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Klinische Forschung
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Publications Huwyler Jörg

Core-Shell Structured Chitosan-Polyethylenimine Nanoparticles for Gene Delivery: Improved Stability, Cellular Uptake, and Transfection Efficiency.

Casper J; Nicolle L; Willimann M; Kuzucu EÜ; Tran A; Robin P; Detampel P; Grisch-Chan HM; Thöny B; Huwyler J; Gerber-Lemaire S. Macromolecular bioscience. 2023.

A Scoping Review on the Therapeutic Potential of Resin From the Species Larix decidua Mill. [Pinaceae] to Treat Ulcerating Wounds

Batista J.V.C.; Uecker A.; Holandino C.; Boylan F.; Maier J.; Huwyler J.; Baumgartner S.. Frontiers in Pharmacology. 2022.

Comparative hard x-ray tomography for virtual histology of zebrafish larva, human tooth cementum, and porcine nerve.

Migga A; Schulz G; Rodgers G; Osterwalder M; Tanner C; Blank H; Jerjen I; Salmon P; Twengström W; Scheel M; Weitkamp T; Schlepütz CM; Bolten JS; Huwyler J; Hotz G; Madduri S; Müller B. Journal of medical imaging (Bellingham, Wash.). 2022.

Incorporation of phosphatidylserine improves efficiency of lipid based gene delivery systems

Lotter C.; Alter C.L.; Bolten J.S.; Detampel P.; Palivan C.G.; Einfalt T.; Huwyler J.. European Journal of Pharmaceutics and Biopharmaceutics. 2022.

In vivo acoustic manipulation of microparticles in zebrafish embryos

Jooss V.M.; Bolten J.S.; Huwyler J.; Ahmed D.. Science Advances. 2022.

Magnesium sensing via LFA-1 regulates CD8(+) T cell effector function.

Lötscher J; Martí I Líndez AA; Kirchhammer N; Cribioli E; Giordano Attianese GMP; Trefny MP; Lenz M; Rothschild SI; Strati P; Künzli M; Lotter C; Schenk SH; Dehio P; Löliger J; Litzler L; Schreiner D; Koch V; Page N; Lee D; Grählert J; Kuzmin D; Burgener AV; Merkler D; Pless M; Balmer ML; Reith W; Huwyler J; Irving M; King CG; Zippelius A; Hess C. Cell. 2022.

Sodium arsenite but not aluminum chloride stimulates ABC transporter activity in renal proximal tubules of killifish (Fundulus heteroclitus)

Oezen G.; Schentarra E.-M.; Bolten J.S.; Huwyler J.; Fricker G.. Aquatic Toxicology. 2022.

Zebrafish (Danio rerio) larva as an in vivo vertebrate model to study renal function

Bolten J.S.; Pratsinis A.; Alter C.L.; Fricker G.; Huwyler J.. American Journal of Physiology - Renal Physiology. 2022.

4-Hydroxynonenal - A Toxic Leachable from Clinically Used Administration Materials.

Schröter A; Mahler HC; Sayed NB; Koulov AV; Huwyler J; Jahn M. Journal of Pharmaceutical Sciences. 2021.

4-Hydroxynonenal is An Oxidative Degradation Product of Polysorbate 80.

Schröter A; Koulov AV; Huwyler J; Mahler HC; Jahn M. Journal of Pharmaceutical Sciences. 2021.

Analytical Challenges Assessing Protein Aggregation and Fragmentation Under Physiologic Conditions.

Schuster J; Mahler HC; Joerg S; Huwyler J; Mathaes R. Journal of Pharmaceutical Sciences. 2021.

Assessing Particle Formation of Biotherapeutics in Biological Fluids.

Schuster J; Probst CE; Mahler HC; Joerg S; Huwyler J; Mathaes R. Journal of Pharmaceutical Sciences. 2021.

Buprenorphine loaded PLGA microparticles: Characterization of a sustained-release formulation

Schreiner V.; Detampel P.; Jirkof P.; Puchkov M.; Huwyler J.. Journal of Drug Delivery Science and Technology. 2021.

Buprenorphine loaded PLGA microparticles: Characterization of a sustained-release formulation

Schreiner, Viktoria; Detampel, Pascal; Jirkof, Paulin; Puchkov, Maxim; Huwyler, Jörg. . 2021.

Challenges for Cell-Based Medicinal Products From a Pharmaceutical Product Perspective.

Jere D; Sediq AS; Huwyler J; Vollrath I; Kardorff M; Mahler HC. Journal of Pharmaceutical Sciences. 2021.

Colonic delivery of metronidazole-loaded capsules for local treatment of bacterial infections: A clinical pharmacoscintigraphy study.

Preisig D; Varum F; Bravo R; Hartig C; Spleiss J; Abbes S; Caobelli F; Wild D; Puchkov M; Huwyler J; Haschke M. European Journal of Pharmaceutics and Biopharmaceutics. 2021.

Development of Covalent Chitosan-Polyethylenimine Derivatives as Gene Delivery Vehicle: Synthesis, Characterization, and Evaluation.

Nicolle L; Casper J; Willimann M; Journot CMA; Detampel P; Einfalt T; Grisch-Chan HM; Thöny B; Gerber-Lemaire S; Huwyler J. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021.

Hard X-ray microtomography of Zebrafish larvae

Osterwalder M.; Bolten J.S.; Rodgers G.; Humbel M.; Schulz G.; Tanner C.; Huwyler J.; Muller B.. . 2021.

High Acceptability of an Orally Dispersible Tablet Formulation by Children.

Wagner-Hattler L; Kiene K; Bielicki J; Pfister M; Puchkov M; Huwyler J. Children. 2021.

Hydroxychloroquine Immediate Release Tablets: Formulation and Evaluation of a Solid Dosage Form

Einfalt, Tomaz, Detampel, Pascal; Häussinger, Daniel; Casper, Jens; Meier, Christoph R.; Puchkov, Maxim; Huwyler, Jörg. . 2021.

Identification of an Oxidizing Leachable from a Clinical Syringe Rubber Stopper

Schroter A.; Peter S.; Mahler H.-C.; Zerr A.; Danton O.; Chalus P.; Koulov A.V.; Huwyler J.; Jahn M.. Journal of Pharmaceutical Sciences. 2021.

Laboratory-based phase and absorption tomography for microimaging of annual layers in human tooth cementum, paraffinembedded nerve and zebrafish embryo

Migga A.; Schulz G.; Rodgers G.; Osterwalder M.; Tanner C.; Blank H.; Jerjen I.; Salmon P.; Twengstrom W.; Scheel M.; Weitkamp T.; Schleputz C.M.; Bolten J.S.; Huwyler J.; Hotz G.; Madduri S.; Muller B.. . 2021.

Low-Volume Aseptic Filling Using a Linear Peristaltic Pump.

Dreckmann T; Ludwig IS; Luemkemann J; Huwyler J. PDA journal of pharmaceutical science and technology. 2021.

Metamizole is a Moderate Cytochrome P450 Inducer Via the Constitutive Androstane Receptor and a Weak Inhibitor of CYP1A2.

Bachmann F; Duthaler U; Meyer Zu Schwabedissen HE; Puchkov M; Huwyler J; Haschke M; Krähenbühl S. Clinical Pharmacology and Therapeutics. 2021.

Non-viral gene delivery of the oncotoxic protein NS1 for treatment of hepatocellular carcinoma.

Witzigmann D; Grossen P; Quintavalle C; Lanzafame M; Schenk SH; Tran XT; Englinger B; Hauswirth P; Grünig D; van Schoonhoven S; Krähenbühl S; Terracciano LM; Berger W; Piscuoglio S; Quagliata L; Rommelaere J; Nüesch JPF; Huwyler J. Journal of controlled release : official journal of the Controlled Release Society. 2021.

Particle Forming Amorphous Solid Dispersions: A Mechanistic Randomized Pharmacokinetic Study in Humans.

Schittny A; Waldner S; Duthaler U; Vorobyev A; Abramovich R; Krähenbühl S; Puchkov M; Huwyler J. Pharmaceutics. 2021.

Stability of monoclonal antibodies after simulated subcutaneous administration.

Schuster J; Mahler HC; Joerg S; Kamuju V; Huwyler J; Mathaes R. Journal of Pharmaceutical Sciences. 2021.

