Klinische Forschung
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Publications Heim Markus H.

Computed tomography (CT) and magnetic resonance imaging (MRI) of diffuse liver disease: a multiparametric predictive modelling algorithm can aid categorization of liver parenchyma.

Donners R; Zaugg C; Gehweiler JE; Boldanova T; Heim MH; Terracciano LM; Boll DT. Quantitative imaging in medicine and surgery. 2022.

Epigenetic priming in chronic liver disease impacts the transcriptional and genetic landscapes of hepatocellular carcinoma.

Gallon J; Coto-Llerena M; Ercan C; Bianco G; Paradiso V; Nuciforo S; Taha-Melitz S; Meier MA; Boldanova T; Pérez-Del-Pulgar S; Rodríguez-Tajes S; von Flüe M; Soysal SD; Kollmar O; Llovet JM; Villanueva A; Terracciano LM; Heim MH; Ng CKY; Piscuoglio S. Molecular oncology. 2022.

Genomic analysis of focal nodular hyperplasia with associated hepatocellular carcinoma unveils its malignant potential: a case report.

Ercan C; Coto-Llerena M; Gallon J; Fourie L; Marinucci M; Hess GF; Vosbeck J; Taha-Mehlitz S; Boldanova T; Meier MA; Tzankov A; Matter MS; Hoffmann MHK; Di Tommaso L; von Flüe M; Ng CKY; Heim MH; Soysal SD; Terracciano LM; Kollmar O; Piscuoglio S. Communications medicine. 2022.

Impact of propofol sedation on the diagnostic accuracy of hepatic venous pressure gradient measurements in patients with cirrhosis.

Ebrahimi F; Semela D; Heim M. Hepatology international. 2022.

Integrative proteogenomic characterization of hepatocellular carcinoma across etiologies and stages.

Ng CKY; Dazert E; Boldanova T; Coto-Llerena M; Nuciforo S; Ercan C; Suslov A; Meier MA; Bock T; Schmidt A; Ketterer S; Wang X; Wieland S; Matter MS; Colombi M; Piscuoglio S; Terracciano LM; Hall MN; Heim MH. Nature Communications. 2022.

Multi-omics subtyping of hepatocellular carcinoma patients using a Bayesian network mixture model

Suter P.; Dazert E.; Kuipers J.; Ng C.K.Y.; Boldanova T.; Hall M.N.; Heim M.H.; Beerenwinkel N.. PLoS Computational Biology. 2022.

Patient-derived tumor organoids for personalized medicine in a patient with rare hepatocellular carcinoma with neuroendocrine differentiation: a case report.

Meier MA; Nuciforo S; Coto-Llerena M; Gallon J; Matter MS; Ercan C; Vosbeck J; Terracciano LM; Soysal SD; Boll D; Kollmar O; Delaloye R; Piscuoglio S; Heim MH. Communications medicine. 2022.

Stimulatory MAIT cell antigens reach the circulation and are efficiently metabolised and presented by human liver cells.

Lett MJ; Mehta H; Keogh A; Jaeger T; Jacquet M; Powell K; Meier MA; Fofana I; Melhem H; Vosbeck J; Cathomas G; Heigl A; Heim MH; Burri E; Mertz KD; Niess JH; Kollmar O; Zech CJ; Ivanek R; Duthaler U; Klenerman P; Stroka D; Filipowicz Sinnreich M. Gut. 2022.

Studying Hepatitis Virus-Host Interactions in Patient Liver Biopsies.

Suslov A; Heim MH; Wieland S. Viruses. 2022.

Transcription factors TEAD2 and E2A globally repress acetyl-CoA synthesis to promote tumorigenesis

Park S.; Mossmann D.; Chen Q.; Wang X.; Dazert E.; Colombi M.; Schmidt A.; Ryback B.; Ng C.K.Y.; Terracciano L.M.; Heim M.H.; Hall M.N.. Molecular Cell. 2022.

Interferon lambda 4 can directly activate human CD19(+) B cells and CD8(+) T cells.

Coto-Llerena M; Lepore M; Spagnuolo J; Di Blasi D; Calabrese D; Suslov A; Bantug G; Duong FH; Terracciano LM; De Libero G; Heim MH. Life Science Alliance. 2021.

Interferon lambda 4 impairs hepatitis C viral antigen presentation and attenuates T cell responses.

Chen Q; Coto-Llerena M; Suslov A; Teixeira RD; Fofana I; Nuciforo S; Hofmann M; Thimme R; Hensel N; Lohmann V; Ng CKY; Rosenberger G; Wieland S; Heim MH. Nature Communications. 2021.

Organoids to model liver disease.

Nuciforo S; Heim MH. JHEP reports : innovation in hepatology. 2021.

Peroxisomal β-oxidation acts as a sensor for intracellular fatty acids and regulates lipolysis

Ding L.; Sun W.; Balaz M.; He A.; Klug M.; Wieland S.; Caiazzo R.; Raverdy V.; Pattou F.; Lefebvre P.; Lodhi I.J.; Staels B.; Heim M.; Wolfrum C.. Nature Metabolism. 2021.

Response prediction of hepatocellular carcinoma undergoing transcatheter arterial chemoembolization: unlocking the potential of CT texture analysis through nested decision tree models.

Vosshenrich J; Zech CJ; Heye T; Boldanova T; Fucile G; Wieland S; Heim MH; Boll DT. European Radiology. 2021.

Supervised learning based on tumor imaging and biopsy transcriptomics predicts response of hepatocellular carcinoma to transarterial chemoembolization.

Boldanova T; Fucile G; Vosshenrich J; Suslov A; Ercan C; Coto-Llerena M; Terracciano LM; Zech CJ; Boll DT; Wieland S; Heim MH. Cell reports. Medicine. 2021.

Transition to HBeAg-negative chronic hepatitis B virus infection is associated with reduced cccDNA transcriptional activity.

Suslov A; Meier MA; Ketterer S; Wang X; Wieland S; Heim MH. Journal of Hepatology. 2021.

Ubiquitous expression of HBsAg from integrated HBV DNA in patients with low viral load.

Meier MA; Calabrese D; Suslov A; Terracciano LM; Heim MH; Wieland S. Journal of Hepatology. 2021.

USP29-mediated HIF1α stabilization is associated with Sorafenib resistance of hepatocellular carcinoma cells by upregulating glycolysis

Gao R.; Buechel D.; Kalathur R.K.R.; Morini M.F.; Coto-Llerena M.; Ercan C.; Piscuoglio S.; Chen Q.; Blumer T.; Wang X.; Dazert E.; Heim M.H.; Hall M.N.; Tang F.; Christofori G.. Oncogenesis. 2021.

All-cause mortality and causes of death in the swiss hepatitis C cohort study (SCCS)

Roelens M.; Bertisch B.; Moradpour D.; Cerny A.; Semmo N.; Schmid P.; Mullhaupt B.; Clerc O.; Semela D.; Junker C.; Negro F.; Keiser O.; Negro F.; Kaiser L.; Heim M.; Hirsch H.; Semmo N.; Suter F.; Moradpour D.; Aubert V.; Siegrist H.; Cerny A.; Martinetti-Lucchini G.; Clerc O.; Semela D.; Schmid P.; Dollenmaier G.; Mullhaupt B.; Probst-Muller E.; Benkert P.; Fabbro T.; Rutquist M.; Sluka C.. Open Forum Infectious Diseases. 2020.

C19orf66 is an interferon-induced inhibitor of HCV replication that restricts formation of the viral replication organelle.

Kinast V; Plociennikowska A; Anggakusuma; Bracht T; Todt D; Brown RJP; Boldanova T; Zhang Y; Brüggemann Y; Friesland M; Engelmann M; Vieyres G; Broering R; Vondran FWR; Heim MH; Sitek B; Bartenschlager R; Pietschmann T; Steinmann E. Journal of Hepatology. 2020.

Corrigendum to "HMGA1 expression in human hepatocellular carcinoma correlates with poor prognosis and promotes tumor growth and migration in in vitro models" [Neoplasia 18 (2016) 724-731].

Andreozzi M; Quintavalle C; Benz D; Quagliata L; Matter M; Calabrese D; Tosti N; Ruiz C; Trapani F; Tornillo L; Fusco A; Heim MH; Ng CKY; Pallante P; Terracciano LM; Piscuoglio S. . 2020.

Expression of AXL receptor tyrosine kinase relates to monocyte dysfunction and severity of cirrhosis.

Brenig R; Pop OT; Triantafyllou E; Geng A; Singanayagam A; Perez-Shibayama C; Besse L; Cupovic J; Künzler P; Boldanova T; Brand S; Semela D; Duong FH; Weston CJ; Ludewig B; Heim MH; Wendon J; Antoniades CG; Bernsmeier C. Life Science Alliance. 2020.

Management of hepatocellular carcinoma: SASL expert opinion statement.

Goossens N; Toso C; Heim MH. Swiss medical weekly. 2020.

Mechano-modulatory synthetic niches for liver organoid derivation.

