Departement
Klinische Forschung
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Publications Osthoff Michael

Community-acquired and hospital-acquired respiratory tract infection and bloodstream infection in patients hospitalized with COVID-19 pneumonia.

Søgaard KK; Baettig V; Osthoff M; Marsch S; Leuzinger K; Schweitzer M; Meier J; Bassetti S; Bingisser R; Nickel CH; Khanna N; Tschudin-Sutter S; Weisser M; Battegay M; Hirsch HH; Pargger H; Siegemund M; Egli A. Journal of Intensive Care. 2021.

Epidemiology and precision of SARS-CoV-2 detection following lockdown and relaxation measures.

Leuzinger K; Gosert R; Søgaard KK; Naegele K; Bielicki J; Roloff T; Bingisser R; Nickel CH; Khanna N; Sutter ST; Widmer AF; Rentsch K; Pargger H; Siegemund M; Stolz D; Tamm M; Bassetti S; Osthoff M; Battegay M; Egli A; Hirsch HH. Journal of medical virology. 2021.

More than Meets the Eye: Bacteremic Pneumococcal Pneumonia as the Initial Presentation of Multiple Myeloma.

Jautz J; Potlukova E; Zeeh F; Osthoff M. The American journal of case reports. 2021.

Probability of pharmacological target attainment with flucloxacillin in Staphylococcus aureus bloodstream infection: a prospective cohort study of unbound plasma and individual MICs.

Moser S; Rehm S; Guertler N; Hinic V; Dräger S; Bassetti S; Rentsch KM; Sendi P; Osthoff M. The Journal of antimicrobial chemotherapy. 2021.

Recombinant human C1 esterase inhibitor (conestat alfa) in the prevention of severe SARS-CoV-2 infection in hospitalized patients with COVID-19: A structured summary of a study protocol for a randomized, parallel-group, open-label, multi-center pilot trial (PROTECT-COVID-19).

Urwyler P; Charitos P; Moser S; Heijnen IAFM; Trendelenburg M; Thoma R; Sumer J; Camacho-Ortiz A; Bacci MR; Huber LC; Stüssi-Helbling M; Albrich WC; Sendi P; Osthoff M. . 2021.

Relative bradycardia in patients with COVID-19.

Capoferri G; Osthoff M; Egli A; Stoeckle M; Bassetti S. . 2021.

SARS-CoV-2 outbreak in a tri-national urban area is dominated by a B.1 lineage variant linked to a mass gathering event.

Stange M; Mari A; Roloff T; Seth-Smith HM; Schweitzer M; Brunner M; Leuzinger K; Søgaard KK; Gensch A; Tschudin-Sutter S; Fuchs S; Bielicki J; Pargger H; Siegemund M; Nickel CH; Bingisser R; Osthoff M; Bassetti S; Schneider-Sliwa R; Battegay M; Hirsch HH; Egli A. PLoS pathogens. 2021.

The Alkaline Phosphatase Flare Phenomenon: A Transient Substantial Increase in Alkaline Phosphatase Concentration in a Prostate Cancer Patient after Starting GnRH Agonist Treatment.

Merlo P; Rochlitz C; Osthoff M. . 2021.

The Detection of Vancomycin in Sweat: A Next-Generation Digital Surrogate Marker for Antibiotic Tissue Penetration: A Pilot Study.

Brasier N; Widmer A; Osthoff M; Mutke M; De Ieso F; Brasier-Lutz P; Brown K; Yao L; Broeckling CD; Prenni J; Eckstein J. Digital biomarkers. 2021.

[Hematochezia and right-sided upper abdominal pain after puncture of a liver abscess in a 75-year-old male].

Gürtler N; Linnemann D; Moser S; Dräger S; Osthoff M. Der Internist. 2020.

A Randomized Trial of Recombinant Human C1-Esterase-Inhibitor in the Prevention of Contrast-Induced Kidney Injury.

Panagiotou A; Trendelenburg M; Heijnen IAFM; Moser S; Bonati LH; Breidthardt T; Fahrni G; Kaiser C; Jeger R; Osthoff M. JACC. Cardiovascular interventions. 2020.

Effect of Systemic Inflammatory Response to SARS-CoV-2 on Lopinavir and Hydroxychloroquine Plasma Concentrations.

