Klinische Forschung
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Publications Osthoff Michael

Community-acquired and hospital-acquired respiratory tract infection and bloodstream infection in patients hospitalized with COVID-19 pneumonia.

Søgaard KK; Baettig V; Osthoff M; Marsch S; Leuzinger K; Schweitzer M; Meier J; Bassetti S; Bingisser R; Nickel CH; Khanna N; Tschudin-Sutter S; Weisser M; Battegay M; Hirsch HH; Pargger H; Siegemund M; Egli A. Journal of Intensive Care. 2021.

Epidemiology and precision of SARS-CoV-2 detection following lockdown and relaxation measures.

Leuzinger K; Gosert R; Søgaard KK; Naegele K; Bielicki J; Roloff T; Bingisser R; Nickel CH; Khanna N; Sutter ST; Widmer AF; Rentsch K; Pargger H; Siegemund M; Stolz D; Tamm M; Bassetti S; Osthoff M; Battegay M; Egli A; Hirsch HH. Journal of medical virology. 2021.

More than Meets the Eye: Bacteremic Pneumococcal Pneumonia as the Initial Presentation of Multiple Myeloma.

Jautz J; Potlukova E; Zeeh F; Osthoff M. The American journal of case reports. 2021.

Probability of pharmacological target attainment with flucloxacillin in Staphylococcus aureus bloodstream infection: a prospective cohort study of unbound plasma and individual MICs.

Moser S; Rehm S; Guertler N; Hinic V; Dräger S; Bassetti S; Rentsch KM; Sendi P; Osthoff M. The Journal of antimicrobial chemotherapy. 2021.

Recombinant human C1 esterase inhibitor (conestat alfa) in the prevention of severe SARS-CoV-2 infection in hospitalized patients with COVID-19: A structured summary of a study protocol for a randomized, parallel-group, open-label, multi-center pilot trial (PROTECT-COVID-19).

Urwyler P; Charitos P; Moser S; Heijnen IAFM; Trendelenburg M; Thoma R; Sumer J; Camacho-Ortiz A; Bacci MR; Huber LC; Stüssi-Helbling M; Albrich WC; Sendi P; Osthoff M. . 2021.

Relative bradycardia in patients with COVID-19.

Capoferri G; Osthoff M; Egli A; Stoeckle M; Bassetti S. . 2021.

SARS-CoV-2 outbreak in a tri-national urban area is dominated by a B.1 lineage variant linked to a mass gathering event.

Stange M; Mari A; Roloff T; Seth-Smith HM; Schweitzer M; Brunner M; Leuzinger K; Søgaard KK; Gensch A; Tschudin-Sutter S; Fuchs S; Bielicki J; Pargger H; Siegemund M; Nickel CH; Bingisser R; Osthoff M; Bassetti S; Schneider-Sliwa R; Battegay M; Hirsch HH; Egli A. PLoS pathogens. 2021.

The Alkaline Phosphatase Flare Phenomenon: A Transient Substantial Increase in Alkaline Phosphatase Concentration in a Prostate Cancer Patient after Starting GnRH Agonist Treatment.

Merlo P; Rochlitz C; Osthoff M. . 2021.

The Detection of Vancomycin in Sweat: A Next-Generation Digital Surrogate Marker for Antibiotic Tissue Penetration: A Pilot Study.

Brasier N; Widmer A; Osthoff M; Mutke M; De Ieso F; Brasier-Lutz P; Brown K; Yao L; Broeckling CD; Prenni J; Eckstein J. Digital biomarkers. 2021.

[Hematochezia and right-sided upper abdominal pain after puncture of a liver abscess in a 75-year-old male].

Gürtler N; Linnemann D; Moser S; Dräger S; Osthoff M. Der Internist. 2020.

A Randomized Trial of Recombinant Human C1-Esterase-Inhibitor in the Prevention of Contrast-Induced Kidney Injury.

Panagiotou A; Trendelenburg M; Heijnen IAFM; Moser S; Bonati LH; Breidthardt T; Fahrni G; Kaiser C; Jeger R; Osthoff M. JACC. Cardiovascular interventions. 2020.

Effect of Systemic Inflammatory Response to SARS-CoV-2 on Lopinavir and Hydroxychloroquine Plasma Concentrations.