Three-dimensional x-ray microscopy of zebrafish larvae

Osterwalder M.; Bolten J.S.; Rodgers G.; Schulz G.; Tanner C.; Corek E.; Huwyler J.; Muller B.. . 2021.

Virus-Derived Peptides for Hepatic Enzyme Delivery.

Pratsinis A; Uhl P; Bolten JS; Hauswirth P; Schenk SH; Urban S; Mier W; Witzigmann D; Huwyler J. Molecular Pharmaceutics. 2021.

[Abuse deterrent drug formulations for opioids].

Matter M; Mühlebach S; Puchkov M; Huwyler J. Therapeutische Umschau. 2020.

Abuse deterrent drug formulations for opioids Missbrauch von Opioiden und mögliche Auswege aus der Opioid-Krise

Matter M.; Muhlebach S.; Puchkov M.; Huwyler J.. Therapeutische Umschau. 2020.

Assessment of Sensor Concepts for 100% In-Process Control of Low-Volume Aseptic Fill-Finish Processes.

Dreckmann T; Aipperspach W; Pfleghar K; TrÖndle J; Ernst A; Huwyler J; Ludwig IS; Luemkemann J. PDA journal of pharmaceutical science and technology. 2020.

Bioinspired Molecular Factories with Architecture and In Vivo Functionalities as Cell Mimics.

Einfalt T; Garni M; Witzigmann D; Sieber S; Baltisberger N; Huwyler J; Meier W; Palivan CG. Advanced Science. 2020.

Controlled Tyrosine Kinase Inhibitor Delivery to Liver Cancer Cells by Gate-Capped Mesoporous Silica Nanoparticles

Sedighi M.; Rahimi F.; Shahbazi M.-A.; Rezayan A.H.; Kettiger H.; Einfalt T.; Huwyler J.; Witzigmann D.. ACS Applied Bio Materials. 2020.

Controlled Tyrosine Kinase Inhibitor Delivery to Liver Cancer Cells by Gate-Capped Mesoporous Silica Nanoparticles

Mahsa Sedighi; Fereshteh Rahimi; Mohammad-Ali Shahbazi; Ali Hossein; Rezayan; Helene Kettiger; Tomaz Einfalt; Jörg Huwyler; Dominik Witzigmann. . 2020.

Correction to: In Vivo Stability of Therapeutic Proteins.

Schuster J; Koulov A; Mahler HC; Detampel P; Huwyler J; Singh S; Mathaes R. . 2020.

Design, Synthesis, and Characterization of a Paclitaxel Formulation Activated by Extracellular MMP9.

Ehrsam D; Sieber S; Oufir M; Porta F; Hamburger M; Huwyler J; Meyer Zu Schwabedissen HE. BIOCONJUGATE CHEMISTRY. 2020.

Design and in vivo evaluation of a microparticulate depot formulation of buprenorphine for veterinary use.

Schreiner V; Durst M; Arras M; Detampel P; Jirkof P; Huwyler J. Scientific Reports. 2020.

DNA-directed arrangement of soft synthetic compartments and their behavior in vitro and in vivo.

Liu J; Craciun I; Belluati A; Wu D; Sieber S; Einfalt T; Witzigmann D; Chami M; Huwyler J; Palivan CG. Nanoscale. 2020.

Efficacy and Safety of Ascending Dosages of Moxidectin and Moxidectin-albendazole Against Trichuris trichiura in Adolescents: A Randomized Controlled Trial.

Keller L; Palmeirim MS; Ame SM; Ali SM; Puchkov M; Huwyler J; Hattendorf J; Keiser J. Clinical Infectious Diseases. 2020.

Excipients for Room Temperature Stable Freeze-Dried Monoclonal Antibody Formulations.

Haeuser C; Goldbach P; Huwyler J; Friess W; Allmendinger A. Journal of Pharmaceutical Sciences. 2020.

Impact of dextran on thermal properties, product quality attributes, and monoclonal antibody stability in freeze-dried formulations.

Haeuser C; Goldbach P; Huwyler J; Friess W; Allmendinger A. European Journal of Pharmaceutics and Biopharmaceutics. 2020.

Impact of Insoluble Separation Layer Mechanical Properties on Disintegration and Dissolution Kinetics of Multilayer Tablets.

Yokoyama R; Kimura G; Huwyler J; Hosoya KI; Puchkov M. Pharmaceutics. 2020.

Improvement of DNA Vector Delivery of DOTAP Lipoplexes by Short-Chain Aminolipids.

Buck J; Mueller D; Mettal U; Ackermann M; Grisch-Chan HM; Thöny B; Zumbuehl A; Huwyler J; Witzigmann D. ACS Omega. 2020.

In Vivo Stability of Therapeutic Proteins.

Schuster J; Koulov A; Mahler HC; Detampel P; Huwyler J; Singh S; Mathaes R. Pharmaceutical Research. 2020.

Low volume aseptic filling: Impact of pump systems on shear stress

Dreckmann, Tim; Boeuf, Julien; Ludwig, Imke-Sonja; Lümkemann, Jörg; Huwyler, Jörg. . 2020.

Low volume aseptic filling: Impact of pump systems on shear stress.

Dreckmann T; Boeuf J; Ludwig IS; Lümkemann J; Huwyler J. European Journal of Pharmaceutics and Biopharmaceutics. 2020.

Mechanisms of increased bioavailability through amorphous solid dispersions: a review.

Schittny A; Huwyler J; Puchkov M. Drug Delivery: Journal of Delivery and Targeting of Therapeutic Agents. 2020.

Mechanistic insights into effect of surfactants on oral bioavailability of amorphous solid dispersions.

Schittny A; Philipp-Bauer S; Detampel P; Huwyler J; Puchkov M. Journal of controlled release : official journal of the Controlled Release Society. 2020.

Particle Analysis of Biotherapeutics in Human Serum Using Machine Learning.

Schuster J; Koulov A; Mahler HC; Joerg S; Huwyler J; Schleicher K; Detampel P; Mathaes R. Journal of Pharmaceutical Sciences. 2020.

Pharmacokinetics and phenotyping properties of the Basel phenotyping cocktail combination capsule in healthy male adults.

Suenderhauf C; Berger B; Puchkov M; Schmid Y; Müller S; Huwyler J; Haschke M; Krähenbühl S; Duthaler U. British Journal of Clinical Pharmacology. 2020.

Protein-Polydimethylsiloxane Particles in Liquid Vial Monoclonal Antibody Formulations Containing Poloxamer 188.

Grapentin C; Müller C; Kishore RSK; Adler M; ElBialy I; Friess W; Huwyler J; Khan TA. Journal of Pharmaceutical Sciences. 2020.

Shedding Light on Metal-Based Nanoparticles in Zebrafish by Computed Tomography with Micrometer Resolution

Corek E.; Rodgers G.; Siegrist S.; Einfalt T.; Detampel P.; Schleputz C.M.; Sieber S.; Fluder P.; Schulz G.; Unterweger H.; Alexiou C.; Muller B.; Puchkov M.; Huwyler J.. Small. 2020.

Spontaneous In Situ Formation of Liposomes from Inert Porous Microparticles for Oral Drug Delivery.

Farzan M; Québatte G; Strittmatter K; Hilty FM; Schoelkopf J; Huwyler J; Puchkov M. Pharmaceutics. 2020.

Stabilizing Polysorbate 20 and 80 Against Oxidative Degradation.

Schmidt A; Koulov A; Huwyler J; Mahler HC; Jahn M. Journal of Pharmaceutical Sciences. 2020.

Study of drug particle distributions within mini-tablets using synchrotron X-ray microtomography and superpixel image clustering.

Wagner-Hattler L; Québatte G; Keiser J; Schoelkopf J; Schlepütz CM; Huwyler J; Puchkov M. International journal of pharmaceutics. 2020.

Subvisible Particulate Contamination in Cell Therapy Products-Can We Distinguish?

Vollrath I; Mathaes R; Sediq AS; Jere D; Jörg S; Huwyler J; Mahler HC. Journal of Pharmaceutical Sciences. 2020.

The use of 4-Hexylresorcinol as antibiotic adjuvant.