Sorrentino G; Rezakhani S; Yildiz E; Nuciforo S; Heim MH; Lutolf MP; Schoonjans K. Nature Communications. 2020.

OCIAD1 is a host mitochondrial substrate of the hepatitis C virus NS3-4A protease.

Tran HTL; Morikawa K; Anggakusuma; Zibi R; Thi VLD; Penin F; Heim MH; Quadroni M; Pietschmann T; Gouttenoire J; Moradpour D. PLoS ONE. 2020.

Unique T-Cell Populations Define Immune-Inflamed Hepatocellular Carcinoma.

Di Blasi D; Boldanova T; Mori L; Terracciano L; Heim MH; De Libero G. Cellular and Molecular Gastroenterology and Hepatology. 2020.

Danger of Herbal Tea: A Case of Acute Cholestatic Hepatitis Due to Artemisia annua Tea.

Ruperti-Repilado FJ; Haefliger S; Rehm S; Zweier M; Rentsch KM; Blum J; Jetter A; Heim M; Leuppi-Taegtmeyer A; Terracciano L; Bernsmeier C. Frontiers in Medicine. 2019.

Hepatocellular Carcinoma Xenografts Established From Needle Biopsies Preserve the Characteristics of the Originating Tumors

Blumer T.; Fofana I.; Matter M.S.; Wang X.; Montazeri H.; Calabrese D.; Coto-Llerena M.; Boldanova T.; Nuciforo S.; Kancherla V.; Tornillo L.; Piscuoglio S.; Wieland S.; Terracciano L.M.; Ng C.K.Y.; Heim M.H.. Hepatology Communications. 2019.

LATS1 but not LATS2 represses autophagy by a kinase-independent scaffold function.

Tang F; Gao R; Jeevan-Raj B; Wyss CB; Kalathur RKR; Piscuoglio S; Ng CKY; Hindupur SK; Nuciforo S; Dazert E; Bock T; Song S; Buechel D; Morini MF; Hergovich A; Matthias P; Lim DS; Terracciano LM; Heim MH; Hall MN; Christofori G. Nature Communications. 2019.

Liver biopsy derived induced pluripotent stem cells provide unlimited supply for the generation of hepatocyte-like cells.

Calabrese D; Roma G; Bergling S; Carbone W; Mele V; Nuciforo S; Fofana I; Campana B; Szkolnicka D; Hay DC; Tchorz J; Bouwmeester T; Wieland S; Heim MH. PLoS ONE. 2019.

Mapping the Heterogeneity of Histone Modifications on Hepatitis B Virus DNA Using Liver Needle Biopsies Obtained from Chronically Infected Patients.

Flecken T; Meier MA; Skewes-Cox P; Barkan DT; Heim MH; Wieland SF; Holdorf MM. . 2019.

The IFN-λ Pony Express.

Wieland SF; Heim MH. . 2019.

Diagnostic Targeted Sequencing Panel for Hepatocellular Carcinoma Genomic Screening.

Paradiso V; Garofoli A; Tosti N; Lanzafame M; Perrina V; Quagliata L; Matter MS; Wieland S; Heim MH; Piscuoglio S; Ng CKY; Terracciano LM. The Journal of molecular diagnostics : JMD. 2018.

Effect of hepatitis B virus on steatosis in hepatitis C virus co-infected subjects: A multi-centre study and systematic review.

Goossens N; de Vito C; Mangia A; Clément S; Cenderello G; Barrera F; D'Ambrosio R; Coppola N; Zampino R; Stanzione M; Adinolfi LE; Wedemeyer H; Semmo N; Müllhaupt B; Semela D; Malinverni R; Moradpour D; Heim M; Trincucci G; Rubbia-Brandt L; Negro F; BOSTIC Study Group. Journal of Viral Hepatitis. 2018.

Genetic profiling using plasma-derived cell-free DNA in therapy-naïve hepatocellular carcinoma patients: a pilot study.

Ng CKY; Di Costanzo GG; Tosti N; Paradiso V; Coto-Llerena M; Roscigno G; Perrina V; Quintavalle C; Boldanova T; Wieland S; Marino-Marsilia G; Lanzafame M; Quagliata L; Condorelli G; Matter MS; Tortora R; Heim MH; Terracciano LM; Piscuoglio S. Annals of Oncology. 2018.

Growth of Epithelial Organoids in a Defined Hydrogel.

Broguiere N; Isenmann L; Hirt C; Ringel T; Placzek S; Cavalli E; Ringnalda F; Villiger L; Züllig R; Lehmann R; Rogler G; Heim MH; Schüler J; Zenobi-Wong M; Schwank G. Advanced Materials. 2018.

Hepatitis B Virus Does Not Interfere With Innate Immune Responses in the Human Liver.

Suslov A; Boldanova T; Wang X; Wieland S; Heim MH. Gastroenterology. 2018.

In vivo analysis at the cellular level reveals similar steatosis induction in both hepatitis C virus genotype 1 and 3 infections.

Campana B; Calabrese D; Matter MS; Terracciano LM; Wieland SF; Heim MH. Journal of Viral Hepatitis. 2018.

miR-135a-5p-mediated downregulation of protein tyrosine phosphatase receptor delta is a candidate driver of HCV-associated hepatocarcinogenesis.

Van Renne N; Roca Suarez AA; Duong FHT; Gondeau C; Calabrese D; Fontaine N; Ababsa A; Bandiera S; Croonenborghs T; Pochet N; De Blasi V; Pessaux P; Piardi T; Sommacale D; Ono A; Chayama K; Fujita M; Nakagawa H; Hoshida Y; Zeisel MB; Heim MH; Baumert TF; Lupberger J. Gut. 2018.

New insights into HDV-induced innate immunity: MDA5 senses HDV replication.

Suslov A; Heim MH; Wieland S. Journal of Hepatology. 2018.

Organoid Models of Human Liver Cancers Derived from Tumor Needle Biopsies.

Nuciforo S; Fofana I; Matter MS; Blumer T; Calabrese D; Boldanova T; Piscuoglio S; Wieland S; Ringnalda F; Schwank G; Terracciano LM; Ng CKY; Heim MH. Cell Reports. 2018.

The protein histidine phosphatase LHPP is a tumour suppressor.

Hindupur SK; Colombi M; Fuhs SR; Matter MS; Guri Y; Adam K; Cornu M; Piscuoglio S; Ng CKY; Betz C; Liko D; Quagliata L; Moes S; Jenoe P; Terracciano LM; Heim MH; Hunter T; Hall MN. Nature. 2018.

A systematic review and meta-analysis of HCV clearance.

Gauthiez E; Habfast-Robertson I; Rüeger S; Kutalik Z; Aubert V; Berg T; Cerny A; Gorgievski M; George J; Heim MH; Malinverni R; Moradpour D; Müllhaupt B; Negro F; Semela D; Semmo N; Villard J; Bibert S; Bochud PY; Swiss Hepatitis C Cohort Study. Liver International. 2017.

Hepatitis B virus covalently closed circular DNA homeostasis is independent of the lymphotoxin pathway during chronic HBV infection.

Meier MA; Suslov A; Ketterer S; Heim MH; Wieland SF. Journal of Viral Hepatitis. 2017.

Hepatitis B virus does not suppress the innate immune responses in the liver

Suslov, A.; Calabrese, D.; Boldanova, T.; Wieland, S.; Heim, M.. Journal of Hepatology. 2017.

Hepatitis C virus-induced epigenetic changes associated with hepatocarcinogenesis persist following viral cure

Juhling, Frank; Hamdane, Nourdine; Thumann, Christine; Oudot, Marine A.; El Saghire, Hussein; Bandiera, Simonetta; Saviano, Antonio; Schmidl, Christian; Bock, Christoph; Davidson, Irwin; Pessaux, Patrick; Habersetzer, FranOois; Wieland, Stefan; Heim, Markus H.; Piardi, Tullio; Sommacale, Daniele; Fuchs, Bryan C.; Bardeesy, Nabeel; Hoshida, Yujin; Zeisel, Mirjam B.; Baumert, Thomas F.. Hepatology. 2017.

Liver damage and senescence increases in patients developing hepatocellular carcinoma.

Rey S; Quintavalle C; Burmeister K; Calabrese D; Schlageter M; Quagliata L; Cathomas G; Diebold J; Molinolo A; Heim MH; Terracciano LM; Matter MS. Journal of gastroenterology and hepatology. 2017.

mTORC2 Promotes Tumorigenesis via Lipid Synthesis

Guri, Yakir; Colombi, Marco; Dazert, Eva; Hindupur, Sravanth K.; Roszik, Jason; Moes, Suzette; Jenoe, Paul; Heim, Markus H.; Riezman, Isabelle; Riezman, Howard; Hall, Michael N.. Cancer Cell. 2017.

Phosphoprotein enriched in diabetes (PED/PEA15) promotes migration in hepatocellular carcinoma and confers resistance to sorafenib.