Marzolini C; Stader F; Stoeckle M; Franzeck F; Egli A; Bassetti S; Hollinger A; Osthoff M; Weisser M; Gebhard CE; Baettig V; Geenen J; Khanna N; Tschudin-Sutter S; Mueller D; Hirsch HH; Battegay M; Sendi P. Antimicrobial agents and chemotherapy. 2020.

Local and Systemic Concentrations of Pattern Recognition Receptors of the Lectin Pathway of Complement in a Cohort of Patients With Interstitial Lung Diseases.

Vogt S; Trendelenburg M; Tamm M; Stolz D; Hostettler KE; Osthoff M. Frontiers in Immunology. 2020.

No association of complement mannose-binding lectin deficiency with cardiovascular disease in patients with Systemic Lupus Erythematosus.

Kieninger-Gräfitsch A; Vogt S; Ribi C; Dubler D; Chizzolini C; Huynh-Do U; Osthoff M; Trendelenburg M. . 2020.

Non-invasive Drug Monitoring of β-Lactam Antibiotics Using Sweat Analysis-A Pilot Study.

Brasier N; Widmer A; Osthoff M; Mutke M; De Ieso F; Brasier-Lutz P; Wolfe L; Aithal V; Broeckling CD; Prenni J; Eckstein J. Frontiers in Medicine. 2020.

OPAT in Switzerland: single-center experience of a model to treat complicated infections.

Erba A; Beuret M; Daly ML; Khanna N; Osthoff M. Infection. 2020.

Relevance of Dermabacter hominis isolated from clinical samples, 2012-2016: a retrospective case series.

Schaub C; Dräger S; Hinic V; Bassetti S; Frei R; Osthoff M. DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE. 2020.

Reversible Hippocratic Fingers in a Patient with Pneumonia.

Diebold M; Kuster S; Osthoff M. AMERICAN JOURNAL OF MEDICINE. 2020.

Simultaneous VZV and HSV-1 Reactivation after Minor Head Injury.

Häfelfinger R; Burgener AV; Osthoff M; Potlukova E. European journal of case reports in internal medicine. 2020.

Treatment of COVID-19 With Conestat Alfa, a Regulator of the Complement, Contact Activation and Kallikrein-Kinin System.

Urwyler P; Moser S; Charitos P; Heijnen IAFM; Rudin M; Sommer G; Giannetti BM; Bassetti S; Sendi P; Trendelenburg M; Osthoff M. Frontiers in Immunology. 2020.

Wither Away: Weight Loss and Persistent Inflammation in a Woman With Whipple Disease.

Schunemann MJ; Vosbeck J; Antwi K; Bassetti S; Osthoff M. AMERICAN JOURNAL OF MEDICINE. 2020.

Zwischen Traum und Trauma - Aufbau und Betrieb einer Kohortenstation für Patient_innen mit COVID-19 in einem Akutspital - Eine Fallstudie.

Rabes C; Bläuer C; Büche V; Gisler Ries I; Knüppel Lauener S; Kuehl R; Osthoff M; Pfeiffer M; Probst S; Todorov V; Panfil EM. Pflege. 2020.

Appropriateness of antimicrobial prescribing in a Swiss tertiary care hospital: a repeated point prevalence survey.

Gürtler N; Erba A; Giehl C; Tschudin-Sutter S; Bassetti S; Osthoff M. Swiss medical weekly. 2019.

IL-4 polymorphism influences susceptibility to Pneumocystis jirovecii pneumonia in HIV-positive patients.

Wójtowicz A; Bibert S; Taffé P; Bernasconi E; Furrer H; Günthard HF; Hoffmann M; Osthoff M; Cavassini M; Bochud PY; Swiss HIV Cohort Study.. AIDS (London, England). 2019.

Influence of a resin-based blood culture medium on the time to clearance of methicillin-susceptible Staphylococcus aureus bloodstream infection - A retrospective cohort study.


Multicenter Population Pharmacokinetic Study of Colistimethate Sodium and Colistin Dosed as in Normal Renal Function in Patients on Continuous Renal Replacement Therapy.

Leuppi-Taegtmeyer AB; Decosterd L; Osthoff M; Mueller NJ; Buclin T; Corti N. Antimicrobial agents and chemotherapy. 2019.

Prosthetic valve endocarditis caused by Pseudomonas aeruginosa with variable antibacterial resistance profiles: a diagnostic challenge.