Nikolaev YA; Tutel'yan AV; Loiko NG; Buck J; Sidorenko SV; Lazareva I; Gostev V; Manzen'yuk OY; Shemyakin IG; Abramovich RA; Huwyler J; El'-Registan GI. PLoS ONE. 2020.

Tracking the physical stability of fluorescent-labeled mAbs under physiologic in vitro conditions in human serum and PBS.

Schuster J; Mahler HC; Koulov A; Joerg S; Racher A; Huwyler J; Detampel P; Mathaes R. European Journal of Pharmaceutics and Biopharmaceutics. 2020.

Be Aggressive! Amorphous Excipients Enabling Single-Step Freeze-Drying of Monoclonal Antibody Formulations.

Haeuser C; Goldbach P; Huwyler J; Friess W; Allmendinger A. Pharmaceutics. 2019.

Insights into possibilities for grouping and read-across for nanomaterials in EU chemicals legislation.

Mech A; Rasmussen K; Jantunen P; Aicher L; Alessandrelli M; Bernauer U; Bleeker EAJ; Bouillard J; Di Prospero Fanghella P; Draisci R; Dusinska M; Encheva G; Flament G; Haase A; Handzhiyski Y; Herzberg F; Huwyler J; Jacobsen NR; Jeliazkov V; Jeliazkova N; Nymark P; Grafström R; Oomen AG; Polci ML; Riebeling C; Sandström J; Shivachev B; Stateva S; Tanasescu S; Tsekovska R; Wallin H; Wilks MF; Zellmer S; Apostolova MD. Nanotoxicology. 2019.

In Vitro and In Vivo Drug-Drug Interaction Study of the Effects of Ivermectin and Oxantel Pamoate on Tribendimidine.

Neodo A; Schulz JD; Huwyler J; Keiser J. Antimicrobial Agents and Chemotherapy. 2019.

Lipid-Based DNA Therapeutics: Hallmarks of Non-Viral Gene Delivery.

Buck J; Grossen P; Cullis PR; Huwyler J; Witzigmann D. ACS Nano. 2019.

Loading of Porous Functionalized Calcium Carbonate Microparticles: Distribution Analysis with Focused Ion Beam Electron Microscopy and Mercury Porosimetry.

Farzan M; Roth R; Québatte G; Schoelkopf J; Huwyler J; Puchkov M. Pharmaceutics. 2019.

Microdosed midazolam for the determination of cytochrome P450 3A activity: Development and clinical evaluation of a buccal film.

Kiene K; Hayasi N; Burhenne J; Uchitomi R; Sünderhauf C; Schmid Y; Haschke M; Haefeli WE; Krähenbühl S; Mikus G; Inada H; Huwyler J. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2019.

Optimization-by-design of hepatotropic lipid nanoparticles targeting the sodium-taurocholate cotransporting polypeptide.

Witzigmann D; Uhl P; Sieber S; Kaufman C; Einfalt T; Schöneweis K; Grossen P; Buck J; Ni Y; Schenk SH; Hussner J; Meyer Zu Schwabedissen HE; Québatte G; Mier W; Urban S; Huwyler J. Elife. 2019.

Poly(Sarcosine) Surface Modification Imparts Stealth-Like Properties to Liposomes.

Bleher S; Buck J; Muhl C; Sieber S; Barnert S; Witzigmann D; Huwyler J; Barz M; Süss R. Small. 2019.

Pooled Population Pharmacokinetic Analysis of Tribendimidine for the Treatment of Opisthorchis viverrini Infections.

Meister I; Assawasuwannakit P; Vanobberghen F; Penny MA; Odermatt P; Sayasone S; Huwyler J; Tarning J; Keiser J. Antimicrobial Agents and Chemotherapy. 2019.

Preclinical hazard evaluation strategy for nanomedicines.

Siegrist S; Cörek E; Detampel P; Sandström J; Wick P; Huwyler J. Nanotoxicology. 2019.

Rapid optimization of liposome characteristics using a combined microfluidics and design-of-experiment approach.

Sedighi M; Sieber S; Rahimi F; Shahbazi MA; Rezayan AH; Huwyler J; Witzigmann D. Drug delivery and translational research. 2019.

Stability investigation of FCC-based tablets for oral suspension with caffeine and oxantel pamoate as model drugs.

Wagner-Hattler L; Schoelkopf J; Huwyler J; Puchkov M. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY. 2019.

Zebrafish as a preclinical in vivo screening model for nanomedicines.

Sieber S; Grossen P; Bussmann J; Campbell F; Kros A; Witzigmann D; Huwyler J. Advanced Drug Delivery Reviews. 2019.

Zebrafish as a predictive screening model to assess macrophage clearance of liposomes in vivo.

Sieber S; Grossen P; Uhl P; Detampel P; Mier W; Witzigmann D; Huwyler J. Nanomedicine : nanotechnology, biology, and medicine. 2019.

A combined mathematical model linking the formation of amorphous solid dispersions with hot-melt-extrusion process parameters.

Schittny A; Ogawa H; Huwyler J; Puchkov M. European Journal of Pharmaceutics and Biopharmaceutics. 2018.

Biomimetic artificial organelles with in vitro and in vivo activity triggered by reduction in microenvironment.

Einfalt T; Witzigmann D; Edlinger C; Sieber S; Goers R; Najer A; Spulber M; Onaca-Fischer O; Huwyler J; Palivan CG. Nature Communications. 2018.

Characterization of surface properties of glass vials used as primary packaging material for parenterals.

Ditter D; Mahler HC; Roehl H; Wahl M; Huwyler J; Nieto A; Allmendinger A. European Journal of Pharmaceutics and Biopharmaceutics. 2018.

Combined cerium oxide nanocapping and layer-by-layer coating of porous silicon containers for controlled drug release

Sedighi M.; Rahimi F.; Rezayan A.H.; Shahbazi M.-A.; Witzigmann D.; Huwyler J.. Journal of Materials Science. 2018.

Directing Nanoparticle Biodistribution through Evasion and Exploitation of Stab2-Dependent Nanoparticle Uptake.

Campbell F; Bos FL; Sieber S; Arias-Alpizar G; Koch BE; Huwyler J; Kros A; Bussmann J. ACS Nano. 2018.

Efficacy and Safety of Ivermectin Against Trichuris trichiura in Preschool-aged and School-aged Children: A Randomized Controlled Dose-finding Trial.

Wimmersberger D; Coulibaly JT; Schulz JD; Puchkow M; Huwyler J; N'Gbesso Y; Hattendorf J; Keiser J. Clinical Infectious Diseases. 2018.

Efficacy and tolerability of moxidectin alone and in co-administration with albendazole and tribendimidine versus albendazole plus oxantel pamoate against Trichuris trichiura infections: a randomised, non-inferiority, single-blind trial.

Barda B; Ame SM; Ali SM; Albonico M; Puchkov M; Huwyler J; Hattendorf J; Keiser J. The Lancet Infectious Diseases. 2018.

Efficacy and tolerability of triple drug therapy with albendazole, pyrantel pamoate, and oxantel pamoate compared with albendazole plus oxantel pamoate, pyrantel pamoate plus oxantel pamoate, and mebendazole plus pyrantel pamoate and oxantel pamoate against hookworm infections in school-aged children in Laos: a randomised, single-blind trial.

Moser W; Sayasone S; Xayavong S; Bounheuang B; Puchkov M; Huwyler J; Hattendorf J; Keiser J. The Lancet Infectious Diseases. 2018.

Evaluation of Glass Delamination Risk in Pharmaceutical 10 mL/10R Vials.

Ditter D; Nieto A; Mahler HC; Roehl H; Wahl M; Huwyler J; Allmendinger A. Journal of Pharmaceutical Sciences. 2018.

Functionalized calcium carbonate microparticles for the delivery of proteins.

Roth R; Schoelkopf J; Huwyler J; Puchkov M. European Journal of Pharmaceutics and Biopharmaceutics. 2018.

Imaging Techniques to Characterize Cake Appearance of Freeze-Dried Products.

Haeuser C; Goldbach P; Huwyler J; Friess W; Allmendinger A. Journal of Pharmaceutical Sciences. 2018.

Impact of non-ideal analyte behavior on the separation of protein aggregates by asymmetric flow field-flow fractionation.