Quintavalle C; Hindupur SK; Quagliata L; Pallante P; Nigro C; Condorelli G; Andersen JB; Tagscherer KE; Roth W; Beguinot F; Heim MH; Ng CKY; Piscuoglio S; Matter MS. Cell death & disease. 2017.

SOCS1 is an inducible negative regulator of interferon lambda (IFN-lambda)-induced gene expression in vivo

Blumer, Tanja; Coto-Llerena, Mairene; Duong, Francois H. T.; Heim, Markus H.. Journal of Biological Chemistry. 2017.

Transcriptional response to hepatitis C virus infection and interferon-alpha treatment in the human liver.

Boldanova T; Suslov A; Heim MH; Necsulea A. EMBO Molecular Medicine. 2017.

Transcriptional response to hepatitis C virus infection in the human liver

Boldanova, T.; Suslov, A.; Heim, M. H.; Necsulea, A.. Journal of Hepatology. 2017.

Trends in Hepatitis C-related mortality in Switzerland

Keiser, O.; Giudici, F.; Bruggmann, P.; Dufour, J. -F.; Moradpour, D.; Semela, D.; Heim, M.; Mullhaupt, B.; Beretta-Piccoli, B. T.; Malinverni, R.; Negro, F.; Sporri, A.. Journal of Hepatology. 2017.

A new 3p25 locus is associated with liver fibrosis progression in human immunodeficiency virus/hepatitis C virus-coinfected patients.

Ulveling D; Le Clerc S; Cobat A; Labib T; Noirel J; Laville V; Coulonges C; Carpentier W; Nalpas B; Heim MH; Poynard T; Cerny A; Pol S; Bochud PY; Dabis F; Theodorou I; Lévy Y; Salmon D; Abel L; Dominguez S; Zagury JF; HEPAVIH ANRS CO13 Cohort Study Group; Swiss Hepatitis C Cohort Study Group; French ANRS HC EP 26 Genoscan Study Group. Hepatology. 2016.

Characteristics of foreign-born persons in the Swiss hepatitis C cohort study: Implications for screening recommendations

Bertisch B.; Giudici F.; Negro F.; Moradpour D.; Mullhaupt B.; Moriggia A.; Estill J.; Keiser O.; Kaiser L.; Heim M.; Hirsch H.; Dufour J.-F.; Gorgievski M.; Aubert V.; Siegrist H.H.; Cerny A.; Lucchini G.M.; Malinverni R.; Semela D.; Schmid P.; Dollenmaier G.; Probst-Muller E.; Fabbro T.; Rudquist M.; Benkert P.. PLoS ONE. 2016.

Gene expression analysis of biopsy samples reveals critical limitations of transcriptome-based molecular classifications of hepatocellular carcinoma.

Makowska Z; Boldanova T; Adametz D; Quagliata L; Vogt JE; Dill MT; Matter MS; Roth V; Terracciano L; Heim MH. The journal of pathology. Clinical research. 2016.

Hepatic Deletion of Janus Kinase 2 Counteracts Oxidative Stress in Mice.

Themanns M; Mueller KM; Kessler SM; Golob-Schwarzl N; Mohr T; Kaltenecker D; Bourgeais J; Paier-Pourani J; Friedbichler K; Schneller D; Schlederer M; Zebedin-Brandl E; Terracciano LM; Han X; Kenner L; Wagner KU; Mikulits W; Kozlov AV; Heim MH; Gouilleux F; Haybaeck J; Moriggl R. Scientific Reports. 2016.

Hepatic Notch1 deletion predisposes to diabetes and steatosis via glucose-6-phosphatase and perilipin-5 upregulation.

Bernsmeier C; Dill MT; Provenzano A; Makowska Z; Krol I; Muscogiuri G; Semela D; Tornillo L; Marra F; Heim MH; Duong FH. Laboratory investigation; a journal of technical methods and pathology. 2016.

Hepatic Notch1 deletion predisposes to diabetes and steatosis via glucose-6-phosphatase and perilipin-5 upregulation.

Bernsmeier C; Dill MT; Provenzano A; Makowska Z; Krol I; Muscogiuri G; Semela D; Tornillo L; Marra F; Heim MH; Duong FH. Laboratory investigation; a journal of technical methods and pathology. 2016.

Hepatitis C Virus-Induced Upregulation of MicroRNA miR-146a-5p in Hepatocytes Promotes Viral Infection and Deregulates Metabolic Pathways Associated with Liver Disease Pathogenesis.

Bandiera S; Pernot S; El Saghire H; Durand SC; Thumann C; Crouchet E; Ye T; Fofana I; Oudot MA; Barths J; Schuster C; Pessaux P; Heim MH; Baumert TF; Zeisel MB. Journal of Virology. 2016.

HMGA1 Expression in Human Hepatocellular Carcinoma Correlates with Poor Prognosis and Promotes Tumor Growth and Migration in in vitro Models.

Andreozzi M; Quintavalle C; Benz D; Quagliata L; Matter M; Calabrese D; Tosti N; Ruiz C; Trapani F; Tornillo L; Fusco A; Heim MH; Ng CK; Pallante P; Terracciano LM; Piscuoglio S. Neoplasia (United States). 2016.

Host - hepatitis C viral interactions: The role of genetics.

Heim MH; Bochud PY; George J. Journal of Hepatology. 2016.


Van Renne, N.; Duong, F. H. T.; Gondeau, C.; Calabrese, D.; Fontaine, N.; Roca-Suarez, A. A.; Pessaux, P.; Heim, M. H.; Baumert, T. F.; Lupberger, J.. Journal of Hepatology. 2016.


Pernot, S.; Bandiera, S.; El Saghire, H.; Durand, S. C.; Ye, T.; Thumann, C.; Crouchet, E.; Schuster, C.; Fofana, I.; Heim, M. H.; Baumert, T. F.; Zeisel, M. B.. Journal of Hepatology. 2016.

Quantitative proteomics and phosphoproteomics on serial tumor biopsies from a sorafenib-treated HCC patient.

Dazert E; Colombi M; Boldanova T; Moes S; Adametz D; Quagliata L; Roth V; Terracciano L; Heim MH; Jenoe P; Hall MN. Proceedings of the National Academy of Sciences of the United States of America. 2016.

The RNA-binding protein vigilin regulates VLDL secretion through modulation of Apob mRNA translation.

Mobin MB; Gerstberger S; Teupser D; Campana B; Charisse K; Heim MH; Manoharan M; Tuschl T; Stoffel M. Nature Communications. 2016.

The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size.

Planas-Paz L; Orsini V; Boulter L; Calabrese D; Pikiolek M; Nigsch F; Xie Y; Roma G; Donovan A; Marti P; Beckmann N; Dill MT; Carbone W; Bergling S; Isken A; Mueller M; Kinzel B; Yang Y; Mao X; Nicholson TB; Zamponi R; Capodieci P; Valdez R; Rivera D; Loew A; Ukomadu C; Terracciano LM; Bouwmeester T; Cong F; Heim MH; Forbes SJ; Ruffner H; Tchorz JS. Nature Cell Biology. 2016.

Virus-induced suppression of the tumor suppressor protein-tyrosine phosphatase delta via miR135a-5p promotes a STAT3 transcriptional program in livers of HCV patients

Van Renne, Nicolaas; Duong, Francois H.; Gondeau, Claire; Calabrese, Diego; Roca-Suarez, Armando A.; Pessaux, Patrick; Heim, Markus H.; Baumert, Thomas F.; Lupberger, Joachim. Hepatology. 2016.

An intrahepatic transcriptional signature of enhanced immune activity predicts response to peginterferon in chronic hepatitis B.

Jansen L; de Niet A; Makowska Z; Dill MT; van Dort KA; Terpstra V; Bart Takkenberg R; Janssen HL; Heim MH; Kootstra NA; Reesink HW. Liver International. 2015.

Clearance of persistent hepatitis C virus infection in humanized mice using a claudin-1-targeting monoclonal antibody.

Mailly L; Xiao F; Lupberger J; Wilson GK; Aubert P; Duong FHT; Calabrese D; Leboeuf C; Fofana I; Thumann C; Bandiera S; Lütgehetmann M; Volz T; Davis C; Harris HJ; Mee CJ; Girardi E; Chane-Woon-Ming B; Ericsson M; Fletcher N; Bartenschlager R; Pessaux P; Vercauteren K; Meuleman P; Villa P; Kaderali L; Pfeffer S; Heim MH; Neunlist M; Zeisel MB; Dandri M; McKeating JA; Robinet E; Baumert TF. Nature Biotechnology. 2015.

Clinical course of infection and viral tissue tropism of hepatitis C virus-like nonprimate hepaciviruses in horses.

Pfaender S; Cavalleri JM; Walter S; Doerrbecker J; Campana B; Brown RJ; Burbelo PD; Postel A; Hahn K; Anggakusuma; Riebesehl N; Baumgärtner W; Becher P; Heim MH; Pietschmann T; Feige K; Steinmann E. Hepatology. 2015.

Corrigendum: reduced IFNλ4 activity is associated with improved HCV clearance and reduced expression of interferon-stimulated genes.