Marzolini C; Stader F; Stoeckle M; Franzeck F; Egli A; Bassetti S; Hollinger A; Osthoff M; Weisser M; Gebhard CE; Baettig V; Geenen J; Khanna N; Tschudin-Sutter S; Mueller D; Hirsch HH; Battegay M; Sendi P. Antimicrobial agents and chemotherapy. 2020.

Local and Systemic Concentrations of Pattern Recognition Receptors of the Lectin Pathway of Complement in a Cohort of Patients With Interstitial Lung Diseases.

Vogt S; Trendelenburg M; Tamm M; Stolz D; Hostettler KE; Osthoff M. Frontiers in Immunology. 2020.

No association of complement mannose-binding lectin deficiency with cardiovascular disease in patients with Systemic Lupus Erythematosus.

Kieninger-Gräfitsch A; Vogt S; Ribi C; Dubler D; Chizzolini C; Huynh-Do U; Osthoff M; Trendelenburg M. . 2020.

Non-invasive Drug Monitoring of β-Lactam Antibiotics Using Sweat Analysis-A Pilot Study.

Brasier N; Widmer A; Osthoff M; Mutke M; De Ieso F; Brasier-Lutz P; Wolfe L; Aithal V; Broeckling CD; Prenni J; Eckstein J. Frontiers in Medicine. 2020.

OPAT in Switzerland: single-center experience of a model to treat complicated infections.

Erba A; Beuret M; Daly ML; Khanna N; Osthoff M. Infection. 2020.

Relevance of Dermabacter hominis isolated from clinical samples, 2012-2016: a retrospective case series.

Schaub C; Dräger S; Hinic V; Bassetti S; Frei R; Osthoff M. DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE. 2020.

Reversible Hippocratic Fingers in a Patient with Pneumonia.

Diebold M; Kuster S; Osthoff M. AMERICAN JOURNAL OF MEDICINE. 2020.

Simultaneous VZV and HSV-1 Reactivation after Minor Head Injury.

Häfelfinger R; Burgener AV; Osthoff M; Potlukova E. European journal of case reports in internal medicine. 2020.

Treatment of COVID-19 With Conestat Alfa, a Regulator of the Complement, Contact Activation and Kallikrein-Kinin System.

Urwyler P; Moser S; Charitos P; Heijnen IAFM; Rudin M; Sommer G; Giannetti BM; Bassetti S; Sendi P; Trendelenburg M; Osthoff M. Frontiers in Immunology. 2020.

Wither Away: Weight Loss and Persistent Inflammation in a Woman With Whipple Disease.

Schunemann MJ; Vosbeck J; Antwi K; Bassetti S; Osthoff M. AMERICAN JOURNAL OF MEDICINE. 2020.

Zwischen Traum und Trauma - Aufbau und Betrieb einer Kohortenstation für Patient_innen mit COVID-19 in einem Akutspital - Eine Fallstudie.

Rabes C; Bläuer C; Büche V; Gisler Ries I; Knüppel Lauener S; Kuehl R; Osthoff M; Pfeiffer M; Probst S; Todorov V; Panfil EM. Pflege. 2020.

Appropriateness of antimicrobial prescribing in a Swiss tertiary care hospital: a repeated point prevalence survey.

Gürtler N; Erba A; Giehl C; Tschudin-Sutter S; Bassetti S; Osthoff M. Swiss medical weekly. 2019.

IL-4 polymorphism influences susceptibility to Pneumocystis jirovecii pneumonia in HIV-positive patients.

Wójtowicz A; Bibert S; Taffé P; Bernasconi E; Furrer H; Günthard HF; Hoffmann M; Osthoff M; Cavassini M; Bochud PY; Swiss HIV Cohort Study.. AIDS (London, England). 2019.

Influence of a resin-based blood culture medium on the time to clearance of methicillin-susceptible Staphylococcus aureus bloodstream infection - A retrospective cohort study.

Gürtler N; Denz A; Egli A; Widmer AF; Osthoff M. DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE. 2019.

Multicenter Population Pharmacokinetic Study of Colistimethate Sodium and Colistin Dosed as in Normal Renal Function in Patients on Continuous Renal Replacement Therapy.

Leuppi-Taegtmeyer AB; Decosterd L; Osthoff M; Mueller NJ; Buclin T; Corti N. Antimicrobial agents and chemotherapy. 2019.

Prosthetic valve endocarditis caused by Pseudomonas aeruginosa with variable antibacterial resistance profiles: a diagnostic challenge.