Boll B; Josse L; Heubach A; Hochenauer S; Finkler C; Huwyler J; Koulov AV. JOURNAL OF SEPARATION SCIENCE. 2018.

Impact of Vial Washing and Depyrogenation on Surface Properties and Delamination Risk of Glass Vials.

Ditter D; Mahler HC; Gohlke L; Nieto A; Roehl H; Huwyler J; Wahl M; Allmendinger A. Pharmaceutical Research. 2018.

Modeling of Disintegration and Dissolution Behavior of Mefenamic Acid Formulation Using Numeric Solution of Noyes-Whitney Equation with Cellular Automata on Microtomographic and Algorithmically Generated Surfaces.

Yokoyama R; Kimura G; Schlepütz CM; Huwyler J; Puchkov M. Pharmaceutics. 2018.

Pharmacokinetics of a Pediatric Tribendimidine Dose-Finding Study To Treat Hookworm Infection in African Children.

Hiroshige N; Coulibaly J; Huwyler J; Bonate PL; Keiser J. Antimicrobial Agents and Chemotherapy. 2018.

Self-assembling chitosan hydrogel: A drug-delivery device enabling the sustained release of proteins

Kiene K.; Porta F.; Topacogullari B.; Detampel P.; Huwyler J.. Journal of Applied Polymer Science. 2018.

A Method To Determine the Kinetics of Solute Mixing in Liquid/Liquid Formulation Dual-Chamber Syringes.

Werk T; Mahler HC; Ludwig IS; Luemkemann J; Huwyler J; Hafner M. PDA journal of pharmaceutical science and technology. 2017.

Assessing the Risk of Drug-Induced Cholestasis Using Unbound Intrahepatic Concentrations.

Riede J; Poller B; Huwyler J; Camenisch G. Drug Metabolism and Disposition. 2017.

Characterization of new functionalized calcium carbonate-polycaprolactone composite material for application in geometry-constrained drug release formulation development.

Wagner-Hattler L; Schoelkopf J; Huwyler J; Puchkov M. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY. 2017.

Current In Vitro Methods to Determine Hepatic Kp(uu): A Comparison of Their Usefulness and Limitations.

Riede J; Camenisch G; Huwyler J; Poller B. Journal of Pharmaceutical Sciences. 2017.

Efficacy and safety of tribendimidine, tribendimidine plus ivermectin, tribendimidine plus oxantel pamoate, and albendazole plus oxantel pamoate against hookworm and concomitant soil-transmitted helminth infections in Tanzania and Côte d'Ivoire: a randomised, controlled, single-blinded, non-inferiority trial.

Moser W; Coulibaly JT; Ali SM; Ame SM; Amour AK; Yapi RB; Albonico M; Puchkov M; Huwyler J; Hattendorf J; Keiser J. The Lancet Infectious Diseases. 2017.

Efficacy of Moxidectin Versus Ivermectin Against Strongyloides stercoralis Infections: A Randomized, Controlled Noninferiority Trial.

Barda B; Sayasone S; Phongluxa K; Xayavong S; Keoduangsy K; Odermatt P; Puchkov M; Huwyler J; Hattendorf J; Keiser J. Clinical Infectious Diseases. 2017.

Extensive Chemical Modifications in the Primary Protein Structure of IgG1 Subvisible Particles Are Necessary for Breaking Immune Tolerance.

Boll B; Bessa J; Folzer E; Ríos Quiroz A; Schmidt R; Bulau P; Finkler C; Mahler HC; Huwyler J; Iglesias A; Koulov AV. Molecular Pharmaceutics. 2017.

Immobilization of Enzymes on PLGA Sub-Micrometer Particles by Crosslinked Layer-by-Layer Deposition.

Sieber S; Siegrist S; Schwarz S; Porta F; Schenk SH; Huwyler J. Macromolecular bioscience. 2017.

In vitro characterization and mouthfeel study of functionalized calcium carbonate in orally disintegrating tablets.

Wagner-Hattler L; Wyss K; Schoelkopf J; Huwyler J; Puchkov M. International journal of pharmaceutics. 2017.

Oral delivery of vancomycin by tetraether lipid liposomes.

Uhl P; Pantze S; Storck P; Parmentier J; Witzigmann D; Hofhaus G; Huwyler J; Mier W; Fricker G. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2017.

PDMS-b-PMOXA polymersomes for hepatocyte targeting and assessment of toxicity.

Kiene K; Schenk SH; Porta F; Ernst A; Witzigmann D; Grossen P; Huwyler J. European Journal of Pharmaceutics and Biopharmaceutics. 2017.

PEG-PCL-based nanomedicines: A biodegradable drug delivery system and its application.

Grossen P; Witzigmann D; Sieber S; Huwyler J. Journal of controlled release : official journal of the Controlled Release Society. 2017.

Removing ring artefacts from synchrotron radiation-based hard x-ray tomography data

Thalmann P.; Bikis C.; Schulz G.; Paleo P.; Mirone A.; Rack A.; Siegrist S.; Corek E.; Huwyler J.; Muller B.. . 2017.

Selective stimulation of the JAK/STAT signaling pathway by silica nanoparticles in human endothelial cells.

Siegrist S; Kettiger H; Fasler-Kan E; Huwyler J. Toxicology in Vitro. 2017.

Zebrafish as an early stage screening tool to study the systemic circulation of nanoparticulate drug delivery systems in vivo.

Sieber S; Grossen P; Detampel P; Siegfried S; Witzigmann D; Huwyler J. Journal of controlled release : official journal of the Controlled Release Society. 2017.

CombiCap: A novel drug formulation for the basel phenotyping cocktail.

Camblin M; Berger B; Haschke M; Krähenbühl S; Huwyler J; Puchkov M. International journal of pharmaceutics. 2016.

Development and validation of an enantioselective LC-MS/MS method for the analysis of the anthelmintic drug praziquantel and its main metabolite in human plasma, blood and dried blood spots.

Meister I; Leonidova A; Kovač J; Duthaler U; Keiser J; Huwyler J. Journal of Pharmaceutical and Biomedical Analysis. 2016.

Efficacy and Safety of Moxidectin, Synriam, Synriam-Praziquantel versus Praziquantel against Schistosoma haematobium and S. mansoni Infections: A Randomized, Exploratory Phase 2 Trial.

Barda B; Coulibaly JT; Puchkov M; Huwyler J; Hattendorf J; Keiser J. PLoS Neglected Tropical Diseases. 2016.

Efficacy and safety of oxantel pamoate in school-aged children infected with Trichuris trichiura on Pemba Island, Tanzania: a parallel, randomised, controlled, dose-ranging study.

Moser W; Ali SM; Ame SM; Speich B; Puchkov M; Huwyler J; Albonico M; Hattendorf J; Keiser J. The Lancet Infectious Diseases. 2016.

Factors Governing the Accuracy of Subvisible Particle Counting Methods.

Ríos Quiroz A; Finkler C; Huwyler J; Mahler HC; Schmidt R; Koulov AV. Journal of Pharmaceutical Sciences. 2016.

Factors Governing the Precision of Subvisible Particle Measurement Methods - A Case Study with a Low-Concentration Therapeutic Protein Product in a Prefilled Syringe.

Ríos Quiroz A; Lamerz J; Da Cunha T; Boillon A; Adler M; Finkler C; Huwyler J; Schmidt R; Mahler HC; Koulov AV. Pharmaceutical Research. 2016.

Functionalized solid-sphere PEG- b -PCL nanoparticles to target brain capillary endothelial cells in vitro

Grossen P.; Quebatte G.; Witzigmann D.; Prescianotto-Baschong C.; Dieu L.-H.; Huwyler J.. Journal of Nanomaterials. 2016.

Impact of Vial Capping on Residual Seal Force and Container Closure Integrity.

Mathaes R; Mahler HC; Roggo Y; Ovadia R; Lam P; Stauch O; Vogt M; Roehl H; Huwyler J; Mohl S; Streubel A. PDA journal of pharmaceutical science and technology. 2016.

Influence of Different Container Closure Systems and Capping Process Parameters on Product Quality and Container Closure Integrity (CCI) in GMP Drug Product Manufacturing.