Terczyńska-Dyla E; Bibert S; Duong FHT; Krol I; Jørgensen S; Collinet E; Kutalik Z; Aubert V; Cerny A; Kaiser L; Malinverni R; Mangia A; Moradpour D; Müllhaupt B; Negro F; Santoro R; Semela D; Semmo N; Swiss Hepatitis C Cohort Study Group; Heim MH; Bochud PY; Hartmann R. Nature Communications. 2015.

Generation of a murine hepatic angiosarcoma cell line and reproducible mouse tumor model.

Rothweiler S; Dill MT; Terracciano L; Makowska Z; Quagliata L; Hlushchuk R; Djonov V; Heim MH; Semela D. Laboratory investigation; a journal of technical methods and pathology. 2015.

Impact of common risk factors of fibrosis progression in chronic hepatitis C.

Rüeger S; Bochud PY; Dufour JF; Müllhaupt B; Semela D; Heim MH; Moradpour D; Cerny A; Malinverni R; Booth DR; Suppiah V; George J; Argiro L; Halfon P; Bourlière M; Talal AH; Jacobson IM; Patin E; Nalpas B; Poynard T; Pol S; Abel L; Kutalik Z; Negro F. Gut. 2015.

Interferon-inducible cholesterol-25-hydroxylase restricts hepatitis C virus replication through blockage of membranous web formation.

Anggakusuma; Romero-Brey I; Berger C; Colpitts CC; Boldanova T; Engelmann M; Todt D; Perin PM; Behrendt P; Vondran FW; Xu S; Goffinet C; Schang LM; Heim MH; Bartenschlager R; Pietschmann T; Steinmann E. Hepatology. 2015.

Interferon signaling

Heim M.H.. . 2015.

Sleep Disruption and Daytime Sleepiness Correlating with Disease Severity and Insulin Resistance in Non-Alcoholic Fatty Liver Disease: A Comparison with Healthy Controls.

Bernsmeier C; Weisskopf DM; Pflueger MO; Mosimann J; Campana B; Terracciano L; Beglinger C; Heim MH; Cajochen C. PLoS ONE. 2015.

Ultrasound surveillance for hepatocellular carcinoma: real-life performance in a hepatology outpatient clinic.

Frey RS; Boldanova T; Heim M. Swiss medical weekly. 2015.

YAP promotes proliferation, chemoresistance, and angiogenesis in human cholangiocarcinoma through TEAD transcription factors.

Marti P; Stein C; Blumer T; Abraham Y; Dill MT; Pikiolek M; Orsini V; Jurisic G; Megel P; Makowska Z; Agarinis C; Tornillo L; Bouwmeester T; Ruffner H; Bauer A; Parker CN; Schmelzle T; Terracciano LM; Heim MH; Tchorz JS. Hepatology. 2015.

[Hepatitis B and C: From molecular virology to new antiviral therapies (part 1)].

Thimme R; Heim M; Baumert TF; Nassal M; Moradpour D. Deutsche Medizinische Wochenschrift. 2014.

[Hepatitis B and C: from molecular virology to new antiviral therapies (part 2)].

Thimme R; Heim M; Baumert TF; Nassal M; Moradpour D. Deutsche Medizinische Wochenschrift. 2014.

Cell entry, efficient RNA replication, and production of infectious hepatitis C virus progeny in mouse liver-derived cells.

Frentzen A; Anggakusuma; Gürlevik E; Hueging K; Knocke S; Ginkel C; Brown RJ; Heim M; Dill MT; Kröger A; Kalinke U; Kaderali L; Kuehnel F; Pietschmann T. Hepatology. 2014.

Clinical significance of the CCR5delta32 allele in hepatitis C.

Morard I; Clément S; Calmy A; Mangia A; Cerny A; De Gottardi A; Gorgievski M; Heim M; Malinverni R; Moradpour D; Müllhaupt B; Semela D; Pascarella S; Bochud PY; Negro F; Swiss Hepatitis C Cohort Study Group. PLoS ONE. 2014.

Downregulation of the endothelial genes Notch1 and ephrinB2 in patients with nodular regenerative hyperplasia.

Rothweiler S; Terracciano L; Tornillo L; Dill MT; Heim MH; Semela D. Liver International. 2014.

Elderly age is not a negative predictive factor for virological response to therapy with pegylated interferon-α and ribavirin in chronic hepatitis C virus patients.

Frei P; Leucht AK; Held U; Kofmehl R; Manser CN; Schmitt J; Mertens J; Rau M; Baur K; Gerlach T; Negro F; Heim M; Moradpour D; Cerny A; Dufour JF; Müllhaupt B; Geier A; Swiss Hepatitis C Cohort Study Group. Liver International. 2014.

Glucose-induced glucagon-like Peptide 1 secretion is deficient in patients with non-alcoholic fatty liver disease.

Bernsmeier C; Meyer-Gerspach AC; Blaser LS; Jeker L; Steinert RE; Heim MH; Beglinger C. PLoS ONE. 2014.

Hepatitis C virus dysregulates glucose homeostasis by a dual mechanism involving induction of PGC1α and dephosphorylation of FoxO1.

Bernsmeier C; Calabrese D; Heim MH; Duong HT. Journal of Viral Hepatitis. 2014.

IFN-λ receptor 1 expression is induced in chronic hepatitis C and correlates with the IFN-λ3 genotype and with nonresponsiveness to IFN-α therapies.

Duong FH; Trincucci G; Boldanova T; Calabrese D; Campana B; Krol I; Durand SC; Heydmann L; Zeisel MB; Baumert TF; Heim MH. Journal of Experimental Medicine. 2014.

Innate and adaptive immune responses in HCV infections.

Heim MH; Thimme R. Journal of Hepatology. 2014.

Isolate-dependent use of claudins for cell entry by hepatitis C virus.

Haid S; Grethe C; Dill MT; Heim M; Kaderali L; Pietschmann T. Hepatology. 2014.

Long noncoding RNA HOTTIP/HOXA13 expression is associated with disease progression and predicts outcome in hepatocellular carcinoma patients.

Quagliata L; Matter MS; Piscuoglio S; Arabi L; Ruiz C; Procino A; Kovac M; Moretti F; Makowska Z; Boldanova T; Andersen JB; Hämmerle M; Tornillo L; Heim MH; Diederichs S; Cillo C; Terracciano LM. Hepatology. 2014.

Nodular regenerative hyperplasia in a patient with generalized essential telangiectasia: endotheliopathy as a causal factor.

Rothweiler S; Heim MH; Semela D. Hepatology. 2014.

Novel approach identifies SNPs in SLC2A10 and KCNK9 with evidence for parent-of-origin effect on body mass index.

Hoggart CJ; Venturini G; Mangino M; Gomez F; Ascari G; Zhao JH; Teumer A; Winkler TW; Tšernikova N; Luan J; Mihailov E; Ehret GB; Zhang W; Lamparter D; Esko T; Macé A; Rüeger S; Bochud PY; Barcella M; Dauvilliers Y; Benyamin B; Evans DM; Hayward C; Lopez MF; Franke L; Russo A; Heid IM; Salvi E; Vendantam S; Arking DE; Boerwinkle E; Chambers JC; Fiorito G; Grallert H; Guarrera S; Homuth G; Huffman JE; Porteous D; Generation Scotland Consortium; LifeLines Cohort study; GIANT Consortium; Moradpour D; Iranzo A; Hebebrand J; Kemp JP; Lammers GJ; Aubert V; Heim MH; Martin NG; Montgomery GW; Peraita-Adrados R; Santamaria J; Negro F; Schmidt CO; Scott RA; Spector TD; Strauch K; Völzke H; Wareham NJ; Yuan W; Bell JT; Chakravarti A; Kooner JS; Peters A; Matullo G; Wallaschofski H; Whitfield JB; Paccaud F; Vollenweider P; Bergmann S; Beckmann JS; Tafti M; Hastie ND; Cusi D; Bochud M; Frayling TM; Metspalu A; Jarvelin MR; Scherag A; Smith GD; Borecki IB; Rousson V; Hirschhorn JN; Rivolta C; Loos RJ; Kutalik Z. PLoS Genetics. 2014.

Pegylated IFN-α regulates hepatic gene expression through transient Jak/STAT activation.

Dill MT; Makowska Z; Trincucci G; Gruber AJ; Vogt JE; Filipowicz M; Calabrese D; Krol I; Lau DT; Terracciano L; van Nimwegen E; Roth V; Heim MH. Journal of Clinical Investigation. 2014.

Protein phosphatase 2A promotes hepatocellular carcinogenesis in the diethylnitrosamine mouse model through inhibition of p53.

Duong FH; Dill MT; Matter MS; Makowska Z; Calabrese D; Dietsche T; Ketterer S; Terracciano L; Heim MH. Carcinogenesis. 2014.

Quantitative proteomics identifies the membrane-associated peroxidase GPx8 as a cellular substrate of the hepatitis C virus NS3-4A protease.