Gürtler N; Osthoff M; Rueter F; Wüthrich D; Zimmerli L; Egli A; Bassetti S. BMC Infectious Diseases. 2019.

Role of lectin pathway complement proteins and genetic variants in organ damage and disease severity of systemic sclerosis: a cross-sectional study.

Osthoff M; Jaeger VK; Heijnen IAFM; Trendelenburg M; Jordan S; Distler O; Walker UA. Arthritis research & therapy. 2019.

<i>Escherichia coli</i> bloodstream infection preceding the diagnosis of rectal carcinoma.

Thoma R; Häuptle P; Degen L; Bassetti S; Osthoff M. Oxford medical case reports. 2018.

Discovery and Characterization of <i>Mycobacterium basiliense</i> sp. nov., a Nontuberculous Mycobacterium Isolated From Human Lungs.

Seth-Smith HMB; Imkamp F; Tagini F; Cuénod A; Hömke R; Jahn K; Tschacher A; Grendelmeier P; Bättig V; Erb S; Reinhard M; Rütimann G; Borrell S; Gagneux S; Casanova C; Droz S; Osthoff M; Tamm M; Nübel U; Greub G; Keller PM; Egli A. Frontiers in Microbiology. 2018.

Interferon lambda 3/4 polymorphisms are associated with AIDS-related Kaposi's sarcoma.

Bibert S; Wójtowicz A; Taffé P; Tarr PE; Bernasconi E; Furrer H; Günthard HF; Hoffmann M; Kaiser L; Osthoff M; Fellay J; Cavassini M; Bochud PY; Swiss HIV Cohort Study.. AIDS (London, England). 2018.

Sodium Polystyrene Sulfonate and Cytomegalovirus-Associated Hemorrhagic Duodenitis: More than Meets the Eye.

Gürtler N; Hirt-Minkowski P; Brunner SS; König K; Glatz K; Reichenstein D; Bassetti S; Osthoff M. American Journal of Case Reports. 2018.

The Lectin Pathway of Complement in Myocardial Ischemia/Reperfusion Injury-Review of Its Significance and the Potential Impact of Therapeutic Interference by C1 Esterase Inhibitor.

Panagiotou A; Trendelenburg M; Osthoff M. Frontiers in Immunology. 2018.

Association of Lectin Pathway Protein Levels and Genetic Variants Early after Injury with Outcomes after Severe Traumatic Brain Injury: A Prospective Cohort Study.

Osthoff M; Walder B; Delhumeau C; Trendelenburg M; Turck N. JOURNAL OF NEUROTRAUMA. 2017.

Ceftazidime-Avibactam as Salvage Therapy for Infections Caused by Carbapenem-Resistant Organisms.

Temkin E; Torre-Cisneros J; Beovic B; Benito N; Giannella M; Gilarranz R; Jeremiah C; Loeches B; Machuca I; Jiménez-Martín MJ; Martínez JA; Mora-Rillo M; Navas E; Osthoff M; Pozo JC; Ramos Ramos JC; Rodriguez M; Sánchez-García M; Viale P; Wolff M; Carmeli Y. Antimicrobial agents and chemotherapy. 2017.

Evaluation of existing and desired antimicrobial stewardship activities and strategies in Swiss hospitals.

Osthoff M; Bielicki J; Widmer AF; For Swissnoso. Swiss medical weekly. 2017.

Impact of MALDI-TOF-MS-based identification directly from positive blood cultures on patient management: a controlled clinical trial.

Osthoff M; Gürtler N; Bassetti S; Balestra G; Marsch S; Pargger H; Weisser M; Egli A. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. 2017.

Painless swelling of the forefoot and recurrent subcutaneous abscesses of the lower leg-Two distinct presentations illustrating the spectrum of eumycetoma in a nonendemic country.

Schibli A; Goldenberger D; Krieg A; Hirschmann A; Bruder E; Osthoff M. PLoS neglected tropical diseases. 2017.

Quantifying the Effects of Prior Acetyl-Salicylic Acid on Sepsis-Related Deaths: An Individual Patient Data Meta-Analysis Using Propensity Matching.

Trauer J; Muhi S; McBryde ES; Al Harbi SA; Arabi YM; Boyle AJ; Cartin-Ceba R; Chen W; Chen YT; Falcone M; Gajic O; Godsell J; Gong MN; Kor D; Lösche W; McAuley DF; O'Neal HR Jr; Osthoff M; Otto GP; Sossdorf M; Tsai MJ; Valerio-Rojas JC; van der Poll T; Violi F; Ware L; Widmer AF; Wiewel MA; Winning J; Eisen DP. Critical care medicine. 2017.