Mathaes R; Mahler HC; Roggo Y; Huwyler J; Eder J; Fritsch K; Posset T; Mohl S; Streubel A. PDA journal of pharmaceutical science and technology. 2016.

In silico and in vitro methods to optimize the performance of experimental gastroretentive floating mini-tablets.

Eberle VA; Häring A; Schoelkopf J; Gane PA; Huwyler J; Puchkov M. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY. 2016.

Interactions between silica nanoparticles and phospholipid membranes.

Kettiger H; Québatte G; Perrone B; Huwyler J. Biochimica et biophysica acta. 2016.

Isolation of multiantennary: N -glycans from glycoproteins for hepatocyte specific targeting via the asialoglycoprotein receptor

Witzigmann D.; Detampel P.; Porta F.; Huwyler J.. RSC Advances. 2016.

Mucoadhesive microparticles for local treatment of gastrointestinal diseases.

Preisig D; Roth R; Tognola S; Varum FJ; Bravo R; Cetinkaya Y; Huwyler J; Puchkov M. European Journal of Pharmaceutics and Biopharmaceutics. 2016.

New IVIVE method for the prediction of total human clearance and relative elimination pathway contributions from in vitro hepatocyte and microsome data.

Riede J; Poller B; Umehara K; Huwyler J; Camenisch G. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2016.

New Processes for Freeze-Drying in Dual-Chamber Systems.

Werk T; Ludwig IS; Luemkemann J; Huwyler J; Mahler HC; Haeuser CR; Hafner M. PDA journal of pharmaceutical science and technology. 2016.

Pediatric Dispersible Tablets: a Modular Approach for Rapid Prototyping.

Buck J; Huwyler J; Kühl P; Dischinger A. Pharmaceutical Research. 2016.

Pharmacokinetics of the Antischistosomal Lead Ozonide OZ418 in Uninfected Mice Determined by Liquid Chromatography-Tandem Mass Spectrometry.

Leonidova A; Vargas M; Huwyler J; Keiser J. Antimicrobial Agents and Chemotherapy. 2016.

Pharmacokinetic Study of Praziquantel Enantiomers and Its Main Metabolite R-trans-4-OH-PZQ in Plasma, Blood and Dried Blood Spots in Opisthorchis viverrini-Infected Patients.

Meister I; Kovac J; Duthaler U; Odermatt P; Huwyler J; Vanobberghen F; Sayasone S; Keiser J. PLoS Neglected Tropical Diseases. 2016.

Secreted Matrix Metalloproteinase-9 of Proliferating Smooth Muscle Cells as a Trigger for Drug Release from Stent Surface Polymers in Coronary Arteries.

Gliesche DG; Hussner J; Witzigmann D; Porta F; Glatter T; Schmidt A; Huwyler J; Meyer Zu Schwabedissen HE. Molecular Pharmaceutics. 2016.

Single-Ascending-Dose Pharmacokinetic Study of Tribendimidine in Opisthorchis viverrini-Infected Patients.

Duthaler U; Sayasone S; Vanobbergen F; Penny MA; Odermatt P; Huwyler J; Keiser J. Antimicrobial Agents and Chemotherapy. 2016.

Technology, Applications, and Process Challenges of Dual Chamber Systems.

Werk T; Ludwig IS; Luemkemann J; Mahler HC; Huwyler J; Hafner M. Journal of Pharmaceutical Sciences. 2016.

The Effect of Formulation, Process, and Method Variables on the Reconstitution Time in Dual Chamber Syringes.

Werk T; Ludwig IS; Mahler HC; Luemkemann J; Huwyler J; Hafner M. PDA journal of pharmaceutical science and technology. 2016.

The Pharmaceutical Capping Process-Correlation between Residual Seal Force, Torque Moment, and Flip-off Removal Force.

Mathaes R; Mahler HC; Vorgrimler L; Steinberg H; Dreher S; Roggo Y; Nieto A; Brown H; Roehl H; Adler M; Luemkemann J; Huwyler J; Lam P; Stauch O; Mohl S; Streubel A. PDA journal of pharmaceutical science and technology. 2016.

The pharmaceutical vial capping process: Container closure systems, capping equipment, regulatory framework, and seal quality tests.

Mathaes R; Mahler HC; Buettiker JP; Roehl H; Lam P; Brown H; Luemkemann J; Adler M; Huwyler J; Streubel A; Mohl S. European Journal of Pharmaceutics and Biopharmaceutics. 2016.

Variable asialoglycoprotein receptor 1 expression in liver disease: Implications for therapeutic intervention.

Witzigmann D; Quagliata L; Schenk SH; Quintavalle C; Terracciano LM; Huwyler J. Hepatology research : the official journal of the Japan Society of Hepatology. 2016.

An Impedance-Based Method to Determine Reconstitution Time for Freeze-Dried Pharmaceuticals.

Werk T; Huwyler J; Hafner M; Luemkemann J; Mahler HC. Journal of Pharmaceutical Sciences. 2015.

Application of the extended clearance concept classification system (ECCCS) to predict the victim drug-drug interaction potential of statins.

Kunze A; Poller B; Huwyler J; Camenisch G. Drug metabolism and personalized therapy. 2015.

ATP-induced cellular stress and mitochondrial toxicity in cells expressing purinergic P2X7 receptor.

Seeland S; Kettiger H; Murphy M; Treiber A; Giller J; Kiss A; Sube R; Krähenbühl S; Hafner M; Huwyler J. Pharmacology Research & Perspectives. 2015.

Biocompatible polymer-Peptide hybrid-based DNA nanoparticles for gene delivery.

Witzigmann D; Wu D; Schenk SH; Balasubramanian V; Meier W; Huwyler J. ACS Applied Materials and Interfaces. 2015.

Comparative Evaluation of Two Methods for Preparative Fractionation of Proteinaceous Subvisible Particles--Differential Centrifugation and FACS.

Boll B; Folzer E; Finkler C; Huwyler J; Mahler HC; Schmidt R; Koulov AV. Pharmaceutical Research. 2015.

Comparative safety evaluation of silica-based particles.

Kettiger H; Sen Karaman D; Schiesser L; Rosenholm JM; Huwyler J. Toxicology in Vitro. 2015.

Determination of the Density of Protein Particles Using a Suspended Microchannel Resonator.

Folzer E; Khan TA; Schmidt R; Finkler C; Huwyler J; Mahler HC; Koulov AV. Journal of Pharmaceutical Sciences. 2015.

Efficacy and safety of albendazole plus ivermectin, albendazole plus mebendazole, albendazole plus oxantel pamoate, and mebendazole alone against Trichuris trichiura and concomitant soil-transmitted helminth infections: a four-arm, randomised controlled trial.

Speich B; Ali SM; Ame SM; Bogoch II; Alles R; Huwyler J; Albonico M; Hattendorf J; Utzinger J; Keiser J. The Lancet Infectious Diseases. 2015.

Formation of lipid and polymer based gold nanohybrids using a nanoreactor approach

Witzigmann D.; Sieber S.; Porta F.; Grossen P.; Bieri A.; Strelnikova N.; Pfohl T.; Prescianotto-Baschong C.; Huwyler J.. RSC Advances. 2015.

LC-MS/MS method for the determination of two metabolites of tribendimidine, deacylated amidantel and its acetylated metabolite in plasma, blood and dried blood spots.

Duthaler U; Keiser J; Huwyler J. Journal of Pharmaceutical and Biomedical Analysis. 2015.

Marker-ion analysis for quantification of mucoadhesivity of microparticles in particle-retention assays.

Preisig D; Weingartner M; Varum FJ; Bravo R; Alles R; Huwyler J; Puchkov M. International journal of pharmaceutics. 2015.

Measuring Subvisible Particles in Protein Formulations Using a Modified Light Obscuration Sensor with Improved Detection Capabilities.

Ríos Quiroz A; Québatte G; Stump F; Finkler C; Huwyler J; Schmidt R; Mahler HC; Koulov AV; Adler M. Analytical Chemistry. 2015.

Measuring tissue back-pressure--in vivo injection forces during subcutaneous injection.

Allmendinger A; Mueller R; Schwarb E; Chipperfield M; Huwyler J; Mahler HC; Fischer S. Pharmaceutical Research. 2015.

Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases.