Morikawa K; Gouttenoire J; Hernandez C; Dao Thi VL; Tran HT; Lange CM; Dill MT; Heim MH; Donzé O; Penin F; Quadroni M; Moradpour D. Hepatology. 2014.

Reduced IFNλ4 activity is associated with improved HCV clearance and reduced expression of interferon-stimulated genes.

Terczyńska-Dyla E; Bibert S; Duong FH; Krol I; Jørgensen S; Collinet E; Kutalik Z; Aubert V; Cerny A; Kaiser L; Malinverni R; Mangia A; Moradpour D; Müllhaupt B; Negro F; Santoro R; Semela D; Semmo N; Swiss Hepatitis C Cohort Study Group; Heim MH; Bochud PY; Hartmann R. Nature Communications. 2014.

SH2D4A is frequently downregulated in hepatocellular carcinoma and cirrhotic nodules.

Quagliata L; Andreozzi M; Kovac M; Tornillo L; Makowska Z; Moretti F; Heim MH; Heinimann K; Piscuoglio S; Terracciano LM. European Journal of Cancer. 2014.

Simultaneous detection of hepatitis C virus and interferon stimulated gene expression in infected human liver.

Wieland S; Makowska Z; Campana B; Calabrese D; Dill MT; Chung J; Chisari FV; Heim MH. Hepatology. 2014.

Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA.

Lucifora J; Xia Y; Reisinger F; Zhang K; Stadler D; Cheng X; Sprinzl MF; Koppensteiner H; Makowska Z; Volz T; Remouchamps C; Chou WM; Thasler WE; Hüser N; Durantel D; Liang TJ; Münk C; Heim MH; Browning JL; Dejardin E; Dandri M; Schindler M; Heikenwalder M; Protzer U. Science. 2014.

Symptomatic hepatocellular liver injury with hyperbilirubinemia in two patients treated with rivaroxaban.

Liakoni E; Rätz Bravo AE; Terracciano L; Heim M; Krähenbühl S. JAMA internal medicine. 2014.

The liver may act as a firewall mediating mutualism between the host and its gut commensal microbiota.

Balmer ML; Slack E; de Gottardi A; Lawson MA; Hapfelmeier S; Miele L; Grieco A; Van Vlierberghe H; Fahrner R; Patuto N; Bernsmeier C; Ronchi F; Wyss M; Stroka D; Dickgreber N; Heim MH; McCoy KD; Macpherson AJ. Science Translational Medicine. 2014.

Vitamin D receptor and Jak-STAT signaling crosstalk results in calcitriol-mediated increase of hepatocellular response to IFN-α.

Lange CM; Gouttenoire J; Duong FH; Morikawa K; Heim MH; Moradpour D. Journal of Immunology. 2014.

[Severe hypertriglyceridemia].

Heim M; Wertli M. Praxis. 2013.

25 years of interferon-based treatment of chronic hepatitis C: an epoch coming to an end

Heim, Markus H.. Nature reviews. Immunology. 2013.

Constitutive Notch2 signaling induces hepatic tumors in mice.

Dill MT; Tornillo L; Fritzius T; Terracciano L; Semela D; Bettler B; Heim MH; Tchorz JS. Hepatology. 2013.

Epidermal growth factor receptor signaling impairs the antiviral activity of interferon-alpha.

Lupberger J; Duong FH; Fofana I; Zona L; Xiao F; Thumann C; Durand SC; Pessaux P; Zeisel MB; Heim MH; Baumert TF. Hepatology. 2013.

Faldaprevir (BI 201335), deleobuvir (BI 207127) and ribavirin oral therapy for treatment-naive HCV genotype 1: SOUND-C1 final results.

Zeuzem S; Asselah T; Angus P; Zarski JP; Larrey D; Müllhaupt B; Gane E; Schuchmann M; Lohse AW; Pol S; Bronowicki JP; Roberts S; Arasteh K; Zoulim F; Heim M; Stern JO; Nehmiz G; Kukolj G; Böcher WO; Mensa FJ. Antiviral Therapy. 2013.

Genetic analyses reveal a role for vitamin D insufficiency in HCV-associated hepatocellular carcinoma development.

Lange CM; Miki D; Ochi H; Nischalke HD; Bojunga J; Bibert S; Morikawa K; Gouttenoire J; Cerny A; Dufour JF; Gorgievski-Hrisoho M; Heim MH; Malinverni R; Müllhaupt B; Negro F; Semela D; Kutalik Z; Müller T; Spengler U; Berg T; Chayama K; Moradpour D; Bochud PY; Hiroshima Liver Study Group; Swiss Hepatitis C Cohort Study Group. PLoS ONE. 2013.

HRas signal transduction promotes hepatitis C virus cell entry by triggering assembly of the host tetraspanin receptor complex.

Zona L; Lupberger J; Sidahmed-Adrar N; Thumann C; Harris HJ; Barnes A; Florentin J; Tawar RG; Xiao F; Turek M; Durand SC; Duong FH; Heim MH; Cosset FL; Hirsch I; Samuel D; Brino L; Zeisel MB; Le Naour F; McKeating JA; Baumert TF. Cell Host and Microbe. 2013.

Innate immunity and HCV.

Heim MH. Journal of Hepatology. 2013.

Protein phosphatase 2A impairs IFNα-induced antiviral activity against the hepatitis C virus through the inhibition of STAT1 tyrosine phosphorylation

Shanker V.; Trincucci G.; Heim H.M.; Duong H.T.F.. Journal of Viral Hepatitis. 2013.

Reply to miR-122, IL28B genotype and the response to interferon in chronic hepatitis C virus infection.

Heim M. Nature reviews. Immunology. 2013.

Sequential induction of type I and II interferons mediates a long-lasting gene induction in the liver in response to a novel toll-like receptor 9 agonist.

Makowska Z; Blumer T; Duong FH; La Monica N; Kandimalla ER; Heim MH. Journal of Hepatology. 2013.

A genetic validation study reveals a role of vitamin D metabolism in the response to interferon-alfa-based therapy of chronic hepatitis C.

Lange CM; Bibert S; Kutalik Z; Burgisser P; Cerny A; Dufour JF; Geier A; Gerlach TJ; Heim MH; Malinverni R; Negro F; Regenass S; Badenhoop K; Bojunga J; Sarrazin C; Zeuzem S; Müller T; Berg T; Bochud PY; Moradpour D; Swiss Hepatitis C Cohort Study Group. PLoS ONE. 2012.

Characteristics of patients with chronic hepatitis C who develop hepatocellular carcinoma

Kuske L.; Mensen A.; Mullhaupt B.; Negro F.; Semela D.; Moradpour D.; Male P.J.; Heim M.H.; Malinverni R.; Cerny A.; Dufour J.-F.. Swiss Medical Weekly. 2012.

Critical review of the use of erythropoietin in the treatment of anaemia during therapy for chronic hepatitis C.

Stickel F; Helbling B; Heim M; Geier A; Hirschi C; Terziroli B; Wehr K; De Gottardi A; Negro F; Gerlach T. Journal of Viral Hepatitis. 2012.

Disruption of Notch1 induces vascular remodeling, intussusceptive angiogenesis, and angiosarcomas in livers of mice.

Dill MT; Rothweiler S; Djonov V; Hlushchuk R; Tornillo L; Terracciano L; Meili-Butz S; Radtke F; Heim MH; Semela D. Gastroenterology. 2012.

Genome-wide association study identifies variants associated with progression of liver fibrosis from HCV infection.

Patin E; Kutalik Z; Guergnon J; Bibert S; Nalpas B; Jouanguy E; Munteanu M; Bousquet L; Argiro L; Halfon P; Boland A; Müllhaupt B; Semela D; Dufour JF; Heim MH; Moradpour D; Cerny A; Malinverni R; Hirsch H; Martinetti G; Suppiah V; Stewart G; Booth DR; George J; Casanova JL; Bréchot C; Rice CM; Talal AH; Jacobson IM; Bourlière M; Theodorou I; Poynard T; Negro F; Pol S; Bochud PY; Abel L; Swiss Hepatitis C Cohort Study Group, International Hepatitis C Genetics Consortium; French ANRS HC EP 26 Genoscan Study Group. Gastroenterology. 2012.

Growth-hormone-induced signal transducer and activator of transcription 5 signaling causes gigantism, inflammation, and premature death but protects mice from aggressive liver cancer.

Friedbichler K; Themanns M; Mueller KM; Schlederer M; Kornfeld JW; Terracciano LM; Kozlov AV; Haindl S; Kenner L; Kolbe T; Mueller M; Snibson KJ; Heim MH; Moriggl R. Hepatology. 2012.

Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1c.

Hagiwara A; Cornu M; Cybulski N; Polak P; Betz C; Trapani F; Terracciano L; Heim MH; Rüegg MA; Hall MN. Cell Metabolism. 2012.

Hepatitis C virus (HCV) induces formation of stress granules whose proteins regulate HCV RNA replication and virus assembly and egress.

Garaigorta U; Heim MH; Boyd B; Wieland S; Chisari FV. Journal of Virology. 2012.