Gürtler N; Osthoff M; Rueter F; Wüthrich D; Zimmerli L; Egli A; Bassetti S. BMC Infectious Diseases. 2019.

Role of lectin pathway complement proteins and genetic variants in organ damage and disease severity of systemic sclerosis: a cross-sectional study.

Osthoff M; Jaeger VK; Heijnen IAFM; Trendelenburg M; Jordan S; Distler O; Walker UA. Arthritis research & therapy. 2019.

<i>Escherichia coli</i> bloodstream infection preceding the diagnosis of rectal carcinoma.

Thoma R; Häuptle P; Degen L; Bassetti S; Osthoff M. Oxford medical case reports. 2018.

Discovery and Characterization of <i>Mycobacterium basiliense</i> sp. nov., a Nontuberculous Mycobacterium Isolated From Human Lungs.

Seth-Smith HMB; Imkamp F; Tagini F; Cuénod A; Hömke R; Jahn K; Tschacher A; Grendelmeier P; Bättig V; Erb S; Reinhard M; Rütimann G; Borrell S; Gagneux S; Casanova C; Droz S; Osthoff M; Tamm M; Nübel U; Greub G; Keller PM; Egli A. Frontiers in Microbiology. 2018.

Interferon lambda 3/4 polymorphisms are associated with AIDS-related Kaposi's sarcoma.

Bibert S; Wójtowicz A; Taffé P; Tarr PE; Bernasconi E; Furrer H; Günthard HF; Hoffmann M; Kaiser L; Osthoff M; Fellay J; Cavassini M; Bochud PY; Swiss HIV Cohort Study.. AIDS (London, England). 2018.

Sodium Polystyrene Sulfonate and Cytomegalovirus-Associated Hemorrhagic Duodenitis: More than Meets the Eye.

Gürtler N; Hirt-Minkowski P; Brunner SS; König K; Glatz K; Reichenstein D; Bassetti S; Osthoff M. American Journal of Case Reports. 2018.

The Lectin Pathway of Complement in Myocardial Ischemia/Reperfusion Injury-Review of Its Significance and the Potential Impact of Therapeutic Interference by C1 Esterase Inhibitor.

Panagiotou A; Trendelenburg M; Osthoff M. Frontiers in Immunology. 2018.

Association of Lectin Pathway Protein Levels and Genetic Variants Early after Injury with Outcomes after Severe Traumatic Brain Injury: A Prospective Cohort Study.

Osthoff M; Walder B; Delhumeau C; Trendelenburg M; Turck N. JOURNAL OF NEUROTRAUMA. 2017.

Ceftazidime-Avibactam as Salvage Therapy for Infections Caused by Carbapenem-Resistant Organisms.

Temkin E; Torre-Cisneros J; Beovic B; Benito N; Giannella M; Gilarranz R; Jeremiah C; Loeches B; Machuca I; Jiménez-Martín MJ; Martínez JA; Mora-Rillo M; Navas E; Osthoff M; Pozo JC; Ramos Ramos JC; Rodriguez M; Sánchez-García M; Viale P; Wolff M; Carmeli Y. Antimicrobial agents and chemotherapy. 2017.

Evaluation of existing and desired antimicrobial stewardship activities and strategies in Swiss hospitals.

Osthoff M; Bielicki J; Widmer AF; For Swissnoso. Swiss medical weekly. 2017.

Impact of MALDI-TOF-MS-based identification directly from positive blood cultures on patient management: a controlled clinical trial.

Osthoff M; Gürtler N; Bassetti S; Balestra G; Marsch S; Pargger H; Weisser M; Egli A. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. 2017.

Painless swelling of the forefoot and recurrent subcutaneous abscesses of the lower leg-Two distinct presentations illustrating the spectrum of eumycetoma in a nonendemic country.

Schibli A; Goldenberger D; Krieg A; Hirschmann A; Bruder E; Osthoff M. PLoS neglected tropical diseases. 2017.

Quantifying the Effects of Prior Acetyl-Salicylic Acid on Sepsis-Related Deaths: An Individual Patient Data Meta-Analysis Using Propensity Matching.