Jaeschke G; Kolczewski S; Spooren W; Vieira E; Bitter-Stoll N; Boissin P; Borroni E; Büttelmann B; Ceccarelli S; Clemann N; David B; Funk C; Guba W; Harrison A; Hartung T; Honer M; Huwyler J; Kuratli M; Niederhauser U; Pähler A; Peters JU; Petersen A; Prinssen E; Ricci A; Rueher D; Rueher M; Schneider M; Spurr P; Stoll T; Tännler D; Wichmann J; Porter RH; Wettstein JG; Lindemann L. Journal of Medicinal Chemistry. 2015.

Nanomedicine in cancer therapy: challenges, opportunities, and clinical applications.

Wicki A; Witzigmann D; Balasubramanian V; Huwyler J. Journal of controlled release : official journal of the Controlled Release Society. 2015.

Scientific Basis for Regulatory Decision-Making of Nanomaterials Report on the Workshop, 20-21 January 2014, Center of Applied Ecotoxicology, Dübendorf.

Studer C; Aicher L; Gasic B; von Goetz N; Hoet P; Huwyler J; Kägi R; Kase R; Kobe A; Nowack B; Rothen-Rutishauser B; Schirmer K; Schneider G; Vermeissen E; Wick P; Walser T. Chimia. 2015.

Selective Oxidation of Methionine and Tryptophan Residues in a Therapeutic IgG1 Molecule.

Folzer E; Diepold K; Bomans K; Finkler C; Schmidt R; Bulau P; Huwyler J; Mahler HC; Koulov AV. Journal of Pharmaceutical Sciences. 2015.

Sterile Filtration of Highly Concentrated Protein Formulations: Impact of Protein Concentration, Formulation Composition, and Filter Material.

Allmendinger A; Mueller R; Huwyler J; Mahler HC; Fischer S. Journal of Pharmaceutical Sciences. 2015.

The extended clearance model and its use for the interpretation of hepatobiliary elimination data

Camenisch G.; Riede J.; Kunze A.; Huwyler J.; Poller B.; Umehara K.. ADMET and DMPK. 2015.

Translational Medicine: Nanoscience and Nanotechnology to Improve Patient Care

Muller B.; Zumbuehl A.; Walter M.A.; Pfohl T.; Cattin P.C.; Huwyler J.; Hieber S.E.. The Nano-Micro Interface: Bridging the Micro and Nano Worlds: Second Edition. 2015.

Compaction of functionalized calcium carbonate, a porous and crystalline microparticulate material with a lamellar surface

Stirnimann T.; Atria S.; Schoelkopf J.; Gane P.A.C.; Alles R.; Huwyler J.; Puchkov M.. International journal of pharmaceutics. 2014.

Drug loading into porous calcium carbonate microparticles by solvent evaporation

Preisig D.; Haid D.; Varum F.J.O.; Bravo R.; Alles R.; Huwyler J.; Puchkov M.. European Journal of Pharmaceutics and Biopharmaceutics. 2014.

Floating gastroretentive drug delivery systems:Comparison of experimental and simulated dissolution profiles and floatation behavior

Eberle V.A.; Schoelkopf J.; Gane P.A.C.; Alles R.; Huwyler J.; Puchkov M.. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2014.

Hepatocyte targeting using pegylated asialofetuin-conjugated liposomes.

Detampel P; Witzigmann D; Krähenbühl S; Huwyler J. Journal of drug targeting. 2014.

High-throughput viscosity measurement using capillary electrophoresis instrumentation and its application to protein formulation

Allmendinger A.; Dieu L.-H.; Fischer S.; Mueller R.; Mahler H.-C.; Huwyler J.. Journal of Pharmaceutical and Biomedical Analysis. 2014.

In vitro-in vivo extrapolation method to predict human renal clearance of drugs

Kunze A.; Huwyler J.; Poller B.; Gutmann H.; Camenisch G.. Journal of Pharmaceutical Sciences. 2014.

Oxantel pamoate-albendazole for trichuris trichiura infection

Speich B.; Ame S.M.; Ali S.M.; Alles R.; Huwyler J.; Hattendorf J.; Utzinger J.; Albonico M.; Keiser J.. The New England journal of medicine. 2014.

Polymersomes conjugated to 83-14 monoclonal antibodies: In vitro targeting of brain capillary endothelial cells

Dieu L.-H.; Wu D.; Palivan C.G.; Balasubramanian V.; Huwyler J.. European Journal of Pharmaceutics and Biopharmaceutics. 2014.

Polymersomes containing quantum dots for cellular imaging

Camblin M.; Detampel P.; Kettiger H.; Wu D.; Balasubramanian V.; Huwyler J.. International Journal of Nanomedicine. 2014.

Prediction of organic anion-transporting polypeptide 1B1- and 1B3- mediated hepatic uptake of statins based on transporter protein expression and activity data

Kunze A.; Huwyler J.; Camenisch G.; Poller B.. Drug Metabolism and Disposition. 2014.

Rheological characterization and injection forces of concentrated protein formulations: An alternative predictive model for non-Newtonian solutions

Allmendinger A.; Fischer S.; Huwyler J.; Mahler H.-C.; Schwarb E.; Zarraga I.E.; Mueller R.. European Journal of Pharmaceutics and Biopharmaceutics. 2014.

A cell-based, multiparametric sensor approach characterises drug-induced cytotoxicity in human liver HepG2 cells

Seeland S.; Torok M.; Kettiger H.; Treiber A.; Hafner M.; Huwyler J.. Toxicology in Vitro. 2013.

Development of oxantel tablets for pediatric clinical studies: A technical note

Alles R.; Puchkov M.; Jablonski C.; Speich B.; Keiser J.; Huwyler J.. Journal of Drug Delivery Science and Technology. 2013.

Efficacy and pharmacokinetics of OZ78 and MT04 against a natural infection with Fasciola hepatica in sheep

Meister I.; Duthaler U.; Huwyler J.; Rinaldi L.; Bosco A.; Cringoli G.; Keiser J.. Veterinary Parasitology. 2013.

Engineered nanomaterial uptake and tissue distribution: From cell to organism

Kettiger H.; Schipanski A.; Wick P.; Huwyler J.. International Journal of Nanomedicine. 2013.

Functionalized calcium carbonate as a novel pharmaceutical excipient for the preparation of orally dispersible tablets

Stirnimann T.; Di Maiuta N.; Gerard D.E.; Alles R.; Huwyler J.; Puchkov M.. Pharmaceutical Research. 2013.

Human cytokines activate JAK-STAT signaling pathway in porcine ocular tissue

Fasler-Kan E.; Barteneva N.S.; Ketterer S.; Wunderlich K.; Reschner A.; Nurzhanova A.; Flammer J.; Huwyler J.; Meyer P.. Xenotransplantation. 2013.

Indocyanine green loaded biocompatible nanoparticles: Stabilization of indocyanine green (ICG) using biocompatible silica-poly(ε-caprolactone) grafted nanocomposites

Schonbachler A.; Glaied O.; Huwyler J.; Frenz M.; Pieles U.. Journal of Photochemistry and Photobiology A: Chemistry. 2013.

Pharmacological characterization of designer cathinones in vitro

Simmler L.D.; Buser T.A.; Donzelli M.; Schramm Y.; Dieu L.-H.; Huwyler J.; Chaboz S.; Hoener M.C.; Liechti M.E.. British Journal of Pharmacology. 2013.

Stable human brain microvascular endothelial cell line retaining its barrier-specific nature independent of the passage number

Sano Y.; Kashiwamura Y.; Abe M.; Dieu L.-H.; Huwyler J.; Shimizu F.; Haruki H.; Maeda T.; Saito K.; Tasaki A.; Kanda T.. Clinical and Experimental Neuroimmunology. 2013.

Computational prediction of blood-brain barrier permeability using decision tree induction

Suenderhauf C.; Hammann F.; Huwyler J.. Molecules. 2012.

Drug interaction potential of resveratrol

Detampel P.; Beck M.; Krahenbuhl S.; Huwyler J.. Drug Metabolism Reviews. 2012.

Duloxetine inhibits effects of MDMA ("ecstasy") in vitro and in humans in a randomized placebo-controlled laboratory study.

Hysek CM; Simmler LD; Nicola VG; Vischer N; Donzelli M; Krähenbühl S; Grouzmann E; Huwyler J; Hoener MC; Liechti ME. PLoS ONE. 2012.