IL28B alleles associated with poor hepatitis C virus (HCV) clearance protect against inflammation and fibrosis in patients infected with non-1 HCV genotypes.

Bochud PY; Bibert S; Kutalik Z; Patin E; Guergnon J; Nalpas B; Goossens N; Kuske L; Müllhaupt B; Gerlach T; Heim MH; Moradpour D; Cerny A; Malinverni R; Regenass S; Dollenmaier G; Hirsch H; Martinetti G; Gorgiewski M; Bourlière M; Poynard T; Theodorou I; Abel L; Pol S; Dufour JF; Negro F; Swiss Hepatitis C Cohort Study Group; ANRS HC EP 26 Genoscan Study Group. Hepatology. 2012.

Interferons and hepatitis C virus.

Heim MH. Swiss Medical Weekly. 2012.

Interferon signaling in the liver during hepatitis C virus infection.

Makowska Z; Heim MH. Cytokine. 2012.

Interferon-γ-stimulated genes, but not USP18, are expressed in livers of patients with acute hepatitis C.

Dill MT; Makowska Z; Duong FHT; Merkofer F; Filipowicz M; Baumert TF; Tornillo L; Terracciano L; Heim MH. Gastroenterology. 2012.

Rapid and strong antiviral activity of the non-nucleosidic NS5B polymerase inhibitor BI 207127 in combination with peginterferon alfa 2a and ribavirin.

Larrey D; Lohse AW; de Ledinghen V; Trepo C; Gerlach T; Zarski JP; Tran A; Mathurin P; Thimme R; Arastéh K; Trautwein C; Cerny A; Dikopoulos N; Schuchmann M; Heim MH; Gerken G; Stern JO; Wu K; Abdallah N; Girlich B; Scherer J; Berger F; Marquis M; Kukolj G; Böcher W; Steffgen J. Journal of Hepatology. 2012.

Serum ferritin levels are associated with a distinct phenotype of chronic hepatitis C poorly responding to pegylated interferon-alpha and ribavirin therapy.

Lange CM; Kutalik Z; Morikawa K; Bibert S; Cerny A; Dollenmaier G; Dufour JF; Gerlach TJ; Heim MH; Malinverni R; Müllhaupt B; Negro F; Moradpour D; Bochud PY; Swiss Hepatitis C Cohort Study Group. Hepatology. 2012.

Vaniprevir with pegylated interferon alpha-2a and ribavirin in treatment-naïve patients with chronic hepatitis C: A randomized phase II study

Manns M.P.; Gane E.; Rodriguez-Torres M.; Stoehr A.; Yeh C.-T.; Marcellin P.; Wiedmann R.T.; Hwang P.M.; Caro L.; Barnard R.J.; Lee A.W.; Baruch Y.; Benhamou Y.; Cave M.; Davis; Faruqui S.; Fried M.; Godofsky E.; Gschwantler M.; Heim M.; Lai M.-Y.; Lawitz E.; Lurie Y.; Moradpour D.; Mullhaupt B.; Negro F.; Pedersen C.; Planas Vila R.; Russo M.; Safadi R.; Soza A.; Spengler U.; Stauber R.; Urbanek P.; Volchkova E.; Volfova M.; Zeuzem S.. Hepatology. 2012.

[Hepatocellular carcinoma].

Semela D; Heim M. Therapeutische Umschau. 2011.

[Hepatocellular carcinoma].

Semela,David; Heim,Markus. Therapeutische Umschau. 2011.

Efficacy of the Protease Inhibitor BI 201335, Polymerase Inhibitor BI 207127, and Ribavirin in Patients With Chronic HCV Infection

Zeuzem, Stefan; Asselah, Tarik; Angus, Peter; Zarski, Jean-Pierre; Larrey, Dominique; Muellhaupt, Beat; Gane, Ed; Schuchmann, Marcus; Lohse, Ansgar; Pol, Stanislas; Bronowicki, Jean-Pierre; Roberts, Stuart; Arasteh, Keikawus; Zoulim, Fabien; Heim, Markus; Stern, Jerry O.; Kukolj, George; Nehmiz, Gerhard; Haefner, Carla; Boecher, Wulf Otto. Gastroenterology. 2011.

Impairment of hepatic growth hormone and glucocorticoid receptor signaling causes steatosis and hepatocellular carcinoma in mice.

Mueller KM; Kornfeld JW; Friedbichler K; Blaas L; Egger G; Esterbauer H; Hasselblatt P; Schlederer M; Haindl S; Wagner KU; Engblom D; Haemmerle G; Kratky D; Sexl V; Kenner L; Kozlov AV; Terracciano L; Zechner R; Schuetz G; Casanova E; Pospisilik JA; Heim MH; Moriggl R. Hepatology. 2011.

Interferon-induced gene expression is a stronger predictor of treatment response than IL28B genotype in patients with hepatitis C.

Dill MT; Duong FH; Vogt JE; Bibert S; Bochud PY; Terracciano L; Papassotiropoulos A; Roth V; Heim MH. Gastroenterology. 2011.

Interferon-β and interferon-λ signaling is not affected by interferon-induced refractoriness to interferon-α in vivo.

Makowska Z; Duong FH; Trincucci G; Tough DF; Heim MH. Hepatology. 2011.

Is tumor biopsy necessary?

Müllhaupt B; Durand F; Roskams T; Dutkowski P; Heim M. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. 2011.

MicroRNAs 103 and 107 regulate insulin sensitivity.

Trajkovski M; Hausser J; Soutschek J; Bhat B; Akin A; Zavolan M; Heim MH; Stoffel M. Nature. 2011.

Viral genotype-specific role of PNPLA3, PPARG, MTTP, and IL28B in hepatitis C virus-associated steatosis

Cai, Tao; Dufour, Jean-Francois; Muellhaupt, Beat; Gerlach, Tilman; Heim, Markus; Moradpour, Darius; Cerny, Andreas; Malinverni, Raffaele; Kaddai, Vincent; Bochud, Murielle; Negro, Francesco; Bochud, Pierre-Yves. Journal of Hepatology. 2011.

[44 year old gardener with lower back pain, myalgia and fever].

Bareiss D; Semela D; Heim M; Terracciano L; Hunziker S. Praxis. 2010.

[Prophylaxis, diagnosis and therapy of hepatitis C virus (HCV) infection: the German guidelines on the management of HCV infection].

Sarrazin C; Berg T; Ross RS; Schirmacher P; Wedemeyer H; Neumann U; Schmidt HH; Spengler U; Wirth S; Kessler HH; Peck-Radosavljevic M; Ferenci P; Vogel W; Moradpour D; Heim M; Cornberg M; Protzer U; Manns MP; Fleig WE; Dollinger MM; Zeuzem S. Zeitschrift fur Gastroenterologie. 2010.

Cleavage of mitochondrial antiviral signaling protein in the liver of patients with chronic hepatitis C correlates with a reduced activation of the endogenous interferon system.

Bellecave P; Sarasin-Filipowicz M; Donzé O; Kennel A; Gouttenoire J; Meylan E; Terracciano L; Tschopp J; Sarrazin C; Berg T; Moradpour D; Heim MH. Hepatology. 2010.

Continuous administration of sorafenib in combination with transarterial chemoembolization in patients with hepatocellular carcinoma: results of a phase I study.

Dufour JF; Hoppe H; Heim MH; Helbling B; Maurhofer O; Szucs-Farkas Z; Kickuth R; Borner M; Candinas D; Saar B. ONCOLOGIST. 2010.

Effect of antiviral therapy on circulating cytokeratin-18 fragments in patients with chronic hepatitis C.

Sgier C; Müllhaupt B; Gerlach T; Moradpour D; Negro F; Malé PJ; Heim MH; Malinverni R; Cerny A; Dufour JF. Journal of Viral Hepatitis. 2010.

Effect of corticosteroids during ongoing drug exposure in pantoprazole-induced interstitial nephritis.

Kim MJ; Heim M; Mayr M. Nephrology Dialysis Transplantation. 2010.

Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: a genome-wide association study.

Rauch A; Kutalik Z; Descombes P; Cai T; Di Iulio J; Mueller T; Bochud M; Battegay M; Bernasconi E; Borovicka J; Colombo S; Cerny A; Dufour JF; Furrer H; Günthard HF; Heim M; Hirschel B; Malinverni R; Moradpour D; Müllhaupt B; Witteck A; Beckmann JS; Berg T; Bergmann S; Negro F; Telenti A; Bochud PY; Swiss Hepatitis C Cohort Study; Swiss HIV Cohort Study. Gastroenterology. 2010.

Hepatitis C virus-induced up-regulation of protein phosphatase 2A inhibits histone modification and DNA damage repair.

Duong FH; Christen V; Lin S; Heim MH. Hepatology. 2010.

Hepatitis C virus-linked mitochondrial dysfunction promotes hypoxia-inducible factor 1 alpha-mediated glycolytic adaptation.

Ripoli M; D'Aprile A; Quarato G; Sarasin-Filipowicz M; Gouttenoire J; Scrima R; Cela O; Boffoli D; Heim MH; Moradpour D; Capitanio N; Piccoli C. Journal of Virology. 2010.

