHNOLOGY. 2016.

Pediatric Dispersible Tablets: a Modular Approach for Rapid Prototyping.

Buck J; Huwyler J; Kühl P; Dischinger A. PHARMACEUTICAL RESEARCH. 2016.

Pharmacokinetics of the Antischistosomal Lead Ozonide OZ418 in Uninfected Mice Determined by Liquid Chromatography-Tandem Mass Spectrometry.

Leonidova A; Vargas M; Huwyler J; Keiser J. Antimicrobial agents and chemotherapy. 2016.

Pharmacokinetic Study of Praziquantel Enantiomers and Its Main Metabolite R-trans-4-OH-PZQ in Plasma, Blood and Dried Blood Spots in Opisthorchis viverrini-Infected Patients.

Meister I; Kovac J; Duthaler U; Odermatt P; Huwyler J; Vanobberghen F; Sayasone S; Keiser J. PLoS Neglected Tropical Diseases. 2016.

Secreted Matrix Metalloproteinase-9 of Proliferating Smooth Muscle Cells as a Trigger for Drug Release from Stent Surface Polymers in Coronary Arteries.

Gliesche DG; Hussner J; Witzigmann D; Porta F; Glatter T; Schmidt A; Huwyler J; Meyer Zu Schwabedissen HE. MOLECULAR PHARMACEUTICS. 2016.

Single-Ascending-Dose Pharmacokinetic Study of Tribendimidine in Opisthorchis viverrini-Infected Patients.

Duthaler U; Sayasone S; Vanobbergen F; Penny MA; Odermatt P; Huwyler J; Keiser J. Antimicrobial agents and chemotherapy. 2016.

Technology, Applications, and Process Challenges of Dual Chamber Systems.

Werk T; Ludwig IS; Luemkemann J; Mahler HC; Huwyler J; Hafner M. JOURNAL OF PHARMACEUTICAL SCIENCES. 2016.

The Effect of Formulation, Process, and Method Variables on the Reconstitution Time in Dual Chamber Syringes.

Werk T; Ludwig IS; Mahler HC; Luemkemann J; Huwyler J; Hafner M. PDA JOURNAL OF PHARMACEUTICAL SCIENCE AND TECHNOLOGY. 2016.

The Pharmaceutical Capping Process-Correlation between Residual Seal Force, Torque Moment, and Flip-off Removal Force.

Mathaes R; Mahler HC; Vorgrimler L; Steinberg H; Dreher S; Roggo Y; Nieto A; Brown H; Roehl H; Adler M; Luemkemann J; Huwyler J; Lam P; Stauch O; Mohl S; Streubel A. PDA JOURNAL OF PHARMACEUTICAL SCIENCE AND TECHNOLOGY. 2016.

The pharmaceutical vial capping process: Container closure systems, capping equipment, regulatory framework, and seal quality tests.

Mathaes R; Mahler HC; Buettiker JP; Roehl H; Lam P; Brown H; Luemkemann J; Adler M; Huwyler J; Streubel A; Mohl S. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 2016.

Variable asialoglycoprotein receptor 1 expression in liver disease: Implications for therapeutic intervention.

Witzigmann D; Quagliata L; Schenk SH; Quintavalle C; Terracciano LM; Huwyler J. HEPATOLOGY RESEARCH. 2016.

An Impedance-Based Method to Determine Reconstitution Time for Freeze-Dried Pharmaceuticals.

Werk T; Huwyler J; Hafner M; Luemkemann J; Mahler HC. JOURNAL OF PHARMACEUTICAL SCIENCES. 2015.

Application of the extended clearance concept classification system (ECCCS) to predict the victim drug-drug interaction potential of statins.

Kunze A; Poller B; Huwyler J; Camenisch G. Drug metabolism and personalized therapy. 2015.

ATP-induced cellular stress and mitochondrial toxicity in cells expressing purinergic P2X7 receptor.

Seeland S; Kettiger H; Murphy M; Treiber A; Giller J; Kiss A; Sube R; Krähenbühl S; Hafner M; Huwyler J. Pharmacology research &amp; perspectives. 2015.

Biocompatible polymer-Peptide hybrid-based DNA nanoparticles for gene delivery.

Witzigmann D; Wu D; Schenk SH; Balasubramanian V; Meier W; Huwyler J. ACS Applied Materials & Interfaces. 2015.