Trauer J; Muhi S; McBryde ES; Al Harbi SA; Arabi YM; Boyle AJ; Cartin-Ceba R; Chen W; Chen YT; Falcone M; Gajic O; Godsell J; Gong MN; Kor D; Lösche W; McAuley DF; O'Neal HR Jr; Osthoff M; Otto GP; Sossdorf M; Tsai MJ; Valerio-Rojas JC; van der Poll T; Violi F; Ware L; Widmer AF; Wiewel MA; Winning J; Eisen DP. Critical care medicine. 2017.

Septic arthritis due to Legionella cincinnatiensis: case report and review of the literature.

Banderet F; Blaich A; Soleman E; Gaia V; Osthoff M. Infection. 2017.

The EMPIRICUS trial-the final nail in the coffin of empirical antifungal therapy in the intensive care unit?

Osthoff M; Khanna N; Siegemund M. Journal of Thoracic Disease. 2017.

Association of lectin pathway proteins with intra-abdominal Candida infection in high-risk surgical intensive-care unit patients. A prospective cohort study within the fungal infection network of Switzerland

Osthoff M.; Wojtowicz A.; Tissot F.; Jorgensen C.; Thiel S.; Zimmerli S.; Marchetti O.; Khanna N.; Bochud P.-Y.; Trendelenburg M.; Bregenzer T.; Conen A.; Fankhauser H.; Fluckiger U.; Frei R.; Heininger U.; Hertel R.; Franciolli M.; Dolina M.; Rothen M.; Dubuis O.; Tarr P.; Graf S.; Fleisch F.; Risch M.; Ritzler E.; Chuard C.; Erard V.; Fracheboud D.; Emonet S.; Genne D.; Lienhardt R.; Chave J.-P.; Andreutti-Zaugg C.; Gallusser A.; Graber P.; Monotti R.; Bernasconi E.; Krause M.; Herzog K.; Piso R.-J.; Schibli U.; Bally F.; Troillet N.; Tissiere L.; Boggian K.; Bruderer T.; Gubler J.; Eich G.; Berger C.. JOURNAL OF INFECTION. 2016.

Isavuconazole Isavuconazol

Osthoff M.; Battig V.; Khanna N.. Therapeutische Umschau. Revue therapeutique. 2016.

Louse-borne relapsing fever - report of four cases in Switzerland, June-December 2015.

Osthoff M; Schibli A; Fadini D; Lardelli P; Goldenberger D. BMC Infectious Diseases. 2016.

Low-Dose Acetylsalicylic Acid Treatment and Impact on Short-Term Mortality in Staphylococcus aureus Bloodstream Infection: A Propensity Score-Matched Cohort Study.

Osthoff M; Sidler JA; Lakatos B; Frei R; Dangel M; Weisser M; Battegay M; Widmer AF. Critical care medicine. 2016.

Neuraminidase Inhibitors and Influenza Infection.

Osthoff M; Erb S. JAMA Intern Med. 2016.

Neuraminidase Inhibitors and Influenza Infection.

Osthoff M; Erb S. JAMA Intern Med. 2016.

Prolonged administration of β-lactam antibiotics - a comprehensive review and critical appraisal.

Osthoff M; Siegemund M; Balestra G; Abdul-Aziz MH; Roberts JA. Schweizerische Medizinische Wochenschrift. 2016.

The authors reply.

Osthoff M; Sidler JA; Widmer AF. Critical care medicine. 2016.

[Weight loss and chronic diarrhea in a 54-year-old man with HIV infection].

Pickel S; Filipowicz M; Bruder E; Battegay M; Osthoff M. Der Internist. 2015.

Association Study of Mannose-Binding Lectin Levels and Genetic Variants in Lectin Pathway Proteins with Susceptibility to Age-Related Macular Degeneration: A Case-Control Study.

Osthoff M; Dean MM; Baird PN; Richardson AJ; Daniell M; Guymer RH; Eisen DP. PLoS One. 2015.

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF) directly from positive blood culture flasks allows rapid identification of bloodstream infections in immunosuppressed hosts.

Egli A; Osthoff M; Goldenberger D; Halter J; Schaub S; Steiger J; Weisser M; Frei R. Transplant infectious disease : an official journal of the Transplantation Society. 2015.

Urinary tract infections due to extended-spectrum beta-lactamase-producing Gram-negative bacteria: identification of risk factors and outcome predictors in an Australian tertiary referral hospital

Osthoff, Michael; McGuinness, Sarah L.; Wagen, Aaron Z.; Eisen, Damon P.. Int J Infect Dis. 2015.