Interferon-induced gene expression in chronic hepatitis C

Sarasin-Filipowicz M.; Heim M.H.. Future Virology. 2010.

S-adenosyl-methionine and betaine improve early virological response in chronic hepatitis C patients with previous nonresponse.

Filipowicz M; Bernsmeier C; Terracciano L; Duong FH; Heim MH. PLoS ONE. 2010.

Treatment of hepatitis C in HCV mono-infected and in HIV-HCV co-infected patients: an open-labelled comparison study.

Gonvers JJ; Heim MH; Cavassini M; Müllhaupt B; Genné D; Bernasconi E; Borovicka J; Cerny A; Chave JP; Chuard C; Dufour F; Dutoit V; Malinverni R; Monnat M; Negro F; Troilliet N; Oneta C. Swiss medical weekly. 2010.

Alpha interferon induces long-lasting refractoriness of JAK-STAT signaling in the mouse liver through induction of USP18/UBP43.

Sarasin-Filipowicz M; Wang X; Yan M; Duong FH; Poli V; Hilton DJ; Zhang DE; Heim MH. Molecular and Cellular Biology. 2009.

Decreased levels of microRNA miR-122 in individuals with hepatitis C responding poorly to interferon therapy.

Sarasin-Filipowicz M; Krol J; Markiewicz I; Heim MH; Filipowicz W. Nature Medicine. 2009.

Genotype 3 is associated with accelerated fibrosis progression in chronic hepatitis C.

Bochud PY; Cai T; Overbeck K; Bochud M; Dufour JF; Müllhaupt B; Borovicka J; Heim M; Moradpour D; Cerny A; Malinverni R; Francioli P; Negro F; Swiss Hepatitis C Cohort Study Group. Journal of Hepatology. 2009.

HCV innate immune responses.

Heim MH. Viruses. 2009.

Insulin resistance in chronic hepatitis C: Mechanisms and clinical relevance

Bernsmeier C.; Heim M.H.. Swiss Medical Weekly. 2009.

Insulin resistance in chronic hepatitis C: mechanisms and clinical relevance.

Bernsmeier C; Heim MH. Swiss medical weekly. 2009.

Notch2 signaling promotes biliary epithelial cell fate specification and tubulogenesis during bile duct development in mice.

Tchorz JS; Kinter J; Müller M; Tornillo L; Heim MH; Bettler B. Hepatology. 2009.

Pegylated interferon-alpha2a/ribavirin treatment of recurrent hepatitis C after liver transplantation.

Dinges S; Morard I; Heim M; Dufour JF; Müllhaupt B; Giostra E; Clavien PA; Mentha G; Negro F; Swiss Association for the Study of the Liver (SASL 17). Transplant Infectious Disease. 2009.

Hepatitis with fibrin-ring granulomas.

Khanlari B; Bodmer M; Terracciano L; Heim MH; Fluckiger U; Weisser M. Infection. 2008.

Host- rather than virus-related factors reduce health-related quality of life in hepatitis C virus infection.

Helbling B; Overbeck K; Gonvers JJ; Malinverni R; Dufour JF; Borovicka J; Heim M; Cerny A; Negro F; Bucher S; Rickenbach M; Renner EL; Mullhaupt B; Swiss Hepatitis C Cohort Study. Gut. 2008.

Interferon signaling and treatment outcome in chronic hepatitis C.

Sarasin-Filipowicz M; Oakeley EJ; Duong FH; Christen V; Terracciano L; Filipowicz W; Heim MH. Proceedings of the National Academy of Sciences of the United States of America. 2008.

MRI of hepatic adenomatosis: initial observations with gadoxetic acid contrast agent in three patients.

Giovanoli O; Heim M; Terracciano L; Bongartz G; Ledermann HP. American Journal of Roentgenology. 2008.

Polyfunctional HCV-specific T-cell responses are associated with effective control of HCV replication.

Ciuffreda D; Comte D; Cavassini M; Giostra E; Bühler L; Perruchoud M; Heim MH; Battegay M; Genné D; Mulhaupt B; Malinverni R; Oneta C; Bernasconi E; Monnat M; Cerny A; Chuard C; Borovicka J; Mentha G; Pascual M; Gonvers JJ; Pantaleo G; Dutoit V. European Journal of Immunology. 2008.

Regulatory polymorphisms in the promoter of CXCL10 gene and disease progression in male hepatitis B virus carriers.

Deng G; Zhou G; Zhang R; Zhai Y; Zhao W; Yan Z; Deng C; Yuan X; Xu B; Dong X; Zhang X; Zhang X; Yao Z; Shen Y; Qiang B; Wang Y; He F. Gastroenterology. 2008.

Virus-induced over-expression of protein phosphatase 2A inhibits insulin signalling in chronic hepatitis C.

Bernsmeier C; Duong FH; Christen V; Pugnale P; Negro F; Terracciano L; Heim MH. Journal of Hepatology. 2008.

[Delayed upper abdominal pain and tarry stool after transjugular liver biopsy. A 24-old man with hemophilia].

Sawatzki M; Heim M. Praxis. 2007.

Activation of endoplasmic reticulum stress response by hepatitis viruses up-regulates protein phosphatase 2A.

Christen V; Treves S; Duong FH; Heim MH. Hepatology. 2007.

Epidemiology of diseases of the bile ducts and gallbladder

Heim M.H.. . 2007.

Inhibition of alpha interferon signaling by hepatitis B virus.

Christen V; Duong F; Bernsmeier C; Sun D; Nassal M; Heim MH. Journal of Virology. 2007.

Iodide mumps after contrast media imaging: a rare adverse effect to iodine.

Gilgen-Anner Y; Heim M; Ledermann HP; Bircher AJ. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology. 2007.

Mechanisms of interferon resistance

Moradpour D.; Heim M.H.; Blum H.E.. . 2007.

The angiotensin II receptor antagonist candesartan is not effective in reducing portal hypertension in patients with cirrhosis.

Heim MH; Jacob L; Beglinger C. Digestion. 2007.

Comparative immunogenicity of a PreS/S hepatitis B vaccine in non- and low responders to conventional vaccine.

Rendi-Wagner P; Shouval D; Genton B; Lurie Y; Rümke H; Boland G; Cerny A; Heim M; Bach D; Schroeder M; Kollaritsch H. Vaccine. 2006.

S-Adenosylmethionine and betaine correct hepatitis C virus induced inhibition of interferon signaling in vitro.

Duong FH; Christen V; Filipowicz M; Heim MH. Hepatology. 2006.

Contrary to HIV, hepatitis C virus is not associated with erythrocytes in vivo.

Sadallah S; Heim M; Hess C; Klimkait T; Battegay M; Schifferli JA. Journal of Hepatology. 2005.

IL-17 reduces TNF-induced Rantes and VCAM-1 expression.

Schnyder B; Schnyder-Candrian S; Pansky A; Schmitz ML; Heim M; Ryffel B; Moser R. Cytokine. 2005.

Inducible inactivation of Notch1 causes nodular regenerative hyperplasia in mice.

Croquelois A; Blindenbacher A; Terracciano L; Wang X; Langer I; Radtke F; Heim MH. Hepatology. 2005.

Mechanisms of interferon resistance

Moradpour,D; Heim,MH; Blum,HE. . 2005.

RIG-I: an essential regulator of virus-induced interferon production.

Heim MH. Journal of Hepatology. 2005.

Upregulation of protein phosphatase 2Ac by hepatitis C virus modulates NS3 helicase activity through inhibition of protein arginine methyltransferase 1.

Duong FH; Christen V; Berke JM; Penna SH; Moradpour D; Heim MH. Journal of Virology. 2005.

[Autoimmune hepatitis].

Heim MH. Therapeutische Umschau. 2004.

Hepatitis C virus inhibits interferon signaling through up-regulation of protein phosphatase 2A.

Duong FH; Filipowicz M; Tripodi M; La Monica N; Heim MH. Gastroenterology. 2004.

IL-4 and IL-13 up-regulate intestinal trefoil factor expression: requirement for STAT6 and de novo protein synthesis.

Blanchard C; Durual S; Estienne M; Bouzakri K; Heim MH; Blin N; Cuber JC. Journal of Immunology. 2004.

A new survival trick of hepatitis C virus: blocking the activation of interferon regulatory factor-3.

Heim MH. Hepatology. 2003.

Cell lines that allow regulated expression of HCV proteins: Principles and applications

Moradpour D.; Heim M.H.; Cerny A.; Rice C.M.; Blum H.E.. . 2003.

Characterization of phosphopeptide motifs specific for the Src homology 2 domains of signal transducer and activator of transcription 1 (STAT1) and STAT3.

Wiederkehr-Adam M; Ernst P; Müller K; Bieck E; Gombert FO; Ottl J; Graff P; Grossmüller F; Heim MH. Journal of Biological Chemistry. 2003.

Expression of hepatitis c virus proteins inhibits interferon alpha signaling in the liver of transgenic mice.