Evaluation of the pharmacokinetic profile of artesunate, artemether and their metabolites in sheep naturally infected with Fasciola hepatica

Duthaler U.; Huwyler J.; Rinaldi L.; Cringoli G.; Keiser J.. Veterinary Parasitology. 2012.

Interaction of the antiviral drug telaprevir with renal and hepatic drug transporters

Kunze A.; Huwyler J.; Camenisch G.; Gutmann H.. Biochemical pharmacology. 2012.

Pharmacokinetics of the fasciocidal drug candidates MT04 and OZ78 in uninfected rats and in vitro pharmacodynamic studies

Kirchhofer C.; Vargas M.; Huwyler J.; Keiser J.. International Journal for Parasitology: Drugs and Drug Resistance. 2012.

A binary Ant Colony Optimization classifier for molecular activities

Hammann F.; Suenderhauf C.; Huwyler J.. Journal of Chemical Information and Modeling. 2011.

Combinatorial QSAR modeling of human intestinal absorption

Suenderhauf C.; Hammann F.; Maunz A.; Helma C.; Huwyler J.. Molecular Pharmaceutics. 2011.

Development and validation of a liquid chromatography and ion spray tandem mass spectrometry method for the quantification of artesunate, artemether and their major metabolites dihydroartemisinin and dihydroartemisinin-glucuronide in sheep plasma

Duthaler U.; Keiser J.; Huwyler J.. Journal of Mass Spectrometry. 2011.

In vitro assessment of the formation of ceftriaxone-calcium precipitates in human plasma

Schmutz H.-R.; Detampel P.; Buhler T.; Buttler A.; Gygax B.; Huwyler J.. Journal of Pharmaceutical Sciences. 2011.

On-line identification of P-glycoprotein substrates by monitoring of extracellular acidification and respiration rates in living cells

Seeland S.; Treiber A.; Hafner M.; Huwyler J.. Biochimica et Biophysica Acta - Biomembranes. 2011.

The norepinephrine transporter inhibitor reboxetine reduces stimulant effects of MDMA (ecstasy) in humans

Hysek C.M.; Simmler L.D.; Ineichen M.; Grouzmann E.; Hoener M.C.; Brenneisen R.; Huwyler J.; Liechti M.E.. Clinical Pharmacology and Therapeutics. 2011.

Activation of the JAK-STAT intracellular pathway in human retinal pigment epithelial cell line ARPE-19

Fasler-Kan E.; Barteneva N.; Ketterer S.; Wunderlich K.; Huwyler J.; Gygax D.; Flammer J.; Meyer P.. International Journal of Interferon, Cytokine and Mediator Research. 2010.

Aryl- and heteroaryl-substituted aminobenzo[a]quinolizines as dipeptidyl peptidase IV inhibitors.

Boehringer M; Fischer H; Hennig M; Hunziker D; Huwyler J; Kuhn B; Loeffler BM; Luebbers T; Mattei P; Narquizian R; Sebokova E; Sprecher U; Wessel HP. Bioorganic & medicinal chemistry letters. 2010.

Cytokine signaling in the human brain capillary endothelial cell line hCMEC/D3

Fasler-Kan E.; Suenderhauf C.; Barteneva N.; Poller B.; Gygax D.; Huwyler J.. Brain Research. 2010.

Development and validation of a liquid chromatography/mass spectrometry method for pharmacokinetic studies of OZ78, a fasciocidal drug candidate

Kirchhofer C.; Keiser J.; Huwyler J.. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 2010.

Discovery of carmegliptin: a potent and long-acting dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.

Mattei P; Boehringer M; Di Giorgio P; Fischer H; Hennig M; Huwyler J; Koçer B; Kuhn B; Loeffler BM; Macdonald A; Narquizian R; Rauber E; Sebokova E; Sprecher U. Bioorganic & medicinal chemistry letters. 2010.

Discovery of potent and selective histamine H3 receptor inverse agonists based on the 3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one scaffold.

Richter HG; Freichel C; Huwyler J; Nakagawa T; Nettekoven M; Plancher JM; Raab S; Roche O; Schuler F; Taylor S; Ullmer C; Wiegand R. Bioorganic & medicinal chemistry letters. 2010.

Efficacy, safety and pharmacokinetics of 1,2,4-trioxolane OZ78 against an experimental infection with Fasciola hepatica in sheep

Keiser J.; Kirchhofer C.; Haschke M.; Huwyler J.; Dong Y.; Vennerstrom J.L.; Vanhoff K.; Kaminsky R.; Malikides N.. Veterinary Parasitology. 2010.

Regulation of BCRP (ABCG2) and P-glycoprotein (ABCB1) by cytokines in a model of the human blood-brain barrier.

Poller B; Drewe J; Krähenbühl S; Huwyler J; Gutmann H. Cellular and molecular neurobiology. 2010.

Synthesis and characterization of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: Part 4. In vivo active potent and selective non-competitive metabotropic glutamate receptor 2/3 antagonists.

Woltering TJ; Wichmann J; Goetschi E; Knoflach F; Ballard TM; Huwyler J; Gatti S. Bioorganic & medicinal chemistry letters. 2010.

5-hydroxyindole-2-carboxylic acid amides: novel histamine-3 receptor inverse agonists for the treatment of obesity.

Pierson PD; Fettes A; Freichel C; Gatti-McArthur S; Hertel C; Huwyler J; Mohr P; Nakagawa T; Nettekoven M; Plancher JM; Raab S; Richter H; Roche O; Rodríguez Sarmiento RM; Schmitt M; Schuler F; Takahashi T; Taylor S; Ullmer C; Wiegand R. Journal of Medicinal Chemistry. 2009.

Fluorinated 9H-xanthene-9-carboxylic acid oxazol-2-yl-amides as potent, orally available mGlu1 receptor enhancers.

Vieira E; Huwyler J; Jolidon S; Knoflach F; Mutel V; Wichmann J. Bioorganic & medicinal chemistry letters. 2009.

Characterization of (R,S)-5,7-di-tert-butyl-3-hydroxy-3-trifluoromethyl-3H-benzofuran-2-one as a positive allosteric modulator of GABAB receptors.

Malherbe P; Masciadri R; Norcross RD; Knoflach F; Kratzeisen C; Zenner MT; Kolb Y; Marcuz A; Huwyler J; Nakagawa T; Porter RH; Thomas AW; Wettstein JG; Sleight AJ; Spooren W; Prinssen EP. British Journal of Pharmacology. 2008.

Computational aqueous solubility prediction for drug-like compounds in congeneric series.

Du-Cuny L; Huwyler J; Wiese M; Kansy M. European Journal of Medicinal Chemistry. 2008.

In silico prediction of brain and CSF permeation of small molecules using PLS regression models.

Bendels S; Kansy M; Wagner B; Huwyler J. European Journal of Medicinal Chemistry. 2008.

Synthesis and characterization of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: Part 3. New potent non-competitive metabotropic glutamate receptor 2/3 antagonists.

Woltering TJ; Wichmann J; Goetschi E; Adam G; Kew JN; Knoflach F; Ballard TM; Huwyler J; Mutel V; Gatti S. Bioorganic & medicinal chemistry letters. 2008.

The human brain endothelial cell line hCMEC/D3 as a human blood-brain barrier model for drug transport studies

Poller B.; Gutmann H.; Krahenbuhl S.; Weksler B.; Romero I.; Couraud P.-O.; Tuffin G.; Drewe J.; Huwyler J.. Journal of neurochemistry. 2008.

Tumor targeting using liposomal antineoplastic drugs

Huwyler J.; Drewe J.; Krahenbuhl S.. International Journal of Nanomedicine. 2008.

A potentiometric titration method for the crystallization of drug-like organic molecules.

Du-Cuny L; Huwyler J; Fischer H; Kansy M. International journal of pharmaceutics. 2007.

Rational design, synthesis, and structure-activity relationship of benzoxazolones: new potent mglu5 receptor antagonists based on the fenobam structure.

Ceccarelli SM; Jaeschke G; Buettelmann B; Huwyler J; Kolczewski S; Peters JU; Prinssen E; Porter R; Spooren W; Vieira E. Bioorganic & medicinal chemistry letters. 2007.