Septic arthritis due to Legionella cincinnatiensis: case report and review of the literature.

Banderet F; Blaich A; Soleman E; Gaia V; Osthoff M. Infection. 2017.

The EMPIRICUS trial-the final nail in the coffin of empirical antifungal therapy in the intensive care unit?

Osthoff M; Khanna N; Siegemund M. Journal of Thoracic Disease. 2017.

Association of lectin pathway proteins with intra-abdominal Candida infection in high-risk surgical intensive-care unit patients. A prospective cohort study within the fungal infection network of Switzerland

Osthoff M.; Wojtowicz A.; Tissot F.; Jorgensen C.; Thiel S.; Zimmerli S.; Marchetti O.; Khanna N.; Bochud P.-Y.; Trendelenburg M.; Bregenzer T.; Conen A.; Fankhauser H.; Fluckiger U.; Frei R.; Heininger U.; Hertel R.; Franciolli M.; Dolina M.; Rothen M.; Dubuis O.; Tarr P.; Graf S.; Fleisch F.; Risch M.; Ritzler E.; Chuard C.; Erard V.; Fracheboud D.; Emonet S.; Genne D.; Lienhardt R.; Chave J.-P.; Andreutti-Zaugg C.; Gallusser A.; Graber P.; Monotti R.; Bernasconi E.; Krause M.; Herzog K.; Piso R.-J.; Schibli U.; Bally F.; Troillet N.; Tissiere L.; Boggian K.; Bruderer T.; Gubler J.; Eich G.; Berger C.. JOURNAL OF INFECTION. 2016.

Isavuconazole Isavuconazol

Osthoff M.; Battig V.; Khanna N.. Therapeutische Umschau. Revue therapeutique. 2016.

Louse-borne relapsing fever - report of four cases in Switzerland, June-December 2015.

Osthoff M; Schibli A; Fadini D; Lardelli P; Goldenberger D. BMC Infectious Diseases. 2016.

Low-Dose Acetylsalicylic Acid Treatment and Impact on Short-Term Mortality in Staphylococcus aureus Bloodstream Infection: A Propensity Score-Matched Cohort Study.

Osthoff M; Sidler JA; Lakatos B; Frei R; Dangel M; Weisser M; Battegay M; Widmer AF. Critical care medicine. 2016.

Neuraminidase Inhibitors and Influenza Infection.

Osthoff M; Erb S. JAMA Intern Med. 2016.

Neuraminidase Inhibitors and Influenza Infection.

Osthoff M; Erb S. JAMA Intern Med. 2016.

Prolonged administration of β-lactam antibiotics - a comprehensive review and critical appraisal.

Osthoff M; Siegemund M; Balestra G; Abdul-Aziz MH; Roberts JA. Schweizerische Medizinische Wochenschrift. 2016.

The authors reply.

Osthoff M; Sidler JA; Widmer AF. Critical care medicine. 2016.

[Weight loss and chronic diarrhea in a 54-year-old man with HIV infection].

Pickel S; Filipowicz M; Bruder E; Battegay M; Osthoff M. Der Internist. 2015.

Association Study of Mannose-Binding Lectin Levels and Genetic Variants in Lectin Pathway Proteins with Susceptibility to Age-Related Macular Degeneration: A Case-Control Study.

Osthoff M; Dean MM; Baird PN; Richardson AJ; Daniell M; Guymer RH; Eisen DP. PLoS One. 2015.

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF) directly from positive blood culture flasks allows rapid identification of bloodstream infections in immunosuppressed hosts.

Egli A; Osthoff M; Goldenberger D; Halter J; Schaub S; Steiger J; Weisser M; Frei R. Transplant infectious disease : an official journal of the Transplantation Society. 2015.

Urinary tract infections due to extended-spectrum beta-lactamase-producing Gram-negative bacteria: identification of risk factors and outcome predictors in an Australian tertiary referral hospital

Osthoff, Michael; McGuinness, Sarah L.; Wagen, Aaron Z.; Eisen, Damon P.. Int J Infect Dis. 2015.

Activation of the lectin pathway of complement in experimental human keratitis with Pseudomonas aeruginosa.