Comparative Evaluation of Two Methods for Preparative Fractionation of Proteinaceous Subvisible Particles--Differential Centrifugation and FACS.

Boll B; Folzer E; Finkler C; Huwyler J; Mahler HC; Schmidt R; Koulov AV. PHARMACEUTICAL RESEARCH. 2015.

Comparative safety evaluation of silica-based particles.

Kettiger H; Sen Karaman D; Schiesser L; Rosenholm JM; Huwyler J. TOXICOLOGY IN VITRO. 2015.

Determination of the Density of Protein Particles Using a Suspended Microchannel Resonator.

Folzer E; Khan TA; Schmidt R; Finkler C; Huwyler J; Mahler HC; Koulov AV. JOURNAL OF PHARMACEUTICAL SCIENCES. 2015.

Efficacy and safety of albendazole plus ivermectin, albendazole plus mebendazole, albendazole plus oxantel pamoate, and mebendazole alone against Trichuris trichiura and concomitant soil-transmitted helminth infections: a four-arm, randomised controlled trial.

Speich B; Ali SM; Ame SM; Bogoch II; Alles R; Huwyler J; Albonico M; Hattendorf J; Utzinger J; Keiser J. The Lancet. Infectious diseases. 2015.

LC-MS/MS method for the determination of two metabolites of tribendimidine, deacylated amidantel and its acetylated metabolite in plasma, blood and dried blood spots.

Duthaler U; Keiser J; Huwyler J. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. 2015.

Marker-ion analysis for quantification of mucoadhesivity of microparticles in particle-retention assays.

Preisig D; Weingartner M; Varum FJ; Bravo R; Alles R; Huwyler J; Puchkov M. INTERNATIONAL JOURNAL OF PHARMACEUTICS. 2015.

Measuring Subvisible Particles in Protein Formulations Using a Modified Light Obscuration Sensor with Improved Detection Capabilities.

Ríos Quiroz A; Québatte G; Stump F; Finkler C; Huwyler J; Schmidt R; Mahler HC; Koulov AV; Adler M. ANALYTICAL CHEMISTRY. 2015.

Measuring tissue back-pressure--in vivo injection forces during subcutaneous injection.

Allmendinger A; Mueller R; Schwarb E; Chipperfield M; Huwyler J; Mahler HC; Fischer S. PHARMACEUTICAL RESEARCH. 2015.

Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases.

Jaeschke G; Kolczewski S; Spooren W; Vieira E; Bitter-Stoll N; Boissin P; Borroni E; Büttelmann B; Ceccarelli S; Clemann N; David B; Funk C; Guba W; Harrison A; Hartung T; Honer M; Huwyler J; Kuratli M; Niederhauser U; Pähler A; Peters JU; Petersen A; Prinssen E; Ricci A; Rueher D; Rueher M; Schneider M; Spurr P; Stoll T; Tännler D; Wichmann J; Porter RH; Wettstein JG; Lindemann L. Journal of medicinal chemistry. 2015.

Nanomedicine in cancer therapy: challenges, opportunities, and clinical applications.

Wicki A; Witzigmann D; Balasubramanian V; Huwyler J. JOURNAL OF CONTROLLED RELEASE. 2015.

Scientific Basis for Regulatory Decision-Making of Nanomaterials Report on the Workshop, 20-21 January 2014, Center of Applied Ecotoxicology, Dübendorf.

Studer C; Aicher L; Gasic B; von Goetz N; Hoet P; Huwyler J; Kägi R; Kase R; Kobe A; Nowack B; Rothen-Rutishauser B; Schirmer K; Schneider G; Vermeissen E; Wick P; Walser T. CHIMIA. 2015.

Selective Oxidation of Methionine and Tryptophan Residues in a Therapeutic IgG1 Molecule.

Folzer E; Diepold K; Bomans K; Finkler C; Schmidt R; Bulau P; Huwyler J; Mahler HC; Koulov AV. JOURNAL OF PHARMACEUTICAL SCIENCES. 2015.

Sterile Filtration of Highly Concentrated Protein Formulations: Impact of Protein Concentration, Formulation Composition, and Filter Material.

Allmendinger A; Mueller R; Huwyler J; Mahler HC; Fischer S. JOURNAL OF PHARMACEUTICAL SCIENCES. 2015.