Synthesis and biological evaluation of fenobam analogs as mGlu5 receptor antagonists.

Jaeschke G; Porter R; Büttelmann B; Ceccarelli SM; Guba W; Kuhn B; Kolczewski S; Huwyler J; Mutel V; Peters JU; Ballard T; Prinssen E; Vieira E; Wichmann J; Spooren W. Bioorganic & medicinal chemistry letters. 2007.

Arylmethoxypyridines as novel, potent and orally active mGlu5 receptor antagonists.

Büttelmann B; Peters JU; Ceccarelli S; Kolczewski S; Vieira E; Prinssen EP; Spooren W; Schuler F; Huwyler J; Porter RH; Jaeschke G. Bioorganic & medicinal chemistry letters. 2006.

Induction of cytochrome P450 3A4 and P-glycoprotein by the isoxazolyl-penicillin antibiotic flucloxacillin

Huwyler J.; Wright M.B.; Gutmann H.; Drewe J.. Current drug metabolism. 2006.

9H-Xanthene-9-carboxylic acid [1,2,4]oxadiazol-3-yl- and (2H-tetrazol-5-yl)-amides as potent, orally available mGlu1 receptor enhancers.

Vieira E; Huwyler J; Jolidon S; Knoflach F; Mutel V; Wichmann J. Bioorganic & medicinal chemistry letters. 2005.

Drug transport to brain with targeted liposomes.

Schnyder A; Huwyler J. NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics. 2005.

Targeting of daunomycin using biotinylated immunoliposomes: Pharmacokinetics, tissue distribution and in vitro pharmacological effects

Schnyder A.; Krahenbuhl S.; Drewe J.; Huwyler J.. Journal of Drug Targeting. 2005.

The effect of the mGlu5 receptor antagonist MPEP in rodent tests of anxiety and cognition: a comparison.

Ballard TM; Woolley ML; Prinssen E; Huwyler J; Porter R; Spooren W. Psychopharmacology. 2005.

In vitro investigation on the impact of the surface-active excipients Cremophor EL, Tween 80 and Solutol HS 15 on the metabolism of midazolam.

Bravo González RC; Huwyler J; Boess F; Walter I; Bittner B. Biopharmaceutics & drug disposition. 2004.

Targeting of skeletal muscle in vitro using biotinylated immunoliposomes

Schnyder A.; Krahenbuhl S.; Torok M.; Drewe J.; Huwyler J.. Biochemical Journal. 2004.

Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery.

Schwab D; Fischer H; Tabatabaei A; Poli S; Huwyler J. Journal of Medicinal Chemistry. 2003.

Evaluation of the NR2B-selective NMDA receptor antagonist Ro 63-1908 on rodent behaviour: evidence for an involvement of NR2B NMDA receptors in response inhibition.

Higgins GA; Ballard TM; Huwyler J; Kemp JA; Gill R. Neuropharmacology. 2003.

Impact of Solutol HS 15 on the pharmacokinetic behaviour of colchicine upon intravenous administration to male Wistar rats.

Bittner B; González RC; Walter I; Kapps M; Huwyler J. Biopharmaceutics & drug disposition. 2003.

Modulation of transendothelial permeability and expression of ATP-binding cassette transporters in cultured brain capillary endothelial cells by astrocytic factors and cell-culture conditions.

Török M; Huwyler J; Gutmann H; Fricker G; Drewe J. Experimental brain research. 2003.

By-passing of P-glycoprotein using immunoliposomes.

Huwyler J; Cerletti A; Fricker G; Eberle AN; Drewe J. Journal of Drug Targeting. 2002.

Improved oral bioavailability of cyclosporin A in male Wistar rats. Comparison of a Solutol HS 15 containing self-dispersing formulation and a microsuspension.

Bravo González RC; Huwyler J; Walter I; Mountfield R; Bittner B. International journal of pharmaceutics. 2002.

Targeting of the photocytotoxic compound A1PcS4 to Hela cells by transferrin conjugated PEG-liposomes

Gijsens A.; Derycke A.; Missiaen L.; De Vos D.; Huwyler J.; Eberle A.; De Witte P.. International Journal of Cancer. 2002.

Endocytosis and transcytosis of an immunoliposome-based brain drug delivery system.

Cerletti A; Drewe J; Fricker G; Eberle AN; Huwyler J. Journal of Drug Targeting. 2000.

Evidence that nicotinic alpha(7) receptors are not involved in the hyperlocomotor and rewarding effects of nicotine.

Grottick AJ; Trube G; Corrigall WA; Huwyler J; Malherbe P; Wyler R; Higgins GA. The Journal of pharmacology and experimental therapeutics. 2000.

Characterization of transferrin receptor in an immortalized cell line of rat brain endothelial cells, RBE4.

Huwyler J; Froidevaux S; Roux F; Eberle AN. Journal of Receptors and Signal Transduction. 1999.

HIV protease inhibitor ritonavir: a more potent inhibitor of P-glycoprotein than the cyclosporine analog SDZ PSC 833.

Drewe J; Gutmann H; Fricker G; Török M; Beglinger C; Huwyler J. Biochemical pharmacology. 1999.

Examination of blood-brain barrier transferrin receptor by confocal fluorescent microscopy of unfixed isolated rat brain capillaries

Huwyler J.; Pardridge W.M.. Journal of neurochemistry. 1998.

Treatment of large solid tumors in mice with daunomycin-loaded sterically stabilized liposomes

Golden P.L.; Huwyler J.; Pardridge W.M.. Drug Delivery: Journal of Delivery and Targeting of Therapeutic Agents. 1998.

High-performance liquid chromatographic method for an automated determination of local anaesthetics in human plasma

Drewe J.; Rufer S.; Huwyler J.; Kusters E.. Journal of Chromatography B: Biomedical Applications. 1997.

Receptor mediated delivery of daunomycin using immunoliposomes: Pharmacokinetics and tissue distribution in the rat

Huwyler J.; Yang J.; Pardridge W.M.. The Journal of pharmacology and experimental therapeutics. 1997.

Brain drug delivery of small molecules using immunoliposomes

Huwyler J.; Wu D.; Pardridge W.M.. Proceedings of the National Academy of Sciences of the United States of America. 1996.

Evidence for P-glycoprotein-modulated penetration of morphine-6-glucuronide into brain capillary endothelium.

Huwyler J; Drewe J; Klusemann C; Fricker G. British Journal of Pharmacology. 1996.

Rapid and highly automated determination of morphine and morphine glucuronides in plasma by on-line solid-phase extraction and column liquid chromatography

Huwyler J.; Rufer S.; Kusters E.; Drewe J.. Journal of Chromatography B: Biomedical Sciences and Applications. 1995.

Leukotriene B4 formation upon halothane-induced lipid peroxidation in liver membrane fractions under low O2 concentrations in vitro.

Gut J; Huwyler J. European journal of biochemistry. 1994.

Mechanisms of halothane toxicity: novel insights.

Gut J; Christen U; Huwyler J. Pharmacology & therapeutics. 1993.

Exposure to the chlorofluorocarbon substitute 2,2-dichloro-1,1,1- trifluoroethane and the anesthetic agent halothane is associated with transient protein adduct formation in the heart.

Huwyler J; Gut J. Biochemical and Biophysical Research Communications. 1992.

Halothane metabolism. Impairment of hepatic omega-oxidation of leukotrienes in vivo and in vitro.

Huwyler J; Jedlitschky G; Keppler D; Gut J. European journal of biochemistry. 1992.

Molecular mimicry of trifluoroacetylated human liver protein adducts by constitutive proteins and immunochemical evidence for its impairment in halothane hepatitis.

Gut J; Christen U; Huwyler J; Bürgin M; Kenna JG. European journal of biochemistry. 1992.

The kidney as a novel target tissue for protein adduct formation associated with metabolism of halothane and the candidate chlorofluorocarbon replacement 2,2-dichloro-1,1,1-trifluoroethane.

Huwyler J; Aeschlimann D; Christen U; Gut J. European journal of biochemistry. 1992.

Single-step organic extraction of leukotrienes and related compounds and their simultaneous analysis by high-performance liquid chromatography.

Huwyler J; Gut J. Analytical biochemistry. 1990.