Osthoff M; Brown KD; Kong DC; Daniell M; Eisen DP. MOLECULAR VISION. 2014.

If there is an evolutionary selection pressure for the high frequency of MBL2 polymorphisms, what is it?

Eisen DP; Osthoff M. Clinical and experimental immunology. 2014.

Mannose-binding lectin and ficolin-2 do not influence humoral immune response to hepatitis B vaccine.

Osthoff M; Irungu E; Ngure K; Mugo N; Thomas KK; Baeten JM; Eisen DP. Vaccine. 2014.

Potential role of the lectin pathway of complement in the pathogenesis and disease manifestations of systemic sclerosis: a case-control and cohort study.

Osthoff M; Ngian GS; Dean MM; Nikpour M; Stevens W; Proudman S; Eisen DP; Sahhar J. Arthritis research & therapy. 2014.

The IFNL3/4 ΔG variant increases susceptibility to cytomegalovirus retinitis among HIV-infected patients.

Bibert S; Wojtowicz A; Taffé P; Manuel O; Bernasconi E; Furrer H; Günthard HF; Hoffmann M; Kaiser L; Osthoff M; Cavassini M; Bochud PY; Swiss HIV Cohort Study.. AIDS (London, England). 2014.

Disseminated toxoplasmosis after allogeneic stem cell transplantation in a seronegative recipient

Osthoff, M.; Chew, E.; Bajel, A.; Kelsey, G.; Panek-Hudson, Y.; Mason, K.; Szer, J.; Ritchie, D.; Slavin, M.. Transplant infectious disease : an official journal of the Transplantation Society. 2013.

Impact of mannose-binding lectin deficiency on radiocontrast-induced renal dysfunction.

Osthoff M; Trendelenburg M. BioMed research international. 2013.

Low levels of mannan-binding lectin or ficolins are not associated with an increased risk of cytomegalovirus disease in HIV-infected patients.

Egli A; Schäfer J; Osthoff M; Thiel S; Mikkelsen C; Rauch A; Hirsch HH; Bucher HC; Young J; Jensenius JC; Battegay M; Trendelenburg M; Swiss HIV Cohort Study.. PLoS One. 2013.

Procalcitonin as a diagnostic marker for sepsis.

Osthoff M; Eisen DP. The Lancet. Infectious diseases. 2013.

Significance of mannose-binding lectin deficiency and nucleotide-binding oligomerization domain 2 polymorphisms in Staphylococcus aureus bloodstream infections: a case-control study.

Osthoff M; Au Yong HM; Dean MM; Eisen DP. PLoS One. 2013.

Identification of a major linear C1q epitope allows detection of systemic lupus erythematosus anti-C1q antibodies by a specific peptide-based enzyme-linked immunosorbent assay

Vanhecke, Dominique; Roumenina, Lubka T.; Wan, Hui; Osthoff, Michael; Schaller, Monica; Trendelenburg, Marten. ARTHRITIS AND RHEUMATISM. 2012.

Impact of mannose-binding lectin deficiency on radiocontrast-induced renal dysfunction: a post-hoc analysis of a multicenter randomized controlled trial.

Osthoff M; Piezzi V; Klima T; Christ A; Marana I; Hartwiger S; Breidthardt T; Marenzi G; Trendelenburg M; Mueller C. BMC Nephrology. 2012.

Mannose-binding lectin deficiency is associated with smaller infarction size and favorable outcome in ischemic stroke patients.

Osthoff M; Katan M; Fluri F; Schuetz P; Bingisser R; Kappos L; Steck AJ; Engelter ST; Mueller B; Christ-Crain M; Trendelenburg M. PLoS One. 2011.

Mannose-binding lectin-the forgotten molecule?

Osthoff M; Trendelenburg G; Eisen DP; Trendelenburg M. Nature medicine. 2011.

Mannose-binding lectin levels and major infections in a cohort of very long-term survivors after allogeneic stem cell transplantation.

Osthoff M; Rovó A; Stern M; Danner D; Gratwohl A; Tichelli A; Trendelenburg M. Haematologica. 2010.

Autoantibodies against complement C1q specifically target C1q bound on early apoptotic cells.

Bigler C; Schaller M; Perahud I; Osthoff M; Trendelenburg M. JOURNAL OF IMMUNOLOGY. 2009.