Blindenbacher A; Duong FH; Hunziker L; Stutvoet ST; Wang X; Terracciano L; Moradpour D; Blum HE; Alonzi T; Tripodi M; La Monica N; Heim MH. Gastroenterology. 2003.

Fulminant liver failure associated with clarithromycin.

Tietz A; Heim MH; Eriksson U; Marsch S; Terracciano L; Krähenbühl S. ANNALS OF PHARMACOTHERAPY. 2003.

Interleukin 6 is important for survival after partial hepatectomy in mice.

Blindenbacher A; Wang X; Langer I; Savino R; Terracciano L; Heim MH. Hepatology. 2003.

Resolving the Role of IL-6 in Liver Regeneration [2] (multiple letters)

Zimmers T.A.; Pierce R.H.; McKillop I.H.; Koniaris L.G.; Heim M.H.. Hepatology. 2003.

The STAT protein family

Heim,MH. . 2003.

CT findings in eosinophilic enterocolitis with predominantly serosal and muscular bowel wall infiltration.

Wiesner W; Kocher T; Heim M; Bongartz G. JBR-BTR. 2002.

Phytochemical inhibition of interleukin-4-activated Stat6 and expression of VCAM-1.

Schnyder B; Schnyder-Candrian S; Panski A; Bömmel H; Heim M; Duschl A; Moser R. Biochemical and Biophysical Research Communications. 2002.

Potentially misleading CT findings in fatty liver cirrhosis [1]

Staedele H.; Wiesner W.; Heim M.; Bongartz G.. European Radiology. 2002.

Hepatitis C: a concise review.

Moradpour D; Wölk B; Cerny A; Heim MH; Blum HE. MINERVA MEDICA. 2001.

Hepatitis C: an update.

Moradpour D; Cerny A; Heim MH; Blum HE. Swiss Medical Weekly. 2001.

Defective Jak-STAT signal transduction pathway in melanoma cells resistant to growth inhibition by interferon-alpha.

Pansky A; Hildebrand P; Fasler-Kan E; Baselgia L; Ketterer S; Beglinger C; Heim MH. International Journal of Cancer. 2000.

Intracellular signalling and antiviral effects of interferons.


Locally inducible CD66a (CEACAM1) as an amplifier of the human intestinal T cell response.

Donda A; Mori L; Shamshiev A; Carena I; Mottet C; Heim MH; Beglinger C; Grunert F; Rochlitz C; Terracciano L; Jantscheff P; De Libero G. European Journal of Immunology. 2000.

Expression of hepatitis C virus proteins inhibits signal transduction through the Jak-STAT pathway.

Heim MH; Moradpour D; Blum HE. Journal of Virology. 1999.

The Jak-STAT pathway: cytokine signalling from the receptor to the nucleus.

Heim MH. Journal of Receptors and Signal Transduction. 1999.

Biological efficacy and signal transduction through STAT proteins of recombinant duck interferon in duck hepatitis B virus infection.

Heuss LT; Heim MH; Schultz U; Wissmann D; Offensperger WB; Staeheli P; Blum HE. The Journal of general virology. 1998.

Growth effects of alpha-interferon but not of bombesin or angiotensin II are mediated by activation of STAT proteins.

Pansky A; Hildebrand P; Heim MH; Eberhard M; Kissel T; Beglinger C. European Journal of Clinical Investigation. 1998.

Interferon-alpha activates signal transducers and activators of transcription 5 and 6 in Daudi cells.

Fasler-Kan E; Pansky A; Wiederkehr M; Battegay M; Heim MH. European journal of biochemistry. 1998.

Interferon-gamma receptor signaling is not required in the effector phase of the alloimmune response.

Steiger JU; Nickerson PW; Hermle M; Thiel G; Heim MH. Transplantation. 1998.

The interleukin-4/interleukin-13 receptor of human synovial fibroblasts: overexpression of the nonsignaling interleukin-13 receptor alpha2.

Feng N; Lugli SM; Schnyder B; Gauchat JF; Graber P; Schlagenhauf E; Schnarr B; Wiederkehr-Adam M; Duschl A; Heim MH; Lutz RA; Moser R. Laboratory investigation; a journal of technical methods and pathology. 1998.

Comparison of the transactivation domains of Stat5 and Stat6 in lymphoid cells and mammary epithelial cells.

Moriggl R; Berchtold S; Friedrich K; Standke GJ; Kammer W; Heim M; Wissler M; Stöcklin E; Gouilleux F; Groner B. Molecular and Cellular Biology. 1997.

Receptors that induce erythroid differentiation of Ba/F3 cells: structural requirements and effect on STAT5 binding.

Pless M; Norga K; Carroll M; Heim MH; D'Andrea AD; Mathey-Prevot B. Blood. 1997.

Specific activation of AP-1 but not Stat3 in regenerating liver in mice.

Heim MH; Gamboni G; Beglinger C; Gyr K. European Journal of Clinical Investigation. 1997.

Tumor necrosis factor alpha enhances the expression of the interleukin (IL)-4 receptor alpha-chain on endothelial cells increasing IL-4 or IL-13-induced Stat6 activation.

Lugli SM; Feng N; Heim MH; Adam M; Schnyder B; Etter H; Yamage M; Eugster HP; Lutz RA; Zurawski G; Moser R. Journal of Biological Chemistry. 1997.

[A case from practice (355). Acute myeloid leukemia. Small and large intestine diverticulosis with suspicion of a covered perforation with chronic abscess formation].

Heim MH. Praxis. 1996.

[A case from practice (357)].

Heim M. Praxis. 1996.

Defective STAT signaling by the leptin receptor in diabetic mice.

Ghilardi N; Ziegler S; Wiestner A; Stoffel R; Heim MH; Skoda RC. Proceedings of the National Academy of Sciences of the United States of America. 1996.

Der fall aus der Praxis (355) patient: Herr F. S., geb. 1919. Leitsymptome: Abdominalschmerzen und gewichtsabnahme

Heim M.H.. Praxis. 1996.

The Jak-STAT pathway: specific signal transduction from the cell membrane to the nucleus.

Heim MH. European Journal of Clinical Investigation. 1996.

Contribution of STAT SH2 groups to specific interferon signaling by the Jak-STAT pathway.

Heim MH; Kerr IM; Stark GR; Darnell JE Jr. Science. 1995.

Evolution of a highly polymorphic human cytochrome P450 gene cluster: CYP2D6.

Heim MH; Meyer UA. GENOMICS. 1992.

Polymerase chain reaction and its potential as a pharmacokinetic tool.

Heim MH. Clinical Pharmacokinetics. 1992.

Acetylation of serotonin in the rabbit pineal gland: an N-acetyltransferase with properties distinct from NAT1 and NAT2 is responsible.

Heim MH; Blum M; Beer M; Meyer UA. Journal of neurochemistry. 1991.

Debrisoquine/sparteine hydroxylation genotype and phenotype: analysis of common mutations and alleles of CYP2D6 in a European population.

Broly F; Gaedigk A; Heim M; Eichelbaum M; Morike K; Meyer UA. DNA AND CELL BIOLOGY. 1991.

Genetic analysis of the interethnic difference between Chinese and Caucasians in the polymorphic metabolism of debrisoquine and codeine.

Johansson I; Yue QY; Dahl ML; Heim M; Säwe J; Bertilsson L; Meyer UA; Sjöqvist F; Ingelman-Sundberg M. European Journal of Clinical Pharmacology. 1991.

Genetic polymorphism of debrisoquine oxidation: restriction fragment analysis and allele-specific amplification of mutant alleles of CYP2D6.

Heim MH; Meyer UA. Methods in Enzymology. 1991.

Molecular mechanism of slow acetylation of drugs and carcinogens in humans.

Blum M; Demierre A; Grant DM; Heim M; Meyer UA. Proceedings of the National Academy of Sciences of the United States of America. 1991.

Predicting debrisoquine phenotype.

Heim M; Meyer UA. The Lancet. 1991.

Genotyping of poor metabolisers of debrisoquine by allele-specific PCR amplification.

Heim M; Meyer UA. The Lancet. 1990.

Human arylamine N-acetyltransferase genes: isolation, chromosomal localization, and functional expression.

Blum M; Grant DM; McBride W; Heim M; Meyer UA. DNA AND CELL BIOLOGY. 1990.

Multiple mutations of the human cytochrome P450IID6 gene (CYP2D6) in poor metabolizers of debrisoquine. Study of the functional significance of individual mutations by expression of chimeric genes.

Kagimoto M; Heim M; Kagimoto K; Zeugin T; Meyer UA. Journal of Biological Chemistry. 1990.

Nucleotide sequence of rabbit NAT1 encoding monomorphic arylamine N-acetyltransferase.

Blum M; Heim M; Meyer UA. Nucleic Acids Research. 1990.

Nucleotide sequence of rabbit NAT2 encoding polymorphic liver arylamine N-acetyltransferase (NAT).

Blum M; Heim M; Meyer UA. Nucleic Acids Research. 1990.