Activation of the lectin pathway of complement in experimental human keratitis with Pseudomonas aeruginosa.

Osthoff M; Brown KD; Kong DC; Daniell M; Eisen DP. MOLECULAR VISION. 2014.

If there is an evolutionary selection pressure for the high frequency of MBL2 polymorphisms, what is it?

Eisen DP; Osthoff M. Clinical and experimental immunology. 2014.

Mannose-binding lectin and ficolin-2 do not influence humoral immune response to hepatitis B vaccine.

Osthoff M; Irungu E; Ngure K; Mugo N; Thomas KK; Baeten JM; Eisen DP. Vaccine. 2014.

Potential role of the lectin pathway of complement in the pathogenesis and disease manifestations of systemic sclerosis: a case-control and cohort study.

Osthoff M; Ngian GS; Dean MM; Nikpour M; Stevens W; Proudman S; Eisen DP; Sahhar J. Arthritis research & therapy. 2014.

The IFNL3/4 ΔG variant increases susceptibility to cytomegalovirus retinitis among HIV-infected patients.

Bibert S; Wojtowicz A; Taffé P; Manuel O; Bernasconi E; Furrer H; Günthard HF; Hoffmann M; Kaiser L; Osthoff M; Cavassini M; Bochud PY; Swiss HIV Cohort Study.. AIDS (London, England). 2014.

Disseminated toxoplasmosis after allogeneic stem cell transplantation in a seronegative recipient

Osthoff, M.; Chew, E.; Bajel, A.; Kelsey, G.; Panek-Hudson, Y.; Mason, K.; Szer, J.; Ritchie, D.; Slavin, M.. Transplant infectious disease : an official journal of the Transplantation Society. 2013.

Impact of mannose-binding lectin deficiency on radiocontrast-induced renal dysfunction.

Osthoff M; Trendelenburg M. BioMed research international. 2013.

Low levels of mannan-binding lectin or ficolins are not associated with an increased risk of cytomegalovirus disease in HIV-infected patients.

Egli A; Schäfer J; Osthoff M; Thiel S; Mikkelsen C; Rauch A; Hirsch HH; Bucher HC; Young J; Jensenius JC; Battegay M; Trendelenburg M; Swiss HIV Cohort Study.. PLoS One. 2013.

Procalcitonin as a diagnostic marker for sepsis.

Osthoff M; Eisen DP. The Lancet. Infectious diseases. 2013.

Significance of mannose-binding lectin deficiency and nucleotide-binding oligomerization domain 2 polymorphisms in Staphylococcus aureus bloodstream infections: a case-control study.

Osthoff M; Au Yong HM; Dean MM; Eisen DP. PLoS One. 2013.

Identification of a major linear C1q epitope allows detection of systemic lupus erythematosus anti-C1q antibodies by a specific peptide-based enzyme-linked immunosorbent assay

Vanhecke, Dominique; Roumenina, Lubka T.; Wan, Hui; Osthoff, Michael; Schaller, Monica; Trendelenburg, Marten. ARTHRITIS AND RHEUMATISM. 2012.

Impact of mannose-binding lectin deficiency on radiocontrast-induced renal dysfunction: a post-hoc analysis of a multicenter randomized controlled trial.

Osthoff M; Piezzi V; Klima T; Christ A; Marana I; Hartwiger S; Breidthardt T; Marenzi G; Trendelenburg M; Mueller C. BMC Nephrology. 2012.

Mannose-binding lectin deficiency is associated with smaller infarction size and favorable outcome in ischemic stroke patients.

Osthoff M; Katan M; Fluri F; Schuetz P; Bingisser R; Kappos L; Steck AJ; Engelter ST; Mueller B; Christ-Crain M; Trendelenburg M. PLoS One. 2011.

Mannose-binding lectin-the forgotten molecule?

Osthoff M; Trendelenburg G; Eisen DP; Trendelenburg M. Nature medicine. 2011.

Mannose-binding lectin levels and major infections in a cohort of very long-term survivors after allogeneic stem cell transplantation.

Osthoff M; Rovó A; Stern M; Danner D; Gratwohl A; Tichelli A; Trendelenburg M. Haematologica. 2010.

Autoantibodies against complement C1q specifically target C1q bound on early apoptotic cells.

Bigler C; Schaller M; Perahud I; Osthoff M; Trendelenburg M. JOURNAL OF IMMUNOLOGY. 2009.